LOCUS       NM_029627                773 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lymphocyte antigen 6 family member K (Ly6k), mRNA.
ACCESSION   NM_029627 XM_354933
VERSION     NM_029627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 773)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   2  (bases 1 to 773)
  AUTHORS   Fujihara,Y., Noda,T., Kobayashi,K., Oji,A., Kobayashi,S.,
            Matsumura,T., Larasati,T., Oura,S., Kojima-Kita,K., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Identification of multiple male reproductive tract-specific
            proteins that regulate sperm migration through the oviduct in mice
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18498-18506 (2019)
   PUBMED   31455729
REFERENCE   3  (bases 1 to 773)
  AUTHORS   Fujihara,Y., Oji,A., Kojima-Kita,K., Larasati,T. and Ikawa,M.
  TITLE     Co-expression of sperm membrane proteins CMTM2A and CMTM2B is
            essential for ADAM3 localization and male fertility in mice
  JOURNAL   J Cell Sci 131 (19) (2018)
   PUBMED   30209135
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 773)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 773)
  AUTHORS   Endo,S., Yoshitake,H., Tsukamoto,H., Matsuura,H., Kato,K.,
            Sakuraba,M., Takamori,K., Fujiwara,H., Takeda,S. and Araki,Y.
  TITLE     TEX101, a glycoprotein essential for sperm fertility, is required
            for stable expression of Ly6k on testicular germ cells
  JOURNAL   Sci Rep 6, 23616 (2016)
   PUBMED   27005865
  REMARK    GeneRIF: Study demonstrated that both TEX101 and Ly6k contribute
            mutually for their protein expression in the testicular germ cells,
            suggesting that the expression-balance of these two proteins is
            essential for fertile sperm formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 773)
  AUTHORS   Fujihara,Y., Okabe,M. and Ikawa,M.
  TITLE     GPI-anchored protein complex, LY6K/TEX101, is required for sperm
            migration into the oviduct and male fertility in mice
  JOURNAL   Biol Reprod 90 (3), 60 (2014)
   PUBMED   24501175
  REMARK    GeneRIF: LY6K is a newly identified factor involved in sperm
            fertilizing ability
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 773)
  AUTHORS   Maruyama,M., Yoshitake,H., Tsukamoto,H., Takamori,K. and Araki,Y.
  TITLE     Molecular expression of Ly6k, a putative
            glycosylphosphatidyl-inositol-anchored membrane protein on the
            mouse testicular germ cells
  JOURNAL   Biochem Biophys Res Commun 402 (1), 75-81 (2010)
   PUBMED   20920470
  REMARK    GeneRIF: This information is essential for the molecular
            classification of Ly6k, and may help uncover the detailed
            physiological role of Ly6k in gametogenesis, or cancer biology.
REFERENCE   8  (bases 1 to 773)
  AUTHORS   Yoshitake,H., Tsukamoto,H., Maruyama-Fukushima,M., Takamori,K.,
            Ogawa,H. and Araki,Y.
  TITLE     TEX101, a germ cell-marker glycoprotein, is associated with
            lymphocyte antigen 6 complex locus k within the mouse testis
  JOURNAL   Biochem Biophys Res Commun 372 (2), 277-282 (2008)
   PUBMED   18503752
  REMARK    GeneRIF: This study confirmed the biological interaction between
            TEX101 and Ly6k.
REFERENCE   9  (bases 1 to 773)
  AUTHORS   von Allmen,C.E., Bauer,M., Dietmeier,K., Buser,R.B., Gwerder,M.,
            Muntwiler,S., Utzinger,S., Saudan,P., Bachmann,M.F. and Beerli,R.R.
  TITLE     Identification of Ly-6K as a novel marker for mouse plasma cells
  JOURNAL   Mol Immunol 45 (10), 2727-2733 (2008)
   PUBMED   18372042
  REMARK    GeneRIF: Expression profiling confirmed that mLy-6K is expressed by
            plasma cells but not B cells or tissues not containing plasma
            cells.
REFERENCE   10 (bases 1 to 773)
  AUTHORS   de Nooij-van Dalen,A.G., van Dongen,G.A., Smeets,S.J.,
            Nieuwenhuis,E.J., Stigter-van Walsum,M., Snow,G.B. and
            Brakenhoff,R.H.
  TITLE     Characterization of the human Ly-6 antigens, the newly annotated
            member Ly-6K included, as molecular markers for head-and-neck
            squamous cell carcinoma
  JOURNAL   Int J Cancer 103 (6), 768-774 (2003)
   PUBMED   12516096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK010485.1.
            
            On Jun 30, 2008 this sequence version replaced NM_029627.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010485.1, BY709908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-773               AK010485.1         5-777
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.28 cM"
     gene            1..773
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /note="lymphocyte antigen 6 family member K"
                     /db_xref="GeneID:76486"
                     /db_xref="MGI:MGI:1923736"
     exon            1..199
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /inference="alignment:Splign:2.1.0"
     exon            200..276
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..683
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /note="lymphocyte antigen 6K; ly-6K; lymphocyte antigen 6
                     complex, locus K"
                     /codon_start=1
                     /product="lymphocyte antigen 6K precursor"
                     /protein_id="NP_083903.1"
                     /db_xref="CCDS:CCDS27532.1"
                     /db_xref="GeneID:76486"
                     /db_xref="MGI:MGI:1923736"
                     /translation="MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEK
                     KFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCC
                     QWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL"
     exon            277..375
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /inference="alignment:Splign:2.1.0"
     exon            376..773
                     /gene="Ly6k"
                     /gene_synonym="2410015A16Rik; 3110035B01Rik; mLy-6K"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactctgag ctctccgtcc tccctgggcg gacctcaatg agacgcggag gctgcgggag
       61 ccggaatgtt ccagaagggg accaacggca ccctgtaggg ggcagtgtgg gaagagcgac
      121 cccaaactag ctgagtctcc gacttcgcca gtcagacgca gggacccgtg gacacgctga
      181 ggcacgggct gctgaggaag accaggcatc ctctggagat ggcgttccta gtggccttgc
      241 tcgtagttct gggcttacag ttggtgcaga gtaacgcgct cacctgccat gtgtgtgagg
      301 cgcagaacag ctatgcctgc tcgaatccgt cccagtgccc tggagaaaag aaattctgtt
      361 tgttggccgt cacacgaatt tttgaacgtt tcttctatgt gtcgaaacag tgcacccgaa
      421 ggtgtccaac ccccgtagtc agcccgccta gcactaatcc accatctgag cctaaggagt
      481 ttctgataga aaaacccatg cccttcctat tttataagtg ctgtcaatgg gactcatgta
      541 atggtgaggg gccacccact gaccagctct taaaggaaca acctgggaaa gccagtggga
      601 gaagacatag atacattgag ctgttactga ctggcttcat ggtccttact gctaatggcc
      661 tctcagccct ctgcctgctg taagtcacag aaggacctgg atcatgcctt gtgggtcatg
      721 aattctctgt acccctgctg gatccttcta attaaatttg tttttccttc gtc
//
