LOCUS       NM_203345               3115 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leukocyte tyrosine kinase (Ltk), transcript variant 4,
            mRNA.
ACCESSION   NM_203345
VERSION     NM_203345.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Christova,T., Ho,S.K., Liu,Y., Gill,M. and Attisano,L.
  TITLE     LTK and ALK promote neuronal polarity and cortical migration by
            inhibiting IGF1R activity
  JOURNAL   EMBO Rep 24 (7), e56937 (2023)
   PUBMED   37291945
  REMARK    GeneRIF: LTK and ALK promote neuronal polarity and cortical
            migration by inhibiting IGF1R activity.
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Norden,D.M., Trojanowski,P.J., Walker,F.R. and Godbout,J.P.
  TITLE     Insensitivity of astrocytes to interleukin 10 signaling following
            peripheral immune challenge results in prolonged microglial
            activation in the aged brain
  JOURNAL   Neurobiol Aging 44, 22-41 (2016)
   PUBMED   27318131
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Haase,V.H., Snijders,A.J., Cooke,S.M., Teng,M.N., Kaul,D., Le
            Beau,M.M., Bruns,G.A. and Bernards,A.
  TITLE     Alternatively spliced ltk mRNA in neurons predicts a receptor with
            a larger putative extracellular domain
  JOURNAL   Oncogene 6 (12), 2319-2325 (1991)
   PUBMED   1662793
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Lawler,J., Duquette,M., Ferro,P., Copeland,N.G., Gilbert,D.J. and
            Jenkins,N.A.
  TITLE     Characterization of the murine thrombospondin gene
  JOURNAL   Genomics 11 (3), 587-600 (1991)
   PUBMED   1774063
REFERENCE   8  (bases 1 to 3115)
  AUTHORS   Bernards,A. and de la Monte,S.M.
  TITLE     The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes
            and cerebral neurons and uses a non-AUG translational initiator
  JOURNAL   EMBO J 9 (7), 2279-2287 (1990)
   PUBMED   2357970
  REMARK    GeneRIF: Translation initiates from a non-AUG codon (CUG) in some
            Ltk transcript variants.
REFERENCE   9  (bases 1 to 3115)
  AUTHORS   Siracusa,L.D., Silan,C.M., Justice,M.J., Mercer,J.A., Bauskin,A.R.,
            Ben-Neriah,Y., Duboule,D., Hastie,N.D., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 2
  JOURNAL   Genomics 6 (3), 491-504 (1990)
   PUBMED   1970329
REFERENCE   10 (bases 1 to 3115)
  AUTHORS   Ben-Neriah,Y. and Bauskin,A.R.
  TITLE     Leukocytes express a novel gene encoding a putative transmembrane
            protein-kinase devoid of an extracellular domain
  JOURNAL   Nature 333 (6174), 672-676 (1988)
   PUBMED   2836739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M90470.1, AL844536.13 and
            BC047138.1.
            
            On Nov 2, 2007 this sequence version replaced NM_203345.1.
            
            Summary: The protein encoded by this gene is a member of the
            ros/insulin receptor family of tyrosine kinases. Tyrosine-specific
            phosphorylation of proteins is a key to the control of diverse
            pathways leading to cell growth and differentiation. Four
            alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. These transcripts are
            expressed in a tissue-specific manner in lymphocytes, brain and
            neuroblastoma cells, and the encoded isoforms exhibit different
            subcellular localization. The lymphocyte and brain specific
            variants initiate translation at non-AUG (CUG) start codons.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (D), is expressed in neuroblastoma cells, and initiates translation
            from the standard AUG start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M90470.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               M90470.1           1-131
            132-133             AL844536.13        221937-221938       c
            134-212             M90470.1           134-212
            213-214             AL844536.13        221305-221306       c
            215-474             M90470.1           215-474
            475-476             AL844536.13        220953-220954       c
            477-1387            M90470.1           477-1387
            1388-3115           BC047138.1         542-2269
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..3115
                     /gene="Ltk"
                     /note="leukocyte tyrosine kinase"
                     /db_xref="GeneID:17005"
                     /db_xref="MGI:MGI:96840"
     exon            1..180
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2804
                     /gene="Ltk"
                     /EC_number="2.7.10.1"
                     /note="isoform D precursor is encoded by transcript
                     variant 4; leukocyte receptor tyrosine kinase"
                     /codon_start=1
                     /product="leukocyte tyrosine kinase receptor isoform D
                     precursor"
                     /protein_id="NP_976220.2"
                     /db_xref="CCDS:CCDS16608.1"
                     /db_xref="GeneID:17005"
                     /db_xref="MGI:MGI:96840"
                     /translation="MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQ
                     KVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAA
                     GPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILV
                     GQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLR
                     AGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTS
                     RAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTS
                     ESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAEL
                     WTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKC
                     QGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTL
