LOCUS       NM_025281               1568 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus Ly1 antibody reactive clone (Lyar), mRNA.
ACCESSION   NM_025281
VERSION     NM_025281.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1568)
  AUTHORS   Guo F, Ding Y, Caberoy NB, Alvarado G, Liu R, Shen C, Yu J, Zhou Y,
            Salero E, LeBlanc ME, Wang W and Li W.
  TITLE     Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis
  JOURNAL   J Cell Biochem 116 (10), 2177-2187 (2015)
   PUBMED   25735755
  REMARK    GeneRIF: These results suggest that Lyar is a genuine RPE
            phagocytosis ligand, which in turn supports the validity of OPD/PFC
            as the only available approach for unbiased identification of
            phagocytosis ligands with broad applicability to various phagocytes
REFERENCE   2  (bases 1 to 1568)
  AUTHORS   Yonezawa K, Sugihara Y, Oshima K, Matsuda T and Nadano D.
  TITLE     Lyar, a cell growth-regulating zinc finger protein, was identified
            to be associated with cytoplasmic ribosomes in male germ and cancer
            cells
  JOURNAL   Mol Cell Biochem 395 (1-2), 221-229 (2014)
   PUBMED   24990247
  REMARK    GeneRIF: Results show that LYAR protein expression is
            testis-predominant but can also be found in cancer cells originated
            from tissues other than testis. Lyar seems to promote proliferation
            of NIH-3T3 cells.
REFERENCE   3  (bases 1 to 1568)
  AUTHORS   Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L,
            Zou F, Ma C, Fang M, Tan R, Jane SM and Zhao Q.
  TITLE     Human fetal globin gene expression is regulated by LYAR
  JOURNAL   Nucleic Acids Res 42 (15), 9740-9752 (2014)
   PUBMED   25092918
REFERENCE   4  (bases 1 to 1568)
  AUTHORS   Lee B, Jin S, Choi H, Kwon JT, Kim J, Jeong J, Kwon YI and Cho C.
  TITLE     Expression and function of the testis-predominant protein LYAR in
            mice
  JOURNAL   Mol Cells 35 (1), 54-60 (2013)
   PUBMED   23212345
REFERENCE   5  (bases 1 to 1568)
  AUTHORS   Wang G, Fulkerson CM, Malek R, Ghassemifar S, Snyder PW and
            Mendrysa SM.
  TITLE     Mutations in Lyar and p53 are synergistically lethal in female mice
  JOURNAL   Birth Defects Res A Clin Mol Teratol 94 (9), 729-737 (2012)
   PUBMED   22815056
  REMARK    GeneRIF: Lyar is a novel candidate gene for a role in human neural
            tube defects.
REFERENCE   6  (bases 1 to 1568)
  AUTHORS   Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW,
            Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN,
            Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T,
            Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA and Chesler
            L.
  TITLE     Pleiotropic role for MYCN in medulloblastoma
  JOURNAL   Genes Dev 24 (10), 1059-1072 (2010)
   PUBMED   20478998
REFERENCE   7  (bases 1 to 1568)
  AUTHORS   Kogo H, Kowa-Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T,
            Inagaki H, Taniguchi M, Toda T and Kurahashi H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   8  (bases 1 to 1568)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1568)
  AUTHORS   Hurle B, Lane K, Kenney J, Tarantino LM, Bucan M, Brownstein BH and
            Ornitz DM.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   10 (bases 1 to 1568)
  AUTHORS   Su L, Hershberger RJ and Weissman IL.
  TITLE     LYAR, a novel nucleolar protein with zinc finger DNA-binding
            motifs, is involved in cell growth regulation
  JOURNAL   Genes Dev 7 (5), 735-748 (1993)
   PUBMED   8491376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099797.1, BC116923.1 and CD776101.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_025281.4.
