LOCUS       NM_145100               6480 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus Ly6/Plaur domain containing 1 (Lypd1), transcript
            variant 1, mRNA.
ACCESSION   NM_145100
VERSION     NM_145100.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6480)
  AUTHORS   Zhang,D., Ren,M., Bi,Z., Gu,Y., Li,S., Wang,G., Li,X. and Liu,Z.
  TITLE     Lypd1-DTR/+: A New Mouse Model for Specifically Damaging the Type
            Ic Spiral Ganglion Neurons of the Cochlea
  JOURNAL   Neurosci Bull 39 (9), 1459-1462 (2023)
   PUBMED   37222854
REFERENCE   2  (bases 1 to 6480)
  AUTHORS   Fu,Y., Miyazaki,K., Chiba,Y., Funada,K., Yuta,T., Tian,T.,
            Mizuta,K., Kawahara,J., Zhang,L., Martin,D., Iwamoto,T.,
            Takahashi,I., Fukumoto,S. and Yoshizaki,K.
  TITLE     Identification of GPI-anchored protein LYPD1 as an essential factor
            for odontoblast differentiation in tooth development
  JOURNAL   J Biol Chem 299 (5), 104638 (2023)
   PUBMED   36963497
  REMARK    GeneRIF: Identification of GPI-anchored protein LYPD1 as an
            essential factor for odontoblast differentiation in tooth
            development.
REFERENCE   3  (bases 1 to 6480)
  AUTHORS   Shrestha,B.R., Wu,L. and Goodrich,L.V.
  TITLE     Runx1 controls auditory sensory neuron diversity in mice
  JOURNAL   Dev Cell 58 (4), 306-319 (2023)
   PUBMED   36800995
REFERENCE   4  (bases 1 to 6480)
  AUTHORS   Sanders,T.R. and Kelley,M.W.
  TITLE     Specification of neuronal subtypes in the spiral ganglion begins
            prior to birth in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 119 (48), e2203935119 (2022)
   PUBMED   36409884
REFERENCE   5  (bases 1 to 6480)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6480)
  AUTHORS   Tekinay,A.B., Nong,Y., Miwa,J.M., Lieberam,I., Ibanez-Tallon,I.,
            Greengard,P. and Heintz,N.
  TITLE     A role for LYNX2 in anxiety-related behavior
  JOURNAL   Proc Natl Acad Sci U S A 106 (11), 4477-4482 (2009)
   PUBMED   19246390
  REMARK    GeneRIF: altered glutamatergic signaling in the prefrontal cortex
            of Lynx2 mutant mice contributes to increased anxiety-related
            behaviors
REFERENCE   7  (bases 1 to 6480)
  AUTHORS   Yu,D.H., Fan,W., Liu,G., Nguy,V., Chatterton,J.E., Long,S., Ke,N.,
            Meyhack,B., Bruengger,A., Brachat,A., Wong-Staal,F. and Li,Q.X.
  TITLE     PHTS, a novel putative tumor suppressor, is involved in the
            transformation reversion of HeLaHF cells independently of the p53
            pathway
  JOURNAL   Exp Cell Res 312 (6), 865-876 (2006)
   PUBMED   16413018
REFERENCE   8  (bases 1 to 6480)
  AUTHORS   Dessaud,E., Salaun,D., Gayet,O., Chabbert,M. and deLapeyriere,O.
  TITLE     Identification of lynx2, a novel member of the ly-6/neurotoxin
            superfamily, expressed in neuronal subpopulations during mouse
            development
  JOURNAL   Mol Cell Neurosci 31 (2), 232-242 (2006)
   PUBMED   16236524
  REMARK    GeneRIF: cloning and characterization of lynx2; lynx2 is expressed
            in a large number of neuronal structures but only in discrete
            postmitotic neurons
REFERENCE   9  (bases 1 to 6480)
  AUTHORS   Zhang,J., Moseley,A., Jegga,A.G., Gupta,A., Witte,D.P., Sartor,M.,
            Medvedovic,M., Williams,S.S., Ley-Ebert,C., Coolen,L.M.,
            Egnaczyk,G., Genter,M.B., Lehman,M., Lingrel,J., Maggio,J.,
            Parysek,L., Walsh,R., Xu,M. and Aronow,B.J.
  TITLE     Neural system-enriched gene expression: relationship to biological
            pathways and neurological diseases
  JOURNAL   Physiol Genomics 18 (2), 167-183 (2004)
   PUBMED   15126645
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6480)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045592.1, AC153655.4 and BQ175060.1.
