LOCUS       NM_008521                680 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus leukotriene C4 synthase (Ltc4s), transcript variant 1,
            mRNA.
ACCESSION   NM_008521
VERSION     NM_008521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 680)
  AUTHORS   Florsheim,E.B., Bachtel,N.D., Cullen,J.L., Lima,B.G.C.,
            Godazgar,M., Carvalho,F., Chatain,C.P., Zimmer,M.R., Zhang,C.,
            Gautier,G., Launay,P., Wang,A., Dietrich,M.O. and Medzhitov,R.
  TITLE     Immune sensing of food allergens promotes avoidance behaviour
  JOURNAL   Nature 620 (7974), 643-650 (2023)
   PUBMED   37437602
REFERENCE   2  (bases 1 to 680)
  AUTHORS   Ualiyeva,S., Lemire,E., Aviles,E.C., Wong,C., Boyd,A.A., Lai,J.,
            Liu,T., Matsumoto,I., Barrett,N.A., Boyce,J.A., Haber,A.L. and
            Bankova,L.G.
  TITLE     Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically
            initiate lung type 2 inflammation
  JOURNAL   Sci Immunol 6 (66), eabj0474 (2021)
   PUBMED   34932383
REFERENCE   3  (bases 1 to 680)
  AUTHORS   Sasaki,F. and Yokomizo,T.
  TITLE     The leukotriene receptors as therapeutic targets of inflammatory
            diseases
  JOURNAL   Int Immunol 31 (9), 607-615 (2019)
   PUBMED   31135881
  REMARK    Review article
REFERENCE   4  (bases 1 to 680)
  AUTHORS   Montford,J.R., Bauer,C., Dobrinskikh,E., Hopp,K., Levi,M.,
            Weiser-Evans,M., Nemenoff,R. and Furgeson,S.B.
  TITLE     Inhibition of 5-lipoxygenase decreases renal fibrosis and
            progression of chronic kidney disease
  JOURNAL   Am J Physiol Renal Physiol 316 (4), F732-F742 (2019)
   PUBMED   30649890
REFERENCE   5  (bases 1 to 680)
  AUTHORS   Bankova,L.G., Dwyer,D.F., Yoshimoto,E., Ualiyeva,S., McGinty,J.W.,
            Raff,H., von Moltke,J., Kanaoka,Y., Frank Austen,K. and
            Barrett,N.A.
  TITLE     The cysteinyl leukotriene 3 receptor regulates expansion of
            IL-25-producing airway brush cells leading to type 2 inflammation
  JOURNAL   Sci Immunol 3 (28) (2018)
   PUBMED   30291131
REFERENCE   6  (bases 1 to 680)
  AUTHORS   Christmas,P., Weber,B.M., McKee,M., Brown,D. and Soberman,R.J.
  TITLE     Membrane localization and topology of leukotriene C4 synthase
  JOURNAL   J Biol Chem 277 (32), 28902-28908 (2002)
   PUBMED   12023288
REFERENCE   7  (bases 1 to 680)
  AUTHORS   Hevko,J.M. and Murphy,R.C.
  TITLE     Formation of murine macrophage-derived
            5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is
            catalyzed by leukotriene C4 synthase
  JOURNAL   J Biol Chem 277 (9), 7037-7043 (2002)
   PUBMED   11748223
  REMARK    GeneRIF: These results suggest that LTC(4) synthase, thought to be
            specific for the conjugation of GSH to LTA(4), can also recognize
            5-oxoETE as an electrophilic substrate.
REFERENCE   8  (bases 1 to 680)
  AUTHORS   Kanaoka,Y., Maekawa,A., Penrose,J.F., Austen,K.F. and Lam,B.K.
  TITLE     Attenuated zymosan-induced peritoneal vascular permeability and
            IgE-dependent passive cutaneous anaphylaxis in mice lacking
            leukotriene C4 synthase
  JOURNAL   J Biol Chem 276 (25), 22608-22613 (2001)
   PUBMED   11319240
REFERENCE   9  (bases 1 to 680)
  AUTHORS   Penrose,J.F., Baldasaro,M.H., Webster,M., Xu,K., Austen,K.F. and
            Lam,B.K.
