LOCUS       NM_011838               3952 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Ly6/neurotoxin 1 (Lynx1), mRNA.
ACCESSION   NM_011838
VERSION     NM_011838.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3952)
  AUTHORS   Bychkov,M.L., Kirichenko,A.V., Paramonov,A.S., Kirpichnikov,M.P.
            and Lukmanova,E.N.
  TITLE     Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and
            Lypd6B Expression in the Hippocampus and Increased Expression of
            Proinflammatory Cytokines in the Hippocampus and Blood Serum
  JOURNAL   Dokl Biochem Biophys 511 (1), 145-150 (2023)
   PUBMED   37833597
  REMARK    GeneRIF: Accumulation of beta-Amyloid Leads to a Decrease in Lynx1
            and Lypd6B Expression in the Hippocampus and Increased Expression
            of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
REFERENCE   2  (bases 1 to 3952)
  AUTHORS   Doss,S.V., Barbat-Artigas,S., Lopes,M., Pradhan,B.S.,
            Proszynski,T.J., Robitaille,R. and Valdez,G.
  TITLE     Expression and Roles of Lynx1, a Modulator of Cholinergic
            Transmission, in Skeletal Muscles and Neuromuscular Junctions in
            Mice
  JOURNAL   Front Cell Dev Biol 10, 838612 (2022)
   PUBMED   35372356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3952)
  AUTHORS   Falk,E.N., Norman,K.J., Garkun,Y., Demars,M.P., Im,S., Taccheri,G.,
            Short,J., Caro,K., McCraney,S.E., Cho,C., Smith,M.R., Lin,H.M.,
            Koike,H., Bateh,J., Maccario,P., Waltrip,L., Janis,M. and
            Morishita,H.
  TITLE     Nicotinic regulation of local and long-range input balance drives
            top-down attentional circuit maturation
  JOURNAL   Sci Adv 7 (10) (2021)
   PUBMED   33674307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3952)
  AUTHORS   Nissen,N.I., Anderson,K.R., Wang,H., Lee,H.S., Garrison,C.,
            Eichelberger,S.A., Ackerman,K., Im,W. and Miwa,J.M.
  TITLE     Augmenting the antinociceptive effects of nicotinic acetylcholine
            receptor activity through lynx1 modulation
  JOURNAL   PLoS One 13 (7), e0199643 (2018)
   PUBMED   29969495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3952)
  AUTHORS   Takesian,A.E., Bogart,L.J., Lichtman,J.W. and Hensch,T.K.
  TITLE     Inhibitory circuit gating of auditory critical-period plasticity
  JOURNAL   Nat Neurosci 21 (2), 218-227 (2018)
   PUBMED   29358666
  REMARK    Erratum:[Nat Neurosci. 2018 Oct;21(10):1495. doi:
            10.1038/s41593-018-0161-x.. PMID: 29915196]
REFERENCE   6  (bases 1 to 3952)
  AUTHORS   Tekinay,A.B., Nong,Y., Miwa,J.M., Lieberam,I., Ibanez-Tallon,I.,
            Greengard,P. and Heintz,N.
  TITLE     A role for LYNX2 in anxiety-related behavior
  JOURNAL   Proc Natl Acad Sci U S A 106 (11), 4477-4482 (2009)
   PUBMED   19246390
REFERENCE   7  (bases 1 to 3952)
  AUTHORS   Miwa,J.M., Stevens,T.R., King,S.L., Caldarone,B.J.,
            Ibanez-Tallon,I., Xiao,C., Fitzsimonds,R.M., Pavlides,C.,
            Lester,H.A., Picciotto,M.R. and Heintz,N.
  TITLE     The prototoxin lynx1 acts on nicotinic acetylcholine receptors to
            balance neuronal activity and survival in vivo
  JOURNAL   Neuron 51 (5), 587-600 (2006)
   PUBMED   16950157
REFERENCE   8  (bases 1 to 3952)
  AUTHORS   Dessaud,E., Salaun,D., Gayet,O., Chabbert,M. and deLapeyriere,O.
  TITLE     Identification of lynx2, a novel member of the ly-6/neurotoxin
            superfamily, expressed in neuronal subpopulations during mouse
            development
  JOURNAL   Mol Cell Neurosci 31 (2), 232-242 (2006)
   PUBMED   16236524
REFERENCE   9  (bases 1 to 3952)
  AUTHORS   Ibanez-Tallon,I., Miwa,J.M., Wang,H.L., Adams,N.C., Crabtree,G.W.,
            Sine,S.M. and Heintz,N.
