LOCUS       NM_008524               2075 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus lumican (Lum), mRNA.
ACCESSION   NM_008524
VERSION     NM_008524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Zhang,X., Cui,S., Ding,Y., Li,Y., Wu,B., Gao,J., Li,M., Xu,L. and
            Xia,H.
  TITLE     Downregulation of B4GALT5 attenuates cardiac fibrosis through
            Lumican and Akt/GSK-3beta/beta-catenin pathway
  JOURNAL   Eur J Pharmacol 963, 176263 (2024)
   PUBMED   38081351
  REMARK    GeneRIF: Downregulation of B4GALT5 attenuates cardiac fibrosis
            through Lumican and Akt/GSK-3beta/beta-catenin pathway.
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Suzuki,E., Sumioka,T., Saika,S., Miyajima,M., Yasuda,S.,
            Iwanishi,H., Takada,Y., Ichikawa,K., Venkatakrishnan,J., Liu,C.Y.,
            Whei-Yang Kao,W. and Okada,Y.
  TITLE     Impaired healing in an incision wound in corneal stroma in a
            lumican-null mouse
  JOURNAL   Ocul Surf 30, 286-294 (2023)
   PUBMED   37972853
  REMARK    GeneRIF: Impaired healing in an incision wound in corneal stroma in
            a lumican-null mouse.
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Baxi,A., Jourdeuil,K., Cox,T.C., Clouthier,D.E. and Tavares,A.L.P.
  TITLE     Transcriptomic analysis reveals the role of SIX1 in mouse cranial
            neural crest patterning and bone development
  JOURNAL   Dev Dyn 252 (10), 1303-1315 (2023)
   PUBMED   37183792
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Vallecillo-Garcia,P., Orgeur,M., Comai,G., Poehle-Kronawitter,S.,
            Fischer,C., Gloger,M., Dumas,C.E., Giesecke-Thiel,C., Sauer,S.,
            Tajbakhsh,S., Hopken,U.E. and Stricker,S.
  TITLE     A local subset of mesenchymal cells expressing the transcription
            factor Osr1 orchestrates lymph node initiation
  JOURNAL   Immunity 56 (6), 1204-1219 (2023)
   PUBMED   37160119
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Dunlevy,J.R., Chakravarti,S., Gyalzen,P., Vergnes,J.P. and
            Hassell,J.R.
  TITLE     Cloning and chromosomal localization of mouse keratocan, a corneal
            keratan sulfate proteoglycan
  JOURNAL   Mamm Genome 9 (4), 316-319 (1998)
   PUBMED   9530631
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Loster,J., Immervoll,T., Schmitt-John,T. and Graw,J.
  TITLE     Cat3vl and Cat3vao cataract mutations on mouse chromosome 10:
            phenotypic characterization, linkage studies and analysis of
            candidate genes
  JOURNAL   Mol Gen Genet 257 (1), 97-102 (1997)
   PUBMED   9439574
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Ying,S., Shiraishi,A., Kao,C.W., Converse,R.L., Funderburgh,J.L.,
            Swiergiel,J., Roth,M.R., Conrad,G.W. and Kao,W.W.
  TITLE     Characterization and expression of the mouse lumican gene
  JOURNAL   J Biol Chem 272 (48), 30306-30313 (1997)
   PUBMED   9374517
REFERENCE   9  (bases 1 to 2075)
  AUTHORS   Funderburgh,J.L., Funderburgh,M.L., Hevelone,N.D., Stech,M.E.,
            Justice,M.J., Liu,C.Y., Kao,W.W. and Conrad,G.W.
  TITLE     Sequence, molecular properties, and chromosomal mapping of mouse
            lumican
  JOURNAL   Invest Ophthalmol Vis Sci 36 (11), 2296-2303 (1995)
   PUBMED   7558724
REFERENCE   10 (bases 1 to 2075)
  AUTHORS   Chakravarti,S. and Magnuson,T.
  TITLE     Localization of mouse lumican (keratan sulfate proteoglycan) to
            distal chromosome 10
  JOURNAL   Mamm Genome 6 (5), 367-368 (1995)
   PUBMED   7626890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF731113.1 and AK075737.1.
