LOCUS       NM_001419044            1735 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus lysophospholipase 2 (Lypla2), transcript variant 2,
            mRNA.
ACCESSION   NM_001419044
VERSION     NM_001419044.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Zhang,N., Zhang,J., Yang,Y., Shan,H., Hou,S., Fang,H., Ma,M.,
            Chen,Z., Tan,L. and Xu,D.
  TITLE     A palmitoylation-depalmitoylation relay spatiotemporally controls
            GSDMD activation in pyroptosis
  JOURNAL   Nat Cell Biol 26 (5), 757-769 (2024)
   PUBMED   38538834
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Speck,S.L., Bhatt,D.P., Zhang,Q., Adak,S., Yin,L., Dong,G.,
            Feng,C., Zhang,W., Ben Major,M., Wei,X. and Semenkovich,C.F.
  TITLE     Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein
            proximity networks link lipid modification and mitochondria
  JOURNAL   Cell Rep 42 (11), 113389 (2023)
   PUBMED   37925639
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Dong,G., Adak,S., Spyropoulos,G., Zhang,Q., Feng,C., Yin,L.,
            Speck,S.L., Shyr,Z., Morikawa,S., Kitamura,R.A., Kathayat,R.S.,
            Dickinson,B.C., Ng,X.W., Piston,D.W., Urano,F., Remedi,M.S., Wei,X.
            and Semenkovich,C.F.
  TITLE     Palmitoylation couples insulin hypersecretion with beta cell
            failure in diabetes
  JOURNAL   Cell Metab 35 (2), 332-344 (2023)
   PUBMED   36634673
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Wei,X., Adak,S., Zayed,M., Yin,L., Feng,C., Speck,S.L.,
            Kathayat,R.S., Zhang,Q., Dickinson,B.C. and Semenkovich,C.F.
  TITLE     Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in
            Peripheral Artery Disease
  JOURNAL   Circ Res 127 (2), 249-265 (2020)
   PUBMED   32233916
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Won,S.J. and Martin,B.R.
  TITLE     Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle
  JOURNAL   ACS Chem Biol 13 (6), 1560-1568 (2018)
   PUBMED   29733200
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Kong,E., Peng,S., Chandra,G., Sarkar,C., Zhang,Z., Bagh,M.B. and
            Mukherjee,A.B.
  TITLE     Dynamic palmitoylation links cytosol-membrane shuttling of
            acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with
            that of proto-oncogene H-ras product and growth-associated
            protein-43
  JOURNAL   J Biol Chem 288 (13), 9112-9125 (2013)
   PUBMED   23396970
  REMARK    GeneRIF: Dynamic palmitoylation links cytosol-membrane shuttling of
            acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with
            that of proto-oncogene H-ras product and growth-associated
            protein-43
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Fukunishi,Y., Suzuki,H., Yoshino,M., Konno,H. and Hayashizaki,Y.
  TITLE     Prediction of human cDNA from its homologous mouse full-length cDNA
            and human shotgun database
  JOURNAL   FEBS Lett 464 (3), 129-132 (1999)
   PUBMED   10618491
  REMARK    Erratum:[FEBS Lett 2000 Apr 14;471(2-3):261]
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Toyoda,T., Sugimoto,H. and Yamashita,S.
