LOCUS       NM_010748              11806 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus lysosomal trafficking regulator (Lyst), mRNA.
ACCESSION   NM_010748
VERSION     NM_010748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11806)
  AUTHORS   Kogl,T., Chang,H.F., Staniek,J., Chiang,S.C.C., Thoulass,G.,
            Lao,J., Weissert,K., Dettmer-Monaco,V., Geiger,K., Manna,P.T.,
            Beziat,V., Momenilandi,M., Tu,S.M., Keppler,S.J., Pattu,V.,
            Wolf,P., Kupferschmid,L., Tholen,S., Covill,L.E., Ebert,K.,
            Straub,T., Gross,M., Gather,R., Engel,H., Salzer,U., Schell,C.,
            Maier,S., Lehmberg,K., Cornu,T.I., Pircher,H., Shahrooei,M.,
            Parvaneh,N., Elling,R., Rizzi,M., Bryceson,Y.T., Ehl,S., Aichele,P.
            and Ammann,S.
  TITLE     Patients and mice with deficiency in the SNARE protein SYNTAXIN-11
            have a secondary B cell defect
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38722309
  REMARK    Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi:
            10.1084/jem.2022112205142024c. PMID: 38771261]
REFERENCE   2  (bases 1 to 11806)
  AUTHORS   Finlay,J.B., Ireland,A.S., Hawgood,S.B., Reyes,T., Ko,T.,
            Olsen,R.R., Abi Hachem,R., Jang,D.W., Bell,D., Chan,J.M.,
            Goldstein,B.J. and Oliver,T.G.
  TITLE     Olfactory neuroblastoma mimics molecular heterogeneity and lineage
            trajectories of small-cell lung cancer
  JOURNAL   Cancer Cell 42 (6), 1086-1105 (2024)
   PUBMED   38788720
REFERENCE   3  (bases 1 to 11806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 11806)
  AUTHORS   Schuster,E.M., Epple,M.W., Glaser,K.M., Mihlan,M., Lucht,K.,
            Zimmermann,J.A., Bremser,A., Polyzou,A., Obier,N.,
            Cabezas-Wallscheid,N., Trompouki,E., Ballabio,A., Vogel,J.,
            Buescher,J.M., Westermann,A.J. and Rambold,A.S.
  TITLE     TFEB induces mitochondrial itaconate synthesis to suppress
            bacterial growth in macrophages
  JOURNAL   Nat Metab 4 (7), 856-866 (2022)
   PUBMED   35864246
REFERENCE   5  (bases 1 to 11806)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 11806)
  AUTHORS   Roder,J.C.
  TITLE     The beige mutation in the mouse. I. A stem cell predetermined
            impairment in natural killer cell function
  JOURNAL   J Immunol 123 (5), 2168-2173 (1979)
   PUBMED   489978
REFERENCE   7  (bases 1 to 11806)
  AUTHORS   LaVail,J.H., Nixon,R.A. and Sidman,R.L.
  TITLE     Genetic control of retinal ganglion cell projections
  JOURNAL   J Comp Neurol 182 (3), 399-421 (1978)
   PUBMED   102659
REFERENCE   8  (bases 1 to 11806)
  AUTHORS   Prueitt,J.L., Chi,E.Y. and Lagunoff,D.
  TITLE     Pulmonary surface-active materials in the Chediak-Higashi syndrome
  JOURNAL   J Lipid Res 19 (4), 410-415 (1978)
   PUBMED   580786
REFERENCE   9  (bases 1 to 11806)
  AUTHORS   Oliver,J.M.
  TITLE     Impaired microtubule function correctable by cyclic GMP and
            cholinergic agonists in the Chediak-Higashi syndrome
  JOURNAL   Am J Pathol 85 (2), 395-418 (1976)
   PUBMED   187062
  REMARK    Review article
REFERENCE   10 (bases 1 to 11806)
  AUTHORS   Brandt,E.J., Elliott,R.W. and Swank,R.T.
  TITLE     Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi
            (beige) mice
  JOURNAL   J Cell Biol 67 (3), 774-788 (1975)
   PUBMED   408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U70015.1 and CT010431.7.
