LOCUS       NM_010745                997 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus lymphocyte antigen 86 (Ly86), mRNA.
ACCESSION   NM_010745
VERSION     NM_010745.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Shi T, Wang G, Peng J and Chen M.
  TITLE     Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling
            in Diabetic Cardiomyopathy by Activating the TLR4/NF-kappaB
            Signalling Pathway
  JOURNAL   Pharmacology 108 (4), 311-320 (2023)
   PUBMED   37231994
  REMARK    GeneRIF: Loss of MD1 Promotes Inflammatory and Apoptotic Atrial
            Remodelling in Diabetic Cardiomyopathy by Activating the
            TLR4/NF-kappaB Signalling Pathway.
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Fu H, Shuai W, Kong B, Jiang X and Huang H.
  TITLE     MD1 Depletion Predisposes to Ventricular Arrhythmias in the Setting
            of Myocardial Infarction
  JOURNAL   Heart Lung Circ 30 (6), 869-881 (2021)
   PUBMED   33257269
  REMARK    GeneRIF: MD1 Depletion Predisposes to Ventricular Arrhythmias in
            the Setting of Myocardial Infarction.
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Song Z, Xu Y, Zhang L, Zhou L, Zhang Y, Han Y, Li X, Yu P, Qu Y,
            Zhao W and Qin C.
  TITLE     Comprehensive Proteomic Profiling of Urinary Exosomes and
            Identification of Potential Non-invasive Early Biomarkers of
            Alzheimer's Disease in 5XFAD Mouse Model
  JOURNAL   Front Genet 11, 565479 (2020)
   PUBMED   33250918
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Yang HJ, Kong B, Shuai W, Zhang JJ and Huang H.
  TITLE     MD1 deletion exaggerates cardiomyocyte autophagy induced by heart
            failure with preserved ejection fraction through ROS/MAPK
            signalling pathway
  JOURNAL   J Cell Mol Med 24 (16), 9300-9312 (2020)
   PUBMED   32648659
  REMARK    GeneRIF: MD1 deletion exaggerates cardiomyocyte autophagy induced
            by heart failure with preserved ejection fraction through ROS/MAPK
            signalling pathway.
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Nagai Y, Shimazu R, Ogata H, Akashi S, Sudo K, Yamasaki H, Hayashi
            S, Iwakura Y, Kimoto M and Miyake K.
  TITLE     Requirement for MD-1 in cell surface expression of RP105/CD180 and
            B-cell responsiveness to lipopolysaccharide
  JOURNAL   Blood 99 (5), 1699-1705 (2002)
   PUBMED   11861286
  REMARK    GeneRIF: Required for cell surface expression of RP105/CD180 and
            B-cell responsiveness to lipopolysaccharide . RP105/MD-1 has
            structural similarity to Toll-like receptor 4(TRL4)
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Gorczynski RM, Chen Z, Clark DA, Hu J, Yu G, Li X, Tsang W and
            Hadidi S.
  TITLE     Regulation of gene expression of murine MD-1 regulates subsequent T
            cell activation and cytokine production
  JOURNAL   J Immunol 165 (4), 1925-1932 (2000)
   PUBMED   10925274
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbrauker I,
            Rajewsky K, Kimoto M and Tarakhovsky A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
REFERENCE   9  (bases 1 to 997)
  AUTHORS   Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K and
            Kimoto M.
  TITLE     MD-2, a molecule that confers lipopolysaccharide responsiveness on
            Toll-like receptor 4
  JOURNAL   J Exp Med 189 (11), 1777-1782 (1999)
   PUBMED   10359581
REFERENCE   10 (bases 1 to 997)
  AUTHORS   Miyake K, Shimazu R, Kondo J, Niki T, Akashi S, Ogata H, Yamashita
            Y, Miura Y and Kimoto M.
  TITLE     Mouse MD-1, a molecule that is physically associated with RP105 and
            positively regulates its expression
  JOURNAL   J Immunol 161 (3), 1348-1353 (1998)
   PUBMED   9686597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB007599.1 and BE200280.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by NM_010745.3.
            
            On Dec 19, 2009 this sequence version replaced NM_010745.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007599.1, AK027929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-768               AB007599.1         1-768
            769-997             BE200280.1         1-229               c
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.7 cM"
     gene            1..997
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /note="lymphocyte antigen 86"
                     /db_xref="GeneID:17084"
                     /db_xref="MGI:MGI:1321404"
     exon            1..230
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..583
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /note="ly-86; protein MD-1"
                     /codon_start=1
                     /product="lymphocyte antigen 86 precursor"
                     /protein_id="NP_034875.1"
                     /db_xref="CCDS:CCDS26457.1"
                     /db_xref="GeneID:17084"
                     /db_xref="MGI:MGI:1321404"
                     /translation="MNGVAAALLVWILTSPSSSDHGSENGWPKHTACNSGGLEVVYQS
                     CDPLQDFGLSIDQCSKQIQSNLNIRFGIILRQDIRKLFLDITLMAKGSSILNYSYPLC
                     EEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENRATVACANATVT
                     SS"
     exon            231..317
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..446
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..499
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..997
                     /gene="Ly86"
                     /gene_synonym="ly86_tv2; MD-1; MD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaactgaac atactactcc ttcaggggga ggacgagctt cggaggtctt tttattgggc
       61 tggcttacca ttgggcacac acaaccccct cgccatgaat ggtgtcgcag ctgccctcct
      121 tgtgtggatt ctgacttctc cgagcagcag tgaccatggc agcgaaaatg gttggcccaa
      181 gcacacggcc tgcaacagtg ggggcttgga agtagtctac cagagctgtg atcccttaca
      241 ggattttggc ctttccattg accagtgttc caagcagatc caatcaaatc tcaacattag
      301 atttggcatc attctgagac aggatatcag aaagctgttt ctggacataa ctctgatggc
      361 aaaaggctct tctattctga actactccta tcccctttgt gaggaggacc agcccaagtt
      421 ctcattctgt ggaagaagaa aaggagaaca gatatactat gccggccctg tcaataaccc
      481 tggacttgat gttccacagg gagaatatca gctcttgctg gaactgtaca atgaaaaccg
      541 tgctactgtg gcttgtgcca atgccactgt cacctcctcc tgagcatggt ctgcaaggaa
      601 atgcacagta aactcaatct caggggaccc caaggtccct ggactcacct agctgcaaga
      661 accactgata accaagagag gctttacaaa gaaatttctt gtgggtcact cttccgatct
      721 tagctccagg gacagatgtt cccagaccca acagatgtaa taaaccctca aaaactatct
      781 atttctgagg accctgagta gtcttgaagc cctattgtag tacctctcct tatgtaatta
      841 cgtttcatca aagctacttc cttgcctgct ccttagcaac acttccttga agttgcctgg
      901 gatgtaaaaa ataaaataaa ataaaataaa ataaaataaa ataaaataaa atgaaatgaa
      961 aaataaataa aataaaacaa aatctgccct gcaccta
//
