LOCUS       NM_013825               6871 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus lymphocyte antigen 75 (Ly75), mRNA.
ACCESSION   NM_013825
VERSION     NM_013825.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6871)
  AUTHORS   Chen,S.T., Oliveira,T.Y., Gazumyan,A., Cipolla,M. and
            Nussenzweig,M.C.
  TITLE     B cell receptor signaling in germinal centers prolongs survival and
            primes B cells for selection
  JOURNAL   Immunity 56 (3), 547-561 (2023)
   PUBMED   36882061
REFERENCE   2  (bases 1 to 6871)
  AUTHORS   Mlynarczyk,C., Teater,M., Pae,J., Chin,C.R., Wang,L., Arulraj,T.,
            Barisic,D., Papin,A., Hoehn,K.B., Kots,E., Ersching,J.,
            Bandyopadhyay,A., Barin,E., Poh,H.X., Evans,C.M., Chadburn,A.,
            Chen,Z., Shen,H., Isles,H.M., Pelzer,B., Tsialta,I., Doane,A.S.,
            Geng,H., Rehman,M.H., Melnick,J., Morgan,W., Nguyen,D.T.T.,
            Elemento,O., Kharas,M.G., Jaffrey,S.R., Scott,D.W., Khelashvili,G.,
            Meyer-Hermann,M., Victora,G.D. and Melnick,A.
  TITLE     BTG1 mutation yields supercompetitive B cells primed for malignant
            transformation
  JOURNAL   Science 379 (6629), eabj7412 (2023)
   PUBMED   36656933
REFERENCE   3  (bases 1 to 6871)
  AUTHORS   Ford,S.L., O'Sullivan,K.M., Kitching,A.R., Holdsworth,S.R.,
            Gan,P.Y. and Summers,S.A.
  TITLE     Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes
            Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis
  JOURNAL   Int J Mol Sci 24 (2), 1339 (2023)
   PUBMED   36674855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6871)
  AUTHORS   Jing,Z., McCarron,M.J., Dustin,M.L. and Fooksman,D.R.
  TITLE     Germinal center expansion but not plasmablast differentiation is
            proportional to peptide-MHCII density via CD40-CD40L signaling
            strength
  JOURNAL   Cell Rep 39 (5), 110763 (2022)
   PUBMED   35508132
REFERENCE   5  (bases 1 to 6871)
  AUTHORS   Enterina,J.R., Sarkar,S., Streith,L., Jung,J., Arlian,B.M.,
            Meyer,S.J., Takematsu,H., Xiao,C., Baldwin,T.A., Nitschke,L.,
            Shlomchick,M.J., Paulson,J.C. and Macauley,M.S.
  TITLE     Coordinated changes in glycosylation regulate the germinal center
            through CD22
  JOURNAL   Cell Rep 38 (11), 110512 (2022)
   PUBMED   35294874
REFERENCE   6  (bases 1 to 6871)
  AUTHORS   Guo,M., Gong,S., Maric,S., Misulovin,Z., Pack,M., Mahnke,K.,
            Nussenzweig,M.C. and Steinman,R.M.
  TITLE     A monoclonal antibody to the DEC-205 endocytosis receptor on human
            dendritic cells
  JOURNAL   Hum Immunol 61 (8), 729-738 (2000)
   PUBMED   10980384
REFERENCE   7  (bases 1 to 6871)
  AUTHORS   Kronin,V., Wu,L., Gong,S., Nussenzweig,M.C. and Shortman,K.
  TITLE     DEC-205 as a marker of dendritic cells with regulatory effects on
            CD8 T cell responses
  JOURNAL   Int Immunol 12 (5), 731-735 (2000)
   PUBMED   10784619
REFERENCE   8  (bases 1 to 6871)
  AUTHORS   Guerriero,A., Langmuir,P.B., Spain,L.M. and Scott,E.W.
  TITLE     PU.1 is required for myeloid-derived but not lymphoid-derived
            dendritic cells
  JOURNAL   Blood 95 (3), 879-885 (2000)
   PUBMED   10648399
REFERENCE   9  (bases 1 to 6871)
  AUTHORS   Swiggard,W.J., Mirza,A., Nussenzweig,M.C. and Steinman,R.M.