            
            On Aug 11, 2006 this sequence version replaced NM_010748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U70015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1517              U70015.1           1-1517
            1518-2336           CT010431.7         165459-166277
            2337-2586           U70015.1           2337-2586
            2587-3492           CT010431.7         167786-168691
            3493-4244           U70015.1           3493-4244
            4245-4245           CT010431.7         177482-177482
            4246-4590           U70015.1           4246-4590
            4591-4614           CT010431.7         179230-179253
            4615-11806          U70015.1           4618-11809
FEATURES             Location/Qualifiers
     source          1..11806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.28 cM"
     gene            1..11806
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /note="lysosomal trafficking regulator"
                     /db_xref="GeneID:17101"
                     /db_xref="MGI:MGI:107448"
     exon            1..88
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            89..174
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            175..373
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            374..464
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            465..2544
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..3553
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3715
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3872
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4099
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4166
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4276
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4703
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4848
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..5022
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5023..5183
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5184..5374
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5620
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5621..5794
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5795..5944
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            5945..6082
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6281
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            6282..6413
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..7029
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7030..7207
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7208..7377
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7378..7608
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7609..7775
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7776..7919
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            7920..8111
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8112..8290
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8291..8497
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8498..8674
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8675..8751
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8752..8940
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            8941..9086
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9087..9183
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9184..9245
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9246..9301
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9302..9454
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9455..9699
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9700..9766
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9767..9923
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            9924..10064
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10065..10282
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10283..10513
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10514..10703
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10704..10840
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10841..10939
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            10940..11079
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            11080..11177
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            11178..11334
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            11335..11406
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     exon            11407..11806
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11749..11754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /note="hexamer: ATTAAA"
     polyA_site      11782
                     /gene="Lyst"
                     /gene_synonym="beige; bg; D13Sfk13"
                     /note="major polyA site"
ORIGIN      
        1 tgagagctca cgctggcctg gcagccttgg tgagtcggga ttctcctgca ccggcgggcg
       61 agagcgcgcg gcggaccaca gagcggaggt gaagccttat gctgagacag ttttatctag
      121 ttcatgaacc caaattatat acaagctgaa tgttacagaa gtgctgaaag actgctctgt
      181 catgagcacg gacagcaact cattggcacg tgagtttctg attgatgtca accagctttg
      241 caatgcagtg gtccagaggg cagaagccag ggaagaagaa gaagaggaga cacacatggc
      301 aactcttgga cagtaccttg tccatggacg aggatttctg ttacttacca aactaaattc
      361 tatcattgat caggccctga catgcagaga agaactcctg actcttcttc tgtcgctcct
      421 tcccttggtg tggaagatac ctgtccagga acagcaggca acagatttta acctgccact
      481 gtcatctgat ataatcctga ccaaagaaaa gaactcaagt ttgcaaaaat caactcaggg
      541 aaaattatat ttagaaggaa gtgctccatc tggtcaggtt tctgcaaaag taaacctttt
      601 tcgaaaaatc aggcgacagc gtaaaagtac ccatcgttat tctgtaagag atgcaagaaa
      661 gacacagctc tccacctctg actccgaagg caactcagat gaaaagagta cggttgtgag
      721 taaacacagg aggctccacg cgctgccacg gttcctgacg cagtctccta aggaaggcca
      781 cctcgtagcc aaacctgacc cctctgccac caaagaacag gtcctttctg acaccatgtc
      841 tgtggaaaac tccagagaag tcattctgag acaggattca aatggtgaca tattaagtga
      901 gccagctgct ttgtctattc tcagtaacat gaataattct ccttttgact tatgtcatgt
      961 tttgttatct ctattggaaa aagtttgtaa gtttgacatt gctttgaatc ataattcttc
     1021 cctagcactc agtgtagtac ccacactgac tgagttccta gcaggctttg gggactgctg
     1081 taaccagagt gacactttgg agggacaact ggtttctgca ggttggacag aagagccggt
     1141 agctttggtt caacggatgc tctttcgaac cgtgctgcac cttatgtcag tagacgttag
     1201 cactgcagag gcaatgccag aaagtcttag gaaaaatttg actgaattgc ttagggcagc
     1261 tttaaaaatt agagcttgct tggaaaagca gcctgagcct ttctccccga gacaaaagaa
     1321 aacactacag gaggtccagg agggctttgt attttccaag tatcgtcacc gagcccttct
