LOCUS       NM_016753               1092 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus latexin (Lxn), mRNA.
ACCESSION   NM_016753
VERSION     NM_016753.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Sun,X., Chen,X., Ni,Y., Li,X., Song,J., Wang,J., Xu,S., Shu,W. and
            Chen,M.
  TITLE     Latexin (LXN) enhances tumor immune surveillance in mice by
            inhibiting Treg cells through the macrophage exosome pathway
  JOURNAL   Int J Biol Macromol 289, 138822 (2025)
   PUBMED   39694381
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   He,G., Ni,Y., Hua,R., Wan,H., Tan,Y., Chen,Q., Xu,S., Yang,Y.,
            Zhang,L., Shu,W., Huang,K.B., Mo,Y., Liang,H. and Chen,M.
  TITLE     Latexin deficiency limits foam cell formation and ameliorates
            atherosclerosis by promoting macrophage phenotype differentiation
  JOURNAL   Cell Death Dis 15 (10), 754 (2024)
   PUBMED   39424784
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Cui,X., Zhang,C., Wang,F., Zhao,X., Wang,S., Liu,J., He,D.,
            Wang,C., Yang,F.C., Tong,S. and Liang,Y.
  TITLE     Latexin regulates sex dimorphism in hematopoiesis via
            gender-specific differential expression of microRNA 98-3p and
            thrombospondin 1
  JOURNAL   Cell Rep 42 (3), 112274 (2023)
   PUBMED   36933218
  REMARK    GeneRIF: Latexin regulates sex dimorphism in hematopoiesis via
            gender-specific differential expression of microRNA 98-3p and
            thrombospondin 1.
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Kan,S., Li,R., Tan,Y., Yang,F., Xu,S., Wang,L., Zhang,L., Sun,X.,
            Chen,X., Yang,Y., Shu,W., Wan,H., Chen,Z.F., Liang,H. and Chen,M.
  TITLE     Latexin deficiency attenuates adipocyte differentiation and
            protects mice against obesity and metabolic disorders induced by
            high-fat diet
  JOURNAL   Cell Death Dis 13 (2), 175 (2022)
   PUBMED   35210404
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   He,G., Kan,S., Xu,S., Sun,X., Li,R., Shu,W. and Chen,M.
  TITLE     LXN deficiency regulates cytoskeleton remodelling by promoting
            proteolytic cleavage of Filamin A in vascular endothelial cells
  JOURNAL   J Cell Mol Med 25 (14), 6815-6827 (2021)
   PUBMED   34085389
  REMARK    GeneRIF: LXN deficiency regulates cytoskeleton remodelling by
            promoting proteolytic cleavage of Filamin A in vascular endothelial
            cells.
REFERENCE   6  (bases 1 to 1092)
  AUTHORS   Mariani,M., Baldessari,D., Francisconi,S., Viggiano,L., Rocchi,M.,
            Zappavigna,V., Malgaretti,N. and Consalez,G.G.
  TITLE     Two murine and human homologs of mab-21, a cell fate determination
            gene involved in Caenorhabditis elegans neural development
  JOURNAL   Hum Mol Genet 8 (13), 2397-2406 (1999)
   PUBMED   10556287
REFERENCE   7  (bases 1 to 1092)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   8  (bases 1 to 1092)
  AUTHORS   Besirli,C.G., Gong,T.W. and Lomax,M.I.
  TITLE     The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse
            chromosome 9, and a related gene, Atp1b3-rs, maps to mouse
            chromosome 3
  JOURNAL   Mamm Genome 9 (2), 171-172 (1998)
   PUBMED   9457684
REFERENCE   9  (bases 1 to 1092)
  AUTHORS   Ellison,J.W., Wardak,Z., Young,M.F., Gehron Robey,P.,
            Laig-Webster,M. and Chiong,W.
  TITLE     PHOG, a candidate gene for involvement in the short stature of
            Turner syndrome
  JOURNAL   Hum Mol Genet 6 (8), 1341-1347 (1997)
   PUBMED   9259282
REFERENCE   10 (bases 1 to 1092)
  AUTHORS   Jin,M., Uratani,Y. and Arimatsu,Y.
