LOCUS       NM_001081068            7657 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus listerin E3 ubiquitin protein ligase 1 (Ltn1),
            transcript variant 1, mRNA.
ACCESSION   NM_001081068 XM_128374
VERSION     NM_001081068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7657)
  AUTHORS   Qin,F., Cai,B., Wang,P., Cao,R., Zhang,Y., Wen,H., Zheng,Y.,
            Zhao,W., Gao,C. and Liu,B.
  TITLE     LTN1 promotes RLR degradation to inhibit immune response to RNA
            virus through the ESCRT pathway
  JOURNAL   Autophagy 20 (6), 1270-1285 (2024)
   PUBMED   38060409
  REMARK    GeneRIF: LTN1 promotes RLR degradation to inhibit immune response
            to RNA virus through the ESCRT pathway.
REFERENCE   2  (bases 1 to 7657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7657)
  AUTHORS   Qin,F., Cai,B., Cao,R., Bai,X., Yuan,J., Zhang,Y., Liu,Y., Chen,T.,
            Liu,F., Sun,W., Zheng,Y., Qi,X., Zhao,W., Liu,B. and Gao,C.
  TITLE     Listerin promotes cGAS protein degradation through the ESCRT
            pathway to negatively regulate cGAS-mediated immune response
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2308853120 (2023)
   PUBMED   38109536
  REMARK    GeneRIF: Listerin promotes cGAS protein degradation through the
            ESCRT pathway to negatively regulate cGAS-mediated immune response.
REFERENCE   4  (bases 1 to 7657)
  AUTHORS   Endo,R., Chen,Y.K., Burke,J., Takashima,N., Suryawanshi,N.,
            Hui,K.K., Miyazaki,T. and Tanaka,M.
  TITLE     Dysregulation of ribosome-associated quality control elicits
            cognitive disorders via overaccumulation of TTC3
  JOURNAL   Proc Natl Acad Sci U S A 120 (12), e2211522120 (2023)
   PUBMED   36917672
REFERENCE   5  (bases 1 to 7657)
  AUTHORS   De Angelis,M.T., Russo,F., D'Angelo,F., Federico,A., Gemei,M., Del
            Vecchio,L., Ceccarelli,M., De Felice,M. and Falco,G.
  TITLE     Novel pancreas organogenesis markers refine the pancreatic
            differentiation roadmap of embryonic stem cells
  JOURNAL   Stem Cell Rev Rep 10 (2), 269-279 (2014)
   PUBMED   24390927
REFERENCE   6  (bases 1 to 7657)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 7657)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7657)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 7657)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 7657)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140319.3.
            
            On Jan 11, 2023 this sequence version replaced NM_001081068.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173009.1, SRR10223970.18672.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC140319.3         9022-9122
            102-305             AC140319.3         13756-13959
            306-404             AC140319.3         15204-15302
            405-635             AC140319.3         15750-15980
            636-688             AC140319.3         16667-16719
            689-869             AC140319.3         17970-18150
            870-1043            AC140319.3         20566-20739
            1044-1234           AC140319.3         21185-21375
            1235-1370           AC140319.3         22978-23113
            1371-2180           AC140319.3         25188-25997
            2181-2222           AC140319.3         26353-26394
            2223-2409           AC140319.3         28987-29173