  TITLE     DEC-205, a 205-kDa protein abundant on mouse dendritic cells and
            thymic epithelium that is detected by the monoclonal antibody
            NLDC-145: purification, characterization, and N-terminal amino acid
            sequence
  JOURNAL   Cell Immunol 165 (2), 302-311 (1995)
   PUBMED   7553896
REFERENCE   10 (bases 1 to 6871)
  AUTHORS   Jiang,W., Swiggard,W.J., Heufler,C., Peng,M., Mirza,A.,
            Steinman,R.M. and Nussenzweig,M.C.
  TITLE     The receptor DEC-205 expressed by dendritic cells and thymic
            epithelial cells is involved in antigen processing
  JOURNAL   Nature 375 (6527), 151-155 (1995)
   PUBMED   7753172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935326.13.
            
            On Jun 21, 2019 this sequence version replaced NM_013825.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U19271.1, BC150734.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL935326.13        218255-218390       c
            137-508             AL935326.13        210975-211346       c
            509-679             AL935326.13        203876-204046       c
            680-844             AL935326.13        200128-200292       c
            845-955             AL935326.13        193585-193695       c
            956-1096            AL935326.13        192394-192534       c
            1097-1288           AL935326.13        190486-190677       c
            1289-1446           AL935326.13        189522-189679       c
            1447-1557           AL935326.13        188039-188149       c
            1558-1646           AL935326.13        187471-187559       c
            1647-1816           AL935326.13        187173-187342       c
            1817-2016           AL935326.13        184975-185174       c
            2017-2159           AL935326.13        183470-183612       c
            2160-2241           AL935326.13        175270-175351       c
            2242-2310           AL935326.13        173412-173480       c
            2311-2425           AL935326.13        169567-169681       c
            2426-2461           AL935326.13        168042-168077       c
            2462-2637           AL935326.13        167436-167611       c
            2638-2705           AL935326.13        166194-166261       c
            2706-2788           AL935326.13        165843-165925       c
            2789-2928           AL935326.13        165093-165232       c
            2929-3034           AL935326.13        163507-163612       c
            3035-3195           AL935326.13        162904-163064       c
            3196-3325           AL935326.13        158936-159065       c
            3326-3552           AL935326.13        156815-157041       c
            3553-3718           AL935326.13        153425-153590       c
            3719-3886           AL935326.13        151206-151373       c
            3887-4003           AL935326.13        149274-149390       c
            4004-4198           AL935326.13        146726-146920       c
            4199-4425           AL935326.13        143256-143482       c
            4426-4594           AL935326.13        141447-141615       c
            4595-4744           AL935326.13        138695-138844       c
            4745-4867           AL935326.13        136072-136194       c
            4868-5035           AL935326.13        134164-134331       c
            5036-6871           AL935326.13        127220-129055       c
FEATURES             Location/Qualifiers