  TITLE     Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn)
            expressed in neocortical neurons in a region-specific manner
  JOURNAL   Genomics 39 (3), 419-421 (1997)
   PUBMED   9119386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124190.4.
            
            On Apr 28, 2007 this sequence version replaced NM_016753.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032170.1, AK149981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC124190.4         50284-50605
            323-385             AC124190.4         51770-51832
            386-563             AC124190.4         52702-52879
            564-700             AC124190.4         53133-53269
            701-763             AC124190.4         55535-55597
            764-1092            AC124190.4         55864-56192
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.98 cM"
     gene            1..1092
                     /gene="Lxn"
                     /note="latexin"
                     /db_xref="GeneID:17035"
                     /db_xref="MGI:MGI:107633"
     exon            1..322
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..862
                     /gene="Lxn"
                     /note="ECI; TCI; tissue carboxypeptidase inhibitor;
                     endogenous carboxypeptidase inhibitor"
                     /codon_start=1
                     /product="latexin"
                     /protein_id="NP_058033.2"
                     /db_xref="CCDS:CCDS17397.1"
                     /db_xref="GeneID:17035"
                     /db_xref="MGI:MGI:107633"
                     /translation="MEIPPTHYAASRAASVAENCINYQQGTPHKLFLVQTVQQASKED
                     IPGRGHKYHLKFSVEEIIQKQVTVNCTAEVLYPQMGQGSAPEVNFTFEGEIGKNPDEE
                     DNTFYQSLMSLKRPLEAQDIPDNFGNVSPQMKPVQHLAWVACGYVMWQNSTEDTWYKM
                     LKIQTVKQVQRNDDFIELDYTILLHDIASQEIIPWQMQVLWHPQYGTKVKHNSRLPKE
                     GQAE"
     exon            323..385
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            386..563
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            564..700
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            701..763
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1092
                     /gene="Lxn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaagag ggaaggaagg cgctgaggag cgagcaagcg cgcacgccca gcccagctac
       61 cgactgactt caccacctca ccgacaccca cttggacacc cactcggctg gccagcactc
      121 cacactgacg ggaccctggc tgcacccgcc gtgatctctt tgaactagga tagcccgcgc
      181 tgtctccccc aagatggaaa tcccacccac ccactatgct gcgtccaggg ccgcctcggt
      241 ggcggagaac tgcattaact accagcaggg gactccccac aagctgttcc tggtgcagac
      301 ggtccagcag gccagcaagg aggatatccc aggaagaggg cacaagtacc atcttaagtt
      361 ttctgtggaa gaaattatcc aaaaacaagt tacagtgaac tgcacagctg aagttcttta
      421 cccccaaatg ggacaaggct ctgcaccaga agtcaacttc acattcgaag gagaaatcgg
      481 caagaaccca gatgaggaag ataacacatt ttatcaaagc ctcatgtctc tgaagagacc
      541 gctggaagca caggacatcc cagacaattt tggaaatgtg tctccacaaa tgaagccagt
      601 ccagcactta gcctgggtcg cctgcggtta tgtaatgtgg cagaattcga ctgaagacac
      661 atggtataaa atgttaaaaa ttcagacggt caagcaagtg caaagaaacg atgacttcat
      721 tgagttagat tacaccattc tactccacga cattgcatcg caggagatta ttccctggca
      781 aatgcaagtc ctgtggcatc cacagtacgg cacaaaagta aaacacaaca gccgcctccc
      841 aaaggaaggg caggcggagt gaacaagacg ctaacccgta gacaaccgtc agcatgctcg
      901 ctaaccacgt gtgtgactgg cctcactggc atctagccta acgggccaaa ggaataccag
      961 tgtcactctt tatgtcttgg ctacagtacc gagctgcata gattccataa taaagaatag
     1021 tactacctaa aaatgtcttt ccaacagtaa tggtactatg tctatcccct aataaaactt
     1081 cacttcagcc tc
//
