LOCUS       NM_016923                603 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lymphocyte antigen 96 (Ly96), transcript variant 1,
            mRNA.
ACCESSION   NM_016923
VERSION     NM_016923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Wang,M., Zhang,Q., Lou,S., Jin,L., Wu,G., Wu,W., Tang,Q., Wang,Y.,
            Long,X., Huang,P., Luo,W. and Liang,G.
  TITLE     Inhibition of MD2 by natural product-drived JM-9 attenuates renal
            inflammation and diabetic nephropathy in mice
  JOURNAL   Biomed Pharmacother 168, 115660 (2023)
   PUBMED   37806092
REFERENCE   2  (bases 1 to 603)
  AUTHORS   Li,J., Chen,Y., Li,R., Zhang,X., Chen,T., Mei,F., Liu,R., Chen,M.,
            Ge,Y., Hu,H., Wei,R., Chen,Z., Fan,H., Zeng,Z., Deng,Y., Luo,H.,
            Hu,S., Cai,S., Wu,F., Shi,N., Wang,Z., Zeng,Y., Xie,M., Jiang,Y.,
            Chen,Z., Jia,W. and Chen,P.
  TITLE     Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2
            complex to attenuate inflammation and protect against sepsis
  JOURNAL   Mol Ther 31 (4), 1017-1032 (2023)
   PUBMED   36698311
  REMARK    GeneRIF: Gut microbial metabolite hyodeoxycholic acid targets the
            TLR4/MD2 complex to attenuate inflammation and protect against
            sepsis.
REFERENCE   3  (bases 1 to 603)
  AUTHORS   Lin,J., Lin,K., Huang,L., Jiang,Y., Ding,X., Luo,W.,
            Samorodov,A.V., Pavlov,V.N., Liang,G., Qian,J. and Wang,Y.
  TITLE     Heme induces inflammatory injury by directly binding to the complex
            of myeloid differentiation protein 2 and toll-like receptor 4
  JOURNAL   Toxicol Lett 370, 15-23 (2022)
   PUBMED   36115635
  REMARK    GeneRIF: Heme induces inflammatory injury by directly binding to
            the complex of myeloid differentiation protein 2 and toll-like
            receptor 4.
REFERENCE   4  (bases 1 to 603)
  AUTHORS   Qian,J., Zhuang,F., Chen,Y., Fan,X., Wang,J., Wang,Z., Wang,Y.,
            Xu,M., Samorodov,A.V., Pavlov,V.N. and Liang,G.
  TITLE     Myeloid differential protein-2 inhibition improves diabetic
            cardiomyopathy via p38MAPK inhibition and AMPK pathway activation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (5), 166369 (2022)
   PUBMED   35176461
REFERENCE   5  (bases 1 to 603)
  AUTHORS   Luo,W., Ye,L., Hu,X.T., Wang,M.H., Wang,M.X., Jin,L.M., Xiao,Z.X.,
            Qian,J.C., Wang,Y., Zuo,W., Huang,L.J. and Liang,G.
  TITLE     MD2 deficiency prevents high-fat diet-induced AMPK suppression and
            lipid accumulation through regulating TBK1 in non-alcoholic fatty
            liver disease
  JOURNAL   Clin Transl Med 12 (3), e777 (2022)
   PUBMED   35343085
REFERENCE   6  (bases 1 to 603)
  AUTHORS   Gomi,K., Kawasaki,K., Kawai,Y., Shiozaki,M. and Nishijima,M.
  TITLE     Toll-like receptor 4-MD-2 complex mediates the signal transduction
            induced by flavolipin, an amino acid-containing lipid unique to
            Flavobacterium meningosepticum
  JOURNAL   J Immunol 168 (6), 2939-2943 (2002)
   PUBMED   11884465
  REMARK    GeneRIF: MD-2 in complex with toll-like receptor 4 mediates signal
            transduction induced by the amino acid-containing bacterial lipid,
            flavolipin.
