LOCUS       NM_008522               2742 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus lactotransferrin (Ltf), mRNA.
ACCESSION   NM_008522
VERSION     NM_008522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Zhao,X., Ting,S.M., Sun,G., Bautista Garrido,J., Obertas,L. and
            Aronowski,J.
  TITLE     Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is
            Beneficial and Is Assisted by Lactoferrin and CD91
  JOURNAL   Stroke 55 (1), 166-176 (2024)
   PUBMED   38063014
  REMARK    GeneRIF: Clearance of Neutrophils From ICH-Affected Brain by
            Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Wang,W., Cheng,Z., Wang,X., An,Q., Huang,K., Dai,Y., Meng,Q. and
            Zhang,Y.
  TITLE     Lactoferrin deficiency during lactation increases the risk of
            depressive-like behavior in adult mice
  JOURNAL   BMC Biol 21 (1), 242 (2023)
   PUBMED   37907907
  REMARK    GeneRIF: Lactoferrin deficiency during lactation increases the risk
            of depressive-like behavior in adult mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Fukui,Y., Hirota,Y., Aikawa,S., Sakashita,A., Shimizu-Hirota,R.,
            Takeda,N., Ishizawa,C., Iida,R., Kaku,T., Hirata,T., Hiraoka,T.,
            Akaeda,S., Matsuo,M. and Osuga,Y.
  TITLE     The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and
            differentiation for blastocyst invasion
  JOURNAL   Cell Death Dis 14 (5), 320 (2023)
   PUBMED   37198149
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Namiki,T., Terakawa,J., Karakama,H., Noguchi,M., Murakami,H.,
            Hasegawa,Y., Ohara,O., Daikoku,T., Ito,J. and Kashiwazaki,N.
  TITLE     Uterine epithelial Gp130 orchestrates hormone response and
            epithelial remodeling for successful embryo attachment in mice
  JOURNAL   Sci Rep 13 (1), 854 (2023)
   PUBMED   36646738
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Cunningham,G.A., Headon,D.R. and Conneely,O.M.
  TITLE     Structural organization of the mouse lactoferrin gene
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1725-1731 (1992)
   PUBMED   1482377
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Shirsat,N.V., Bittenbender,S., Kreider,B.L. and Rovera,G.
  TITLE     Structure of the murine lactotransferrin gene is similar to the
            structure of other transferrin-encoding genes and shares a putative
            regulatory region with the murine myeloperoxidase gene
  JOURNAL   Gene 110 (2), 229-233 (1992)
   PUBMED   1311279
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Liu,Y.H. and Teng,C.T.
  TITLE     Characterization of estrogen-responsive mouse lactoferrin promoter
  JOURNAL   J Biol Chem 266 (32), 21880-21885 (1991)
   PUBMED   1939212
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Moscinski,L.C. and Prystowsky,M.B.
  TITLE     Identification of a series of differentiation-associated gene
            sequences from GM-CSF stimulated bone marrow
  JOURNAL   Oncogene 5 (1), 31-37 (1990)
   PUBMED   2181376
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Servenius,B., Rask,L. and Peterson,P.A.
  TITLE     Class II genes of the human major histocompatibility complex. The
            DO beta gene is a divergent member of the class II beta gene family
  JOURNAL   J Biol Chem 262 (18), 8759-8766 (1987)
   PUBMED   3036827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036491.1.
            
            On Apr 5, 2007 this sequence version replaced NM_008522.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036491.1, AK144556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2742              AK036491.1         2-2743
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.79 cM"
     gene            1..2742
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /note="lactotransferrin"
                     /db_xref="GeneID:17002"
                     /db_xref="MGI:MGI:96837"
     exon            1..77
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2158
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /note="N lobe; lactoferrin; minisatellite 10r detected by
                     probe MMS10"
                     /codon_start=1
                     /product="lactotransferrin precursor"
                     /protein_id="NP_032548.2"
                     /db_xref="CCDS:CCDS23581.1"
                     /db_xref="GeneID:17002"
                     /db_xref="MGI:MGI:96837"
                     /translation="MRLLIPSLIFLEALGLCLAKATTVQWCAVSNSEEEKCLRWQNEM
                     RKVGGPPLSCVKKSSTRQCIQAIVTNRADAMTLDGGTMFDAGKPPYKLRPVAAEVYGT
                     KEQPRTHYYAVAVVKNSSNFHLNQLQGLRSCHTGIGRSAGWKIPIGTLRPYLNWNGPP
                     ASLEEAVSKFFSKSCVPGAQKDRFPNLCSSCAGTGANKCASSPEEPYSGYAGALRCLR
                     DNAGDVAFTRGSTVFEELPNKAERDQYKLLCPDNTWKPVTEYKECHLAQVPSHAVVSR
                     STNDKEEAIWELLRQSQEKFGKKQASGFQLFASPSGQKDLLFKESAIGFVRVPQKVDV
                     GLYLTFSYTTSIQNLNKKQQDVIASKARVTWCAVGSEEKRKCDQWNRASRGRVTCISF
                     PTTEDCIVAIMKGDADAMSLDGGYIYTAGKCGLVPVLAENQKSSKSNGLDCVNRPVEG