     1381 actacctgag cttctggaag gagttctaca gctcctcatc tcttgtcttc agagtgcagc
     1441 ttcaaatccc ttttacttca gtcaagccat ggatttagtt caagaattta tccagcacca
     1501 aggatttaat ctctttgaaa cagcagttct tcagatggaa tggctgcttt caagggacgg
     1561 tgttccttca gaagctgcag aacatttgaa agctctgata aacagtgtaa taaaaataat
     1621 gagtactgtg aaaaaggtga aatcagagca acttcatcat tccatgtgca caaggaaaag
     1681 acaccggcgt tgtgagtatt cccacttcat gcagcaccac cgcgatcttt cagggctcct
     1741 ggtttcagct tttaaaaatc agctttctaa aagccccttt gaagagaccg cagagggaga
     1801 tgtgcagtat ccagagcgct gctgctgcat cgccgtgtgc gctcaccagt gcttgcgctt
     1861 gctgcagcag gtttccctga gcaccacgtg tgtccagatc ctatcaggtg tacacagtgt
     1921 tggaatctgt tgttgtatgg atcctaagtc tgtgatcgtc cctttactgc atgcttttaa
     1981 gttgccagca ctgaaagctt tccagcagca tatactgaat gtcctgagca aacttctttt
     2041 ggatcagtta ggaggagcag agctatcacc gagaattaaa aaagcagctt gcaacatctg
     2101 tactgtggac tctgaccaac tggctaagtt aggagagaca ctgcaaggca ccttgtgtgg
     2161 tgctggtcct acctccggct tgcccagtcc ttcctaccga tttcagggga tcctgcccag
     2221 cagcggctct gaagacttgc tgtggaagtg ggatgcatta gaggcttatc agagctttgt
     2281 ctttcaagaa gacagattac ataacattca gattgcaaat cacatttgta atttaatcca
     2341 gaaaggcaat gtagttgttc agtggaaatt gtataattat atctttaatc ctgtgctcca
     2401 aagaggagtt gaattagtac atcattgtca acagctaagc attccttcag ctcagactca
     2461 catgtgtagc caactgaaac agtatttgcc tcaggaagtg cttcagattt atttaaaaac
     2521 tctacctgtc ctacttaaat ccagggtaat aagagatttg tttttaagtt gtaatggagt
     2581 aaaccaaata attgaactaa attacttaga tgggattcga agtcattccc tgaaagcatt
     2641 tgaaactctg attgtcagcc taggggaaca acagaaagat gctgcagttc tagacgtcga
     2701 tgggttagac atccaacagg agttgccgtc cttaagtgtg ggtccttctc ttcataagca
     2761 gcaagcttct tcagattctc cttgcagtct caggaagttt tatgccagcc tcagagagcc
     2821 tgatccaaaa aaacgaaaga ccattcacca ggatgttcac ataaacacca taaacctctt
     2881 cctctgtgtg gcttttctat gtgtcagtaa agaagcagac tctgataggg agtctgccaa
     2941 tgagtcagaa gatacttctg gctatgacag cactgccagt gagccattaa gtcacatgct
     3001 accatgtctg tctcttgaga acgttgtctt accttcccct gaatgtttgc accatgcagc
     3061 agacatttgg tccatgtgtc gttggatcta catgttgaac tcagtcttcc agaaacaatt
     3121 tcacaggctt ggtggtttcc aagtgtgcca tgaattaata tttatgataa tccagaaact
     3181 attcagaagt catacagagg atcaaggaag aaggcaggga gaaatgagta gaaatgaaaa
     3241 ccaagagcta atcaggatat cttaccccga gctgacactg aagggagatg tatcatctgc
     3301 aacagcacca gacctgggat ttctgagaaa gagtgctgac agcgtgcgtg gattccagtc
     3361 acagcctgtg cttcccacaa gtgcagagca gattgtggct actgaatctg ttcctgggga
     3421 acgaaaggca tttatgagtc aacaaagtga gacttctctc cagagcatac gacttttgga
     3481 gtctctcctg gccatttgtc ttcatagtgc cagagcctgt caacagaaga tggaattgga
     3541 gctaccgtct cagggcttgt ctgtggaaaa tatattgtgt gaactgaggg aacacctttc
     3601 ccagtcaaag gtggcagaaa cagaattagc aaagccttta tttgatgccc tgcttcgagt
     3661 agccctgggg aatcattcag cagatttggg ccctggtgat gctgtgactg agaagagtca
     3721 tccctctgag gaagagctgt tgtcccagcc cggagatttt tcagaagaag ctgaggattc
     3781 tcagtgttgt agtttgaaac ttctgggtga ggaagaaggc tatgaagcgg atagtgaaag
     3841 caatcctgag gatgttgaca cccaagacga tggagtagaa ttaaatcctg aagcagaagg
     3901 tttcagtgga tcgattgttt caaacaactt acttgaaaac ctcactcacg gggaaataat