  TITLE     Sequence, expression in Escherichia coli, and characterization of
            lysophospholipase II
  JOURNAL   Biochim Biophys Acta 1437 (2), 182-193 (1999)
   PUBMED   10064901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672076.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3156086.1,
                                           SRR10662774.2092472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AL672076.10        151219-151442       c
            225-330             AL672076.10        149971-150076       c
            331-362             AL672076.10        149719-149750       c
            363-428             AL672076.10        149565-149630       c
            429-476             AL672076.10        149070-149117       c
            477-547             AL672076.10        148914-148984       c
            548-621             AL672076.10        148712-148785       c
            622-723             AL672076.10        148539-148640       c
            724-897             AL672076.10        148255-148428       c
            898-1735            AL672076.10        147341-148178       c
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.33 cM"
     gene            1..1735
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /note="lysophospholipase 2"
                     /db_xref="GeneID:26394"
                     /db_xref="MGI:MGI:1347000"
     exon            1..224
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            225..330
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..948
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /EC_number="3.1.2.22"
                     /note="APT-2; LPL-II; mLyso II; lysoPLA II;
                     lysophospholipase II; palmitoyl-protein hydrolase"
                     /codon_start=1
                     /product="acyl-protein thioesterase 2"
                     /protein_id="NP_001405973.1"
                     /db_xref="GeneID:26394"
                     /db_xref="MGI:MGI:1347000"
                     /translation="MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADAL
                     STIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKAL
                     IEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAAN
                     GSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMA
                     AVKEFLEKLLPPV"
     exon            331..362
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            363..428
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            429..476
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            477..547
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            548..621
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            622..723
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            724..897
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1735
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /note="hexamer: ATTAAA"
     polyA_site      1735
                     /gene="Lypla2"
                     /gene_synonym="LysoII"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcaggt gcgagccgtg gggcaaggca gcaaatgcca ccgtagggat gtgatgaccc
       61 tggctcagaa cccaagttcc cactgtggag aatgggagac gacggtcatc ctttggagag
      121 tgggagccgg gtggagtggg agtccccaga gcttagaagg aaggggatcc tagcttaggg
      181 tgtcaggtgc attccctgtg gaaagaggaa ccccagagtc agaggcccag cctgcaggaa
      241 gccctgcagt gtatgtgtgg taacaccatg tctgtgcccc tgctcaccga cgcagccacc
      301 gtgtctggag ctgagcggga aacggccgcg gttatttttt tacatggact tggagacaca
      361 gggcacagct gggctgacgc cctctccacc atccggcttc ctcatgtcaa gtacatctgt
      421 ccccatgcgc ccaggatccc tgtgacactc aacatgaaga tggtgatgcc ctcctggttt
      481 gacctgatgg ggctgagtcc ggatgcccca gaggatgaag ctggcatcaa gaaggccgca
      541 gagaacatca aggctttgat tgaacatgag atgaagaacg ggattcctgc caaccggatc
      601 gtcctgggtg gcttctcgca gggtggggcc ctgtccctct atacagcact tacctgcccc
      661 caccctctgg ctggcattgt ggcattgagc tgctggctgc ctctgcaccg gaacttcccc
      721 caagcagcca atggcagtgc caaggacctg gccatccttc agtgccacgg ggagctggac
      781 cccatggtac ctgttcggtt tggagccctg acagctgaga agctccggac tgttgtcaca
      841 cctgccaggg tccagtttaa gacataccca ggtgtcatgc acagctcctg tcctcaggag
      901 atggcagctg taaaggaatt tctggagaaa cttctgcctc cggtctaact agttgctggc
      961 tcccaccatg gtcccccagc tcatggggga cccagcaagc aagcaccgca tcatcttgga
     1021 tctgagccgg tcgagcccct gtcccttctc ttcccaccct atcctcttcc cacaggcctc
     1081 tggggcaggt cgccgaggct ggccaggcct tcttgctggc cttggccatc tggaagtcag
     1141 cagcggggtg ggctgctctc ttatcctgcg tccccagagg cgggccccag cagcagtatt
     1201 ggaggggctg taggcggcgg gaggaagggg cccagctgct gacccgctca ctcaggacct
     1261 cacccactag ccccgctttg ggccccctcc cgtgacctca gggtttggcc cgtggggccc
     1321 tcgtgggccc ctccccccat gactctgccc ggataatcgt ctctcctgcc tcgctgcagc
     1381 cgcttctgtc acgaatgtgt ccatggcccg gggcccttgc tgctgtgggc tgcctgctcc
     1441 aggacaggct ggccagtgag gaggtagagt ccctcggggc ctcccctcag cccctccccg
     1501 agaggggctg gaccctgcct ccccatggcc cttccttgca ggcctggagc ctgcagggct
     1561 ggattgaggt tcaagggccc ccccaactcc ctgctgtctc acccccacta tgtcccccct
     1621 tagggccagg gaggtggtgg gggaggagtt gtgtcttgtc ttctgtcttc atgtggtttt
     1681 gggtgttttt ctcgttttgt cctggattcc gataaaatta aaggaattgc ttcaa
//
