LOCUS       NM_001252056             822 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus lymphocyte antigen 6 family member C1 (Ly6c1),
            transcript variant 3, mRNA.
ACCESSION   NM_001252056
VERSION     NM_001252056.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Shay,T.F., Sullivan,E.E., Ding,X., Chen,X., Ravindra Kumar,S.,
            Goertsen,D., Brown,D., Crosby,A., Vielmetter,J., Borsos,M.,
            Wolfe,D.A., Lam,A.W. and Gradinaru,V.
  TITLE     Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1
            enable blood-brain barrier crossing by engineered viral vectors
  JOURNAL   Sci Adv 9 (16), eadg6618 (2023)
   PUBMED   37075114
  REMARK    GeneRIF: Primate-conserved carbonic anhydrase IV and
            murine-restricted LY6C1 enable blood-brain barrier crossing by
            engineered viral vectors.
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Dang,Y., Souchet,C., Moresi,F., Jeljeli,M., Raquillet,B., Nicco,C.,
            Chouzenoux,S., Lagoutte,I., Marcellin,L., Batteux,F. and Doridot,L.
  TITLE     BCG-trained innate immunity leads to fetal growth restriction by
            altering immune cell profile in the mouse developing placenta
  JOURNAL   J Leukoc Biol 111 (5), 1009-1020 (2022)
   PUBMED   34533228
REFERENCE   4  (bases 1 to 822)
  AUTHORS   Kleefeldt,F., Upcin,B., Bommel,H., Schulz,C., Eckner,G.,
            Allmanritter,J., Bauer,J., Braunger,B., Rueckschloss,U. and
            Ergun,S.
  TITLE     Bone marrow-independent adventitial macrophage progenitor cells
            contribute to angiogenesis
  JOURNAL   Cell Death Dis 13 (3), 220 (2022)
   PUBMED   35264563
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Martinez-Carmona,M., Lucas-Ruiz,F., Gallego-Ortega,A.,
            Galindo-Romero,C., Norte-Munoz,M., Gonzalez-Riquelme,M.J.,
            Valiente-Soriano,F.J., Vidal-Sanz,M. and Agudo-Barriuso,M.
  TITLE     Ly6c as a New Marker of Mouse Blood Vessels: Qualitative and
            Quantitative Analyses on Intact and Ischemic Retinas
  JOURNAL   Int J Mol Sci 23 (1), 19 (2021)
   PUBMED   35008441
  REMARK    GeneRIF: Ly6c as a New Marker of Mouse Blood Vessels: Qualitative
            and Quantitative Analyses on Intact and Ischemic Retinas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 822)
  AUTHORS   Bamezai,A.
  TITLE     Mouse Ly-6 proteins and their extended family: markers of cell
            differentiation and regulators of cell signaling
  JOURNAL   Arch Immunol Ther Exp (Warsz) 52 (4), 255-266 (2004)
   PUBMED   15467490
  REMARK    Review article
REFERENCE   7  (bases 1 to 822)
  AUTHORS   Horowitz,M.C., Fields,A., DeMeo,D., Qian,H.Y., Bothwell,A.L. and
            Trepman,E.
  TITLE     Expression and regulation of Ly-6 differentiation antigens by
            murine osteoblasts
  JOURNAL   Endocrinology 135 (3), 1032-1043 (1994)
   PUBMED   7520861
REFERENCE   8  (bases 1 to 822)
  AUTHORS   Philbrick,W.M., Maher,S.E., Bridgett,M.M. and Bothwell,A.L.
  TITLE     A recombination event in the 5' flanking region of the Ly-6C gene
            correlates with impaired expression in the NOD, NZB and ST strains
            of mice
  JOURNAL   EMBO J 9 (8), 2485-2492 (1990)
   PUBMED   2164472
REFERENCE   9  (bases 1 to 822)
  AUTHORS   Bothwell,A., Pace,P.E. and LeClair,K.P.
  TITLE     Isolation and expression of an IFN-responsive Ly-6C chromosomal
            gene
  JOURNAL   J Immunol 140 (8), 2815-2820 (1988)
   PUBMED   3356904
REFERENCE   10 (bases 1 to 822)
  AUTHORS   Palfree,R.G., Sirlin,S., Dumont,F.J. and Hammerling,U.
  TITLE     N-terminal and cDNA characterization of murine lymphocyte antigen
            Ly-6C.2
  JOURNAL   J Immunol 140 (1), 305-310 (1988)
   PUBMED   3335781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124637.10.
            
            On Aug 24, 2022 this sequence version replaced NM_001252056.1.
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (3)
            has a longer and distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.243463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC124637.10        159267-159323       c
            58-140              AC124637.10        158924-159006       c
            141-257             AC124637.10        157835-157951       c
            258-395             AC124637.10        155955-156092       c
            396-507             AC124637.10        155037-155148       c
            508-822             AC124637.10        154500-154814       c
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.29 cM"
     gene            1..822
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /note="lymphocyte antigen 6 family member C1"
                     /db_xref="GeneID:17067"
                     /db_xref="MGI:MGI:96882"
     exon            1..57
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
     exon            58..140
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..514
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; lymphocyte antigen 6 complex, locus C;
                     Lymphocyte antigen Ly-6C; lymphocyte antigen 6C1;
                     lymphocyte antigen 6 complex, locus C1"
                     /codon_start=1
                     /product="lymphocyte antigen 6C1 isoform 2 precursor"
                     /protein_id="NP_001238985.1"
                     /db_xref="CCDS:CCDS79375.1"
                     /db_xref="GeneID:17067"
                     /db_xref="MGI:MGI:96882"
                     /translation="MDTSHTTKSCVLILLVALLCAERAQGLQCYECYGVPIETSCPAV
                     TCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDPNIRERTSCCSEDLCN
                     AAVPTAGIQGLMRVKKHHQAHISTGHFQGDPACGGEAQEMSNQRL"
     exon            141..257
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
     exon            258..395
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
     exon            396..507
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
     exon            508..822
                     /gene="Ly6c1"
                     /gene_synonym="Ly-6C; Ly-6C1; Ly6c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcagtcca catctgacag aacttgccac tgtgcctgca accttgtctg agaggaaccc
       61 ttctctgagg atggacactt ctcacactac aaagtcctgt gtgctcattc ttcttgtggc
      121 cctactgtgt gcagaaagag ctcagggact gcagtgctac gagtgctatg gagtgccaat
      181 tgagacttcc tgcccagcag ttacctgccg cgcctctgat ggattctgca ttgctcaaaa
      241 catagaattg attgaggact ctcaaagaag gaaactaaag acccgtcagt gcctttcttt
      301 ctgccctgct ggtgtgccaa tcagggatcc taacatcagg gagaggactt cctgttgcag
      361 cgaagacctc tgcaatgcag cagttcccac tgcaggaatc cagggcctca tgcgtgtgaa
      421 gaagcatcat caagcacaca tcagcacagg gcacttccaa ggagaccctg cttgtggtgg
      481 ggaagcccag gagatgagca atcaaaggtt atgaaattca tccttgtcag agatatccta
      541 cgtattttac aaaagcctaa gtgactatct aatctttgga ccaggccaac cctgacacca
      601 ttagtcatta cattcacctc aatccagttg ttcttcctag atcattatct tgagcattgt
      661 ttctaagtca acaagaaacc atcttatgga tgaagctata tgtaaagatt ttcaatgtca
      721 acgtgtctta agctttactg tactcatgga gctgagtcga tcattagctg cataattctt
      781 cgaaatgtgt gctgtgctta attaaatatg gataaaatac aa
//