     3961 ataccctgag atttgcatgc tgggattaaa tttgctttct gctagcaaag ctaaacttga
     4021 tgtgcttgct catgtgtttg agagctttct gaaaattgtc aggcagaagg aaaagaacat
     4081 ttctctcctc atacaacagg gaactgtgaa aatccttcta ggcgggttct tgaatatttt
     4141 aacacaaact aactctgatt tccaagcatg ccagagagta ctggtggatc tcttggtatc
     4201 tttgatgagc tcaagaacgt gttcagaaga cttaactctt cttttgagaa tatttctgga
     4261 gaaatctcct tgtacagaaa ttcttctcct tggtattcac aaaattgttg aaagtgattt
     4321 tactatgagc ccttcacagt gtctgacctt tcctttcctg cataccccga gtttaagcaa
     4381 tggtgtctta tcacagaaac ctcctgggat tcttaacagt aaagccttag gcttattgag
     4441 aagagcacgg atttcccgag gcaagaaaga ggctgataga gagagttttc cctataggct
     4501 gctttcctct tggcatatag ccccaatcca cctgccgttg ctgggacaga actgctggcc
     4561 acacctgtca gaaggattta gtgtttctct gtggtttaat gtggaataca tccatgaatc
     4621 cgagagtgct gcagaaaggg gaaaaagagt aaagaaaaga aacaaaccat cagttctgga
     4681 agacagcagt tttgaaggag cagaaggtga tagaccagaa gttacagaat ccatcaatcc
     4741 tggtgacaga ctcatagaag acggctgtat tcatttgatt tcactggggt ccaaagcatt
     4801 gatgatccaa gtgtgggctg atccccacag tggcactttt atctttcgtg tgtgcatgga
     4861 ctcaaatgat gacacgaaag ctgtctcact agcacaggtg gaatcacagg agaatatttt
     4921 ctttccaagc aaatggcaac acttagtact tacctatatt cagcatcctc aagggaaaaa
     4981 gaatgtccat ggggaaatct ccatatgggt ctctgggcag aggaagactg atgtcatctt
     5041 ggattttgtg ctcccaagaa aaacaagctt atcatcagac agcaataaaa cattttgcat
     5101 gattggtcat tgcttaacat cccaagaaga gtctctgcaa ttagctggaa aatgggacct
     5161 ggggaacttg ctcctcttca atggagctaa aattggctca caagaggcct ttttcctgta
     5221 tgcttgtgga cccaactaca catccatcat gccgtgtaaa tatggacagc cagtcattga
     5281 ctactccaaa tacattaata aagacatttt gagatgtgat gaaatcagag acctttttat
     5341 gaccaagaaa gaagtggatg ttggtctctt aattgaaagt ctttcagttg tttatacaac
     5401 ttgctgtcct gctcagtaca ccatctatga accagtgatt cgactcaagg gccaagtgaa
     5461 aactcagccc tctcaaagac ccttcagctc aaaggaagcc cagagcatct tgctagaacc
     5521 ttctcaactc aaaggcctcc aacctacgga atgtaaagcc atccagggca ttctgcatga
     5581 gattggtggg gctggcacat ttgtttttct ctttgctagg gttgttgaac ttagtagctg
     5641 tgaagaaact caagcattag cactgcgggt tatactgtct ttaattaagt acagccaaca
     5701 gagaacacag gaactggaaa attgtaatgg actctctatg attcaccaag tgttggtcaa
     5761 acagaaatgc attgttggct ttcacatttt gaagaccctt cttgaaggtt gctgcggtga
     5821 agaagttatc cacgtcagtg agcatggaga gttcaagctg gatgttgagt ctcatgctat
     5881 aatccaagat gttaagctgc tgcaggaact gttacttgac tggaagatat ggaataaggc
     5941 agagcaaggt gtgtgggaga ctctgctagc agctttggaa gtcctcatcc gggtagagca
     6001 ccaccagcag cagtttaata ttaagcagtt gctgaacgcc cacgtggttc accacttcct
     6061 actgacctgt caggttttac aggaacacag agaggggcag cttacatcta tgccccgaga
     6121 agtttgtaga tcatttgtga aaatcattgc agaagtcctt ggttctcctc cagacttgga
     6181 attattgaca gttattttca atttcctgtt agctgtacac cctcctacta atacttatgt
     6241 ttgtcacaat cccacaaact tctacttctc tttgcacata gatggcaaga tctttcagga
     6301 gaaagtgcag tcactcgcgt acctgaggca ttctagcagc ggagggcaag cctttcccag
     6361 ccctggattc ctggtaataa gcccatctgc ctttactgca gctcctcctg aaggaaccag
     6421 ttcttccaat attgttccac agcggatggc tgctcagatg gttcgatcta gaagtctacc
     6481 agcatttcct acttatttac cactaatacg agcacaaaaa ctggctgcaa gtttgggttt
     6541 tagtgttgac aagttacaaa atattgcaga tgccaaccca gagaaacaga atcttttagg