            2410-2649           AC140319.3         29690-29929
            2650-2803           AC140319.3         31088-31241
            2804-2948           AC140319.3         32102-32246
            2949-3135           AC140319.3         32662-32848
            3136-3295           AC140319.3         35863-36022
            3296-3400           AC140319.3         37438-37542
            3401-3543           AC140319.3         39380-39522
            3544-3679           AC140319.3         41084-41219
            3680-3830           AC140319.3         41385-41535
            3831-4044           AC140319.3         42683-42896
            4045-4282           AC140319.3         43524-43761
            4283-4357           AC140319.3         44320-44394
            4358-4544           AC140319.3         46840-47026
            4545-4716           AC140319.3         58762-58933
            4717-4937           AC140319.3         59866-60086
            4938-5132           AC140319.3         60687-60881
            5133-5300           AC140319.3         61705-61872
            5301-7657           AC140319.3         62541-64897
FEATURES             Location/Qualifiers
     source          1..7657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 49.52 cM"
     gene            1..7657
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /note="listerin E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:78913"
                     /db_xref="MGI:MGI:1926163"
     exon            1..101
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            102..305
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            306..404
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            405..635
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            636..688
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            689..869
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1043
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1234
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1370
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..2180
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2222
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2409
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2649
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2803
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2948
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3135
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3295
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3400
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3543
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3679
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3830
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4044
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4282
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4357
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4544
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4716
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4717..4937
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            4938..5132
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5300
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..7657
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6706..6711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /note="hexamer: AATAAA"
     polyA_site      6729
