LOCUS       NM_001310438             922 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus lymphocyte antigen 6 family member G (Ly6g),
            transcript variant 1, mRNA.
ACCESSION   NM_001310438 XM_001475753
VERSION     NM_001310438.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Rosenzweig,N., Kleemann,K.L., Rust,T., Carpenter,M., Grucci,M.,
            Aronchik,M., Brouwer,N., Valenbreder,I., Cooper-Hohn,J., Iyer,M.,
            Krishnan,R.K., Sivanathan,K.N., Brandao,W., Yahya,T., Durao,A.,
            Yin,Z., Chadarevian,J.P., Properzi,M.J., Nowarski,R., Davtyan,H.,
            Weiner,H.L., Blurton-Jones,M., Yang,H.S., Eggen,B.J.L.,
            Sperling,R.A. and Butovsky,O.
  TITLE     Sex-dependent APOE4 neutrophil-microglia interactions drive
            cognitive impairment in Alzheimer's disease
  JOURNAL   Nat Med 30 (10), 2990-3003 (2024)
   PUBMED   38961225
REFERENCE   2  (bases 1 to 922)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 922)
  AUTHORS   Haist,K.C., Gibbings,S.L., Jacobelli,J., Mould,K.J., Henson,P.M.
            and Bratton,D.L.
  TITLE     A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in
            chronic granulomatous disease
  JOURNAL   iScience 27 (4), 109589 (2024)
   PUBMED   38623335
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 922)
  AUTHORS   Passino,R., Finneran,M.C., Hafner,H., Feng,Q., Huffman,L.D.,
            Zhao,X.F., Johnson,C.N., Kawaguchi,R., Oses-Prieto,J.A.,
            Burlingame,A.L., Geschwind,D.H., Benowitz,L.I. and Giger,R.J.
  TITLE     Neutrophil-inflicted vasculature damage suppresses immune-mediated
            optic nerve regeneration
  JOURNAL   Cell Rep 43 (3), 113931 (2024)
   PUBMED   38492223
REFERENCE   5  (bases 1 to 922)
  AUTHORS   Alsamraae,M., Costanzo-Garvey,D., Teply,B.A., Boyle,S.,
            Sommerville,G., Herbert,Z.T., Morrissey,C., Dafferner,A.J.,
            Abdalla,M.Y., Fallet,R.W., Kielian,T., Jensen-Smith,H.,
            deOliveira,E.I., Chen,K., Bettencourt,I.A., Wang,J.M.,
            McVicar,D.W., Keeley,T., Yu,F. and Cook,L.M.
  TITLE     Androgen receptor inhibition suppresses anti-tumor neutrophil
            response against bone metastatic prostate cancer via regulation of
            TbetaRI expression
  JOURNAL   Cancer Lett 579, 216468 (2023)
   PUBMED   37940068
REFERENCE   6  (bases 1 to 922)
  AUTHORS   Kina,T., Ikuta,K., Takayama,E., Wada,K., Majumdar,A.S.,
            Weissman,I.L. and Katsura,Y.
  TITLE     The monoclonal antibody TER-119 recognizes a molecule associated
            with glycophorin A and specifically marks the late stages of murine
            erythroid lineage
  JOURNAL   Br J Haematol 109 (2), 280-287 (2000)
   PUBMED   10848813
REFERENCE   7  (bases 1 to 922)
  AUTHORS   Moriggl,R., Topham,D.J., Teglund,S., Sexl,V., McKay,C., Wang,D.,
            Hoffmeyer,A., van Deursen,J., Sangster,M.Y., Bunting,K.D.,
            Grosveld,G.C. and Ihle,J.N.
  TITLE     Stat5 is required for IL-2-induced cell cycle progression of
            peripheral T cells
  JOURNAL   Immunity 10 (2), 249-259 (1999)
   PUBMED   10072077
REFERENCE   8  (bases 1 to 922)
  AUTHORS   Lai,L., Alaverdi,N., Maltais,L. and Morse,H.C. 3rd.
  TITLE     Mouse cell surface antigens: nomenclature and immunophenotyping
  JOURNAL   J Immunol 160 (8), 3861-3868 (1998)
   PUBMED   9558091
  REMARK    Review article
REFERENCE   9  (bases 1 to 922)
  AUTHORS   Li,T., Ramirez,K. and Palacios,R.