            
            On May 15, 2008 this sequence version replaced NM_025281.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006373.1, BC116923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BY099797.1         14-157
            145-1415            BC116923.1         1-1271
            1416-1568           CD776101.1         1-153               c
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.29 cM"
     gene            1..1568
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /note="Ly1 antibody reactive clone"
                     /db_xref="GeneID:17089"
                     /db_xref="MGI:MGI:107470"
     exon            1..154
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            155..325
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1370
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /note="protein expressed in male leptotene and zygotene
                     spermatocytes 264; ly1 antibody-reactive protein"
                     /codon_start=1
                     /product="cell growth-regulating nucleolar protein"
                     /protein_id="NP_079557.2"
                     /db_xref="CCDS:CCDS19253.1"
                     /db_xref="GeneID:17089"
                     /db_xref="MGI:MGI:107470"
                     /translation="MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDD
                     YKSHVKCISEGQKYGGKGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQIS
                     AFDNVPRKKAKFQNWMKNSLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAE
                     MPITKVPSAKTNGTTEEQTEAKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPK
                     KRKKNQEAGHEAAGEEAAEASGPPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAA
                     GKRKRPKHSGAESGYKKKKMKLPEQPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDN
                     EISVKKLKKKVIAQYHAVMNDHHTSEEELLAIFNRKISRNPTFKVLKDRVKLLK"
     exon            326..440
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            441..548
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            549..632
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1062
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1149
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1235
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1551
                     /gene="Lyar"
                     /gene_synonym="MLZ-264"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtggcctct gcgcgcacgc gcgttggcgc gcgccgccgg gattgagttc tgcgcggggt
       61 ggctgggcga gccggtggcg gtgctacgct gggtggctgc cgctccacgt gctcccggcg
      121 gccggttgag accgttggcg gggtcggctg acagggcaag agttcaaacc tatatcagaa
      181 aatttctaat tatttaacca aaaatggtat tttttacatg caatgcatgt ggtgaatccg
      241 tgaagaaaat acaagtggaa aagcatgtgt ctaactgcag aaactgtgaa tgtctttcct
      301 gcattgactg tgggaaagat ttctggggtg atgactacaa aagccatgtg aagtgcatca
      361 gtgaaggtca gaagtacgga ggcaaaggct atgaagccaa gacacacaaa ggtgatgcaa
      421 aacagcaggc atggattcag aaaattaatg agttaataaa gaaacccaac gtcagcccca
      481 aggtgcgaga acttttgcag caaatcagtg cttttgataa tgttcccaga aaaaaggcga
      541 agtttcagaa ctggatgaaa aacagcctga aagtgcacag cgactccgtt ctagagcagg
      601 tgtgggatat cttctccgaa gcatccagca gtgagcaaga tcagcagcag ccacccagcc
      661 acacggccaa gccacatgca gagatgccga tcactaaagt tccatctgca aaaacaaatg
      721 gcaccacaga agagcaaacc gaggcgaaga agaataaaag agaaaggaag gaggaacggc
      781 agaaaaacag gaagaaagag aagaaagagc tgaagctaga aaaccaccag gaaaacctga
      841 ggggccagaa gccaaagaag cgcaagaaga accaggaggc cggacatgag gctgctgggg
      901 aggaggccgc cgaggccagc ggcccaccgg agaagaagaa agcccaggga ggacaggctt
      961 ctgaagaggg agcagacaga aatgggggcc ctggggagga tgctgccgag gggcagacca
     1021 agacagcagc agggaaacgg aagcggccaa agcactcagg agctgagtct ggttacaaga
     1081 aaaaaaagat gaagttacca gagcagcctg aagagggaga ggccaaggac cacgaggctc
     1141 catcgaaagg taaattcaac tggaagggga ccattaaggc tgttttgaaa caggctccag
     1201 acaacgagat atcagtcaag aagttaaaga aaaaggttat agctcagtac catgcggtga
     1261 tgaacgacca tcacacatcg gaggaggagc tcctggccat cttcaacagg aagatcagca
     1321 ggaaccccac ctttaaggtg ctgaaggaca gagtaaagct tctgaagtga ggctctgtgg
     1381 cttcacactc tgtcatccta ttggctgctt ccctctacta tttgtaaaat gtgtagtgaa
     1441 ttataacaac ctgaagattg ctttctgaaa ctgtttttaa gttaagggaa aaagtatatt
     1501 tttgttaaaa ctttcatgaa aaaataaaat atatccttgt cgaattctgt aaaaaaaaaa
     1561 aaaaaaaa
//