     source          1..6871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 34.54 cM"
     gene            1..6871
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /note="lymphocyte antigen 75"
                     /db_xref="GeneID:17076"
                     /db_xref="MGI:MGI:106662"
     exon            1..136
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..5214
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /note="ly-75"
                     /codon_start=1
                     /product="lymphocyte antigen 75 precursor"
                     /protein_id="NP_038853.2"
                     /db_xref="CCDS:CCDS38126.1"
                     /db_xref="GeneID:17076"
                     /db_xref="MGI:MGI:106662"
                     /translation="MRTGRVTPGLAAGLLLLLLRSFGLVEPSESSGNDPFTIVHENTG
                     KCIQPLSDWVVAQDCSGTNNMLWKWVSQHRLFHLESQKCLGLDITKATDNLRMFSCDS
                     TVMLWWKCEHHSLYTAAQYRLALKDGYAVANTNTSDVWKKGGSEENLCAQPYHEIYTR
                     DGNSYGRPCEFPFLIGETWYHDCIHDEDHSGPWCATTLSYEYDQKWGICLLPESGCEG
                     NWEKNEQIGSCYQFNNQEILSWKEAYVSCQNQGADLLSIHSAAELAYITGKEDIARLV
                     WLGLNQLYSARGWEWSDFRPLKFLNWDPGTPVAPVIGGSSCARMDTESGLWQSVSCES
                     QQPYVCKKPLNNTLELPDVWTYTDTHCHVGWLPNNGFCYLLANESSSWDAAHLKCKAF
                     GADLISMHSLADVEVVVTKLHNGDVKKEIWTGLKNTNSPALFQWSDGTEVTLTYWNEN
                     EPSVPFNKTPNCVSYLGKLGQWKVQSCEKKLRYVCKKKGEITKDAESDKLCPPDEGWK
                     RHGETCYKIYEKEAPFGTNCNLTITSRFEQEFLNYMMKNYDKSLRKYFWTGLRDPDSR
                     GEYSWAVAQGVKQAVTFSNWNFLEPASPGGCVAMSTGKTLGKWEVKNCRSFRALSICK
                     KVSEPQEPEEAAPKPDDPCPEGWHTFPSSLSCYKVFHIERIVRKRNWEEAERFCQALG
                     AHLPSFSRREEIKDFVHLLKDQFSGQRWLWIGLNKRSPDLQGSWQWSDRTPVSAVMME
                     PEFQQDFDIRDCAAIKVLDVPWRRVWHLYEDKDYAYWKPFACDAKLEWVCQIPKGSTP
                     QMPDWYNPERTGIHGPPVIIEGSEYWFVADPHLNYEEAVLYCASNHSFLATITSFTGL
                     KAIKNKLANISGEEQKWWVKTSENPIDRYFLGSRRRLWHHFPMTFGDECLHMSAKTWL
                     VDLSKRADCNAKLPFICERYNVSSLEKYSPDPAAKVQCTEKWIPFQNKCFLKVNSGPV
                     TFSQASGICHSYGGTLPSVLSRGEQDFIISLLPEMEASLWIGLRWTAYERINRWTDNR
                     ELTYSNFHPLLVGRRLSIPTNFFDDESHFHCALILNLKKSPLTGTWNFTSCSERHSLS
                     LCQKYSETEDGQPWENTSKTVKYLNNLYKIISKPLTWHGALKECMKEKMRLVSITDPY
                     QQAFLAVQATLRNSSFWIGLSSQDDELNFGWSDGKRLQFSNWAGSNEQLDDCVILDTD
                     GFWKTADCDDNQPGAICYYPGNETEEEVRALDTAKCPSPVQSTPWIPFQNSCYNFMIT
                     NNRHKTVTPEEVQSTCEKLHSKAHSLSIRNEEENTFVVEQLLYFNYIASWVMLGITYE
                     NNSLMWFDKTALSYTHWRTGRPTVKNGKFLAGLSTDGFWDIQSFNVIEETLHFYQHSI
                     SACKIEMVDYEDKHNGTLPQFIPYKDGVYSVIQKKVTWYEALNACSQSGGELASVHNP
                     NGKLFLEDIVNRDGFPLWVGLSSHDGSESSFEWSDGRAFDYVPWQSLQSPGDCVVLYP
                     KGIWRREKCLSVKDGAICYKPTKDKKLIFHVKSSKCPVAKRDGPQWVQYGGHCYASDQ
                     VLHSFSEAKQVCQELDHSATVVTIADENENKFVSRLMRENYNITMRVWLGLSQHSLDQ
                     SWSWLDGLDVTFVKWENKTKDGDGKCSILIASNETWRKVHCSRGYARAVCKIPLSPDY
                     TGIAILFAVLCLLGLISLAIWFLLQRSHIRWTGFSSVRYEHGTNEDEVMLPSFHD"
     exon            137..508
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            509..679
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            680..844
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            845..955
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1096
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1288
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1446