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /note="major polyA site"
     regulatory      7029..7034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /note="hexamer: AATAAA"
     polyA_site      7054
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
     regulatory      7636..7641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
                     /note="hexamer: AATAAA"
     polyA_site      7657
                     /gene="Ltn1"
                     /gene_synonym="4930528H02Rik; Listerin; Rnf160; Zfp294"
ORIGIN      
        1 gtggcccgcc cgtgtcaact tcggctctgc agactgagag ccgggctgcc accgccacca
       61 tgggcgggaa gaacaagcag cggactaagg ggaacctcag gccttcaaac agtggccgag
      121 ctgcagaact cctcgccaaa gagcagggaa cagtgcctgg gttcattggt tttggcacat
      181 ctcacagtga cctgggctat gttccggctg ttcaaggcgc ggaagacata gacagtcttg
      241 tagattccga tttccgaatg gtgctgcgga aactttccaa aaaagatgtt acaacaaagc
      301 taaaggcaat gcaagaattt ggaattatgt gcacagagag agacacagaa gccgtcaaag
      361 gggttcttcc atactggcca agaatcttct gcaaaatctc ccttgatcat gatcgccgtg
      421 ttcgagaggc gacgcagcaa gcttttgaaa aacttatcct taaagtaaag aagcacttag
      481 ctccctattt aaaaagcgtg atgggctatt ggttgatggc tcagtgtgac acatatccac
      541 cagctgcact ggcagcaaaa gatgcattcg aagccgcttt ccctccaagc aagcaacctg
      601 aagccatagc gttttgcaag gaagaaatta caactgtgtt acaggaccat cttctgaagg
      661 agactcctga cacactcagt gaccctcaaa ctgtgccaga ggaagagaga gaggctaagt
      721 tccaccgagt cgtgacgtgc tctttattgg cactgaagag attgctttgt ttcttaccta
      781 acaatgagct tgattctctg gaggagaaat ttaaatcact tttatcacag aataaatttt
      841 ggaagtatgg aaaacacagt gtacctcagg tccgctcagc atattttgag ttagtttctg
      901 ctttgtgcca gcacgttccc caggtgatga aagaggaagc tgccaaagtg agtccatctg
      961 tcctgctcag cattgatgac agtgaccctg tggtctgccc agctctctgg gaggctgtgc
     1021 tctacacgct gacaactatt gaggactgtt ggtttcatgt aaatgccaag aaaagtgtgt
     1081 ttccgaagct gatggccatg atccgagagg gtggccgggg cctagctgct gttatgtatc
     1141 cttacctctt accgttcatc agcaaactcc ctcagtccat cacagagcca aagctggact
     1201 tcttcaaaaa cttcctcacc tctctagtta ccgggctgtc aactgagagg accaaatcga
     1261 gctcttctga gtgctcagct gtcatctcgg cattttttga atgcttgcgg tttataatgc
     1321 agcagaactt aggcgaggag gagatggtgc agatgcttat caatgagcag ttgatcccat
     1381 ttattgatac agttctcaaa gactcaggac tgcaccacgg accgatgttt gaccatttag
     1441 cagacacatt gagctcttgg gaagccaaag cagatgcaga gcgagaccct ggagctgttt
     1501 acaacttgga gaacgttctg ctaagcttct ggggaagact gtcagagatc tgcaccgaga
     1561 aaatccgcca gccagaagca gatgtgaagt ccgttctgtg tgtgtctagc ctagtagggg
     1621 tccttcagag gccaaggagc tcactgaagt tacacagaaa gaaaactgct caggtcaggt
     1681 ttgccatcaa tatacctgaa gctcataaag gggatgaaaa gtccatgtct tcagaaggag
     1741 agaacagcga gggctctgac ggaggggctc agtctcctct cagtaataca tcttcagact
     1801 tagtatctcc tttaaggaaa aaacctctgg aagacttagt ctgtaagctg gcagaggtga
     1861 gcattagctt tgtcaacgag cggaagtcag agcagcacct gcagtttctc tccacgctgc
     1921 tcgactcctt ctcctccgtc caagtattta acattctcct cagtgacaaa cagaagaatg
     1981 tcgtcaaagc caaacctctg gaaataacca aacttgcaga aaaaaatcct gcagttaagt
     2041 tcttatatca taaattgata ggctggctaa atgacagcca gaaagaggac gggggcttcc
     2101 tggtggacat cttgtatagt gccctccgat gctgtgacag tggtgtggaa aggaaagaag
     2161 tcttggatga tctaaccaag gaggacctga agtggagttc tcttcttcag gtcattgaaa
     2221 aggcatgttc tagctcagat aaacatgctt tagtaactcc ttggctaaaa ggcagtattc