            
            On Jul 24, 2015 this sequence version replaced NM_145100.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045592.1, AB041649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2043              AK045592.1         2-2044
            2044-6185           AC153655.4         27973-32114
            6186-6480           BQ175060.1         1-295               c
FEATURES             Location/Qualifiers
     source          1..6480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 54.7 cM"
     gene            1..6480
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /note="Ly6/Plaur domain containing 1"
                     /db_xref="GeneID:72585"
                     /db_xref="MGI:MGI:1919835"
     exon            1..376
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..514
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..6464
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2047
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /note="major polyA site"
     regulatory      3676..3681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3704
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
     regulatory      5664..5669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /note="hexamer: AATACA"
     polyA_site      5687
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
     regulatory      6430..6435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      6451
                     /gene="Lypd1"
                     /gene_synonym="2700050C12Rik; C530008O16Rik; Lynx2;
                     Lypdc1"
ORIGIN      
        1 agaagaggcg agactttttt gggtgctccg gatcgccagt agttcttcaa gcctcagcag
       61 ccaactcctc cggaggcgct gcgctccgcc ccagggagcg cgaatccaag gagcctggga
      121 ccagcctctg ggagcccccg gcgcgggcga tgcgggcgcc gcgggcgaca cctgcggctc
      181 ctctcggtgg cagccgtcgc ttgggcggca gcagcgcgag cctcggcagc ctcggcagct
      241 actgtcgccg cggccagaac agcctccgct gcggtcgtgg tctctgatgc tcttgcccgc
      301 tcccggccct gccgatccgg gaggatgtgg gttctcggca tcgcagcaac tttttgcgga
      361 ttgttctggc ttccagggct ggcgctgcaa attcagtgct accagtgtga agaattccag
      421 ctgaacaacg attgctcatc ccctgagttc atcgtaaatt gcaccgtgaa cgttcaagac
      481 atgtgtcaga aagaagtgat ggagcaaagt gctgggatca tgtaccggaa gtcgtgtgca
      541 tcgtcagcag cctgtctcat tgcttcagct gggtaccagt ccttctgttc ccctgggaaa
      601 ctgaactccg tgtgcatcag ctgctgcaac acccctcttt gcaatgggcc gaggcccaag
      661 aagagaggca gctctgcctc ggccatcagg ccagggcttc tcaccactct cctgttcttc
      721 cacttagccc tctgcttggc acactgctga agctaaagga gatgccaacc cctgctgcct
      781 cacctgtctg gcccttcgtc tctcaccttc ccgagtctct tctgggtgtc cttttattct
      841 gggtagacaa gggagtcttt ttgttccctc ctttcaagta acgcaagatt gccgtgcaca
      901 aatacttttg taagctctga accaattcat tctgaatttc tgtgtgtagt tgaagaaaaa
      961 agcatggagc agaaagtcca gaccctccca tcccaatctg gttaaccacc gccaaggcta
     1021 gcctggaaga accagccctt agaagtcatt gagatacgca tctgcctttc ccaaagcctt
     1081 gagcttccat tctgtcccag taggagtcac agtctattca gagactgctg ctgcgtgaag
     1141 gtaactttgc ttttgcggga ggggagagcc agtttcggct caaggcttct gaacttgcca
     1201 ttcatacttc ctgctcctgt aaactatttt ctggggtgga cccagctggt ttggtctctg
     1261 agccagtctg tggtgactca ggactcaagg gctggggctt agcctctcca ggcttggcct