  TITLE     Molecular cloning of the gene for mouse leukotriene-C4 synthase
  JOURNAL   Eur J Biochem 248 (3), 807-813 (1997)
   PUBMED   9342232
REFERENCE   10 (bases 1 to 680)
  AUTHORS   Lam,B.K., Penrose,J.F., Rokach,J., Xu,K., Baldasaro,M.H. and
            Austen,K.F.
  TITLE     Molecular cloning, expression and characterization of mouse
            leukotriene C4 synthase
  JOURNAL   Eur J Biochem 238 (3), 606-612 (1996)
   PUBMED   8706658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE848671.1, U27195.1 and
            BC038518.1.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_008521.3.
            
            On Sep 17, 2015 this sequence version replaced NM_008521.1.
            
            Summary: The protein encoded by this gene is an enzyme that
            catalyzes the synthesis of leukotriene C4 by combining leukotriene
            A4 with reduced glutathione. The encoded protein is found in the
            outer nuclear membrane and in the peripheral endoplasmic reticulum.
            Leukotrienes have been implicated as mediators of anaphylaxis and
            inflammatory conditions such as bronchial asthma in humans. Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI893906.1, AI385612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BE848671.1         85-145
            62-649              U27195.1           1-588
            650-680             BC038518.1         599-629
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.4 cM"
     gene            1..680
                     /gene="Ltc4s"
                     /note="leukotriene C4 synthase"
                     /db_xref="GeneID:17001"
                     /db_xref="MGI:MGI:107498"
     exon            1..155
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..550
                     /gene="Ltc4s"
                     /EC_number="4.4.1.20"
                     /note="isoform 1 is encoded by transcript variant 1; LTC4
                     synthase; leukotriene-C(4) synthase; glutathione
                     S-transferase LTC4"
                     /codon_start=1
                     /product="leukotriene C4 synthase isoform 1"
                     /protein_id="NP_032547.1"
                     /db_xref="CCDS:CCDS24631.1"
                     /db_xref="GeneID:17001"
                     /db_xref="MGI:MGI:107498"
                     /translation="MKDEVALLATVTLVGVLLQAYFSLQVISARRAFHVSPPLTSGPP
                     EFERVFRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQ
                     LRLTPLYASARALWLLVAMAALGLLVHFLPGTLRTALFRWLQMLLPMA"
     exon            156..255
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            256..326
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            327..408
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     exon            409..660
                     /gene="Ltc4s"
                     /inference="alignment:Splign:2.1.0"
     regulatory      631..636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltc4s"
     polyA_site      660
                     /gene="Ltc4s"
ORIGIN      
        1 gagagcgccg aggctcttcc tctcctgggc cagcgtctga gtagcacact gggcgataag
       61 aagaacacca aagctaattc tgcctgtggc tggcaacatg aaggacgaag tggctcttct
      121 ggctaccgtc accctcgtgg gagttctgtt gcaagcctac ttctccctac aggtgatctc
      181 tgcacgaagg gctttccacg tgtcgccgcc gctcacctct ggccctcccg agttcgagcg
      241 cgtcttccga gcccaggtaa actgcagcga gtactttccg ctgttcctcg ccacactctg
      301 ggtcgccggc atcttcttcc acgaaggagc cgcagccctg tgcggactgt tctacctgtt
      361 cgcgcgcctc cgctatttcc agggatacgc gcgctcagcg caactcaggc tgactcccct
      421 atacgcgagc gcgcgcgcac tctggctgct ggtggcgatg gctgcactgg gcttgctagt
      481 ccacttcctc cccggcacgc tacggactgc gctcttcaga tggctccaga tgctcctgcc
      541 gatggcctga ggcgaaggcc ctccgaatca gcagaactgg agatcttcga acaaaacgct
      601 ggggtgcccg cccccgaatc ccagttttta attaaagttc ccacgacggt tccgtctgca
      661 aaaaaaaaaa aaaaaaaaaa
//