     2281 ttggagagaa attggttgcc ttggcagact gtctttgtga taaggacttg gaagccacaa
     2341 catctgaatc ccactcatca gaacagtgga gtctgctaag actggcgtta tcccaacatg
     2401 tcaaaaacga ttacttgatt ggagaagtat acgttggaag aattattgtt aaacttcatg
     2461 aaactttatc taaaacaaag gatttatcag aagcggcaaa cagtgactct tcagtgtctt
     2521 ttgtctgtga tgtggtccat agcttcttca gttcagcagg aggaggcttg ctaatgccac
     2581 catctgaaga cttgttatta actctctttc agttatgcgc tcagagcaaa gaacggacac
     2641 acttgccaga ttttctgatc tgtaaactga agaatacttt gctttctggt gtaaatttat
     2701 tggtccatca aactgcaagt acatatgagc agagtacctt cctacgtttg tctgttctgt
     2761 ggctgaagga ccaggttcag tcttcggctt tggataacac aagtcttcag gtcctcttgt
     2821 ctgctgctgg cgacttgctg ggtactcttg tagagagtga ggacacgtct cttcttggag
     2881 tttatatcgg aagtgtaatg cccagtgaca gcgagtggga aaagatgagg caggctcttc
     2941 ctgttcagtg gttacacaga cctcttttag agggaaggct gagtttaaat tatgaatgct
     3001 tcaagacaga ttttaaggaa caagacacaa agactcttcc caaccatctg tgtacttcat
     3061 cgttattgag caaaatgatc ttagttgccc aaaaaaagaa attagtccta gaagacaacg
     3121 tccttgaaaa aataattgca gagctgctgt attcactgca gtggtgtgaa gaactcgaca
     3181 atgcgccatc tttcctaagt ggattttgtg gaatccttca aaaaatgaat ataacttaca
     3241 gcaacttatc tgtacttagt gagacttcta gcctcttgca gctgttattt gacagatcta
     3301 gaaaaaatgg cacactttgg tctcttatta ttgctaagtt gatcctttcc cgaagtattt
     3361 catctgatga agtgaaacca tactataaaa gaaaagaaag tttcttccct ctaacagaag
     3421 gtagtttgca taccattcaa agtctctgtc cattcttgtc taaagaagaa aagaaggaat
     3481 ttagtgctca gtgtataccc gcttttttgg gttggactaa agaagacctt tgcagtatta
     3541 atggagcctt tggacatctt gccattttca attcttgtct gcaaaccaga agtatagacg
     3601 acaaacagct attgcatggc atattaaaaa ttataacaag ctggaggaaa cagcatgaag
     3661 atatttttct ttttagctgt aatctgtcgg aagcgagtcc agaggtcctt ggtttaaaca
     3721 tagagatcat gcggttcctt tccttgtttc tcaagcactg cgcgtacccg ctcccgctgg
     3781 cagacagtga atgggacttc atcatgtgct ccatgctggc ttggttggag acaaccagtg
     3841 agaaccaggc tctgtactct gttccacttg tgcagctgtt tgcctgtgtc agctttgatc
     3901 tggcctgtga tctctgtgcc ttttttgact caataactcc agatattgtt gacaatcttc
     3961 ctgtaaatct catcagtgag tggaaagagt ttttttctaa aggcatccac agtttgctat
     4021 tacctctttt ggtaaatgct atcggagaaa acaaagacct atctgaaacg tcctttcaga
     4081 acgcaatgct gaaacccatg tgtgaaacac taacatacat ctccaaggac cagctactga
     4141 gccacaagct ccctgcgaga ttggttgcca gccagaaaac aaacttgcca gagcacctcc
     4201 agactctgct gaacactttg accccactgc ttctcttcag agccagacct gtgcaaattg
     4261 ctgcttatca tatgctgtgc aaactgatgc ctgaattgcc acagcatgat caggacaatc
     4321 tgaggtcgta tggagatgaa gaggaagaac cagccttgtc gccgccggcc gcgctgatgt
     4381 ctctcctcag ctctcaggag gagctgctgg agaatgtcct gggctgtgtc cctgtgggcc
     4441 agatcgtgac cgttaagcca ctgagcgagg acttctgcta tgtcctggga tacctcctca
     4501 cttggaagtt aatactgact ttcttcaaag ctgcatcgtc tcagcttcgt gctctgtatt
     4561 caatgtacct tcggaaaaca aagagtctga ataaattact ctatcatctc ttcagactta
     4621 tgccagaaaa ccctacgtac ggagagacag ctattgaggt atcaagtaaa gaccccaaga
     4681 ccttcttcac cgaggaggtt cagctgagta ttagagaaac agcaactctt ccgtatcata
     4741 tcccacacct ggcgtgctcg gtctatcaca tgactttaaa agacttgcct gccatggtta
     4801 ggctatggtg gaatagcagt gagaagcgtg tcttcaatat tgtagataga tttacaagca
     4861 agtatgtcag caatgttctt tcttttcaag aaatatcttc tgtacaaaca agtacacagc
     4921 tattcaatgg catgacggtt aaggcgcgag ctactactcg agaagtgatg gctacgtaca