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1557
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1646
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1816
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2016
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2159
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2241
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2310
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2425
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2461
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2637
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2705
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2788
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2928
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3034
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3195
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3325
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3552
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3718
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3886
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..4003
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4198
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4425
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4426..4594
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4744
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4867
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            4868..5035
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     exon            5036..6871
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6847..6852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /note="hexamer: AATAAA"
     polyA_site      6871
                     /gene="Ly75"
                     /gene_synonym="CD205; DEC-205; DEC205"
                     /note="major polyA site"
ORIGIN      
        1 accgctgaag ccggtgcggg caggagaggc ttgggactgg agatgcggac gggccgggtg
       61 accccgggcc tggcggcggg gctactcctg ctgttgctgc ggtccttcgg gcttgtggag
      121 ccttctgaga gctcaggtaa tgatccattc accatcgtcc atgaaaacac tggcaagtgc
      181 atccagccgc tgtctgactg ggtagtggcc caggactgta gcggaactaa caacatgttg
      241 tggaagtggg tgtcccagca ccgcctcttt cacctggaat cccagaagtg cctcggcctc
      301 gatattacca aagccacgga caacctgcga atgttcagct gtgactccac cgtcatgctg
      361 tggtggaaat gtgagcacca ttcgctgtac accgctgccc agtacaggct agctctgaaa
      421 gatggatatg ccgtagccaa tacgaataca tctgatgtct ggaagaaggg aggctccgag
      481 gaaaaccttt gtgcccagcc ttatcatgag atatacacca gagatgggaa ttcctacggg
      541 agaccttgtg aattcccttt cttgattggt gagacatggt accatgactg cattcatgat
      601 gaagatcata gtgggccatg gtgtgccact accctaagtt atgaatatga tcaaaagtgg
      661 ggcatctgcc tactaccaga aagtggctgt gaaggtaact gggaaaagaa tgagcagatt
      721 ggaagttgct accaatttaa taatcaggaa attctgtctt ggaaagaagc ttatgtttcc
      781 tgtcagaacc aaggagctga cttactgagc atccacagtg ctgccgaatt agcctacatt
      841 acgggaaaag aggacattgc tagacttgtt tggcttggac tgaatcagct ctattctgcg
      901 agaggttggg aatggtcaga cttcaggcca ctcaaatttc ttaactggga tccaggcacg
      961 cccgttgcac ctgtgattgg tgggtcaagc tgtgccagaa tggacacaga gtccgggctg
     1021 tggcaaagtg tttcctgtga atctcagcag ccttacgtct gcaagaagcc actgaacaac
     1081 acgctggagc tcccagatgt ttggacttac acagataccc actgccatgt gggctggctg
     1141 ccaaataatg ggttttgcta tctgctggcg aatgaaagta gttcctggga tgcagcacat
     1201 ttgaaatgca aagccttcgg tgcagacctc atcagcatgc actccttagc agatgtggag