  TITLE     Novel modulation of neuronal nicotinic acetylcholine receptors by
            association with the endogenous prototoxin lynx1
  JOURNAL   Neuron 33 (6), 893-903 (2002)
   PUBMED   11906696
  REMARK    GeneRIF: Results show that lynx1 colocalizes with nAChRs on CNS
            neurons and physically associates with nAChRs and enhances receptor
            desensitization, resulting in a novel type of functional modulation
REFERENCE   10 (bases 1 to 3952)
  AUTHORS   Miwa,J.M., Ibanez-Tallon,I., Crabtree,G.W., Sanchez,R., Sali,A.,
            Role,L.W. and Heintz,N.
  TITLE     lynx1, an endogenous toxin-like modulator of nicotinic
            acetylcholine receptors in the mammalian CNS
  JOURNAL   Neuron 23 (1), 105-114 (1999)
   PUBMED   10402197
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC118022.12.
            
            On Apr 28, 2007 this sequence version replaced NM_011838.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF141377.1, AK165314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC118022.12        182706-182800       c
            96-278              AC118022.12        181676-181858       c
            279-380             AC118022.12        181364-181465       c
            381-3952            AC118022.12        177677-181248       c
FEATURES             Location/Qualifiers
     source          1..3952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.27 cM"
     gene            1..3952
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /note="Ly6/neurotoxin 1"
                     /db_xref="GeneID:23936"
                     /db_xref="MGI:MGI:1345180"
     exon            1..95
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..278
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..577
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /note="ly-6/neurotoxin-like protein 1; GC26; secreted
                     Ly-6/uPAR-related protein 2; secreted Ly-6/uPAR
                     domain-containing protein 2"
                     /codon_start=1
                     /product="ly-6/neurotoxin-like protein 1 precursor"
                     /protein_id="NP_035968.1"
                     /db_xref="CCDS:CCDS27530.1"
                     /db_xref="GeneID:23936"
                     /db_xref="MGI:MGI:1345180"
                     /translation="MTHLLTVFLVALMGLPVAQALECHVCAYNGDNCFKPMRCPAMAT
                     YCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNGAGFATPVTL
                     ALVPALLATFWSLL"
     exon            279..380
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..3952
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3934..3939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /note="hexamer: AATAAA"
     polyA_site      3952
                     /gene="Lynx1"
                     /gene_synonym="SLURP-2"
                     /note="major polyA site"
ORIGIN      
        1 gcctacttgg cctgcctgcg atgcggtacc aacaccgcac gaagtgtgta cagattccca
       61 gttagacagc aggagggacc tgggagcggc cagggggatg ttttatctct aagagaccaa
      121 gagctcaggc agggcttctg tgccctgctt cctccctggc ttgagctgga tcctggacca
      181 gctgctgacc tcctgttcac tctggcactg ccctcacgtc tccgtcatga cccatctgct
      241 cacagtgttc ctggtggccc tgatgggcct gcctgtggcc caggctctgg agtgccacgt
      301 gtgtgcctac aatggagaca actgcttcaa acccatgcgc tgcccagcca tggccaccta
      361 ctgtatgacc acacgaactt acttcacccc ataccggatg aaggtgagga agtcctgtgt
      421 ccccagctgc tttgaaaccg tgtacgatgg ctattccaag catgcatctg ccacctcctg
      481 ttgccagtac tacctctgca acggtgctgg ctttgctacc ccggtgacct tggccctggt
      541 cccagcactc ctagctacct tctggagctt gctgtaaagc tcggttcccc aagccagatc
      601 cactcaaacg caacactctc aaaaaacaca gtttccctct ctctcccaat tcactccacc
      661 caacgctctt ccttctgaca ctcctcaact accacgaggt cccatggcta cctacgaaag
      721 aactgatggc atccagatac ctcactccaa ggtcattttc agaaggctga catgtggacc
      781 tgtaatgtgc ccacccatgg gtggggcagg ctgggcttct cctctaccca agatcagggg