     6601 aagaccctac gcactgaaaa caagcaaaga ggaagcattc atcagcagct gtgagtctgc
     6661 aaagactgtt tgtgaaatgg aggctcttct tggagcccac gcctctgcca atggggtttc
     6721 cagaggatca ccgaggttcc ccagggccag agtagatcac aaagatgtgg gaacagagcc
     6781 cagatcagat gatgacagtc ctggggatga gtcttaccca cgtcggcctg acaacctcaa
     6841 gggactggcc tcattccagc gaagccaaag cactgtcgca agccttgggc tggcgtttcc
     6901 ctctcagaat ggatctgcag ttgctagcag gtggccaagt cttgttgata ggaatgctga
     6961 tgactgggag aactttacct tttctcctgc ttatgaggca agctacaacc gagccacaag
     7021 cacccacagt gtcattgaag actgtctgat acctatctgc tgtggattat atgaactctt
     7081 aagtggggtt cttcttgtcc tgcctgatgc tatgcttgaa gatgtgatgg acaggattat
     7141 tcaagcagat attcttctag tccttgttaa ccacccatca cctgctatcc agcaaggagt
     7201 aattaaactg ttacatgcat acattaatag agcatcaaag gagcaaaagg acaagtttct
     7261 gaagaaccgt ggcttttcct tattagccaa ccagttgtat cttcataggg gaactcagga
     7321 gttgttggag tgctttgttg aaatgttctt tggtcgaccg attggcctgg atgaagaatt
     7381 tgatctggag gaagtgaagc acatggaact gttccagaag tggtctgtca ttcccgttct
     7441 cggactaata gagacctctc tctatgacaa tgtcctcttg cacaatgctc ttttacttct
     7501 tctgcaagtt ttaaactctt gttccaaggt agcagacatg ctactggaca atggtctact
     7561 ctatgtatta tgtaatacag tagcagccct gaatggatta gaaaagaaca ttcctgtgaa
     7621 cgaatacaaa ttgctcgcat gtgatataca gcagcttttc atagcagtta caattcatgc
     7681 ttgcagttcc tcaggcacac agtattttag agtgattgaa gaccttattg tacttcttgg
     7741 atatcttcat aatagcaaaa acaagaggac acaaaatatg gctttggccc tgcagcttag
     7801 agttctccag gctgctttgg aatttataag gagcacagcc aatcatgact ctgaaagtcc
     7861 agtgcactcg ccttctgccc accgccattc agtgcctccg aagcggagaa gcattgctgg
     7921 ttctcgcaaa ttccctctgg ctcagacaga gtctctgctg atgaagatgc gctcagtggc
     7981 cagcgatgag ctacactcta tgatgcagag gaggatgagc caagagcacc ccagccaggc
     8041 ctcggaggca gagctcgctc agaggctgca gaggctcacc atcttagctg tgaacaggat
     8101 tatttaccaa gagttgaatt cagatattat tgacattttg agaactccag aaaatacatc
     8161 ccaaagcaag acctcagttt ctcagactga aatttctgaa gaagacatgc atcatgagca
     8221 accttctgta tataatccat ttcaaaaaga aatgttaacc tatctgttgg atggcttcaa
     8281 agtgtgtatt ggttcaagta aaactagcgt ttctaagcag cagtggacta aaatcctggg
     8341 gtcttgtaaa gaaaccctcc gagaccagct tggaagattg ctagcgcata ttttgtctcc
     8401 aacccacact gtacaagaac ggaagcagat acttgagata gttcatgaac cagctcacca
     8461 ggatatactt cgtgactgtc ttagcccctc cccacaacat ggagccaagt tggttttgta
     8521 tttgtcagag ttgatacata atcatcagga tgagttaagt gaagaagaaa tggacacagc
     8581 agaactgctt atgaatgctc taaagttatg tggccacaag tgcatcccgc ccagtgcccc
     8641 ttccaaacca gagctcatta agatcatcag agaggagcaa aagaagtatg aaagtgaaga
     8701 gagtgtgagc aaaggctcat ggcagaaaac ggtgaacaac aaccagcaaa gtctcttcca
     8761 gaggctcgat ttcaaatcca aggatatatc taaaatcgct gcagacatca cccaggctgt
     8821 atcactctcc caaggcattg aaaggaagaa ggtgatccag cacatcagag ggatgtacaa
     8881 agttgacctg agtgccagca ggcactggca ggaatgcatc cagcagctga cacatgacag
     8941 agcagtctgg tatgacccaa tctactatcc aacttcatgg cagttggatc caacagaagg
     9001 gccaaaccga gagaggagac gtttgcagag atgctatcta actattccca ataagtacct
     9061 cctgagggac agacagaagt cagaaggtgt gctcaggccc ccactctctt acctttttga
     9121 agataaaact cattcttcct tctcctctac tgtcaaagac aaagctgcaa gtgaatccat