                     LRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSH
                     QNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIA
                     QGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLP
                     VKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDP
                     PRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEE
                     EASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNP
                     TYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ"
     exon            181..324
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            325..496
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            497..647
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            648..785
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            786..942
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1125
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1224
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1377
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1473
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1666
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1757
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1822
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1952
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2050
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2143
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2245
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2380
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2471
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..3080
                     /gene="Ltk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltk"
                     /note="hexamer: AATAAA"
     polyA_site      3080
                     /gene="Ltk"
                     /note="major polyA site"
ORIGIN      
        1 gacgtgagtg tatacaggcc agttggaagt cggcagggta gtggtgatag ctctgagact
       61 gctgacacgc ctataaactg cagctaggga atcgagttct caaccatcat cctttgctgg
      121 aaccaaggga ttgggcgatg ggctgctccc accggctgct gctgtggctg ggagctgctg
      181 gaactattct ttgctccaac tcggagttcc agacaccttt tctaacacct tcgcttttgc
      241 cggtgctggt actcaattcc caggagcaga aagtcacccc cacacccagt aaattggagc
      301 cagcttccct cccaaatcct ctaggcacac gggggccttg ggtgtttaac acctgtggcg
      361 ccagcggcag gagcggaccc acacaaacac agtgcgatgg ggcatacaca ggaagcagcg
      421 tgatggtgac agtgggggct gccgggccgc tcaaaggcgt gcagctgtgg cgggtgccag
      481 acacaggcca gtatctgatc tccgcctacg gagcggcggg cggcaagggc gcccaaaacc
      541 acctgtcacg ggcgcacggc atcttcctct cagcagtctt cttcctccgt cgcggggagc
      601 cggtgtacat ccttgtgggg cagcagggcc aggacgcctg tcccggaggg agccctgaga
      661 gccaactcgt ctgtctggga gagtctgggg agcatgcaac cacctatggg accgaaagga
      721 tcccaggctg gagacgctgg gccggcgggg gcgggggtgg cggaggcgcc acctccatct
      781 tccggctgcg cgcgggggag ccagagccgc tgctggtggc ggcgggaggc ggcgggaggt
      841 cctaccggag gcgacctgac cgcggccgga ctcaggccgt ccccgagagg ctggagaccc
      901 gcgcggcggc gccgggcagc ggcgggagag gaggcgcggc aggtggaggg agcggctgga
      961 cgtcgcgagc ccactctccg caggccggac gctcgccgcg ggaaggggcc gagggcggcg
     1021 agggctgcgc ggaggcctgg gctgcgctcc gctgggctgc ggcgggaggc ttcgggggcg
     1081 gcggcggggc ctgcgcggcg ggcggcggtg gcggcggcta ccggggcggt gatacttctg
     1141 agtctgacct cctctgggct gatggggaag atggcacatc ctttgtccac cccagtggtg
     1201 agctctacct acagcctctg gcagtcacag agggccatgg ggaggtggag atccgaaagc
     1261 atcccaactg cagtcactgc cctttcaaag actgccagtg gcaggcagag ctctggacgg
     1321 ccgaatgcac gtgcccagag ggcacggagc tagctgtgga taatgtcact tgcatggacc
     1381 tgccaaccac cgcaagccct ctgatcctga tgggagctgt agtggcagcc ttggcactga
     1441 gtctcctaat gatgtgtgca gtcctgattc tagtgaacca gaagtgtcag ggcctgtggg
     1501 ggaccaggct gccaggccct gagcttgagc taagcaagct tcgatcctct gccatcagga
     1561 cagcacccaa cccttactat tgtcaggtgg gactcagtcc tgcccagccc tggcctttgc
     1621 ccccagggct cactgaggtt tcaccagcca atgtcactct actcagagcc cttggccatg
     1681 gtgcctttgg ggaagtgtac gagggactag tgactggtct tcctggggac tccagtcctc
     1741 ttccagtggc tattaagact ctgccagagc tctgctccca tcaggatgag ctggattttc
     1801 tcatggaggc tctgatcatc agcaagttca gccatcagaa cattgtacgc tgtgtggggc
     1861 tcagctttcg gtctgccccg cgcctcattc tgctggagct gatgtctggt ggggacatga
     1921 agagcttttt gaggcacagc agaccacacc caggacaact ggcacctctg accatgcagg
     1981 acctattgca gctggcccag gatatagccc agggctgcca ctacctggag gaaaatcact
     2041 tcattcacag agacattgct gcccgtaact gtctgcttag ctgcagtgga gccagccgag
     2101 tggccaagat tggagatttt ggaatggcaa gagatatcta ccaggccagt tattatcgca
     2161 agggtggccg gaccttgctc ccagtcaagt ggatgccgcc agaagctctc ctggagggcc
     2221 ttttcacatc caagacagac tcctggtctt ttggggtcct gctctgggag atcttctcac
     2281 tggggtatat gccctaccct ggacatacca accaggaggt tctagacttc attgccacag
     2341 ggaacaggat ggaccctcct aggaactgtc ctgggccagt gtaccgaatc atgacccagt
     2401 gttggcagca tcagccggag ctccgccctg actttggcag catcttggaa cggattcagt
     2461 actgcactca ggaccctgat gtgctgaact cacccctgcc cgtggaacct gggcccattc
     2521 tagaggagga agaggcctcc aggctgggaa acaggtcact ggagggtctt agatccccaa
     2581 agcccctaga gctgagttct cagaacttga agagctgggg aggaggcctt cttggctctt
     2641 ggctgccctc tggcctcaag accctcaaac ccaggtgcct ccaacctcag aacatttgga
     2701 accccaccta tggctcctgg accccaaggg gcccccaggg tgaagataca ggcattgaac
     2761 actgcaatgg ctcctcctca agttccattc caggcatcca gtaggctctg cccctgtccc
     2821 tgtgctgcat gttcaggcat gtttcaggga tgtgcgggca acctggcctc ccacactgga
     2881 aactagccca gaccctcttg gggaaggtcc taggctactt tcagtctttg gtctttgaaa
     2941 ccagaggcca tccacccact gcaggagtca gttgggaatc ctggattgtc cactcctcat
     3001 aagtatcttt cctctgctca ttccagggct acaaatgttt tagtaataat aatggtaata
     3061 aaaacaataa acccttctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