     4981 ccatcgaaga catagtcatt gaactcataa tacagttgcc ttccaattac ccactgggct
     5041 caataacagt ggaaagtggg aagaggatcg gggtggctgt gcagcagtgg cgaaactgga
     5101 tgctgcagct gagcacgtac ctcactcacc agaacggaag tatcatggaa ggcttagcat
     5161 tatggaagaa taatgtagac aaacggtttg aaggtgttga agattgtatg atctgcttct
     5221 cagttattca tggtttcaac tattctcttc ccaaaaaagc ctgtagaaca tgcaagaaaa
     5281 agtttcactc agcttgcctg tacaaatggt ttacatctag caacaagtcc acttgcccgc
     5341 tctgccgtga gacctttttc tgaggttttt ttcattggaa gttgtcgctg ccgtaggtca
     5401 agccaaaggg aatggattgg ctccaccttg aagtactgat gtgaagccag tgagcatgac
     5461 aaagtgccat ctgtcagtat gatcctcaaa tcaggcaacc tctgcagatt gctttgtaaa
     5521 tcttcggaaa cttttttctt ttacaagaga ctattacata tttgagagaa aatatttata
     5581 ttaatggctt aatctctttg tatgtttaaa attaaaaata aatatatctc ttctcaaaaa
     5641 tattctaaat tatagaactg aaatttgtga aagcataaac tatattataa cttataaaac
     5701 catccagttt tttggtctgt gttgtaaaac agtccaagga taaggcaaat gaattgagag
     5761 ctgatttaca tctgtagata actaagactt gtttgttagt gatgacaaac aatagtttaa
     5821 aattactctg attttcataa attgttttaa tgataaagtg acactgagat attcccaccc
     5881 tcatccagag gtttgaagtg tactgtgaaa tttcacatga agaaggaact gagtgaactc
     5941 taaggggctc tggtgagaat tgtgaaattc ataacttaca tccttgacac taatcttttg
     6001 cttgtgaaag aattatttcc atgttaatga gatttgaatt gtaaatgtgt tggttgaatc
     6061 tattactcag tttagtgagt ctacaaagag tgggaatctg aagtaagcag ttttttgatt
     6121 attttgtgaa gtaaaatgat agcagtctat ctatcaagaa aagaataaat attactaaag
     6181 tataatcatg tgtggagaaa acaatattta aaaatcttgt aggaggctgt acattttgca
     6241 gagtttgcta tacttattag ccatagttac accaattcag gaattggggg agctaattat
     6301 ttaaaactat cagcaatgaa ggatatagta ctaagtaaaa ttaatttttt tttttgcttt
     6361 tgttttgaga caggatttca ctatgttgct ctgggctggg ctgtaactca ctctgtagac
     6421 cagactagcc tggaactcaa gagatctgcc tgtctctgtt tcccaagtgc tggggttaaa
     6481 gtgcaccacc aagcctggtg gaattgtctt aatggattga agtgtgtaaa cttcatgaaa
     6541 cctgcctttg gttacagtac ctttgccttt aaaaactatt cacagtataa cgtgtggaag
     6601 tttggatcac agtcttccat ttcatttcta gtagttagga tacctaaaag tttagtccat
     6661 catctgtgtt tcaaatgttt aattagaagg gtgcaactcg tgtcaaataa aattactgct
     6721 taccatcaac tagtcaaaat gactgttatt gaaatagtct gaaagtggac aggattacag
     6781 tccagagaac tgtgtgtcgg ttacaagtgt agtatcggct tgtctgtctt ctcttttttt
     6841 ctctgtagta gttattatct tacagtcttg aggctcagag acggagtgaa gtgtagatag
     6901 caagactcta ctacctctta gtccctcaca tctccctctt ccctttctgc ctgcctctgg
     6961 cacagcagtc acaaggactg tgtgatgcct ctgggaaaat tactcttttc cttttcaagt
     7021 ggatttacaa taaaattttg tttataacct tccagcattg gttcttgact ttggatccaa
     7081 agccccagta gaagagaaga tggagcagag ctccggcttt ttgcggtgtg tgaccttagt
     7141 agcccctcaa gcttgggact gggaacgcat tctgggagac ttgtgtgcat agctgtcagt
     7201 tcacaccggt tgataatgct aaggaaggct ttccagaagc aagactgaaa ctcagaatgc
     7261 cccattcagg ttttatttat ttagctttga caacactcat ggacaggata ccatccctga
     7321 aaattttagc ataagaggaa cttcaaattg ctagagagtc aaagccctgt tacaaattta
     7381 cttaaaatcc gaaaccaagt agcaatttct aaaattgatt tttatttcat ttttctcatc
     7441 ttttaataca tgtgtatact tttctatggt gtaaataata ttaacacgat acattttatg
     7501 gtacaaataa ttattacttg agtattatac cattaaatta gaaaaatttc aaatatagag
     7561 aaaatagtaa aatagcaata ttttacatgt actcttccca tactattttg ccatattgct
     7621 tctgattttt aaagaaataa aatgttactc ttttgta
//
