LOCUS       NM_010736               2093 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus lymphotoxin B receptor (Ltbr), mRNA.
ACCESSION   NM_010736 XM_982227
VERSION     NM_010736.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Bessell,E., Finlay,R.E., James,L.K., Ludewig,B., Harris,N.L.,
            Krebs,P., Hepworth,M.R. and Dubey,L.K.
  TITLE     Stromal cell and B cell dialogue potentiates IL-33-enriched
            lymphoid niches to support eosinophil recruitment and function
            during type 2 immunity
  JOURNAL   Cell Rep 43 (8), 114620 (2024)
   PUBMED   39141517
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Lim,V.Y., Feng,X., Miao,R., Zehentmeier,S., Ewing-Crystal,N.,
            Lee,M., Tumanov,A.V., Oh,J.E., Iwasaki,A., Wang,A., Choi,J. and
            Pereira,J.P.
  TITLE     Mature B cells and mesenchymal stem cells control emergency
            myelopoiesis
  JOURNAL   Life Sci Alliance 6 (4), e202301924 (2023)
   PUBMED   36717247
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Zehentmeier,S., Lim,V.Y., Ma,Y., Fossati,J., Ito,T., Jiang,Y.,
            Tumanov,A.V., Lee,H.J., Dillinger,L., Kim,J., Csomos,K.,
            Walter,J.E., Choi,J. and Pereira,J.P.
  TITLE     Dysregulated stem cell niches and altered lymphocyte recirculation
            cause B and T cell lymphopenia in WHIM syndrome
  JOURNAL   Sci Immunol 7 (75), eabo3170 (2022)
   PUBMED   36149943
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Hu,Z. and Zhou,G.
  TITLE     CREB1 Transcriptionally Activates LTBR to Promote the NF-kappaB
            Pathway and Apoptosis in Lung Epithelial Cells
  JOURNAL   Comput Math Methods Med 2022, 9588740 (2022)
   PUBMED   36118831
  REMARK    GeneRIF: CREB1 Transcriptionally Activates LTBR to Promote the
            NF-kappaB Pathway and Apoptosis in Lung Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Kotov,J.A., Xu,Y., Carey,N.D. and Cyster,J.G.
  TITLE     LTbetaR overexpression promotes plasma cell accumulation
  JOURNAL   PLoS One 17 (8), e0270907 (2022)
   PUBMED   35925983
  REMARK    GeneRIF: LTbetaR overexpression promotes plasma cell accumulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Matsumoto,M., Mariathasan,S., Nahm,M.H., Baranyay,F., Peschon,J.J.
            and Chaplin,D.D.
  TITLE     Role of lymphotoxin and the type I TNF receptor in the formation of
            germinal centers
  JOURNAL   Science 271 (5253), 1289-1291 (1996)
   PUBMED   8638112
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Force,W.R., Walter,B.N., Hession,C., Tizard,R., Kozak,C.A.,
            Browning,J.L. and Ware,C.F.
  TITLE     Mouse lymphotoxin-beta receptor. Molecular genetics, ligand
            binding, and expression
  JOURNAL   J Immunol 155 (11), 5280-5288 (1995)
   PUBMED   7594541
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Nakamura,T., Tashiro,K., Nazarea,M., Nakano,T., Sasayama,S. and
            Honjo,T.
  TITLE     The murine lymphotoxin-beta receptor cDNA: isolation by the signal
            sequence trap and chromosomal mapping
  JOURNAL   Genomics 30 (2), 312-319 (1995)
   PUBMED   8586432
REFERENCE   9  (bases 1 to 2093)
  AUTHORS   Crowe,P.D., VanArsdale,T.L., Walter,B.N., Ware,C.F., Hession,C.,
            Ehrenfels,B., Browning,J.L., Din,W.S., Goodwin,R.G. and Smith,C.A.
  TITLE     A lymphotoxin-beta-specific receptor
  JOURNAL   Science 264 (5159), 707-710 (1994)
   PUBMED   8171323
REFERENCE   10 (bases 1 to 2093)
  AUTHORS   de Kossodo,S., Grau,G.E., Louis,J.A. and Muller,I.
  TITLE     Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their
            receptors in experimental cutaneous leishmaniasis
  JOURNAL   Infect Immun 62 (4), 1414-1420 (1994)
   PUBMED   8132347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140324.3.