  TITLE     Distinct patterns of Fas cell surface expression during development
            of T- or B-lymphocyte lineages in normal, scid, and mutant mice
            lacking or overexpressing p53, bcl-2, or rag-2 genes
  JOURNAL   Cell Growth Differ 7 (1), 107-114 (1996)
   PUBMED   8788039
REFERENCE   10 (bases 1 to 922)
  AUTHORS   Fleming,T.J., O'hUigin,C. and Malek,T.R.
  TITLE     Characterization of two novel Ly-6 genes. Protein sequence and
            potential structural similarity to alpha-bungarotoxin and other
            neurotoxins
  JOURNAL   J Immunol 150 (12), 5379-5390 (1993)
   PUBMED   8515066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116498.15.
            
            On Jul 14, 2015 this sequence version replaced XM_001475753.3.
            
            Transcript Variant: Both variants 1and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length mouse
            transcript support. Its representation is therefore inferred, but
            it is supported by paralogous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2031831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC116498.15        104105-104204       c
            101-198             AC116498.15        103751-103848       c
            199-315             AC116498.15        102655-102771       c
            316-922             AC116498.15        100337-100943       c
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.29 cM"
     gene            1..922
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /note="lymphocyte antigen 6 family member G"
                     /db_xref="GeneID:546644"
                     /db_xref="MGI:MGI:109440"
     exon            1..100
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /inference="alignment:Splign:2.1.0"
     exon            101..198
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..533
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /note="lymphocyte antigen 6G; ly-6G.1; lymphocyte antigen
                     6 complex, locus G"
                     /codon_start=1
                     /product="lymphocyte antigen 6G precursor"
                     /protein_id="NP_001297367.1"
                     /db_xref="CCDS:CCDS79377.1"
                     /db_xref="GeneID:546644"
                     /db_xref="MGI:MGI:109440"
                     /translation="MDTCHIAKSCVLILLVVLLCAERAQGLECYNCIGVPPETSCNTT
                     TCPFSDGFCVALEIEVIVDSHRSKVKSNLCLPICPTTLDNTEITGNAVNVKTYCCKED
                     LCNAAVPTGGSSWTMAGVLLFSLVSVLLQTFL"
     exon            199..315
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /inference="alignment:Splign:2.1.0"
     exon            316..922
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="Ly6g"
                     /gene_synonym="Gr-1; Gr1; Ly-6G"
                     /note="major polyA site"
ORIGIN      
        1 caggatgcca gctgggaggg gctgagagaa agtaaagtat ttatttcagt ccacttctga
       61 aagaccttgt cactgtgcct gcaacctggt cagagaggaa gttttatctg tgcagccctt
      121 ctcccaggat ggacacttgt cacattgcaa agtcctgtgt gctcatcctt cttgtggtcc
      181 tactgtgtgc agaaagagct caggggctgg agtgctacaa ttgtattggg gtcccacctg
      241 agacttcctg caacacaact acctgcccct tctctgatgg attttgcgtt gctctggaga
      301 tagaagttat tgtggactct cacagaagca aagtcaagag caatctctgc cttcccatct
      361 gccccactac tctggacaat actgagatca ctggtaatgc tgtcaacgtg aagacttact
      421 gttgcaagga agacctctgc aatgcagcag ttcccactgg aggcagctcc tggaccatgg
      481 caggggtgct tctgttcagc ctggtttcag tccttctgca gacctttctc tgatgatcca
      541 ttcaatgacc ttcatccttg tccttttatc ctcacttgca accaatgctt actggagtcc
      601 tctagcgatg aattatgaga tatagaagct ctgagttggg ggtagtgtgt gtgtgtggaa
      661 caccttgttt ccactttata acccctgctg tataggcacc ccactcctct ctaggacttt
      721 caaatctgta cttcctggaa tgttcttttg ttgtggcttg ctgctcttga ccctggaggc
      781 atgtgggcag cacatgaaag aggcagtatt ccaaggtatt atgccatcac catccacaca
      841 taagtatctg gggtcctgca gggttcctat gtgtgctgtt caatgtctcc ctgttgagtc
      901 caataaacac ttcatcctcc ta
//
