LOCUS       NM_177139               3495 bp    mRNA    linear   ROD 17-JAN-2023
DEFINITION  Mus musculus LY6/PLAUR domain containing 6 (Lypd6), transcript
            variant 1, mRNA.
ACCESSION   NM_177139
VERSION     NM_177139.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3495)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   2  (bases 1 to 3495)
  AUTHORS   Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP,
            Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM and Baker
            CVH.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   3  (bases 1 to 3495)
  AUTHORS   Sadahiro M, Demars MP, Burman P, Yevoo P, Zimmer A and Morishita H.
  TITLE     Activation of Somatostatin Interneurons by Nicotinic Modulator
            Lypd6 Enhances Plasticity and Functional Recovery in the Adult
            Mouse Visual Cortex
  JOURNAL   J Neurosci 40 (27), 5214-5227 (2020)
   PUBMED   32467358
  REMARK    GeneRIF: Activation of Somatostatin Interneurons by Nicotinic
            Modulator Lypd6 Enhances Plasticity and Functional Recovery in the
            Adult Mouse Visual Cortex.
REFERENCE   4  (bases 1 to 3495)
  AUTHORS   Yook C, Kim K, Kim D, Kang H, Kim SG, Kim E and Kim SY.
  TITLE     A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical
            Distribution of Interneurons, Increased Inhibitory Synaptic
            Transmission, and Autistic-Like Behavioral Deficits in Mice
  JOURNAL   Front Mol Neurosci 12, 241 (2019)
   PUBMED   31680851
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3495)
  AUTHORS   Arvaniti M, Polli FS, Kohlmeier KA, Thomsen MS and Andreasen JT.
  TITLE     Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced
            responses to nicotine
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 82, 86-94 (2018)
   PUBMED   29195920
  REMARK    GeneRIF: Study employ the marble burying (MB) and elevated zero
            maze (EZM) tests in Lypd6 knock-out (KO) and wild-type (WT) mice
            and find that loss of Lypd6 leads to decreased digging behaviour in
            the MB test and increased time spent in the open area in the EZM
            test; demonstrate that acute nicotine administration reduces
            digging in the MB test in both KO and WT mice and further
            accentuates the inherent genotype difference.
REFERENCE   6  (bases 1 to 3495)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3495)
  AUTHORS   Ozhan G, Sezgin E, Wehner D, Pfister AS, Kuhl SJ, Kagermeier-Schenk
            B, Kuhl M, Schwille P and Weidinger G.
  TITLE     Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6
            phosphorylation in raft plasma membrane domains
  JOURNAL   Dev Cell 26 (4), 331-345 (2013)
   PUBMED   23987510
  REMARK    GeneRIF: Lypd6 appears to control Lrp6 activation specifically in
            membrane rafts, which is essential for downstream signaling.
REFERENCE   8  (bases 1 to 3495)
  AUTHORS   Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le
            Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen
            GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D and Gondin J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   9  (bases 1 to 3495)
  AUTHORS   Chen H, Palmer JS, Thiagarajan RD, Dinger ME, Lesieur E, Chiu H,
            Schulz A, Spiller C, Grimmond SM, Little MH, Koopman P and Wilhelm
            D.
  TITLE     Identification of novel markers of mouse fetal ovary development
  JOURNAL   PLoS One 7 (7), e41683 (2012)
   PUBMED   22844512
REFERENCE   10 (bases 1 to 3495)
  AUTHORS   Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D and Zimmer A.
  TITLE     Modulation of the Ca2+ conductance of nicotinic acetylcholine
            receptors by Lypd6
  JOURNAL   Eur Neuropsychopharmacol 19 (9), 670-681 (2009)
   PUBMED   19403274
  REMARK    GeneRIF: Lypd6 seems to constitute a novel modulator of nAChRs that
            affects receptor function by selectively increasing Ca2+-influx
            through ion channels
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL806528.14, BB653059.1, BC070462.1 and AW547599.2.
            
            [WARNING] On Apr 14, 2023 this sequence was replaced by
            NM_177139.6.