            
            On Jul 27, 2022 this sequence version replaced NM_010736.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29173.1, AK146127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AC140324.3         69294-69575
            283-379             AC140324.3         69679-69775
            380-505             AC140324.3         70046-70171
            506-664             AC140324.3         70255-70413
            665-761             AC140324.3         70799-70895
            762-841             AC140324.3         71043-71122
            842-949             AC140324.3         73599-73706
            950-975             AC140324.3         73946-73971
            976-1192            AC140324.3         75019-75235
            1193-2093           AC140324.3         75694-76594
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..2093
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /note="lymphotoxin B receptor"
                     /db_xref="GeneID:17000"
                     /db_xref="MGI:MGI:104875"
     exon            1..282
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1434
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /note="tumor necrosis factor receptor superfamily member
                     3; lymphotoxin-beta receptor; LT-beta receptor; TNF
                     receptor-related protein"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 3 precursor"
                     /protein_id="NP_034866.1"
                     /db_xref="CCDS:CCDS20549.1"
                     /db_xref="GeneID:17000"
                     /db_xref="MGI:MGI:104875"
                     /translation="MRLPRASSPCGLAWGPLLLGLSGLLVASQPQLVPPYRIENQTCW
                     DQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCR
                     PCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTD
                     EIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEP
                     GAMLLLAILLSLVLFLLFTTVLACAWMRHPSLCRKLGTLLKRHPEGEESPPCPAPRAD
                     PHFPDLAEPLLPMSGDLSPSPAGPPTAPSLEEVVLQQQSPLVQARELEAEPGEHGQVA
                     HGANGIHVTGGSVTVTGNIYIYNGPVLGGTRGPGDPPAPPEPPYPTPEEGAPGPSELS
                     TPYQEDGKAWHLAETETLGCQDL"
     exon            283..379
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            380..505
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..664
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..761
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..841
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..949
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            950..975
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1192
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..2093
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="Ltbr"
                     /gene_synonym="Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR;
                     TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3"
                     /note="major polyA site"
ORIGIN      
        1 actcccactt cctgagcccg gcgctggagc cctggaggcc aggcccggcc gctcccggcc
       61 cccgggggca cgtcggccca gccgccaggc ttgggaagtc gtggccaacg ctgctcagga
      121 cgtccgggct tcccaccttc ctcctaggac tccacccggt ctggtcagcc gagccgaaag
      181 gccgccatgc gcctgccccg ggcctcctct ccctgcggcc tggcctgggg gccactcctg
      241 ctgggactca gcgggcttct ggtggcctct cagccccagc tggtgccccc ttatcgcata
      301 gaaaaccaga cttgctggga ccaggacaag gaatactacg agcccatgca cgacgtctgc
      361 tgctcccgct gtcccccagg cgagtttgtc tttgcggtat gcagccgcag ccaagacacg
      421 gtttgcaaga cttgccccca taattcctat aatgaacact ggaaccatct ctccacctgc
      481 cagctgtgcc gcccctgtga cattgtgctg ggctttgagg aggttgcccc ttgcaccagc
      541 gatcggaaag ccgagtgccg ctgtcagccg gggatgtcct gtgtgtatct ggacaatgag
      601 tgtgtgcact gtgaggagga gcggcttgta ctctgccagc ctggcacaga agccgaggtc
      661 acagatgaaa ttatggatac tgacgtcaac tgtgtcccct gtaagccggg acacttccag
      721 aacacttcct cccctcgagc ccgctgtcaa ccccatacca gatgtgagat ccagggcctg
      781 gtggaggcag ctccaggtac ctcctactcg gataccatct gtaaaaatcc cccagagcca
      841 ggagcaatgc tactgctggc catcctgctg tcgctggtcc tctttctgct cttcaccact
      901 gtcctggcct gtgcctggat gaggcacccg tctctctgca gaaagctggg tactctgctc
      961 aagcggcacc cagagggaga agaatctccc ccttgccccg ctccaagagc cgacccacat
     1021 ttccctgacc tggcagagcc actcctaccc atgtctggag acttgtcccc atcccctgct
     1081 ggacccccaa cggccccctc cttggaggaa gtggtgctac aacagcagag tcccctggtc
     1141 caggccagag agctggaggc tgaacctggg gaacatggcc aggtggccca cggtgcgaat
     1201 ggcattcatg tgaccggggg ctctgtgact gtcaccggca acatctacat atacaatggg
     1261 ccagtgctgg ggggaacacg gggccctgga gaccctccag ctccccctga gcctccatac
     1321 cccactcctg aagagggagc tcctggccct tctgagctgt ctacacccta ccaggaggat
     1381 ggcaaagctt ggcatctggc cgagacagag acactaggat gccaagacct ctgacagggc
     1441 caaggaacct atttgccacc tgtgcctgag ggcacctggg aaaggcaagg agcagagggt
     1501 ccagcacctt ctttctgagg ctgctctact caccaggact cacagggtct ggggaggctc
     1561 tgagaaatag agccctaagg gacttagcct cagacacctc ttcagagcag aaccggacac
     1621 tagcaggcca cagtgcctgc ccaggactct gactaccgcc tgagcaagcc tgagacctag
     1681 tttcagaccc accggctccc agaggcttcg gccattgagc ctcggacaca aggaaggctc
     1741 gtgacccccg ccctgcctct ctgtgttcta aacatggcag aggagggagc tggtcccagg
     1801 gtcactcgca aggatatccc agggacctcg caaagctttg tggtgctcat ccctaccttc
     1861 agaggccttg agagctcata ttgcgtggac caagatagac cctgggggaa ggtgaagtcg
     1921 cgcggaggag caacccctcc cttgctcctg ggggagagga tagagagaag gggaggatgg
     1981 ggccttgggt agcgttagca tgtgtggagg agagtttggg aacaggagaa aaacgacaag
     2041 tgtatttatg agttgtaatc acacacgaat aaaaacaaga tggaggtcct tta
//
