LOCUS       NM_001083884            1095 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus LY6/PLAUR domain containing 8 (Lypd8), transcript
            variant 1, mRNA.
ACCESSION   NM_001083884
VERSION     NM_001083884.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1095)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1095)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1095)
  AUTHORS   Hsu,C.C., Okumura,R., Motooka,D., Sasaki,R., Nakamura,S., Iida,T.
            and Takeda,K.
  TITLE     Alleviation of colonic inflammation by Lypd8 in a mouse model of
            inflammatory bowel disease
  JOURNAL   Int Immunol 33 (7), 359-372 (2021)
   PUBMED   33822948
  REMARK    GeneRIF: Alleviation of colonic inflammation by Lypd8 in a mouse
            model of inflammatory bowel disease.
REFERENCE   4  (bases 1 to 1095)
  AUTHORS   Okumura,R., Kodama,T., Hsu,C.C., Sahlgren,B.H., Hamano,S.,
            Kurakawa,T., Iida,T. and Takeda,K.
  TITLE     Lypd8 inhibits attachment of pathogenic bacteria to colonic
            epithelia
  JOURNAL   Mucosal Immunol 13 (1), 75-85 (2020)
   PUBMED   31659301
  REMARK    GeneRIF: Lypd8 inhibits attachment of pathogenic bacteria to
            colonic epithelia.
REFERENCE   5  (bases 1 to 1095)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1095)
  AUTHORS   Okumura,R., Kurakawa,T., Nakano,T., Kayama,H., Kinoshita,M.,
            Motooka,D., Gotoh,K., Kimura,T., Kamiyama,N., Kusu,T., Ueda,Y.,
            Wu,H., Iijima,H., Barman,S., Osawa,H., Matsuno,H., Nishimura,J.,
            Ohba,Y., Nakamura,S., Iida,T., Yamamoto,M., Umemoto,E., Sano,K. and
            Takeda,K.
  TITLE     Lypd8 promotes the segregation of flagellated microbiota and
            colonic epithelia
  JOURNAL   Nature 532 (7597), 117-121 (2016)
   PUBMED   27027293
  REMARK    GeneRIF: Lypd8 prevents flagellated microbiota invading the colonic
            epithelia in mice; Lypd8 mediates segregation of intestinal
            bacteria and epithelial cells in the colon to preserve intestinal
            homeostasis
REFERENCE   7  (bases 1 to 1095)
  AUTHORS   Simmonds,C.S., Karsenty,G., Karaplis,A.C. and Kovacs,C.S.
  TITLE     Parathyroid hormone regulates fetal-placental mineral homeostasis
  JOURNAL   J Bone Miner Res 25 (3), 594-605 (2010)
   PUBMED   19968565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL663107.13.
            
            On Mar 30, 2023 this sequence version replaced NM_001083884.1.
            
            Summary: This gene encodes a member of the Ly6/PLAUR family of
            cysteine-rich proteins that plays an important role in the
            protection of colonic epithelium from flagellated microbiota. The
            encoded protein undergoes proteolytic processing to generate a
            mature, glycosylphosphatidylinositol-anchored protein that is
            localized to the apical surface of the colonic epithelial cells.
            Mice lacking the encoded protein are sensitive to chemically
            induced intestinal inflammation. [provided by RefSeq, Aug 2016].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008940.1, BY708824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL663107.13        22084-22139
            57-121              AL663107.13        22686-22750
            122-224             AL663107.13        25326-25428
            225-338             AL663107.13        25793-25906
            339-497             AL663107.13        27651-27809
            498-632             AL663107.13        29763-29897
            633-1095            AL663107.13        33118-33580
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.19 cM"
     gene            1..1095
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /note="LY6/PLAUR domain containing 8"
                     /db_xref="GeneID:70163"
                     /db_xref="MGI:MGI:1917413"
     exon            1..56
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            57..121
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            122..224
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..937
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /note="ly6/PLAUR domain-containing protein 8"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 8
                     preproprotein"
                     /protein_id="NP_001077353.1"
                     /db_xref="CCDS:CCDS36163.1"
                     /db_xref="GeneID:70163"
                     /db_xref="MGI:MGI:1917413"
                     /translation="MRGVFIAGVIAAFAITVVDSLNCTQCYTYNSTCDGQATECNEQS
                     FSCVESSINSTLGGFLHVYQNKFCSASNCTENSTEVAFTVHLFDDQRYHFASQCCQGE
                     SCNATHSESGTQNVTDMQCMSCYGHNKTLCEEKPQKCYEGEQCVFIIAEMVNGSGRVE
                     LKGCSDISNSTCQFLSPGNTTVGEFVFKSVECTQPTEYTNSTTTIPPITNTSLTSVTR
                     PGIKTSPASVTPQASMGTKASFTSSIFGSLLLLKLLF"
     exon            225..338
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..497
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..632
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1095
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1095
                     /gene="Lypd8"
                     /gene_synonym="2210415F13Rik"
                     /note="major polyA site"
ORIGIN      
        1 aacacattgc caagttccat cttcctccgg atagtgtccc tggctggacc cagaaggatt
       61 gccacaaggc tctgcctctc tgctgtctgc tagccaggtc ctgaattctc tgggtctgga
      121 ggtttgaggc tctgtggccc catcctctgg ggaagccaac tccagcatca tgagaggcgt
      181 cttcatcgct ggtgtcattg cggcattcgc catcacagtt gtagactccc tgaattgtac
      241 acagtgttat acgtacaata gcacctgtga tggccaggcc actgaatgca atgagcagtc
      301 cttcagttgt gtggagtcct ctatcaactc cactctagga gggttcctgc atgtgtacca
      361 gaacaagttc tgctccgcat cgaattgcac cgagaacagc acggaggtgg ccttcactgt
      421 ccatctattt gatgaccaaa gataccattt tgcaagccag tgctgccaag gagagtcctg
      481 caatgccacc cactctgaat ccggaacaca gaatgtaact gacatgcagt gcatgtcttg
      541 ctatggtcac aacaaaacac tctgcgagga gaaaccccaa aagtgttacg aaggagaaca
      601 atgtgtcttc atcattgcgg agatggtaaa tggctctggc agagtggagc tgaagggctg
      661 ttctgatatc agcaactcta cttgtcaatt cctgtcccct gggaacacaa cagttggaga
      721 gtttgttttc aagtcggttg aatgtacgca acccactgag tataccaact cgaccaccac
      781 tatcccacca atcaccaaca cttccctcac ctctgttacc cgaccaggca tcaaaacttc
      841 ccccgcctct gttaccccac aggctagcat gggcaccaaa gcttccttca cctcctctat
      901 cttcggcagc cttcttcttc tgaagctgct gttctgaggt tcctgggctc tgctccatcc
      961 agtatcccat gggtgtcaac acctttctct tcatatacct tccagttaga ctgtccagtg
     1021 ggttggaagt cacaggactc caggcaatgc tagcagccac agtatctcct ttattaaagt
     1081 gttgcttgag gtcta
//
