LOCUS       NM_001379382            2059 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus LY6/PLAUR domain containing 6B (Lypd6b), transcript
            variant 3, mRNA.
ACCESSION   NM_001379382 XM_006498356
VERSION     NM_001379382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Bychkov,M.L., Kirichenko,A.V., Paramonov,A.S., Kirpichnikov,M.P.
            and Lukmanova,E.N.
  TITLE     Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and
            Lypd6B Expression in the Hippocampus and Increased Expression of
            Proinflammatory Cytokines in the Hippocampus and Blood Serum
  JOURNAL   Dokl Biochem Biophys 511 (1), 145-150 (2023)
   PUBMED   37833597
  REMARK    GeneRIF: Accumulation of beta-Amyloid Leads to a Decrease in Lynx1
            and Lypd6B Expression in the Hippocampus and Increased Expression
            of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929069.10, BX813318.3 and AL806528.14.
            
            On Apr 1, 2020 this sequence version replaced XM_006498356.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.174769.1,
                                           SRR7345562.2977554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL929069.10        31414-31504
            92-187              AL929069.10        107542-107637
            188-247             BX813318.3         58357-58416
            248-399             AL806528.14        5749-5900
            400-498             AL806528.14        6826-6924
            499-629             AL806528.14        9384-9514
            630-2059            AL806528.14        10724-12153
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 28.74 cM"
     gene            1..2059
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /note="LY6/PLAUR domain containing 6B"
                     /db_xref="GeneID:71897"
                     /db_xref="MGI:MGI:1919147"
     exon            1..91
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            92..187
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            188..247
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            248..399
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..803
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /note="ly6/PLAUR domain-containing protein 6B"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 6B
                     precursor"
                     /protein_id="NP_001366311.1"
                     /db_xref="GeneID:71897"
                     /db_xref="MGI:MGI:1919147"
                     /translation="MLLLCHILAVTILQILIISENWVFAKNINFYNVRPPLDPTPFPN
                     SFKCFTCENAGDNYNCNRWAEDKWCPQDTQYCLTVHHFTSHGRSTSITKKCASKNECH
                     FVGCRHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSVSSVPSPYL
                     LVLAWLFMLPLL"
     exon            400..498
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..629
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            630..2059
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="Lypd6b"
                     /gene_synonym="2310010M24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggccacag ccatcgccag cccggagcgg gtgtctggag cccaggccgg gagccgagcg
       61 aggcgccggg agccggccgg cgtccgcgca gagttatgaa taatccctga ttgctgtcgt
      121 gctgagtggg taaatgacaa agggcagagg gaattttggt gtcagacgcc tgctttctcc
      181 aactctggtg tccttgaatg agagaaacaa ggactagaag aggaggaaga agacttgggt
      241 aaggaagaca cacgactttg acctgcccaa tcagggtgga cagaatgctg ctcctctgcc
      301 acattctagc tgtcaccatc cttcagatct tgatcatctc agagaactgg gtgtttgcaa
      361 agaacatcaa cttctacaat gtgaggcccc ctcttgatcc cacaccattc ccaaacagtt
      421 tcaagtgttt tacttgcgaa aatgcagggg ataattataa ctgcaatcga tgggcagaag
      481 acaagtggtg tccgcaggac acacagtatt gtttgacagt tcatcacttc accagccacg
      541 gaagaagtac gtccatcacg aagaagtgtg cctctaaaaa tgaatgtcat tttgtcggct
      601 gccgacacag ccgagattcg gaacacacgg agtgtaggtc ttgctgtgaa ggaatgatct
      661 gcaacgtaga gttgcccacc aaccacacaa atgcagtctt cgctgtaatg cacgctcaga
      721 ggacgtctgg cagcagtgtc tccagtgtcc ccagtcctta cctcctggtg ctggcctggc
      781 tcttcatgct tcccttgcta tgatgatgca gttcccaaga gaagcagaga ccagcgatgt
      841 aaagcacaga aacagtgggc cagcgaactc tggagcgaag gtccatcttg cacttgataa
      901 agaagatgca ttggactaca aagtagaagg cagaggtttg ctttgctgaa atgctcctgc
      961 atgaggtcag agcactgagc atgaggactt ggtaggaacc aagaggacga cgacctagca
     1021 tccagtgttc tggtccagag atgctgcatt ttgtcagttc tatagaagag ccaaccagca
     1081 tttttgacag caagagtagc ttgataagcc cgggcctgac taggccttca cctggaagga
     1141 cttttttgac ctcatggact ccctcagagt ctgctgggtc agactcttgt ttctgcggct
     1201 atctcagagc atctctgaaa tgtaaccctt ctgcccatta ccgtaataag tacttgagat
     1261 gatccatttg taaagacaaa tggtttgttt gggctcacag ttttggagat tgcagtatat
     1321 cctggtttgg ggcctgtgtt agagagtgag tagccactta taaatagaaa cttgaaaagt
     1381 gggagaggat ggtctggaga gatgtctcag cagttaaggg cagtgactga tctcctggag
     1441 gacccaggtt tgattctcag cactcacata gcagctcaca actaaaagct ccagtgccag
     1501 gagatccaat gctctcttct ggcctctgtg agtactgcag acatgtggtg cacagacata
     1561 catgcaggta aaacacccat atacatagtt ctttgtaata aagggaaagg aaggaaaaag
     1621 agaaagaagc aggggtggga gagagagagc atgcacttaa gattctatag tacccttcaa
     1681 ggttgtgttc ccaacgtcct aagaaattct ctgactagac cctgtttcct aatggtacca
     1741 atgggctgag gaccaaaact ttaaccctgt aacagtcagg atccaaacaa tagtatccac
     1801 taaccaccta gtccgtgagc agagcaactg cagggggagc tttccagttc attctgtgaa
     1861 tccatttgtc aattacgagc tggttgggga tagggtgcaa acctttgagt tagacagtgt
     1921 aatgcatgct gcatgtttct tgacaatgtg gaggcctcta atgaagcaca tttaccagtg
     1981 tcactaaatt tgtgtttcca ggcaccatgg gtgatacatg ctgtctgaaa gaataaaatt
     2041 ctatgctgat gtgacttaa
//