            
            On Nov 15, 2007 this sequence version replaced NM_008524.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075737.1, BC005550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               CF731113.1         1-302
            303-2075            AK075737.1         2-1774
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 50.32 cM"
     gene            1..2075
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /note="lumican"
                     /db_xref="GeneID:17022"
                     /db_xref="MGI:MGI:109347"
     exon            1..385
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     exon            386..1268
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1423
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /note="KSPG lumican; keratan sulfate proteoglycan lumican"
                     /codon_start=1
                     /product="lumican precursor"
                     /protein_id="NP_032550.2"
                     /db_xref="CCDS:CCDS24142.1"
                     /db_xref="GeneID:17022"
                     /db_xref="MGI:MGI:109347"
                     /translation="MNVCAFSLALALVGSVSGQYYDYDIPLFMYGQISPNCAPECNCP
                     HSYPTAMYCDDLKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLL
                     ENSKIKGKVFSKLKQLKKLHINYNNLTESVGPLPKSLQDLQLTNNKISKLGSFDGLVN
                     LTFIYLQHNQLKEDAVSASLKGLKSLEYLDLSFNQMSKLPAGLPTSLLTLYLDNNKIS
                     NIPDEYFKRFTGLQYLRLSHNELADSGVPGNSFNISSLLELDLSYNKLKSIPTVNENL
                     ENYYLEVNELEKFDVKSFCKILGPLSYSKIKHLRLDGNPLTQSSLPPDMYECLRVANE
                     ITVN"
     exon            1269..2075
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /note="putative"
     polyA_site      2075
                     /gene="Lum"
                     /gene_synonym="Ldc; SLRR2D"
                     /note="putative"
ORIGIN      
        1 gaaaccctct cacaccgaac tgcctcattt gtagcaagct cgattcttag gggtttaatc
       61 cagtaaagta cttctctctc tgtctctctc tcttccccca accccgattc cagagtggaa
      121 gggtctgttt tgtccacctg cacttcgtta gagagaagct tgctcagagg caacaccaca
      181 agagcccaca gtgacataac ttcatccaga ggctggcgtg attgggctgg tccccccccc
      241 ccacccccca cgctcctcag ctcttgtatc actgagactc tggcagccag tcccaccctg
      301 acagagttca cagcatatgt tagtggattc ttgttcacag tgtgcctgtt taagaaatta
      361 acggaaacag tgtcaagaga gtaaggtcac agaggacttg ctgaaaatga atgtatgtgc
      421 gttctctctt gccttggcat tagtcggtag tgtcagtggc caatactacg attatgacat
      481 ccctctcttc atgtatgggc aaatatcacc caactgtgca ccagaatgta actgccccca
      541 cagctaccca actgccatgt actgtgatga cctcaagttg aagagtgtgc caatggttcc
      601 tcctggcatc aagtaccttt acctgaggaa taaccaaatc gaccatattg atgagaaggc
      661 ctttgagaac gtcacagacc tgcagtggct cattcttgac cacaaccttc tagaaaactc
      721 caagatcaaa ggaaaggttt tctctaagct gaaacaactg aagaaactgc atataaacta
      781 caacaacctg accgagtccg tcggtccact tccaaagtcc ctgcaagacc tacagctgac
      841 caataataaa atcagcaagc tcggctcctt cgacgggctg gtcaacttga ccttcattta
      901 tcttcaacac aaccagctca aagaggatgc tgtctcggct tctctgaaag gtctcaaatc
      961 actagagtac ctggatttga gcttcaatca gatgagcaag ctgcctgctg gtctacctac
     1021 atctcttcta actctctacc tagacaataa taagatcagc aacattccgg atgagtactt
     1081 caagcgcttc actgggctgc aatacctgcg tttatctcac aatgaactgg ctgatagtgg
     1141 ggtacctgga aactcgttta atatatcatc cttgctcgag cttgatctct cctataataa
     1201 gcttaagagt ataccaacag ttaatgaaaa tcttgaaaat tattacctgg aggtcaatga
     1261 acttgaaaag tttgatgtga agagcttctg taagatcctg ggaccactgt cttactccaa
     1321 gatcaagcat ctgcgcttgg atggcaatcc tctcactcag agcagtctgc ctcctgacat
     1381 gtatgagtgt ctacgtgtag caaatgaaat caccgttaac taacatcctc tcattccaat
     1441 acattgaagt atgttctgga gcagaacttc atggttggga atgtggggga tgttttaaag
     1501 ttttcacaat atccttctcg ttgctggtgg tattacttca tggattttaa ttaatgaagg
     1561 aaatgtttta tgaacattta ccacatttaa ataaaagatg aaaagcaggc ctttttcatc
     1621 ctgagaacag aaatacaaaa cccgttaaac ttaagtcttt atttgtaaat ttaatgtttt
     1681 ctacagctct atgttcagat ggtatgaaag cctttttact gattgcatgg aaatcagcca
     1741 agttttttat ggttcccaga ttttacatta atgatttcaa aaacatgaaa caaatataca
     1801 tggatgtttg ttatcctaat ccaaattatc ttgacatgtc aagtctgttt tgcagacatt
     1861 tatactctgc attttgaagc cagtaatttg caagatacca aagaaaatta atgaagttgc
     1921 atccacttac agaaatgtag ttcgcagtaa gcatttgcac ggttacttag tgaaactttt
     1981 cttgagtcat tttcctctgt catgtgtatg ttcctttttg attgtttgca tgttatgatt
     2041 aatagttgat agcaaaataa aacaatgaag ctggc
//
