LOCUS       NM_001113549            5123 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus latent transforming growth factor beta binding protein
            4 (Ltbp4), transcript variant 2, mRNA.
ACCESSION   NM_001113549
VERSION     NM_001113549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5123)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 5123)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   3  (bases 1 to 5123)
  AUTHORS   Su,C.T., See,D.H.W., Huang,Y.J., Jao,T.M., Liu,S.Y., Chou,C.Y.,
            Lai,C.F., Lin,W.C., Wang,C.Y., Huang,J.W. and Hung,K.Y.
  TITLE     LTBP4 Protects Against Renal Fibrosis via Mitochondrial and
            Vascular Impacts
  JOURNAL   Circ Res 133 (1), 71-85 (2023)
   PUBMED   37232163
  REMARK    GeneRIF: LTBP4 Protects Against Renal Fibrosis via Mitochondrial
            and Vascular Impacts.
REFERENCE   4  (bases 1 to 5123)
  AUTHORS   Hammers,D.W.
  TITLE     NOX4 inhibition promotes the remodeling of dystrophic muscle
  JOURNAL   JCI Insight 7 (20), e158316 (2022)
   PUBMED   36278481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5123)
  AUTHORS   Hou,S., Li,Z., Dong,J., Gao,Y., Chang,Z., Ding,X., Li,S., Li,Y.,
            Zeng,Y., Xin,Q., Wang,B., Ni,Y., Ning,X., Hu,Y., Fan,X., Hou,Y.,
            Li,X., Wen,L., Zhou,B., Liu,B., Tang,F. and Lan,Y.
  TITLE     Heterogeneity in endothelial cells and widespread venous
            arterialization during early vascular development in mammals
  JOURNAL   Cell Res 32 (4), 333-348 (2022)
   PUBMED   35079138
REFERENCE   6  (bases 1 to 5123)
  AUTHORS   Rifkin,D.B.
  TITLE     Latent transforming growth factor-beta (TGF-beta) binding proteins:
            orchestrators of TGF-beta availability
  JOURNAL   J Biol Chem 280 (9), 7409-7412 (2005)
   PUBMED   15611103
  REMARK    Review article
REFERENCE   7  (bases 1 to 5123)
  AUTHORS   Koli,K., Wempe,F., Sterner-Kock,A., Kantola,A., Komor,M.,
            Hofmann,W.K., von Melchner,H. and Keski-Oja,J.
  TITLE     Disruption of LTBP-4 function reduces TGF-beta activation and
            enhances BMP-4 signaling in the lung
  JOURNAL   J Cell Biol 167 (1), 123-133 (2004)
   PUBMED   15466481
  REMARK    GeneRIF: LTBP-4 has a role in targeting and activation of TGF-beta1
            which regulates BMP-4 signaling in mouse lung
REFERENCE   8  (bases 1 to 5123)
  AUTHORS   Sterner-Kock,A., Thorey,I.S., Koli,K., Wempe,F., Otte,J.,
            Bangsow,T., Kuhlmeier,K., Kirchner,T., Jin,S., Keski-Oja,J. and von
            Melchner,H.
  TITLE     Disruption of the gene encoding the latent transforming growth
            factor-beta binding protein 4 (LTBP-4) causes abnormal lung
            development, cardiomyopathy, and colorectal cancer
  JOURNAL   Genes Dev 16 (17), 2264-2273 (2002)
   PUBMED   12208849
  REMARK    GeneRIF: Mice homozygous for the disrupted allele develop severe
            pulmonary emphysema, cardiomyopathy, and colorectal cancer.
REFERENCE   9  (bases 1 to 5123)
  AUTHORS   Saharinen,J., Taipale,J., Monni,O. and Keski-Oja,J.
  TITLE     Identification and characterization of a new latent transforming
            growth factor-beta-binding protein, LTBP-4
  JOURNAL   J Biol Chem 273 (29), 18459-18469 (1998)
   PUBMED   9660815
REFERENCE   10 (bases 1 to 5123)
  AUTHORS   Thorey,I.S., Muth,K., Russ,A.P., Otte,J., Reffelmann,A. and von
            Melchner,H.