     1261 gtggttgtca cgaaactcca taatggggat gtcaaaaaag aaatatggac aggccttaaa
     1321 aacacaaaca gccctgcttt gttccagtgg tcggacggaa cggaagttac tctaacgtac
     1381 tggaatgaga atgagccgag tgttcccttc aacaagactc ccaactgtgt ttcctattta
     1441 ggaaagttag gtcagtggaa agtccagtcc tgtgagaaga aactcagata tgtatgcaag
     1501 aaaaagggag aaataactaa ggatgcagag tcggataagc tgtgtccgcc agacgagggc
     1561 tggaagagac atggagaaac ctgttacaag atttatgaga aagaggcccc tttcggaacg
     1621 aactgcaacc tgaccatcac tagcaggttc gagcaggaat tcttgaatta tatgatgaag
     1681 aactatgata agtcccttcg gaagtacttc tggactggcc tgagagaccc tgactctcga
     1741 ggagaataca gttgggccgt tgctcaggga gtaaagcagg ctgtgacctt ttccaactgg
     1801 aattttcttg aaccggcgtc tccaggcggg tgcgtggcta tgtctactgg aaagactctt
     1861 ggcaagtggg aagtgaagaa ctgcagaagc ttccgtgctc tttcaatatg caagaaagtg
     1921 agcgaacccc aggagcctga agaagcagcc cccaagcccg acgacccctg tcctgaaggc
     1981 tggcacactt tcccctccag cctttcttgt tataaggtgt tccatataga aagaatcgta
     2041 agaaagagga actgggaaga agccgaaagg ttctgccaag cccttggagc tcacctaccc
     2101 agcttcagtc gtagagagga aattaaggac tttgtgcatt tgttaaagga ccagttcagt
     2161 gggcagcgtt ggttgtggat tggtctgaat aagagaagcc ctgatttaca agggtcctgg
     2221 cagtggagtg accggacacc agtgtctgct gtgatgatgg agccggagtt tcaacaggat
     2281 tttgacatca gagactgtgc tgccatcaag gtccttgatg taccttggcg aagagtctgg
     2341 catctctatg aggacaagga ctatgcttac tggaaacctt ttgcttgtga tgccaagctt
     2401 gagtgggtgt gccagattcc aaaaggtagc actccccaga tgccagactg gtataatcca
     2461 gagcgcactg gaattcatgg gcccccagtt ataattgaag gaagtgaata ctggtttgtt
     2521 gctgatcccc acttaaacta cgaagaagcc gtcttatact gtgctagcaa tcacagcttt
     2581 cttgccacga taacatcgtt cacaggacta aaagctatca aaaacaaact agcaaatatt
     2641 tctggcgagg aacagaagtg gtgggtgaaa acgagtgaga atccaattga tcgttacttt
     2701 ctaggctcgc gccgccgcct gtggcaccat ttccccatga cgtttggaga tgaatgtttg
     2761 cacatgtcag ccaagacgtg gcttgttgac ttaagtaaac gagcggactg taatgccaag
     2821 ttgcccttca tctgtgaaag atacaatgtc tcttcattag agaaatacag cccagatcct
     2881 gcagccaaag tacagtgcac tgagaagtgg attccttttc aaaataagtg cttcctaaag
     2941 gtcaactctg ggcccgttac gttttctcaa gcaagcggca tttgtcattc ctacggcggc
     3001 acccttcctt ccgtgctgag ccggggtgaa caagatttca ttatatcctt gcttcctgaa
     3061 atggaagcta gtctatggat tggtctgcgc tggactgcct acgaaaggat aaacagatgg
     3121 acagacaaca gagagctgac ctacagcaac tttcacccac tgctggtcgg tcggaggctg
     3181 agcataccaa cgaatttctt tgatgatgag tcccacttcc actgcgcctt gattcttaat
     3241 ctcaaaaagt caccgcttac tgggacctgg aattttactt cctgttcaga acgacactct
     3301 ctgtctctct gtcaaaaata ctcagagact gaagacggac agccctggga gaacacttca
     3361 aaaacagtga agtatctaaa taacctatac aaaatcatct cgaagcccct gacgtggcac
     3421 ggcgctctga aggagtgcat gaaagagaag atgaggttgg tgagcatcac agacccttac
     3481 cagcaggcct tcctcgcagt gcaggccacc ctgcgcaaca gctccttctg gatcggactc
     3541 tccagtcaag atgatgaact caactttggt tggtcagatg ggaaacgtct tcaatttagt
     3601 aactgggctg gaagcaatga gcaacttgat gactgcgtga tattagacac agatggattc
     3661 tggaaaacag ctgactgtga tgataaccag cctggcgcca tttgctacta tccaggaaat
     3721 gagactgagg aggaggtcag agcactggac actgctaaat gcccgtctcc tgtacagagc
     3781 accccatgga taccattcca gaactcctgc tacaatttca tgattaccaa caacaggcat
     3841 aagacagtca caccggagga agtgcagtcc acgtgcgaga agctgcattc gaaagcacac
     3901 agtctgagca ttcggaatga ggaggagaat acctttgttg tggaacagct tctgtacttc
     3961 aattatattg cctcatgggt catgttagga ataacctatg aaaacaattc tttgatgtgg
     4021 tttgataaaa ctgcattgtc ctacacacac tggagaacgg gaagaccaac tgtgaaaaat