     1321 cagtctgaaa agtgcttaag aaaaccttgt tagttctcct ggaggaagag ttactgcgcc
     1381 gggaggctag gaagatgagg gggctgcggg ctgagctggt gctgtccttg gtggagatga
     1441 agcgggcacg ctggcgtttc tcttggttgg catgctgcag agtcaggcgg cagcagagca
     1501 cctgccagaa caccttccgg aactgctgag aggacacgtt gtagaggaga gggttgacca
     1561 cagagctgag gtagaagaag gtatcagaga agggcaggag gatcatgtat gccctgaagt
     1621 acgttctggt ccagtcatgt ttgggttttg ctgcagccat gatccgtcgg atctgattgg
     1681 gcatccaaca cacggccaac gtcaccacaa tcagtcctgg caggcaagaa caggagagaa
     1741 aaggagacgg ggagagaaac agcatgagaa caaaaataaa taaataaaaa cccataaaat
     1801 attaagcccc ttggttctgt tgcttactgg ccgagaaacg gtaccaatct ttcagctctg
     1861 tgcttgtcgg cttctttttg ccactggcaa aggagaattt aatgctgctt caagctcagg
     1921 ggacttggct atgttaaaaa gcgttaaatg ctttcgacag tgtatttata cttacggctg
     1981 cctgttaatt ttcaaaatgt tttcattgtt gctcgtgtat ccagaaaata tctcacgttg
     2041 gccataaccc tggttttgtc tttttgtttc tagatgagcc cataaggtat agccatagta
     2101 gagggaaacg gtagctgttt ttataaacga ctactgaact atgtgagaag acacagtgat
     2161 attgtgaagt caaatggaag ttgtttcatt ttgcctaaac aaatacattt tgtgatgctg
     2221 attttgcatc cagtttcagg agaagtaaaa tcagggacag gtagtcatgg agaagaggta
     2281 ctactaagcc ctgcccctgt gcgtgaggca ctgagtatcc agacatccat atgaatgccc
     2341 attacattct ggcttacata aacacggcta cttctaaagt atgacaaatg aaatcacagt
     2401 acagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta gaaagtagac
     2461 gatatataaa tgtatgtccc aaaaggtata caacctccat ctatatcagc atctctgctt
     2521 cttttcaaac acttttggaa gccccttcca ccttaactta ggaaaacaaa ttgtccccaa
     2581 acaccaaaat ctcaaaaact catgccatgt acagacaggg gcacaccctc cgcttttgta
     2641 gcactgagct gcagtgtgac tggccaggaa tgatgaggcc ccacagaagc agtgctgctc
     2701 agcccccact gagaatgggg cattagctga ctggacactc atttgcatac ccggagctta
     2761 cattctggct cccactatca catcgaatct atagtctgac aagcacctaa aattcacaag
     2821 actctgactc tttattgata aagcaaagaa acaggcctgg ggaaccttta ggatgttact
     2881 tactcctttt tatgagaagc tgagcatcat agcaaatgtt cccatgagag ggctgatgtt
     2941 atttaaagca agaatttggt agcactgaag agatagctca gcagttaaga tgtaagttct
     3001 gttcccagca cacatcaggt ggctcacaat ggcctgtcac tccagatgct ggggtggggg
     3061 atctctcagc acctgcactt acatgcatat ccctccccat acatacataa taagcatata
     3121 tatatatgta tgtgtatata tatatatgta tgtatatatg tatgtatata tgtatgtata
     3181 tatatttgca ttttacaagt acctcttccc actctgagcc caatttgcta ggaaactact
     3241 gggaaataag aacagggtcc ctgcttcctg cttagggtgt gtggtaaata gctgagtaat
     3301 taaggaccca gggcaagcag acatgtctat gagcccaagg ttagcccaag tatcccttga
     3361 cagtacataa ctcagctgct cccaaagaca gaccctctga acataaccca tctgtcagag
     3421 ggagggccta ggaaactcta gtcctctgaa cttccaagga ttctttctgt caaacctcag
     3481 ccagggcttt gaaatacaca ccaatctgct tatttcttcc ctttgaattt gcttccctga
     3541 gaacagtcag taaatctaag aataaaatag gcaaagtaag atattgatct gataaaaaaa
     3601 aaaggctaaa taaataaata aaactactat ctcaagtcag gagcagattc caaatcacct
     3661 tgttactact gctggattaa aaagtaacaa caacaacaac aaaagcactc actgttctga
     3721 ttttttaaaa aaatcgcctg cccaggaaac tggtactgag gggcttccag ctccccaccc
     3781 cgattttttc tgaagtttct acagctctga gcgaccagtt cagtgttgat tgtgaaggga
     3841 acagatgcct gcgtgcatgg ggaagctgtg tgttttcaca aagcttccca ggctgctttt
