LOCUS       NM_008866               2520 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus lysophospholipase 1 (Lypla1), transcript variant 1,
            mRNA.
ACCESSION   NM_008866
VERSION     NM_008866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Speck,S.L., Bhatt,D.P., Zhang,Q., Adak,S., Yin,L., Dong,G.,
            Feng,C., Zhang,W., Ben Major,M., Wei,X. and Semenkovich,C.F.
  TITLE     Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein
            proximity networks link lipid modification and mitochondria
  JOURNAL   Cell Rep 42 (11), 113389 (2023)
   PUBMED   37925639
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Dong,G., Adak,S., Spyropoulos,G., Zhang,Q., Feng,C., Yin,L.,
            Speck,S.L., Shyr,Z., Morikawa,S., Kitamura,R.A., Kathayat,R.S.,
            Dickinson,B.C., Ng,X.W., Piston,D.W., Urano,F., Remedi,M.S., Wei,X.
            and Semenkovich,C.F.
  TITLE     Palmitoylation couples insulin hypersecretion with beta cell
            failure in diabetes
  JOURNAL   Cell Metab 35 (2), 332-344 (2023)
   PUBMED   36634673
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Wei,X., Adak,S., Zayed,M., Yin,L., Feng,C., Speck,S.L.,
            Kathayat,R.S., Zhang,Q., Dickinson,B.C. and Semenkovich,C.F.
  TITLE     Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in
            Peripheral Artery Disease
  JOURNAL   Circ Res 127 (2), 249-265 (2020)
   PUBMED   32233916
  REMARK    GeneRIF: Endothelial Palmitoylation Cycling Coordinates Vessel
            Remodeling in Peripheral Artery Disease.
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Won,S.J. and Martin,B.R.
  TITLE     Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle
  JOURNAL   ACS Chem Biol 13 (6), 1560-1568 (2018)
   PUBMED   29733200
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Watson,R.A., Gates,A.S., Wynn,E.H., Calvert,F.E., Girousse,A.,
            Lelliott,C.J. and Barroso,I.
  TITLE     Lyplal1 is dispensable for normal fat deposition in mice
  JOURNAL   Dis Model Mech 10 (12), 1481-1488 (2017)
   PUBMED   29084768
  REMARK    GeneRIF: Lyplal1 is dispensable for normal mouse metabolic
            physiology.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Toyoda,T., Sugimoto,H. and Yamashita,S.
  TITLE     Sequence, expression in Escherichia coli, and characterization of
            lysophospholipase II
  JOURNAL   Biochim Biophys Acta 1437 (2), 182-193 (1999)
   PUBMED   10064901
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Wang,A., Loo,R., Chen,Z. and Dennis,E.A.
  TITLE     Regiospecificity and catalytic triad of lysophospholipase I
  JOURNAL   J Biol Chem 272 (35), 22030-22036 (1997)
   PUBMED   9268342
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Wang,A., Deems,R.A. and Dennis,E.A.
  TITLE     Cloning, expression, and catalytic mechanism of murine
            lysophospholipase I
  JOURNAL   J Biol Chem 272 (19), 12723-12729 (1997)
   PUBMED   9139730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102311.10, AK002674.1 and BQ033435.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_008866.4.
            
            On Sep 26, 2017 this sequence version replaced NM_008866.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013536.1, AK002674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC102311.10        108769-108835       c
            68-2502             AK002674.1         2-2436
            2503-2520           BQ033435.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.79 cM"
     gene            1..2520
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /note="lysophospholipase 1"
                     /db_xref="GeneID:18777"
                     /db_xref="MGI:MGI:1344588"
     exon            1..160
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..784
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /EC_number="3.1.2.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-protein thioesterase 1; lysoPLA I; lysophospholipase
                     I; phospholipase 1a; lysophopholipase 1; palmitoyl-protein
                     hydrolase"
                     /codon_start=1
                     /product="acyl-protein thioesterase 1 isoform 1"
                     /protein_id="NP_032892.1"
                     /db_xref="CCDS:CCDS14806.1"
                     /db_xref="GeneID:18777"