                     YLAVAAVRREDAGFTWSSLRGKKSCHTAVDRTAGWNIPMGLLANQTRSCKFNEFFSQS
                     CAPGADPKSNLCALCIGDEKGENKCAPNSKERYQGYTGALRCLAEKAGNVAFLKDSTV
                     LQNTDGKNTEEWARNLKLKDFELLCLDDTRKPVTEAKNCHLAIAPNHAVVSRTDKVEV
                     LQQVLLDQQVQFGRNGQRCPGEFCLFQSKTKNLLFNDNTECLAKIPGKTTSEKYLGKE
                     YVIATERLKQCSSSPLLEACAFLTQ"
     exon            78..238
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            239..347
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            348..530
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            531..678
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            679..734
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            735..913
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1088
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1243
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1334
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1382
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1538
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1680
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1748
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1933
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2123
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2742
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2269..2274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /note="hexamer: AATAAA"
     polyA_site      2300
                     /gene="Ltf"
                     /gene_synonym="Csp82; Lf; MMS10R; Ms10r"
                     /note="major polyA site"
ORIGIN      
        1 aggcttgtcc tctaggtctc ccaagaccac agacatgagg ctgctcatcc cttccttgat
       61 atttcttgag gcccttggac tctgtctagc taaggcaaca actgttcaat ggtgtgctgt
      121 gtcaaattct gaggaagaaa aatgtttaag gtggcagaac gagatgagaa aagtgggtgg
      181 cccgccgctc agttgtgtca agaaatcctc cacccgccag tgcatccagg ccattgtgac
      241 aaacagagct gatgccatga ctcttgatgg tggcactatg ttcgatgcag gaaagccccc
      301 ctacaaactg cgacctgtgg cagctgaagt ctacgggacc aaagagcagc cccggactca
      361 ctactatgcg gtagcagtcg tgaagaacag cagtaacttt catctgaacc aactccaagg
      421 cctgaggtcc tgccacaccg gcattggcag gagtgcgggg tggaaaatcc ctatagggac
      481 acttcgtcca tacctgaatt ggaatgggcc acctgcatcc cttgaggaag cggtatccaa
      541 gttcttctca aagagctgtg ttcccggtgc ccaaaaggat agattcccca acctgtgtag
      601 ctcgtgtgca gggacaggag ccaacaaatg tgcctcttcc cccgaggagc catactcagg
      661 ttatgctgga gccttgaggt gtctgagaga caatgctgga gatgtggctt ttaccagagg
      721 aagcacggta tttgaggagt taccaaataa agccgaaagg gaccagtaca agctgctctg
      781 cccagacaac acctggaagc cggtgacaga atacaaggag tgccacctgg cccaagtccc
      841 ttcacatgct gtcgtatccc gaagcacgaa tgacaaagaa gaggccatct gggagcttct
      901 ccgccagtca caggagaagt ttggaaaaaa acaagcatcg ggattccagc tctttgcctc
      961 cccctcggga cagaaggacc tgctgttcaa ggagtctgcc attggctttg tgagggttcc
     1021 ccagaaggta gatgtagggc tctacctgac cttcagctac accacatcca tacagaacct
     1081 gaataaaaag cagcaggatg tgatagcctc aaaggcccgg gtcacatggt gtgccgtggg
     1141 cagtgaggag aagcgcaagt gtgatcagtg gaacagagca agcagaggca gggtcacctg
     1201 catctcattc cccaccacgg aagactgcat tgtcgcaatc atgaagggag atgctgatgc
     1261 catgagcctg gatggaggct atatctacac tgcgggcaag tgcggtttag ttccagtctt
     1321 ggcagagaac cagaaatcct ccaaaagcaa tggcttggat tgtgtgaaca gaccagtgga
     1381 agggtacctt gctgtagcag cagttagaag agaagatgct ggcttcacct ggagctcttt
     1441 gagaggcaag aagtcctgcc acactgccgt ggacaggacc gcaggctgga acatccccat
     1501 gggcctgctt gctaaccaga ccagatcctg caaatttaat gagttcttta gccaaagctg
     1561 tgcccctggt gctgacccca aatccaatct ctgtgccctg tgtattggtg atgagaaggg
     1621 tgagaacaag tgtgctccca acagcaaaga gagataccaa ggctacactg gggctttaag
     1681 gtgtctggct gagaaggcag gaaatgttgc atttttgaag gactccactg tcttgcagaa
     1741 tactgacggg aagaacactg aagagtgggc taggaactta aagctgaagg actttgagct
     1801 tttgtgcctt gatgacaccc ggaaacctgt gactgaggct aagaactgcc acctagccat
     1861 agccccaaac catgctgtag tgtctcggac agacaaggtg gaagtccttc agcaggtgct
     1921 gcttgaccaa caggttcagt ttgggagaaa tggacagagg tgtccaggag agttttgcct
     1981 gttccagtct aaaaccaaaa accttctgtt caatgacaac actgagtgtc tggccaagat
     2041 ccccggcaaa accacatcgg agaagtatct gggaaaggag tacgtcatag cgaccgagcg
     2101 cctgaagcag tgctccagct ccccactcct ggaagcctgc gcttttctta cccagtgaaa
     2161 acactgagca aatagcagaa ccttcccagg aagtctcatc ccggagccac ggtccggggg
     2221 ccttcagacc atctggtctc ctcactccct gctgtcactt taggtagaaa taaaatgaag
     2281 tagtgttgag tttctcgtca tatgaggtgt cactcattgc tcctcaaagt ttatactgga
     2341 atcctgtgtc tgaccacttg cctgcacact tggacttgct tttggagatt ctcggtccag
     2401 cccttccttt atcctgaagt ttcaggcatg gtgcccattg acctggagtc tggggacaac
     2461 cacgtgatgt ttctgtcccc aggggatctg gtttcttcac atagagatca cagtacatgt
     2521 gcatctgtgt gccccagatc atgcgtgcgt atgggtgacc atgtatgcct caacataagt
     2581 ttgcacatga ctgtgtgcac tccttgcact gatgtttgca taggactgtg tacttgcact
     2641 aatgcttatg tgtgtgtgtg cacacacgtg tgaaagccag aggacaatct ggaatgtcac
     2701 catccacctt ttttaaaaat taaatttatt tatttacatc cc
//