            Erratum:[J Immunol 2002 May 15;168(10):5376]
REFERENCE   7  (bases 1 to 603)
  AUTHORS   Ogata,H., Su,I., Miyake,K., Nagai,Y., Akashi,S., Mecklenbrauker,I.,
            Rajewsky,K., Kimoto,M. and Tarakhovsky,A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
REFERENCE   8  (bases 1 to 603)
  AUTHORS   Kato,K., Morrison,A.M., Nakano,T., Tashiro,K. and Honjo,T.
  TITLE     ESOP-1, a secreted protein expressed in the hematopoietic, nervous,
            and reproductive systems of embryonic and adult mice
  JOURNAL   Blood 96 (1), 362-364 (2000)
   PUBMED   10891475
REFERENCE   9  (bases 1 to 603)
  AUTHORS   Akashi,S., Shimazu,R., Ogata,H., Nagai,Y., Takeda,K., Kimoto,M. and
            Miyake,K.
  TITLE     Cutting edge: cell surface expression and lipopolysaccharide
            signaling via the toll-like receptor 4-MD-2 complex on mouse
            peritoneal macrophages
  JOURNAL   J Immunol 164 (7), 3471-3475 (2000)
   PUBMED   10725698
REFERENCE   10 (bases 1 to 603)
  AUTHORS   Shimazu,R., Akashi,S., Ogata,H., Nagai,Y., Fukudome,K., Miyake,K.
            and Kimoto,M.
  TITLE     MD-2, a molecule that confers lipopolysaccharide responsiveness on
            Toll-like receptor 4
  JOURNAL   J Exp Med 189 (11), 1777-1782 (1999)
   PUBMED   10359581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB018550.1 and AK019283.1.
            
            On Apr 29, 2009 this sequence version replaced NM_016923.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018550.1, AK019283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AB018550.1         1-576
            577-603             AK019283.1         601-627
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 5.1 cM"
     gene            1..603
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /note="lymphocyte antigen 96"
                     /db_xref="GeneID:17087"
                     /db_xref="MGI:MGI:1341909"
     exon            1..164
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..535
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; myeloid differentiation protein-2; ly-96;
                     protein MD-2; myeloid differentiation factor-2"
                     /codon_start=1
                     /product="lymphocyte antigen 96 isoform A precursor"
                     /protein_id="NP_058619.1"
                     /db_xref="CCDS:CCDS14832.1"
                     /db_xref="GeneID:17087"
                     /db_xref="MGI:MGI:1341909"
                     /translation="MLPFILFSTLLSPILTESEKQQWFCNSSDAIISYSYCDHLKFPI
                     SISSEPCIRLRGTNGFVHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDDDY
                     SFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAGDTEEKLFCLNFTIIHRRDVN
                     "
     exon            165..254
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..383
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..436
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..603
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      602
                     /gene="Ly96"
                     /gene_synonym="ESOP-1; MD-2; MD2"
ORIGIN      
        1 gtcgagtccg atggtcttcc tggcgagttt aaagtatcgg agatattaaa tcatgttgcc
       61 atttattctc ttttcgacgc tgctttctcc catattgact gaatctgaga agcaacagtg
      121 gttctgcaac tcctccgatg caattatttc ctacagttat tgtgatcact tgaaattccc
      181 tatttcaatt agttctgaac cctgcataag actgagggga accaatggat ttgtgcatgt
      241 tgagttcatt ccaagaggaa acttaaaata tttatatttc aacctattca tcagtgtcaa
      301 ctccatagag ttgccgaagc gtaaggaagt tctgtgccat ggacatgatg atgactattc
      361 tttttgcaga gctctgaaag gagagactgt gaatacatca ataccattct ctttcgaggg
      421 aatactattt cctaagggcc attacagatg tgttgcagaa gctattgctg gggatactga
      481 agaaaagctc ttctgtttga atttcaccat cattcaccgc cgtgatgtca attagaatat
      541 gctgaataca cacacacaca cacacacaca cacacacata tgtatatata tattttttta
      601 ccc
//