                     /db_xref="MGI:MGI:1344588"
                     /translation="MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGI
                     KSPHIKYICPHAPVMPVTLNMNMAMPSWFDIVGLSPDSQEDESGIKQAAETVKALIDQ
                     EVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSA
                     NRDISVLQCHGDCDPLVPLMFGSLTVERLKALINPANVTFKIYEGMMHSSCQQEMMDV
                     KHFIDKLLPPID"
     exon            161..192
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            193..258
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            259..306
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            307..377
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            378..451
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            452..553
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            554..730
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
     exon            731..2503
                     /gene="Lypla1"
                     /gene_synonym="APT-1; Gm39587; LPL-I; Pla1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgcgcgc ccggaggggc gggctgggac tttcggctgc cgggagcccg agttcccttc
       61 cgcttccgac gcactgtccg ccagccggtg gatgtgcggc aacaacatgt ccgctccgat
      121 gcccgccgtt gtgccggccg cccggaaggc caccgccgcg gttattttcc ttcacggatt
      181 gggagataca gggcatggat gggcagaagc ctttgcaggt atcaaaagtc cccacatcaa
      241 atacatctgt ccacatgccc ctgtgatgcc agtcacatta aatatgaata tggctatgcc
      301 ttcttggttt gatatcgttg gactttcacc agattcccag gaagatgaat ctggaattaa
      361 acaggcagca gaaaccgtaa aagccttgat agatcaagaa gtgaagaatg gcattccttc
      421 taacaggatt attttgggag gattttctca gggaggcgcc ttgtctttat acactgctct
      481 caccacacag cagaaactgg ctggtgtcac tgcactcagt tgctggcttc cacttcgggc
      541 ttcgttttca caggggccga tcaacagtgc taatcgagat atttccgttc tccagtgcca
      601 tggagattgt gaccctttag ttcccctaat gtttggttct cttactgttg aaagactaaa
      661 agcattgata aatccagcca atgtaacctt caaaatctat gaaggcatga tgcacagctc
      721 atgtcagcag gaaatgatgg atgtcaagca cttcattgat aagctcctac ctccaattga
      781 ttgacatcac taagaggcct tgagtagaag ttcaccagca tcacagtagt agagtataaa
      841 cctcttccca tgactgacca tagaacttct aatgtgtgca gtgttaaaat gttttgcaaa
      901 tacataccaa tgatacagac taaatgatgt taccctcatg ggaaatatat gatcctttta
      961 agtgtctatg catatatttg tattatacaa ttcagaatat actaagtatt acagtaggta
     1021 agtgaagcaa ctagattctt tgtctcaaat tcagcaaaat aagataacaa acagttttat
     1081 tacatcattt gaaaattact agtatgttct gtgaagatgt gttcaggtaa gatgtaagtg
     1141 acttcttagt tctgtgagtt agactatagt tttactccac aattgttcag tctccatgca
     1201 gtgtctgtat ttttctgttt gtattcacat agatgatact ataatagcta agaatcagat
     1261 ggtattacat tatccctaat aatggggata atgcttttga gtgtcaaaaa gtaatactgc
     1321 attcttcaat taatggccct tctattggga gaccaggctt tttttccctt ctatgtaatt
     1381 tttctcaaga aaaaacaagg ttcttttttg attttccgta gaaaactaat attgcctctc
     1441 tgtcatatat tttattttga cattttgaga tacagacata gccgggcgtg gtggtgcatg
     1501 cctttaatcc cagcactcgg gaggcagagg caggcggatc tctgtcaata gcctggtcca
     1561 cagagtgagt tccaggacag ccagggctac acagagaaac cctgtctcgg aaacaaacaa
     1621 acaaacaaac cgaaacacag acatacagta tttccaacct aggtaatatg aaaagaaatc
     1681 aaacattact taagtttata tatttcaaat aactgcacct tagtccaact ttagactgta
     1741 gagttataga ctctccagtc ctggtaataa atctgtggtt ttatttttct gtaaaacact
     1801 taaaggggaa gtaatatctt ggcatattta gaaatacttg tgactggctt caaaatataa
     1861 tttcttaaat atcttatagc cgattttaag tttacatttt ctgtacatgt tatgcttaaa
     1921 accaaatact gttcaagatg agcaatcaga cttatgtttt atttttatct gggtaacata
     1981 ttattttgaa attttcatct taagtaaagg agcttttgat aatcagtctc ctgtacaaat
     2041 attaaaataa taatttgatt ttaaatcatc agcatgttca aaatactggt gaaaattatt
     2101 taatataagg actggttaga acattatata tatatcccat atttataact gttaccacac
     2161 agttgaatat gttgcaaaaa ttatggttat ttctgaacgg ttgcttttct tgctgttttc
     2221 caaccaacca agaagcacct ttataaacag gtgctaattg atatgaagat cattttggta
     2281 tgtcctagat agaatgaagc caaatgtctg gatttaaaac aatttcaaac aatcatttac
     2341 tattttgctt tactttaaag aacataaatt tacttcagtt attctatctg taaagattta
     2401 tttggtataa gaaatattcc attgactgtg tgctgtaatg tgggaaaatg tcatgttttt
     2461 cacagtttct atcaatgtga aataaaattt aattttggct ttaaaaaaaa aaaaaaaaaa
//
