LOCUS       NM_146106               1577 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lysophospholipase-like 1 (Lyplal1), mRNA.
ACCESSION   NM_146106
VERSION     NM_146106.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1577)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1577)
  AUTHORS   Vohnoutka,R.B., Kuppa,A., Hegde,Y., Chen,Y., Pant,A., Tohme,M.E.,
            Choi,E.K., McCarty,S.M., Bagchi,D.P., Du,X., Chen,Y., Chen,V.L.,
            Mori,H., Bielak,L.F., Maguire,L.H., Handelman,S.K., Sexton,J.Z.,
            Saunders,T.L., Halligan,B.D. and Speliotes,E.K.
  TITLE     Knockout of murine Lyplal1 confers sex-specific protection against
            diet-induced obesity
  JOURNAL   J Mol Endocrinol 70 (3), e220131 (2023)
   PUBMED   36748836
  REMARK    GeneRIF: Knockout of murine Lyplal1 confers sex-specific protection
            against diet-induced obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1577)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1577)
  AUTHORS   Norheim,F., Hasin-Brumshtein,Y., Vergnes,L., Chella Krishnan,K.,
            Pan,C., Seldin,M.M., Hui,S.T., Mehrabian,M., Zhou,Z., Gupta,S.,
            Parks,B.W., Walch,A., Reue,K., Hofmann,S.M., Arnold,A.P. and
            Lusis,A.J.
  TITLE     Gene-by-Sex Interactions in Mitochondrial Functions and
            Cardio-Metabolic Traits
  JOURNAL   Cell Metab 29 (4), 932-949 (2019)
   PUBMED   30639359
REFERENCE   5  (bases 1 to 1577)
  AUTHORS   Watson,R.A., Gates,A.S., Wynn,E.H., Calvert,F.E., Girousse,A.,
            Lelliott,C.J. and Barroso,I.
  TITLE     Lyplal1 is dispensable for normal fat deposition in mice
  JOURNAL   Dis Model Mech 10 (12), 1481-1488 (2017)
   PUBMED   29084768
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1577)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1577)
  AUTHORS   Lei,X., Callaway,M., Zhou,H., Yang,Y. and Chen,W.
  TITLE     Obesity associated Lyplal1 gene is regulated in diet induced
            obesity but not required for adipocyte differentiation
  JOURNAL   Mol Cell Endocrinol 411, 207-213 (2015)
   PUBMED   25958046
  REMARK    GeneRIF: Lyplal1 mRNA was up-regulated during adipogenesis and
            enriched in mature adipocytes through a PPARgamma-independent
            mechanism. overexpression and knockdown of Lyplal1 did not perturb
            adipogenesis, triacylglycerol accumulation and/or insulin
            signaling.
REFERENCE   8  (bases 1 to 1577)
  AUTHORS   Kirov,J.V., Adkisson,M., Nava,A.J., Cipollone,A., Willis,B.,
            Engelhard,E.K., Lloyd,K.C., de Jong,P. and West,D.B.
  TITLE     Reporter Gene Silencing in Targeted Mouse Mutants Is Associated
            with Promoter CpG Island Methylation
  JOURNAL   PLoS One 10 (8), e0134155 (2015)
   PUBMED   26275310
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1577)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 1577)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121970.2 and AK148533.1.
