LOCUS       NM_026547               1427 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich adaptor protein 1 (Lurap1), mRNA.
ACCESSION   NM_026547 XM_204182 XM_905074
VERSION     NM_026547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Shiraishi,A., Uruno,T., Sanematsu,F., Ushijima,M., Sakata,D.,
            Hara,T. and Fukui,Y.
  TITLE     DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein
            Activation and LRAP35a Protein Interaction
  JOURNAL   J Biol Chem 292 (6), 2191-2202 (2017)
   PUBMED   28028174
  REMARK    GeneRIF: found that DOCK8 associated with LRAP35a, an adaptor
            molecule that binds to the Cdc42 effector myotonic dystrophy
            kinase-related Cdc42-binding kinase, and facilitated its activity
            to phosphorylate myosin II regulatory light chain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611947.11, BC147750.1 and BB749015.1.
            
            On or before Jul 2, 2009 this sequence version replaced
            XM_905074.2, XM_204182.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013564.1, BC147059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL611947.11        44630-44672         c
            44-1190             BC147750.1         1-1147
            1191-1427           BB749015.1         177-413
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.1 cM"
     gene            1..1427
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /note="leucine rich adaptor protein 1"
                     /db_xref="GeneID:68075"
                     /db_xref="MGI:MGI:1915325"
     exon            1..320
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..842
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /note="NF-kappa-B activator C1orf190 homolog; leucine
                     repeat adapter protein 35A"
                     /codon_start=1
                     /product="leucine rich adaptor protein 1"
                     /protein_id="NP_080823.1"
                     /db_xref="CCDS:CCDS51275.1"
                     /db_xref="GeneID:68075"
                     /db_xref="MGI:MGI:1915325"
                     /translation="MEGTAESQTPDLRDVEGKVGRKIPEGLLRGLRGECELGTSGDVL
                     LPGAPSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTS
                     HCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVTPRELDEQG
                     LPGPSCPEIDWAKVIPTEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDGN
                     ANQGFEAHWYWGQCQDDVTFL"
     exon            321..1427
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      857
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /note="major polyA site"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /note="hexamer: ATTACA"
     polyA_site      962
                     /gene="Lurap1"
                     /gene_synonym="1520402A15Rik; Lrp35a"
                     /note="major polyA site"
ORIGIN      
        1 accccacccc ccgcgcgggg cgggcgggga tccacgggtt tcgctccgcg ttcgtagcag
       61 agaagggagg acccttggga accggaccct ggtcgcccag tcctgttctg gcttgggccc
      121 acatggaggg gaccgcggag tcccagacgc cggacttgcg agacgtggag ggcaaggtgg
      181 gcaggaagat ccctgaagga ctgctccgcg ggcttcgagg cgagtgcgag ctgggaacct
      241 ctggggacgt gctgctcccg ggggcgccca gcaccggcca cggcctaggg gacaagatca
      301 tggcgctgag gatggagctg gcttacctgc gagctatcga tgtgaagatc ctgcagcagc
      361 tggtgacctt gaacgagggt attgaggcag tgcgctggct gctggaggag cggggtacac
      421 tgacgagcca ttgcagcagt ctcaccagca gtcagtacag tctgacaggg ggaagcccag
      481 gacgctcaag gcggggcagt tgggacagcc tgccagacac cagttcaact gaccggctgg
      541 acagtgtctc tattggcagc ttcttggaca ctgtgacccc cagagagctg gatgaacaag
      601 gactccctgg gccttcctgt cctgagattg actgggcaaa ggttatcccc actgaggaca
      661 gggccaggac tgaggtggac atgacatcca ctaagctagg gagcttaaca gccacatgga
      721 agctcccggg ggatgggctc cagtgtggac cacctgagcc atcagaggat ggcaatgcta
      781 accagggctt tgaagctcat tggtactggg gacagtgcca ggatgatgtg accttcttgt
      841 aaaaactttc ctacccattt gtactttgtg gctctttcaa cttttggccc aagtctccct
      901 caatttttcc tccacctcca actaactaga cagaggctgt attacaatcc gttaccatgg
      961 aagcctggct tatctctctg gttcctgggg agcctctgca tttatccctc aattattggg
     1021 tccctagagc tatttccata gagatattga ctctagaggc ctagcctgtg gctcctgttg
     1081 taagggtatc tccatgcccc tccccagtga ggtgaatttt atggaacgta gggcctctag
     1141 gagatcactg aagaagagat gggggataat caccccatcc aaagcctagg agccaggatg
     1201 cctcttacag aacggtggag attgaccctg tcagatgcgc aagcctccat ggactggccc
     1261 tcctagatgc ctttggagtt gggagaccaa tcctttcatg cctgctgagt gacttcattg
     1321 cctgtcatga tacatgaagt gcttcctctg taccagtcct ggtgggtgtg gcacttaatg
     1381 tccctgccgc tgcctcctgt gatagggaac ataccgcttt tcctggg
//