      841 catctgggag aatgtttatg gaggaggggt catcactcaa gtcaaggagc actgatttga
      901 tagaattagt agccaaactc caccttcaga accctgcctc agtctaccca gtagaggatg
      961 ggtctgctag aggtgagggg aggagagcgg cggagaataa cgagctggct agaagcagag
     1021 aaagactcag cagggctgtc tccgaagatc agcgcggctt gccagagcaa atgtgatgtg
     1081 gaagccatgt gaggaagccc tttgtcattt ccacttatct gaggaactct gccagacctg
     1141 atgttgggat agccattggc caagggttcc tagcaacggc gtcatttcca taggccactg
     1201 aaatccctcc agccccagct cagcaggccc cttgacctcc actacagtcc ttcattcaca
     1261 caccagctgc tgggccttga agttggcagg gacttgggag caggtgaccc atgctatttt
     1321 ttgtctggcc tgttattctg ggcatggcaa gaagggatca gacgcaggtc agagcagggc
     1381 agtagggcga ctgagacagg gaaacagact tcagccagtg gcttcccagg tcccgtaggc
     1441 agctcctaca tccttcagtc tcttgttaca ttcccgggag acaaatatac agggagccaa
     1501 gccgagtgct aggtgatgac tgcctgtgaa gtctattgtg gccacagact gctgggtacc
     1561 aagtctcagg agaacccagc ctagatttag gagacacaga tctgcctttc atgcagtgta
     1621 gctgtccttg ggagccttac catgctctct aactagtacc tcaactcaca tgtcactgag
     1681 gaacccccta acactggccc agcccagggg tcgggatgct ggccaatgtc catggagtgg
     1741 gactacccat ggagagtcct tgggtcatca catcacaaat gttttattcc aacctcccag
     1801 tggtgagagc tcgggacaca aaggtccatc ctggggacct tcttcctggt tctaggcaga
     1861 cctgaactct gtctgctgct agagctgatg tggttttccg cctcagtttc ctcctccggg
     1921 gataggccac cggaggattt gggagggtgg ggagggcatc ctgctgatgg gctcgccgag
     1981 gttctcagga acaggaacgg gcggggcttt agtacacagg tgagttgggt gggaactggc
     2041 ccggagctga ggagacactg actgggcaga gggaagatga gtctcaaggg agggcaggaa
     2101 aagggagggg gagcgcgcat gcacatgtgc actcagtgca ggctacagag cccaaaaggc
     2161 agcactggct gtggtgtccc ctgaggccca ggcaagatgc taggaggaag ccaatgctgc
     2221 ccccacctga gctcacatgg aacatgcaca ccaccagcag cagcagcaag cattgagact
     2281 gacctgtgga cgccataggg cactggcaag gagggtcaga ggcgggtccc tgactcagtg
     2341 ggtgaggccc gggaaacatt atcctgttac cctgcgtgtg caagatcatt gtccccagct
     2401 agatggcgtc ctcaaccaaa actgagagga gccccagttc aggtcctccc tcctaccaca
     2461 agggggtggt gtggaggagg cttgattgcc cttggagaag caccggtact gcagagctgg
     2521 gggccagctt ctttcatctg tgtctagaca ccgaccagat aggccccaca gtggcaacac
     2581 tgccacacag ccctacaaga agccctgtgc ctagctagca cagagcccca aaaggtgctc
     2641 aattaataca gggccaagcc tgccagtggg ggggatgcag attaggggaa cagacccaga
     2701 tggcctgtcc tgaaccctgt ctggggtggt gtgatgagca tctgtctagc ccactgcagg
     2761 tggctctaca cactccacaa cagttctgca aaagtgtatg aggtggtcat tactgcgccc
     2821 ctctcacagg taaaggcact gaggcacgga ggagtgaggc acttcatttt cctgggccat
     2881 tcaactttcc aggaccaaca cattcaacta tgggtactac tccaatagct ggggttcttt
     2941 gaggctgggc cccctgaaga tgatagtggc ttcatcaacc agagaatttc agagtgcagt
     3001 gttgtaggag cctatgaacc tgaaatgtca gaactggagg tttgaggggc tgaggggtag
     3061 gccaggggtg tctggcccct tgtgtggaga cagagagaga gggaacatgg gatggggtag
     3121 tagagagaag tgcaaaggag cgtcagcctt tctcagggct aatgctgtca gggacgaggg
     3181 ctcaagcctg tgagtgttct cacactgtga taaacagtgg cccctcaaca cagacggtgt
     3241 ccagagtggc cggcagtggt tatctagagt tgcaatctgg aagcctcttg gtagtcactg
     3301 gagagaggcc gcttgatggg acagcaccaa atgtgtgtgc ttctgtggga tgtgaggaag
     3361 ctgggtcagc gcatgaagcc aaagcgtcct tcagagcaga ggggtggctg gtctagtcca
     3421 ccagagacaa gctatccagt gagagtcata ctctgccacc gtctctgtga ttaccttacc
     3481 ccaaagcaga cggggacggg atgcagagca cccgtgtctt catcttctgc ggcaagcacg
     3541 tgagttcaca ttctgaaact ctagaaagat ttccaggagt ggggtgtgcc tttgctttgg
     3601 tgcatggtta cttcctggca agcaccgtgg catcccgcag cactgagtga cctgggctcc
     3661 tcaagccatc tcattggtga aatgacagtg ccagtaccct ctcagctggc tcttggaggc
     3721 ctgtgcatgg ggtctgcaca gaggaggccc ccaaactatg catggacgga cacgtgatgc
     3781 ctagcacttc ccttggttgt gtctctgcca accccaggct ctcacccagc aaggaaatga
     3841 aatccacttt tatgacacat ctccctcccc cagccagctc cattcaccta tatgccaggg
     3901 tggtcccttt caatgtctgt cccccattgg atgaataaac aagcgaagga ca
//