  TITLE     Selective disruption of genes transiently induced in
            differentiating mouse embryonic stem cells by using gene trap
            mutagenesis and site-specific recombination
  JOURNAL   Mol Cell Biol 18 (5), 3081-3088 (1998)
   PUBMED   9566926
  REMARK    Erratum:[Mol Cell Biol 1998 Oct;18(10):6164]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740857.1, AF410799.1, BC059016.1 and BP765237.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. The resulting isoform (b) is
            shorter and has a distinct N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157031.1, BC059016.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY740857.1         2-25
            25-3187             AF410799.1         1-3163
            3188-4756           BC059016.1         3165-4733
            4757-5123           BP765237.1         1-367               c
FEATURES             Location/Qualifiers
     source          1..5123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.87 cM"
     gene            1..5123
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /note="latent transforming growth factor beta binding
                     protein 4"
                     /db_xref="GeneID:108075"
                     /db_xref="MGI:MGI:1321395"
     exon            1..294
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..4847
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; LTBP-4"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 4 isoform b precursor"
                     /protein_id="NP_001107021.1"
                     /db_xref="CCDS:CCDS52158.1"
                     /db_xref="GeneID:108075"
                     /db_xref="MGI:MGI:1321395"
                     /translation="MAGGAQLLWVSLLVLLAQLGPQPVLGRPRERLRVRFTPAVCGLR
                     CIHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRC
                     LCPPDFAGKFCQLHSSGARPPAPAMPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHP
                     QEASVVVHQVERVSGPWEEANPEALARAEAAARAEAAAPYTVLAQSAPREDGYSDASG
                     FGYCFRELRGSECASPLPGLRTQEVCCRGEGLAWGVHDCHPCAEHLRNSNQVSGPNGP
                     CPPGFERVNGSCVDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV
                     ISEAKGPCYRVLHDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC
                     PAGPGYHYSASDLRYNTRPLNQDPPRVTFNQPRVPPATPRPPTGFLPTRRPEPRPDPG
                     PQPEPRPRPEPRPRPESRPRPEPRPRPEPRPQPESQPRPESRPRPESQPWPEFPLPSI
                     PAWTGPEIPESGPSSSMCQRNPQVCGPGRCVPRPSGYTCACDPGFRLGPQGTRCIDID
                     ECRRVPTPCAPGRCENTPGSFRCVCGTGFQAGPRATECLDVDECRRVPPPCDRGRCEN
                     TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGVCENLPGSFRCVCPAGFRGS
                     ACEEDVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECSRSPSPC
                     AYGRCENTEGSFKCVCPTGFQPNAAGSECEDVDECENRLACPGQECVNSPGSFQCRAC
                     PVGHHLHRGRCTDVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYRAPSGQPGPCADIN
                     ECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT
                     DGSFECICPPGHRAGPDLASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYH
                     PGPEGTCDDIDECREYGSAICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR
                     NRSFCGAHAMCQNLPGSFQCVCDQGYEGARDGRHCVDVNECETLQGVCGSALCENVEG
                     SFLCVCPNSPEEFDPMTGRCVPPRAPAGTFPGSQPQAPASPSLPARPPAPPPPRRPSP
                     PRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTET
                     AEYQSLCPHGRGYLVPSGDLSARRDVDECQLFQDQVCKSGVCVNTAPGYSCYCSNGFY
                     YHAHRLECVDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSRRRCVSNESQSL
                     DDNLGVCWQEVGPDLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALC
                     NVLRPPAYGPPRPGGFGIPYEYGPDIGPPYQSLPYGPDLYPPPVLPYDPYPPPPGPFA
                     RREAPYGAPPFDMPDFEDDGGPYGESETPDPPSRGTGWPYRSRDTRGSFPEPEESSER
                     GSYTGALSEPYEGLEAEECGILDGCPHGRCVRVPEGFTCDCFDGYRLDITRMSCVDVN
                     ECDEAEATSPLCVNARCVNTDGSFRCICRPGFAPTHQPHHCAPARPRA"
     exon            295..486
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..734
