LOCUS       NM_001411856            1023 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus lymphocyte antigen 6 family member H (Ly6h),
            transcript variant 4, mRNA.
ACCESSION   NM_001411856 XM_011245606
VERSION     NM_001411856.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Moriwaki,Y., Kubo,N., Watanabe,M., Asano,S., Shinoda,T., Sugino,T.,
            Ichikawa,D., Tsuji,S., Kato,F. and Misawa,H.
  TITLE     Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic
            acetylcholine receptor currents at the plasma membrane
  JOURNAL   Sci Rep 10 (1), 11996 (2020)
   PUBMED   32686737
  REMARK    GeneRIF: Endogenous neurotoxin-like protein Ly6H inhibits alpha7
            nicotinic acetylcholine receptor currents at the plasma membrane.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1023)
  AUTHORS   Kuwahara,A., Lewis,A.E., Coombes,C., Leung,F.S., Percharde,M. and
            Bush,J.O.
  TITLE     Delineating the early transcriptional specification of the
            mammalian trachea and esophagus
  JOURNAL   Elife 9, e55526 (2020)
   PUBMED   32515350
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1023)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1023)
  AUTHORS   Wu,M., Puddifoot,C.A., Taylor,P. and Joiner,W.J.
  TITLE     Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic
            acetylcholine receptors by members of the Ly6 protein family
  JOURNAL   J Biol Chem 290 (40), 24509-24518 (2015)
   PUBMED   26276394
REFERENCE   6  (bases 1 to 1023)
  AUTHORS   Puddifoot,C.A., Wu,M., Sung,R.J. and Joiner,W.J.
  TITLE     Ly6h regulates trafficking of alpha7 nicotinic acetylcholine
            receptors and nicotine-induced potentiation of glutamatergic
            signaling
  JOURNAL   J Neurosci 35 (8), 3420-3430 (2015)
   PUBMED   25716842
  REMARK    GeneRIF: Ly6h regulates alpha7 nAChRs cell-surface expression and
            nicotine-induced potentiation of glutamatergic mEPSC.
REFERENCE   7  (bases 1 to 1023)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 1023)
  AUTHORS   Dessaud,E., Salaun,D., Gayet,O., Chabbert,M. and deLapeyriere,O.
  TITLE     Identification of lynx2, a novel member of the ly-6/neurotoxin
            superfamily, expressed in neuronal subpopulations during mouse
            development
  JOURNAL   Mol Cell Neurosci 31 (2), 232-242 (2006)
   PUBMED   16236524
REFERENCE   9  (bases 1 to 1023)
  AUTHORS   Bamezai,A.
  TITLE     Mouse Ly-6 proteins and their extended family: markers of cell
            differentiation and regulators of cell signaling
  JOURNAL   Arch Immunol Ther Exp (Warsz) 52 (4), 255-266 (2004)
   PUBMED   15467490
  REMARK    Review article
REFERENCE   10 (bases 1 to 1023)
  AUTHORS   Apostolopoulos,J., Chisholm,L.J. and Sandrin,M.S.
  TITLE     Identification of mouse Ly6H and its expression in normal tissue
  JOURNAL   Immunogenetics 49 (11-12), 987-990 (1999)
   PUBMED   10501842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121359.8.
            
            On Sep 7, 2022 this sequence version replaced XM_011245606.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 4 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AU067463.1, SRR17784643.101689.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC121359.8         9778-9891
            115-183             AC121359.8         10155-10223
            184-311             AC121359.8         10727-10854
            312-428             AC121359.8         11287-11403
            429-1023            AC121359.8         11645-12239
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.52 cM"
     gene            1..1023
                     /gene="Ly6h"
                     /note="lymphocyte antigen 6 family member H"
                     /db_xref="GeneID:23934"
                     /db_xref="MGI:MGI:1346030"
     exon            1..114
                     /gene="Ly6h"
                     /inference="alignment:Splign:2.1.0"
     exon            115..183
                     /gene="Ly6h"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..664
                     /gene="Ly6h"
                     /note="isoform a precursor is encoded by transcript
                     variant 4; lymphocyte antigen 6H; ly-6H; lymphocyte
                     antigen 6 complex, locus H"
                     /codon_start=1
                     /product="lymphocyte antigen 6H isoform a precursor"
                     /protein_id="NP_001398785.1"
                     /db_xref="GeneID:23934"
                     /db_xref="MGI:MGI:1346030"
                     /translation="MPAPQRTPACSPRASFRPYRSMLPAAMKSLGLALLALLLCPSPA
                     HGLWCQDCTLANSSHCAPKQCQPTDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKR
                     HFFSDYLMGFINSGILKVDVDCCEKDLCNGASVAGRSPWALAGGLLLSLGPALLWAGP
                     "
     exon            184..311
                     /gene="Ly6h"
                     /inference="alignment:Splign:2.1.0"
     exon            312..428
                     /gene="Ly6h"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1023
                     /gene="Ly6h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1001..1006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ly6h"
                     /note="hexamer: AATAAA"
     polyA_site      1023
                     /gene="Ly6h"
                     /note="major polyA site"
ORIGIN      
        1 gcttccctct ttcgctgcgt ctttgtgcat tttgcttcct ttagcagcca aagctcttcc
       61 gagaatctgc aagggacctc ggccaagcag agtgggagga tcctcccacg ccggggagac
      121 cgaagggcat cgctccccgc gccgtgcccg ccgctgagcc cggagtgcgg acaccccagg
      181 gatgcctgcg ccccagagga cccccgcctg cagcccccgc gcctctttca ggccctatcg
      241 gagcatgctg cctgcagcca tgaagagcct cggtctggcg ctgctggcct tgcttctctg
      301 cccctcgccg gcccatggcc tgtggtgcca ggactgcacc ctggccaatt ccagccattg
      361 cgctccgaag cagtgccagc ccaccgatac cgtttgtgcc agcgtgcgga tcaccgaccc
      421 cagcagcagc aggaaggatc attctgtgaa caagatgtgt gcttcctcct gcgacttcgt
      481 taagcggcac tttttctcag actatctgat ggggttcatt aactctggga tcttaaaagt
      541 cgacgtggac tgctgcgaga aagatttgtg caacggggca tcggtcgcag gacgcagccc
      601 ctgggccctg gctggggggc tcctgctcag cctggggcct gctcttctct gggctgggcc
      661 ctaagacccc tccctccctc ctgctgggct ttggagcttg tcccctaagc ctgttgctgc
      721 ccctccccag cctggcctgg ctggggctgg gacagcaagg gtttggcatc aaggtctgag
      781 gctctcaacc tccctagatg tgagtgagcc ttctccgttt ctccaccagc tccatatccc
      841 aagcagctga atatctccag gagtccagac atcctggcag gaagctgggg taggggggag
      901 ggggagggca agggactgag accctccagg tctccaaggg gagggaggtc aagccaggga
      961 cagcccaaca gcctggcctg aggggcatta actacagaga aataaagtca cttctgagtc
     1021 ttg
//
