LOCUS       NM_008535               1818 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lymphoblastomic leukemia 1 (Lyl1), mRNA.
ACCESSION   NM_008535 XM_001473917
VERSION     NM_008535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Jones,S.S., Ozturk,M., Kieswetter,N.S., Poswayo,S.K.L., Hazra,R.,
            Tamgue,O., Parihar,S.P., Suzuki,H., Brombacher,F. and Guler,R.
  TITLE     Lyl1-deficiency promotes inflammatory responses and increases
            mycobacterial burden in response to Mycobacterium tuberculosis
            infection in mice
  JOURNAL   Front Immunol 13, 948047 (2022)
   PUBMED   36119114
  REMARK    GeneRIF: Lyl1-deficiency promotes inflammatory responses and
            increases mycobacterial burden in response to Mycobacterium
            tuberculosis infection in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Wang,S., Ren,D., Arkoun,B., Kaushik,A.L., Matherat,G., Lecluse,Y.,
            Filipp,D., Vainchenker,W., Raslova,H., Plo,I. and Godin,I.
  TITLE     Lyl-1 regulates primitive macrophages and microglia development
  JOURNAL   Commun Biol 4 (1), 1382 (2021)
   PUBMED   34887504
  REMARK    GeneRIF: Lyl-1 regulates primitive macrophages and microglia
            development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1818)
  AUTHORS   Hussain,A., Deleuze,V., El Kebriti,L., Turali,H., Pirot,N.,
            Glasson,Y., Mathieu,D. and Pinet,V.
  TITLE     In Lyl1-/- mice, adipose stem cell vascular niche impairment leads
            to premature development of fat tissues
  JOURNAL   Stem Cells 39 (1), 78-91 (2021)
   PUBMED   33022858
  REMARK    GeneRIF: In Lyl1(-/-) mice, adipose stem cell vascular niche
            impairment leads to premature development of fat tissues.
REFERENCE   6  (bases 1 to 1818)
  AUTHORS   Terajima,M., Matsui,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Obinata,M.
  TITLE     Structural organization of the mouse glycophorin A gene
  JOURNAL   J Biochem 116 (5), 1105-1110 (1994)
   PUBMED   7896738
REFERENCE   7  (bases 1 to 1818)
  AUTHORS   Baer,R.
  TITLE     TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins
            implicated in T cell acute leukaemia
  JOURNAL   Semin Cancer Biol 4 (6), 341-347 (1993)
   PUBMED   8142619
  REMARK    Review article
REFERENCE   8  (bases 1 to 1818)
  AUTHORS   Kuo,S.S., Mellentin,J.D., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Cleary,M.L.
  TITLE     Structure, chromosome mapping, and expression of the mouse Lyl-1
            gene
  JOURNAL   Oncogene 6 (6), 961-968 (1991)
   PUBMED   2067848
REFERENCE   9  (bases 1 to 1818)
  AUTHORS   Visvader,J., Begley,C.G. and Adams,J.M.
  TITLE     Differential expression of the LYL, SCL and E2A helix-loop-helix
            genes within the hemopoietic system
  JOURNAL   Oncogene 6 (2), 187-194 (1991)
   PUBMED   2000219
REFERENCE   10 (bases 1 to 1818)
  AUTHORS   Cleary,M.L., Mellentin,J.D., Spies,J. and Smith,S.D.
  TITLE     Chromosomal translocation involving the beta T cell receptor gene
            in acute leukemia
  JOURNAL   J Exp Med 167 (2), 682-687 (1988)
   PUBMED   3162254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235816.1, AC145556.4, AK076114.1 and CO044699.1.