            
            On Aug 9, 2011 this sequence version replaced NM_177139.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.9173.1,
                                           SRR7652917.556882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL806528.14        129733-129771
            40-589              BB653059.1         1-550
            590-3490            BC070462.1         611-3511
            3491-3495           AW547599.2         1-5                 c
FEATURES             Location/Qualifiers
     source          1..3495
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..3495
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /note="LY6/PLAUR domain containing 6"
                     /db_xref="GeneID:320343"
                     /db_xref="MGI:MGI:2443848"
     exon            1..156
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            157..345
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..743
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /note="ly6/PLAUR domain-containing protein 6"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 6 precursor"
                     /protein_id="NP_796113.1"
                     /db_xref="CCDS:CCDS16026.1"
                     /db_xref="GeneID:320343"
                     /db_xref="MGI:MGI:2443848"
                     /translation="MEPSPALAWLLLLSLVADCLKAAQSRDFTVKDIIYLHPSTTPYP
                     GGFKCFTCEKAADNYECNRWAPDIYCPRDTRYCYTQHTMEVTGNSISVTKRCVPLEEC
                     LSTGCRDSEHEGYKICTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPHCVSVIV
                     SCLWVWLGLTL"
     exon            346..444
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            445..575
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            576..3495
                     /gene="Lypd6"
                     /gene_synonym="E130115E03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccctccag ccgcgctcgc gccctccttc tcctactgcg ctcccggcac gggccgcgcg
       61 caggcggcgc tccgcattgc acacgcgggg ggcgccgcag tgttcgtggg atggggcagc
      121 gggctgcctc tggcggcagg gacacgagca tcccgggtgc cagttctctt ccaccgtctc
      181 aagtgcccac tctgaggccc tctgtatgag tgacacgcca gtctgccatg gaacctagcc
      241 ctgccctggc ctggctccta ctgctgagcc tggtggctga ttgtctgaag gctgctcagt
      301 cccgagactt cacagtgaaa gacataatct acctccaccc ttcaaccact ccgtatcctg
      361 gtgggtttaa gtgtttcacc tgtgagaaag cagcagacaa ttatgaatgc aaccgatggg
      421 ctcctgacat ctactgtcct cgagacacca gatactgcta cactcagcac acgatggaag
      481 tcacagggaa cagcatctct gtcaccaaac gctgtgtccc gctggaggag tgcttatcca
      541 caggctgccg agactcagag cacgaaggct acaagatctg cacctcctgc tgtgaaggaa
      601 atatctgtaa tctaccactc cctcgaaatg aaactgatgc cacatttgct accacatcac
      661 ctataaacca gacgaatggg cacccacact gtgtttcagt gatcgtgtcc tgcttgtggg
      721 tgtggctggg actcacctta taataaccct ttctctctac caaatgtaga tgagctctgt
      781 gggtttcccc atggcccata gtcatgcatg aagtcattgg cttggcagta gtgacacaac
      841 acaatcacag caaccccaga cgtcatcgca gccacccatt aattaccatt aaccatgaag
      901 aacaagcatt gcttccatgc tgtcatttcc agcctagcta caaccccatc acagtcagcc
      961 tgtccccccc aatagataca gaccctgatt tctatactac aaacctgtga tttcactcca