            
            On Apr 25, 2009 this sequence version replaced NM_146106.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148533.1, BC027340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC121970.2         8996-9029
            35-610              AK148533.1         3-578
            611-611             AC121970.2         37608-37608
            612-1577            AK148533.1         580-1545
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.81 cM"
     gene            1..1577
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /note="lysophospholipase-like 1"
                     /db_xref="GeneID:226791"
                     /db_xref="MGI:MGI:2385115"
     exon            1..154
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..780
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /EC_number="3.1.2.22"
                     /codon_start=1
                     /product="lysophospholipase-like protein 1"
                     /protein_id="NP_666218.2"
                     /db_xref="CCDS:CCDS15600.1"
                     /db_xref="GeneID:226791"
                     /db_xref="MGI:MGI:2385115"
                     /translation="MAAVPSAVHLPRCVVSPTGRHSASLIFLHGSGHSGQGQREWIKH
                     VLNQDLTFQHIKIIYPTAPSRPYTPLKGGLSNVWFDRFKISMDCPEHLESIDSMCQVL
                     SGLVDEEVKTGIQKSRILIGGFSMGGCMAMHLAYRSHPDVAGVFVLSGFLNKASVVYQ
                     DLQQGGRMLPELFQCHGSADNLVLHAWGKETNSKLKSLGVSTTFHSLPNLNHELNKTE
                     LEKLKSWILTRLPGETDGQSE"
     exon            155..254
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /inference="alignment:Splign:2.1.0"
     exon            255..424
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /inference="alignment:Splign:2.1.0"
     exon            425..540
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /inference="alignment:Splign:2.1.0"
     exon            541..1577
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /note="hexamer: AATAAA"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /note="hexamer: AATAAT"
     polyA_site      1429
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
                     /note="major polyA site"
     polyA_site      1459
                     /gene="Lyplal1"
                     /gene_synonym="Q96AVO"
ORIGIN      
        1 gcgcgcgcgg ccccgtgacg ctagggacgt ggccgcgcgc cttgccatct ctcctccgcc
       61 atggctgctg tgcccagcgc tgttcacctg ccgcgttgtg tggtgtcccc gaccgggaga
      121 cacagtgcct cgctgatctt cctgcacggc tcaggtcact ctggccaagg acagagagag
      181 tggatcaagc acgtgctaaa ccaagactta acattccagc acataaagat catttatcca
      241 acggccccct ccaggccgta tactcctctg aagggagggc tctccaatgt gtggtttgac
      301 agatttaaaa tatctatgga ctgcccagaa caccttgaat caattgatag tatgtgtcaa
      361 gtgctcagtg gattggttga tgaagaagta aaaactggca ttcagaagag caggatatta
      421 atagggggat tttctatggg aggctgcatg gcgatgcatt tagcatacag aagtcaccca
      481 gatgtggcag gagtatttgt tctttctggt tttctgaata aagcatctgt tgtttaccag
      541 gaccttcagc aaggtggccg catgctccct gagctcttcc agtgtcacgg ctctgcagat
      601 aacctagttc tgcatgcttg gggcaaggag acaaactcaa aactgaaatc tctaggagtg
      661 agcacaacgt ttcacagtct tccgaatctt aaccatgagc tcaacaaaac tgagctggag
      721 aagctaaagt catggattct cacaaggctg ccaggagaga cagatgggca gagtgaatga
      781 ttcctgacca gcatattgat tgttcatctt ccatttaaca ttttttctta tttgatcctc
      841 acaaaaatta aggtttttga aacagcccgt gcccctatat tatacaaatg aaattgcata
      901 tctgtctatt ttcattcaac aagattgtct tgtaaatcat catgtagtga atgtcaactg
      961 ttcattttgt tgctgcatag gtaccattga gggggcacac tggaatgtgc ttgtccatgc
     1021 atcacagatt tgggtgactt cctgtgtgag gctgtcataa atagggctgc tatgaggtgc
     1081 aaacatccac cctaaggtgg agagctgggt gacagtgtta tagcatcgcc tgaaacggcc
     1141 cagctgcttc tcaatgtggc tttagcacct tccattccag tcagcagtgt ggtggcccct
     1201 gaggcccagt tatgcacctg accttcatct tgtttgttct ggtggcttca tagtgttcac
     1261 gtagcatttg atttctgctt tcttggtgcc aatgatgcga tacagaatcc tacactgaag
     1321 gcttcccaga tttgtgaaaa tcagtttgcc ctgcccaatc tgtttgtaga ttatctttgt
     1381 gaaaattatt cactgccaag ataatgacaa ataaattatg aataaataat ttactgactt
     1441 tcagatttac ttactaaaat gtctagtccc atgatgagta atttagtctt aatacaggtg
     1501 gaattaattt agatcaatag ctgtgcattc tgttttagat aactggtaat aaacacacaa
     1561 agatctttta agtattt
//