            
            On or before Jan 22, 2009 this sequence version replaced
            XM_001473917.1, NM_008535.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005736.1, X57687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               BY235816.1         3-325
            324-324             AC145556.4         172146-172146
            325-359             BY235816.1         327-361
            360-1673            AK076114.1         14-1327
            1674-1818           CO044699.1         1-145               c
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..1818
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /note="lymphoblastomic leukemia 1"
                     /db_xref="GeneID:17095"
                     /db_xref="MGI:MGI:96891"
     exon            1..531
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..887
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..1392
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /note="lymphoblastic leukemia-derived sequence 1"
                     /codon_start=1
                     /product="protein lyl-1"
                     /protein_id="NP_032561.2"
                     /db_xref="CCDS:CCDS22476.1"
                     /db_xref="GeneID:17095"
                     /db_xref="MGI:MGI:96891"
                     /translation="MCPPQARAEVGSAMTEKTEMVCASSPAPAPPSKPASPGPLSTEE
                     VDHRNTCTPWLPPGVPVINLGHTRPIGAAMPTTELSAFRPSLLQLTALGRAPPTLAVH
                     YHPHPFLNSVYIGPAGPFSIFPNSRLKRRPSHSELDLADGHQPQKVARRVFTNSRERW
                     RQQHVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFLVRLLRDQTAVLTSGPSA
                     PGSRKPPARRGVEGSARFGAGHRVEAARSQPVLPGDCDGDPNGSVRPIKLEQTSLSPE
                     VR"
     exon            888..979
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1801
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1801
                     /gene="Lyl1"
                     /gene_synonym="bHLHa18; Lyl-1"
                     /note="major polyA site"
ORIGIN      
        1 ggacatcaga ggcagccttg ccacctttcc cctttgcaca cgtttggcgc tgggctcctg
       61 agggttgggg ggtcttccag tgctgtggga gcagcaaacc ccgaagggtg actagccggg
      121 gtggatcagg aggtgcgcgc tccgtgatcc ctgcccgctg gtttcctccg gggtcagcat
      181 tgcttcttat cagccgcggc caggcagcca gacccttatc tgcacaggcc cagcatcctc
      241 tggcctctgc gccagcgggt aagagggagg aagccaggct gtcgggggcg ggggaaaggg
      301 cgggtcggtc caggagcagc tcactttctc ttggaggtac ccaccacgac gcctccgaag
      361 ctactcaggc cctccggagc ccgggaggtg gcgcagccca gctctgaggc ccaacgggag
      421 ggattacctg gagcacaccg gccgaactgg acagtggaaa ctgtctcctg acctggactg
      481 acaaacctga ccacacagcc gggttctcca agctgtggaa actgctacag ggttagcatt
      541 ctatccgtgg ggtccatgtg cccgccccag gccagagcag aggtgggttc cgccatgact
      601 gagaaaactg agatggtatg tgcctccagc ccagcacctg cccctccctc taagccggcc
      661 tcacctgggc ccctttctac agaggaggtg gaccaccgaa acacgtgcac tccctggttg
      721 cctcccggcg tgccagtgat aaacctggga cacaccaggc ccataggggc agccatgccc
      781 accacagagc tcagtgcctt tcggccctcc ttgctgcagc taactgcctt gggaagagct
      841 ccacctaccc tggctgtaca ttaccaccct caccccttcc tcaacagtgt ctacattggg
      901 ccagcaggac ccttcagcat cttccctaac agccggctga agcgcagacc aagccatagt
      961 gagctggact tggctgacgg gcaccaaccc cagaaggtgg ctcggcgagt gttcaccaac
     1021 agccgtgagc gctggcggca gcagcacgtt aacggcgcct tcgcagagct caggaagctg
     1081 ctgcccaccc acccgcccga ccggaagctg agcaagaacg aggtgctgcg cctggccatg
     1141 aagtatatag gcttcctggt gcggctgctg cgagaccaaa cggctgtgct gacctccggc
     1201 cccagcgctc ccgggtcccg caagccacct gcgcgcaggg gcgtggaggg cagcgcacgc
     1261 ttcggggccg ggcacagagt agaggctgca cgctcacagc ccgtgcttcc tggggactgt
     1321 gatggcgacc ccaatgggtc agtgagaccc atcaagttgg agcagacgtc cctgagtcct
     1381 gaggtgcggt gacccaaggc agaggcgcct cacctgctgt tcagtgaact ccctgtaaaa
     1441 ggatctcagg tcgcccagat gaggaaacgc cctgtagctc tggaagggtg accggcgacg
     1501 ccagggatcc ccagactttt aagaaaaatc tcccacaggc tacttgcagt ggctttgcca
     1561 gtgtcctctt gccagggccg aggccagaga atcgacaagg ccaagtagcc atgggatccc
     1621 agaggtcctg agggaggtag ggaagggtct ggaagcctcc gcgcttctca tcggcgcccc
     1681 ctgctggagg cgggaagacc ctagacaagt gtgtgggagg acctacccca tgaagcccaa
     1741 ctggttgcgc ttgatccatg atcctgttaa ccgcgacaac gaagactcag gcactcttgc
     1801 aaaaaaaaaa aaaaaaaa
//