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            735..837
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            838..912
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1035
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1200
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1350
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1602
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1734
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1860
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1986
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2229
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2355
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2475
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2604
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2730
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2853
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2985
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3117
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3243
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3390
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3657
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3729
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3858
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..4005
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4158
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4539
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4540..4692
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..5102
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5083..5088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5102
                     /gene="Ltbp4"
                     /gene_synonym="2310046A13Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggcgggctg gggcggcggc gcggtggagc gcggcgctgc agccatggcg ggcggcgcgc
       61 agctgctctg ggtgtcgcta ttggtgctgc tggcgcagct ggggccgcag cccgtactgg
      121 gccgaccccg agagcgtctt cgcgtgcgct tcacccccgc tgtgtgcggc ctgcgttgca
      181 tccacgggcc cactggctcc cgctgtaccc cgacctgcgc gccccgcaac gccaccagcg
      241 tggacagcgg cgcgcccggc ggggcggccc cggggggacc cggcttccgc gccttcctat
      301 gtcccttgat ctgtcacaac ggtggtgtgt gtgtgaagcc tgatcgctgc ctttgccccc
      361 cggacttcgc tggcaaattc tgccaattgc attcttcggg ggcccggccc ccggccccag
      421 ccatgccggg ccttacccgc tccgtttata caatgccact agccaaccac cgcgatgatg
      481 aacacggagt agcatcgatg gtgagcgtgc acgtggagca ccctcaggag gcatcagtgg
      541 tggtgcacca agtggaacgt gtgtcgggcc cctgggagga ggcgaaccct gaagccctag
      601 ccagggctga agcggcggca cgggccgagg cggcggcgcc ctacacagtg ctggcacaga
      661 gcgcgccacg cgaggacggc tactcagacg cctccggctt cggttactgt tttagagaac
      721 tgcgcggaag cgaatgtgca tcgccgctgc cagggctccg gacgcaggaa gtctgctgcc
      781 gaggagaggg cttggcctgg ggtgttcatg attgtcaccc gtgcgcggaa cacctgagga
      841 actccaacca agtgagtggc ccaaatggac cttgtccacc cggcttcgag agagttaatg
      901 ggtcctgtgt agatgtggat gagtgcgcca ccggtgggcg ttgccaacac ggggagtgtg
      961 ccaacactcg tggcggctac acgtgtgtat gtccggacgg tttcctcctg gactcttccc
     1021 gcagcagctg catctcccaa cacgtgatct ccgaggcaaa ggggccctgc taccgagtgc
     1081 tgcatgatgg cggatgctcg ctgcccattc ttcgaaatat caccaaacag atctgctgct
     1141 gtagccgtgt gggcaaggcg tggggccgag gctgccagct ctgtccacct tatggttcag
     1201 agggttttcg ggagatctgt ccagctggcc ctggctacca ctattcagct tctgacctcc
     1261 gatacaacac cagaccccta aaccaggatc cacctcgagt gaccttcaat cagccacgtg
     1321 ttccaccagc cacccctcgg ccacctacag gctttctgcc tactcgtcga cctgagcccc
     1381 gccctgaccc tgggccacag cctgaacccc ggcctcggcc tgaaccccgg cctcggcctg
     1441 aatcccgacc tcggcctgaa ccccggcctc ggcctgaacc ccggcctcag cctgaatccc
     1501 agcctaggcc tgaatcccgg cctcggcctg aatcccagcc ttggcctgaa tttcccctgc
     1561 ccagcatccc tgcttggacc ggtccagaga ttcctgaatc aggtccctct tccagcatgt
     1621 gtcagcgaaa tccccaggtt tgtggtcctg gacgctgcgt tcctaggcca agcggctaca
     1681 cttgtgcgtg cgacccaggt ttccggctcg gcccccaggg cactcgctgc attgacatag
     1741 atgaatgtcg ccgcgtccct acaccctgtg ctcctgggcg ttgcgagaat acaccaggca
     1801 gctttcgctg cgtgtgcggc acgggcttcc aagcaggccc gcgggctaca gagtgcctgg
