LOCUS       NM_013590               1282 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lysozyme 1 (Lyz1), mRNA.
ACCESSION   NM_013590
VERSION     NM_013590.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Zhang,C., Xiang,C., Zhou,K., Liu,X., Qiao,G., Zhao,Y., Dong,K.,
            Sun,K. and Liu,Z.
  TITLE     Intestinal lysozyme1 deficiency alters microbiota composition and
            impacts host metabolism through the emergence of NAD+-secreting
            ASTB Qing110 bacteria
  JOURNAL   mSystems 9 (3), e0121423 (2024)
   PUBMED   38364095
  REMARK    GeneRIF: Intestinal lysozyme1 deficiency alters microbiota
            composition and impacts host metabolism through the emergence of
            NAD[+]-secreting ASTB Qing110 bacteria.
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1282)
  AUTHORS   Calafiore,M., Fu,Y.Y., Vinci,P., Arnhold,V., Chang,W.Y.,
            Jansen,S.A., Egorova,A., Takashima,S., Kuttiyara,J., Ito,T.,
            Serody,J., Nakae,S., Turnquist,H., van Es,J., Clevers,H.,
            Lindemans,C.A., Blazar,B.R. and Hanash,A.M.
  TITLE     A tissue-intrinsic IL-33/EGF circuit promotes epithelial
            regeneration after intestinal injury
  JOURNAL   Nat Commun 14 (1), 5411 (2023)
   PUBMED   37669929
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1282)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1282)
  AUTHORS   Du,W., Wang,J., Kuo,T., Wang,L., McKimpson,W.M., Son,J.,
            Watanabe,H., Kitamoto,T., Lee,Y., Creusot,R.J., Ratner,L.E.,
            McCune,K., Chen,Y.W., Grubbs,B.H., Thornton,M.E., Fan,J.,
            Sultana,N., Diaz,B.S., Balasubramanian,I., Gao,N., Belvedere,S. and
            Accili,D.
  TITLE     Pharmacological conversion of gut epithelial cells into
            insulin-producing cells lowers glycemia in diabetic animals
  JOURNAL   J Clin Invest 132 (24), e162720 (2022)
   PUBMED   36282594
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1282)
  AUTHORS   Metzger,M., Conrad,S., Alvarez-Bolado,G., Skutella,T. and Just,L.
  TITLE     Gene expression of the repulsive guidance molecules during
            development of the mouse intestine
  JOURNAL   Dev Dyn 234 (1), 169-175 (2005)
   PUBMED   16032658
REFERENCE   7  (bases 1 to 1282)
  AUTHORS   Markart,P., Faust,N., Graf,T., Na,C.L., Weaver,T.E. and Akinbi,H.T.
  TITLE     Comparison of the microbicidal and muramidase activities of mouse
            lysozyme M and P
  JOURNAL   Biochem J 380 (Pt 2), 385-392 (2004)
   PUBMED   14977423
REFERENCE   8  (bases 1 to 1282)
  AUTHORS   Cortopassi,G.A. and Wilson,A.C.
  TITLE     Recent origin of the P lysozyme gene in mice
  JOURNAL   Nucleic Acids Res 18 (7), 1911 (1990)
   PUBMED   2336377
REFERENCE   9  (bases 1 to 1282)
  AUTHORS   Cross,M. and Renkawitz,R.
  TITLE     Repetitive sequence involvement in the duplication and divergence
            of mouse lysozyme genes
  JOURNAL   EMBO J 9 (4), 1283-1288 (1990)
   PUBMED   2323338
REFERENCE   10 (bases 1 to 1282)
  AUTHORS   Hammer,M.F. and Wilson,A.C.
  TITLE     Regulatory and structural genes for lysozymes of mice
  JOURNAL   Genetics 115 (3), 521-533 (1987)
   PUBMED   3569879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061129.1 and CD742179.1.
