LOCUS       NM_001285959             898 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus LYR motif containing 1 (Lyrm1), transcript variant 2,
            mRNA.
ACCESSION   NM_001285959
VERSION     NM_001285959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Chen,Y.M., Li,X., Song,G.X., Liu,M., Fan,Y., Wu,L.J., Li,H.,
            Zhang,Q.J., Liu,Y.Q. and Qian,L.M.
  TITLE     Effect of LYRM1 knockdown on proliferation, apoptosis,
            differentiation and mitochondrial function in the P19 cell model of
            cardiac differentiation in vitro
  JOURNAL   J Bioenerg Biomembr 48 (1), 33-41 (2016)
   PUBMED   26759027
  REMARK    GeneRIF: knockdown of LYRM1 induced mitochondrial impairment in P19
            cells during differentiation, which was reflected by decreased ATP
            synthesis, lower MMP and increased ROS levels.
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Zhang,M., Qin,Z.Y., Dai,Y.M., Wang,Y.M., Zhu,G.Z., Zhao,Y.P.,
            Ji,C.B., Zhu,J.G., Shi,C.M., Qiu,J., Cao,X.G. and Guo,X.R.
  TITLE     Knockdown of LYRM1 rescues insulin resistance and mitochondrial
            dysfunction induced by FCCP in 3T3-L1 adipocytes
  JOURNAL   Cell Biochem Biophys 70 (1), 667-675 (2014)
   PUBMED   24771405
  REMARK    GeneRIF: FCCP-induced mitochondrial dysfunction and insulin
            resistance are ameliorated by knockdown of LYRM1
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Qin,Z.Y., Zhang,M., Guo,X.R., Wang,Y.M., Zhu,G.Z., Ni,Y.H.,
            Zhao,Y.P., Qiu,J., Kou,C.Z., Qin,R. and Cao,X.G.
  TITLE     alpha-Lipoic acid ameliorates impaired glucose uptake in LYRM1
            overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 44 (5), 579-586 (2012)
   PUBMED   22820890
  REMARK    GeneRIF: alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced
            insulin resistance partially via its capacity to restore
            mitochondrial function and/or increase phosphorylation of IRS-1 and
            Akt.
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Zhu,G.Z., Zhang,M., Kou,C.Z., Ni,Y.H., Ji,C.B., Cao,X.G. and
            Guo,X.R.
  TITLE     Effects of Lyrm1 knockdown on mitochondrial function in 3 T3-L1
            murine adipocytes
  JOURNAL   J Bioenerg Biomembr 44 (1), 225-232 (2012)
   PUBMED   22249831
  REMARK    GeneRIF: Knockdown of the Lyrm1 gene in adipocytes resulted in
            dramatically increased cellular ATP production, mitochondrial
            membrane potentials and levels Ucp2 mRNA, while ROS levels were
            significantly decreased.
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Zhang,M., Zhao,H.M., Qin,Z.Y., Qin,R., Chen,X.H., Zhao,Y.P.,
            Zhang,C.M., Gao,C.L., Zhu,C., Ji,C.B., Cao,X.G. and Guo,X.R.
  TITLE     Regulation of LYRM1 gene expression by free fatty acids,
            adipokines, and rosiglitazone in 3T3-L1 adipocytes
  JOURNAL   Exp Diabetes Res 2012, 820989 (2012)
   PUBMED   22110480
  REMARK    GeneRIF: results suggest that the expression of LYRM1 mRNA is
            affected by a variety of factors that are related to insulin
            sensitivity; LYRM1 may be an important mediator in the development
            of obesity-related insulin resistance
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131702.3, DV043140.1, BU757765.1 and BY464772.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU847510.1, CA463991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC131702.3         105587-105616       c
            31-661              DV043140.1         189-819
            662-896             BU757765.1         18-252              c
            897-898             BY464772.1         427-428
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.31 cM"
     gene            1..898
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /note="LYR motif containing 1"
                     /db_xref="GeneID:73919"
                     /db_xref="MGI:MGI:1921169"
     exon            1..30
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..399
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /codon_start=1
                     /product="LYR motif-containing protein 1"
                     /protein_id="NP_001272888.1"
                     /db_xref="CCDS:CCDS21790.1"
                     /db_xref="GeneID:73919"
                     /db_xref="MGI:MGI:1921169"
                     /translation="MTAATRQEVLCLYRSIFRLARKWQAASGQMEDTIEEKQYILKEA
                     RTLFQKNKNLTDPELIKQCIVECTARIEIGLHYQIPYPRPIHLPPMGLTARRGRGLQT
                     QEKLRKLSKPVYLKSHDEVS"
     exon            31..189
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            190..282
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..898
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /note="hexamer: TATAAA"
     polyA_site      898
                     /gene="Lyrm1"
                     /gene_synonym="1110065L10Rik; 2310004B22Rik;
                     4930404J24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtacgcgagg acgtccgaag ccgtctccaa atgacagcag caacccgaca agaagtcctc
       61 tgcctctacc gaagcatttt caggcttgca cggaaatggc aggcagcatc agggcagatg
      121 gaagacacca tcgaagaaaa acagtacata ctaaaggaag ccagaacact gttccagaaa
      181 aacaaaaatc tcacagaccc agagctgatt aaacaatgca tagttgaatg cacggcccgg
      241 attgagattg gactgcatta ccagatccct tatccacgcc ctatccatct gcctccaatg
      301 ggtctcaccg cacgacgagg tcggggactt caaacccagg aaaaactgag aaaactttcc
      361 aaaccagtgt atctgaagtc tcatgatgaa gtttcctaac aaagaggaca ctttactttt
      421 gagaatggtg agccaactca gttttgaatg taaaccaggc aatatatcct tcttgactag
      481 aagcaaaact actaccttca gacctccaaa attggtctta acctatgaca tgtggctgca
      541 ggcatcccta aggtttttca gggtcttgct tgctgcttga actatgacat tgtccctaga
      601 ggtcatggac tttacatctt cactgaagtt gtccttggga gctatctgcg gcctacagag
      661 gaaggctgaa gggaattctt ggggctgcca tccagtgtgc atcggatgca aagggattag
      721 ctaattgctg caagttcaca tggctccaaa gctacccttc tccccaaaac ttgaggtttt
      781 tccgcaagtt attttcattt gcttaaaact ggtttctgta taggcttttt tgtggtctcc
      841 tgattcttgt aattttcaga tttacccact tataaaggac agctttagat tgatcata
//