     3901 gttcctccgt cactgaattc tgcagaacaa gttcaaccat tatccaagga tgtgtttgtt
     3961 agggtatggg gatggagcac acagctttct gtgtgtgcca tgcgacagac actgtgggac
     4021 gttgctcttt gagaatctag aaagccgact agacgctccc tgtacctccc acgggctgaa
     4081 caagacatag ctttgaaagc ccaccagcaa aggtagtgag agaaggcagg ttgggaagga
     4141 ggagggtgga ggaggaaaga ttttggggga ggaggggagg aacattaggg tggaggagag
     4201 agatttgggg agggatgctg aggagaagta gcatcatgga tctcctttcg cattgcactg
     4261 tctcatctcc tgcttataca gacttccctt agcttcctgc atggccttgc tcagcctcaa
     4321 tcaccctgaa ctggtcactc cattgaaagg agactttagt ttcaaagaaa aaggaatgga
     4381 ataaaagaaa gaagaagaga aaaaggaagg gaagaaaccc agggtctgag tggaagaaag
     4441 ggatggggaa gactgaactg gagcttgctc tgtagtttca gccagggtaa aatcctgact
     4501 gtaagattga gattgaataa caaatgggag accatttgaa tgagtggcag caaataggga
     4561 acaaaatgag aactccgcaa taataagcag atcacaaagc tctctaacta tagaaagaga
     4621 caggtcaggg ggctggagag atggctcagc ggttaagagc attgactgct cttccggagg
     4681 tcctgagttc aaatcccagc aaccacatgg tggctcacaa ccatctgtaa caagacctga
     4741 ttccctcttc tggtatctga agagacaggt tggatgtgga ggacagactt ggaagagaga
     4801 cagagtctga atagaaatgg acagttgtga ctatgccaca caagcaggtt ctagagacag
     4861 aaccagggac aagaagtggg aagggaacta gcttcttttg ctccaggttc tgtgctgagc
     4921 cctcacttcc catgtgggtc tctcttcttc tgacaaccca gagaggtcaa aacaatcagt
     4981 ctcttcacgg aacaaaggag aaagctgcct atctcccaaa catgtgatac aggctccgtt
     5041 ttcctctcaa ggtacaatgc tatctattgg tcccattttc agattgataa agaaacagac
     5101 aagatggcta cagagatggc tcagttttca cagtgcctgc ttctcaagag ttcagatctc
     5161 tggtacccat atgagcactg ggtggatatg atgaacctaa cagtaatacc agtcttggag
     5221 tgtggatact aaagatttct ggagcaacaa ggttagtaag actggacaga ttggtgggct
     5281 ccgaaattga ctgagagccc ctatctcagt gaatatggag gaggagttaa caaggatgat
     5341 actcaacatg aacttttggg cctccacatg tgaactcata tgcccacata caggtaccga
     5401 catgggtatg cagacataca tgcatatatg acacatagag agggacgtga aaattgaaaa
     5461 aaaaaagttt gacaggcaag aaaatagtaa tttatcacaa cccatgcata atgtgactct
     5521 atccactgaa agaacagaag ccgtgtattt aatttaaaaa tttcagtcaa gttaaaaatg
     5581 aaaaaaaaaa acactcagtg ataacaattt ttataatgct acctaagttt gtacacatac
     5641 tgctggattt cttaggaaag cgaaatacag agtcatcata aaaattattg gtgagctaat
     5701 ttttcttctc ctacccccat actaaatctt caactgtccc tttcccaaac atatgcacca
     5761 actaccccaa ggaactgccc aagtcgcctg tgtttgcaaa actctcaagc actcatgaac
     5821 aaggattgga tttcaatggt ttcgactgtt ttgctagcct ctccctagaa accctctgta
     5881 aaagtgatgg ttaaaatagt aagtctacgt tattctgaaa gtacaaaact gtcttttgcc
     5941 tgtctcatca taaattgtgt ctgtctgcat cgcacaaatc acaccaactg cctggcagag
     6001 ctgttgacat agccctcccc ccccccccac cttaaatgga ggtgagaaaa tggctgccat
     6061 taggtctgtg tttcaaaaga taatcttagg aaatctagga aaatggaatg ctgggcctac
     6121 aggcgccacc aatggcagtc tgaggcatgt gcccacgggc attgtgagaa tagaggtagc
     6181 ctttctagaa caggaagcca accagaccct ttgtgcaaaa tttatcattt tacaatgaca
     6241 ggcaattgct tgttgttata tttgaaaaaa aaattgtcct tttctacgat acactgttga
     6301 ggataaatac catactatgt ccagagttaa ctctctattc tggctgtttg aaattgtttc
     6361 agctccactc tcagcaaccc tttagctaac acaatgcttt aaagtcttat tcatggctta
     6421 atggagtgca ttaaagattt gactaaattt atgtttggct gcaaaaaaaa aaaaaaaaaa
//