            
            On Apr 11, 2009 this sequence version replaced NM_013590.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061129.1, BB610427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1263              BC061129.1         1-1263
            1264-1282           CD742179.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.35 cM"
     gene            1..1282
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /note="lysozyme 1"
                     /db_xref="GeneID:17110"
                     /db_xref="MGI:MGI:96902"
     exon            1..166
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..477
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /EC_number="3.2.1.17"
                     /note="lysozyme C-1; lysozyme C type P;
                     1,4-beta-N-acetylmuramidase C; P lysozyme structural;
                     renal amyloidosis; lysozyme f3"
                     /codon_start=1
                     /product="lysozyme C-1 precursor"
                     /protein_id="NP_038618.1"
                     /db_xref="CCDS:CCDS48695.1"
                     /db_xref="GeneID:17110"
                     /db_xref="MGI:MGI:96902"
                     /translation="MKALLTLGLLLLSVTAQAKVYNRCELARILKRNGMDGYRGVKLA
                     DWVCLAQHESNYNTRATNYNRGDRSTDYGIFQINSRYWCNDGKTPRSKNACGINCSAL
                     LQDDITAAIQCAKRVVRDPQGIRAWVAWRTQCQNRDLSQYIRNCGV"
     exon            167..331
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /inference="alignment:Splign:2.1.0"
     exon            332..410
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1265
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /note="hexamer: ATTAAA"
     polyA_site      1265
                     /gene="Lyz1"
                     /gene_synonym="Lyz; Lyzf3; Lzp-s"
                     /note="major polyA site"
ORIGIN      
        1 agccagcagc tgacccagcc tccagtcacc atgaaggctc tcctgactct gggactcctc
       61 ctgctttctg tcactgccca ggccaaggtc tacaatcgtt gtgagttggc cagaattctg
      121 aaaaggaatg gaatggatgg ctaccgtggt gtcaagctgg ctgactgggt gtgtttagct
      181 cagcatgaga gcaattataa cacacgagct acaaactaca accgtggaga ccgaagcacc
      241 gactatggga tatttcagat caatagccga tactggtgta atgatggcaa aaccccaaga
      301 tctaagaatg cctgtgggat caattgcagt gctctgctgc aggatgacat cactgcagcc
      361 atacaatgtg caaagagggt ggtgagagat ccccaaggca ttcgagcatg ggtggcatgg
      421 cgaacacaat gtcaaaaccg agatctgtcc cagtatattc ggaactgcgg agtctgaccg
      481 cggtgtgctt ctactgcagc ccattctgtc tctttctcac tgtaggagta gatatgagag
      541 aggtcacact tcctcgcttt cccctccaag taacaggact tcagcagaaa cagggcaaaa
      601 cagacacttc ctcctcacaa gcttcagctg atgctgtgtt gtgcaaagtc tcccttgtca
      661 gtcagcaaag ccatggatgc tggtgacagt cagccaacac agtgattgcc acacagacat
      721 ctctgtaggt cagttcttca gccaggaagt gattcacatt gacttccatt ggaattcatc
      781 ttaatcagac ctgtgtgaat aaaaatacaa gaactgttta taggagacca gttgatcttg
      841 ggaaaacagc agttgtgtga gctgcagggc tttgtgcagt cccagcaccc agttagaaca
      901 gcctctgtgg tgggccggga gggtttctga gggcacagga atctcagtgg atgagaactg
      961 agattgtctg aactcagaaa cttatcaggg aacctgtgac ctgtctttct tagagctgcc
     1021 cctttcatct tgcttaaaaa ataaattctc agctcatgtg tcagtctgtt taacccttga
     1081 gaggatgttc ccagtgtcat gaggcattca ggaggactag tgagctgtgc ctgtcctgat
     1141 ctttcttaag ttccttcatt catactaact ctgagacaga agagcttgta ccagccaata
     1201 accacaggag caaatctaat ctcacagtga aaaagtacaa atggcattaa atgattttca
     1261 atgcaaaaaa aaaaaaaaaa aa
//