     9181 cagagtgaat cgaagatgta tcagtgttgc accatctaga gagacagctg gggaattgtt
     9241 gttaggtaaa tgtgggatgt actttgtgga agacaatgcc tctgacgcag ttgaaagctc
     9301 gagcctccaa ggggagttag agccggcatc attttcttgg acatatgagg aaattaaaga
     9361 agttcacagg cgctggtggc aactaagaga taatgctgta gaaatctttt taacaaatgg
     9421 cagaacactc ctattagcat ttgacaataa caaggttcgt gatgacgtgt accagagcat
     9481 cctcacaaat aacctcccaa atcttctgga gtacggcaac atcaccgctc tgacaaacct
     9541 gtggtattct ggacaaatta ccaattttga atatttgact catttaaaca agcatgcggg
     9601 ccggtccttc aatgatctca tgcagtaccc ggtgttcccc ttcatccttt ctgactatgt
     9661 tagtgagact cttgacctca atgatccatc tatctacaga aacctatcta agcctatagc
     9721 tgtgcagtat aaagaaaaag aagaccgtta cgttgacaca tacaagtact tggaggagga
     9781 gtatcgcaag ggagctcgag aggatgaccc catgcctcct gtgcaaccct accactatgg
     9841 ctcccactac tccaacagcg gcaccgtgct ccacttcctg gtcaggatgc cgcctttcac
     9901 taaaatgttt ctagcctatc aagatcagag tttcgacatt ccagaccgaa catttcattc
     9961 tacaaacaca acttggcgcc tctcctcctt tgagtccatg actgatgtga aggagctgat
    10021 tccagagttt ttctatcttc ctgagttctt agtgaaccgt gaaggctttg acttcggtgt
    10081 tcgtcagaat ggagagcggg ttaaccacgt caatcttcct ccctgggcac gcaacgatcc
    10141 tcggctgttc atccttattc accggcaagc actagagtct gaccatgtgt cccagaacat
    10201 ctgtcactgg atcgacttag tgtttggcta caagcaaaag gggaaggcgt ctgttcaagc
    10261 catcaatgtc ttccaccctg ctacatattt tggaatggat gtctctgcag ttgaagatcc
    10321 agtgcagaga cgggctttag aaaccatgat aaaaacctac gggcagaccc cacgtcagtt
    10381 gttccacaca gcccatgcca gccgacctgg agccaagctt aacatcgaag gagagcttcc
    10441 agcagctgtt ggcttgttag tccagttcgc tttcagagag acccgagaac cagtcaagga
    10501 agtcactcat ccgagccctt tgtcatggat aaaaggcttg aagtgggggg agtacgtagg
    10561 ttcccccagt gctccagtac ctgtggtctg cttcagccag ccccatggag aaagatttgg
    10621 ttccctgcag gcactgccca ccagagccat ctgtggttta tcacgaaact tctgtcttct
    10681 gatgacctac aacaaggagc aaggtgtgag aagcatgaac aacaccaata ttcagtggtc
    10741 tgctatccta agctggggat atgctgacaa catcttacgg ttgaaaagta agcagagtga
    10801 gccaccaatc aacttcattc agagttcaca gcagcaccag gtaaccagtt gtgcctgggt
    10861 gcctgacagt tgtcagctct tcactgggag caagtgtggt gtcatcacag cctataccaa
    10921 caggctcacc agcagcacgc cctcagaaat tgaaatggag agtcagatgc atctctatgg
    10981 acacacagag gagatcaccg gcttatgtgt ctgcaagccg tacagcgtga tgataagcgt
    11041 gagcagagac gggacctgca tagtatggga cctgaacagg ctgtgctatg tacaaagttt
    11101 ggctggacac aaaagccctg tgacggctgt ctctgccagt gaaacgtcag gtgacattgc
    11161 tactgtgtgt gactcagctg gcgggggcag tgacctgaga ctctggaccg tgaatgggga
    11221 cctcgttgga catgtccact gcagagagat catttgttct gtagctttct ccaaccagcc
    11281 tgagggagtc tccatcaacg tcattgctgg gggattagaa aatggcattg taaggctatg
    11341 gagcacatgg gacttgaagc ctgtgagaga gattacattt cccaaatcaa ataagcccat
    11401 cataagcctg acattctcct gtgatggcca ccatttgtac actgccaaca gtgaggggac
    11461 agtgatcgca tggtgccgga aggaccagca gcgtgtgaag ctgcccatgt tctactcttt
    11521 cctcagcagc tacgcagctg gatgaagaga aggagtgtcc ccacaggaca taagcaccgc
    11581 tctgcgagcc tggctccacc aactgcagaa gcagatgact gagcagatat ccaggaaaga
    11641 caacacacgt gcctctgtgc gcgcttcccc agcctccgtg ggcctgagag taaagccctg
    11701 ccctcattcc ataatggcgt ggaaggctgg gtctgcacac actagccaat taaagtcaga
    11761 atcttgatgc tttttcccaa aaggttaggc tgaatcaaag atcagg
//