     1021 agaaagagtt ctgcatttat taatgtctgg ggttcttgct tcagaatcca tgcatgagct
     1081 gcaggaggcc ctggaccctc tgaggaataa gctatggatg caggaggtat cgttcttttc
     1141 aggaaaagag taaagaacca ttgacttaat tgcaatcaca cctgcaccta tagctttaga
     1201 agtttaaaac tttaaatcca aaataaatgg aatagtttct ttgagattat gatggagtcc
     1261 cggaaagagt tgaaagaact ttgctcaatt taatttcccc agtctcctta tcttaacatt
     1321 gggaaatgtg ttccttctgc tctttgtaga tgttttttta aaaaggcaat tataaaagtt
     1381 tgttgtattt gtaggagtga aaagagaaag agttcctcca acttgatgaa attagcatcc
     1441 acaagataat gttatccctt cttataactg ggcagattgg ccttgactca gttgctaatt
     1501 atgcttcctg agtgccagga ttccagctgg accagcagga ttattttctc caggtgttgc
     1561 attctagtca gatatagctg atgtagtcag agagaggact tcagaataaa aggaagcttt
     1621 ctggaggtta gtcctagctc atttggaagg ctccgaaatg gctaagcaaa attccttctc
     1681 tttccacagt atttactggc acagagctgt ctccttccac aaccacagtg actttaaaga
     1741 gaaagctctg ggttaacttc tcagtagatc aataagataa gagcacactt gtgctagggt
     1801 gagaaaaaga tagattgtaa gtagtatggt ggtctaagga gtacgttttg tttctctctg
     1861 ctactgtttt tgaagaagaa aagactttca ttgtctttca tgtatttttt taacctaaaa
     1921 aattgtgttt gttttcttct cctatgtaaa ttctttaaat gacatttatt tttgtatggt
     1981 ataaactgaa aactatattt caaaaagaat tctttctttt tgtttttctg aacaaaatat
     2041 cagttagaat gcttgctttc aagagcggta gggatgctga ccatggtagg attcctgacc
     2101 atgggaagtt atctgtgttc cttgtactga tgctgaaaat gttactgtgc tatggacaag
     2161 agatgtgcat ttgcctcaag ggtttgactc attgttttcc cagaaatgtt gcccaagaaa
     2221 gattcaggtg gaggccatca ctggtgtgat agtctttgca gggctgtgag gtgtgtccac
     2281 agggaacttg gcagagctat gtcttgaaga ggtcaatgat gttaaaatat atctgtcctg
     2341 cacagggaac tttagcttaa attagaaccc cgctcaggca ccaaatctga accgacggca
     2401 gaaactctga tgcaagtcat tgaagtttca tcacacagcc ttaatgaaga gtttggcagg
     2461 cttatcaatt tcttgcttat aactgcggat gggagagcag gagagaaaga cctgtaataa
     2521 gcacctctta tgtgcccagc actttgctaa gcactttaca tagttaggcc atataaccgt
     2581 acatcaattc tgtaagaaca gaacatattg atgtgtacaa atgaagatcc caaggctcaa
     2641 agaagtttga taaatgaagc cttttccttc agatttagtt tatgtgggat gtgacatgtt
     2701 tgaaaagaaa gaaaaaaaaa actgggggag gggggctgga atttctcagc taggaaaacc
     2761 tctaggcctg acttcatggg aatttcccca tcttatcatg tagaacatat cctgcttctc
     2821 aggatgacat ttgcatgtgt ccccttgtca ctttttcttt ggggaataaa gttatagctt
     2881 ccttatttat cctctggtaa agagaggaga tagttgatct tgcatctaaa gatgctataa
     2941 gacaattaga atttgatgtt gtacatgtct acaagtaccg tttttatgca tggtcacatt
     3001 ctactgacat ttgccaagtc tgcatgcaat ctgaacaaga gacaagggac tgaccacaca
     3061 agagcctccc tggctggttt tcagggattg ggttctcaaa ggtataggct gtcctcacct
     3121 ggggagtagt gccagccaca gtacacatgt gctgcacaca tccatactgc ctttcaaact
     3181 atctttttaa ttctcttgaa agaatatgga tttgctcacc acccccagcc tcaagaagcc
     3241 aaggagggac cattcctgta gaaggtccag gactagttac ccatgtgact gttgtcactt
     3301 taaacttccc attaaacctc accattggtg atggcttaaa atgcaaagag ccatgatgtg
     3361 tatattaacc tatgttctac atatttattt ttagactttc tccaacatcc atgttagtat
     3421 gggattaatg cctaaatgta aatattgtac actttgtaaa tcaatgaata aagattttaa
     3481 gtgtgtttca ttcgg
//