     4081 ggcaaatttt tggctggtct aagtactgat ggattctggg atattcagtc tttcaatgtt
     4141 attgaagaaa cacttcattt ttaccagcac agtatttctg cttgtaaaat tgaaatggtt
     4201 gactatgagg acaaacacaa tggcaccctg ccacagttca ttccatataa ggacggcgtc
     4261 tacagcgtta ttcagaagaa ggtgacgtgg tatgaagcat tgaacgcgtg ctctcaaagt
     4321 gggggagagt tggccagtgt tcacaaccca aatgggaagc tctttctgga agacattgtg
     4381 aaccgtgacg gattccctct ctgggttggg ctctcaagtc atgatggaag cgaatcgagt
     4441 ttcgaatggt ccgatggcag agcatttgac tatgtcccat ggcagagcct acaatctccc
     4501 ggagactgtg tcgtcttata tccaaaagga atttggagac gtgaaaaatg cctgtctgtt
     4561 aaggatggtg ctatttgtta caagcctaca aaagataaaa agctgatctt tcatgtaaaa
     4621 tcatcaaaat gtccagtggc aaagagggat ggtccccagt gggtccagta tgggggccac
     4681 tgttacgctt cggaccaggt actgcacagc ttctcagagg ccaaacaagt gtgtcaagag
     4741 cttgatcatt cggcaactgt tgtcaccata gcagatgaaa atgagaataa gtttgtgagc
     4801 agactgatga gggagaacta taatattact atgagagttt ggcttggcct gtctcagcat
     4861 tcactcgatc agtcttggag ttggctcgat ggattagatg tgacatttgt caaatgggaa
     4921 aataaaacta aggatggtga tgggaaatgt agcattttaa tagcttcaaa tgaaacctgg
     4981 agaaaagtcc attgctcacg tggctatgca agagctgtct gcaaaattcc tctgagcccg
     5041 gactacacag gcatagccat cctgtttgcc gtgctgtgcc tcttagggct catcagcttg
     5101 gcgatttggt tcctcttgca acgatcccat atccgctgga ccggcttctc ctcggttcgg
     5161 tatgaacatg gaaccaacga agacgaggtg atgctccctt ctttccacga ctaacttctt
     5221 ccaagagttt gttcattggc cctggatgtt gcggaagcaa gatgagccac ttagcactgc
     5281 atccccccaa tcagtgtcta actttgtttc taagtagaga agtcttagag atgtattcag
     5341 cgggcgggag gggagagttg ctcagctgat gccctaacgg ccatgctaat gagtcagtta
     5401 tcagagcaga gagacttaaa gccaaaatgg atattcaggt tgttcacagg gggataaatt
     5461 tagctaatgt gaattttctc tgtaaaaatg cagttgctaa atagatacgt acatattgta
     5521 atagcattgt aacagcctca tagaaaatta aaactgtcag tacaagtagg ctccacattt
     5581 accttttatg ggcatctgac caaatgcaaa gttagtaact ccagcaaaaa ctcaactata
     5641 aataagatca atgatgcttc aaaatagcct tttaaggcac tggggaaaaa atacaaaata
     5701 aggcatattt tttatacaga aaacagagcc ccttggaaga tgtttcttat actatttcaa
     5761 agatatgtat actggtatta attaattgtt acatttctgt ttttcattgc ttatattcag
     5821 tgagttggtt tttgtcttta acttaaagtt aatgtttcct aaagttggga acgttgctgt
     5881 taagttgcct gggcgtgctg tatcagcatg tctgcgtttg atgattttct tttttacaag
     5941 gacccaatta cagctgagac ttcagctttt acagttcctg tctttcacat aggagatcag
     6001 ctttctgttg gtggtggctg gggtttttgg ttttgttttg ttgtttttgt ttttgttttg
     6061 ttttgttttt tgaaacatgg tttctttgtg catcatagcc ctggctgtcc tggactgact
     6121 ttgtagacca ggctagccac taattcagag atcccccgcc tctgccttgg gagtgctggg
     6181 atcaaagact gtgctggcac caccccagca agcaggcagg gtatcacctt ttgatgaatg
     6241 tattatgttg ttgccttttt acttgagcga aacataaaag tgatctttga ataatgttgt
     6301 ttgctacttc tgtatttgta aacaatcacc gtccctaaga caatgaaact cagaactctg
     6361 tgattcctgt ggaaatattt aaaactgaaa tgattagtga cacactattt tgttgatgta
     6421 atttccattt gaacatctgg aatatacttt tactagtagt gtcaaaataa atatggtgac
     6481 tgttttattc agtgtttcat atttatactt tagagtattt ttgtacaaga tccagattta
     6541 ttttgcttga ggtgtttatg ctatcataaa gttgtaaata attttctaag actgttttaa
     6601 tgcaatctac agttttccta aaatattttt cttgaggcct cttttaacta tcactaggag
     6661 tttcttcaaa aaactaaatc aataccatgt gaccacagtt gtgatcatgg ctgcttccgt
     6721 ggctgatcct tgcatgtgaa agcatctcta aattaggttt gattgtatcc catgtgtagt
     6781 atgaagagaa ggtgtccagc tattgcgagt taaggtattt taagactttg tgagcacttt
     6841 ttaaagaata aatctttgta tgtctaaatt a
//