     1861 atgtggacga gtgccgccgc gtgccgccgc cgtgtgaccg cgggcgctgc gagaacacgc
     1921 caggcagttt cctatgtgtg tgtcccgccg ggtaccaggc agcaccgcac ggagccagct
     1981 gccaggatgt ggatgaatgc acccagagcc caggcctctg tggtcgcggg gtctgcgaaa
     2041 acctgcccgg ctctttccgc tgtgtttgcc cggctggctt ccggggctcg gcgtgtgaag
     2101 aagatgtgga tgaatgtgcc cagcagcctc cgccttgcgg gccaggccgc tgcgacaaca
     2161 ccgcgggttc gttccactgt gcctgcccag ctggcttccg atcccgagga ccaggagccc
     2221 cctgccaaga tgtggatgaa tgttcccgga gcccctcgcc ttgtgcctat ggccgctgtg
     2281 agaacacgga aggcagcttc aagtgtgtct gcccaacagg cttccaaccc aacgctgcgg
     2341 gctccgagtg cgaggatgtg gatgagtgtg agaaccgctt ggcgtgtcca gggcaggagt
     2401 gtgtgaactc accgggctcc ttccagtgcc gggcctgccc tgttgggcac cacctgcacc
     2461 gtggcagatg tactgatgtg gatgaatgca gttcgggcac cccttgtggt ctccatggcc
     2521 agtgcacaaa tactaaaggc tccttccact gcagctgctc gacaggttac cgggcgccat
     2581 ctggtcaacc tgggccttgt gcagacataa atgagtgtct ggaaggcgac ttctgcttcc
     2641 cccacggaga gtgcctcaac actgatggct cctttacctg tacctgtgcc cctggctacc
     2701 ggcctggacc tcgtggagca tcttgtctgg acgtggacga gtgcagcgaa gaggatcttt
     2761 gccagagcgg catctgtacc aacactgacg gctccttcga gtgcatctgt cctcctggac
     2821 accgcgctgg ccctgacctt gcctcctgcc ttgacattga cgagtgtcgt gaacggggac
     2881 ctgccctgtg cgggtctcag cgctgtgaaa attctcctgg ttcctaccgc tgtgtgcggg
     2941 actgcgatcc aggttaccac cccggccctg agggcacctg tgatgacatt gatgagtgcc
     3001 gagaatacgg ctctgcgatt tgtggtgccc agcgctgtga gaacaccccg ggctcctacc
     3061 gctgcacacc agcctgcgac cctggctatc agcctacacc agggggcggg tgccaagatg
     3121 tggatgaatg ccggaaccgg tctttctgcg gcgcccatgc tatgtgccag aatctgcctg
     3181 ggtcctttca gtgcgtctgt gaccaaggct acgaaggggc acgggacgga cgtcactgcg
     3241 tggatgtgaa tgagtgtgag acactacagg gcgtgtgtgg ctccgcgctg tgtgaaaatg
     3301 ttgaaggctc cttcctgtgt gtctgcccca atagccctga ggaatttgat cccatgactg
     3361 gacgctgtgt tcccccacgg gctcctgcag gcacgttccc tggctcccag ccccaagcac
     3421 ctgccagccc cagtcttcca gccaggccac cagcccctcc cccacctcga agacccagcc
     3481 ctcccaggca gggtcccgtg agcagtggac gtcgcgagtg ctactttgat acagccgctc
     3541 cagatgcgtg tgacaatatc ttggcccgaa acgtgacgtg gcaggagtgc tgctgtactg
     3601 tgggagaagg ctggggcagc ggctgccgca tccaacagtg cccgggcacc gagacagctg
     3661 aataccagtc attgtgtcct cacggccggg gctacctggt gcccagtgga gacctgagtg
     3721 cccggagaga tgtggacgaa tgccaactct tccaggacca ggtgtgcaag agcggagtgt
     3781 gtgtgaacac ggccccaggc tactcttgct attgcagcaa cgggttctac tatcacgcac
     3841 acaggctgga gtgcgttgat aatgacgaat gtgcggacga ggagcctgct tgtgaaggtg
     3901 gccgctgcgt caacacggtg ggctcttacc actgtacctg cgagccccca ctggtgctgg
     3961 acggctcccg gcgacgctgc gtctccaacg agagccagag cctggatgac aatctaggag
     4021 tgtgctggca ggaagtggga cctgatctcg tctgcagtcg cccacgacta gaccggcagg
     4081 ccacctacac cgagtgctgc tgtctctatg gtgaagcctg gggtatggac tgcgctctct
     4141 gtcctgccca ggactcagat gactttgagg ccctttgcaa tgtgctgcgt ccacctgcct
     4201 atggcccgcc gcgccctggt ggctttggaa ttccctatga atatggccca gatataggcc
     4261 caccttatca gagtctcccc tatgggccag atctgtatcc accgccagtg ctaccctacg
     4321 acccctaccc acccccacct ggaccctttg ctcgccggga ggccccttat ggcgccccac
     4381 ccttcgacat gccggacttt gaggatgatg gtggccccta tggcgagtct gagactcctg
     4441 acccacctag ccgaggcact ggttggcctt atcggtccag agacacccgt ggctccttcc
     4501 cagagcctga ggaatcctct gagcgtggaa gctatacagg agccttgtct gagccctatg
     4561 agggcctaga ggccgaagag tgtggtatcc tggatggctg ccctcacggc cgctgtgtgc
     4621 gcgttccaga aggcttcacc tgcgattgtt tcgatggcta ccgcctggac atcacccgca
     4681 tgtcctgtgt cgacgtcaac gagtgtgatg aggcagaggc aacctcccca ctctgcgtca
     4741 atgcgcgctg tgtcaacact gacggctcct tccgctgtat ctgtcgtcca ggatttgctc
     4801 ccacgcatca gccacatcac tgtgcgcctg ctcgaccccg ggcctgagca ggggcgccaa
     4861 atctcccact atacctgagc accgggagct tccagagcac gcctgcctcc ctccctctag
     4921 tctgcatgtg tgcaaggatg tcagacagtc tcgacttagg atggacagac acagaggggt
     4981 gccttctatg gtgccagcct gtcatgccca gtccctccca ccagtgccct gggcctgtcc
     5041 tgggtcccct gacacatttc ttgccctttt atacaatttt caattaaaac acctattttg
     5101 taaaaaaaaa aaaaaaaaaa aaa
//
