LOCUS       NM_008520               5194 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus latent transforming growth factor beta binding protein
            3 (Ltbp3), mRNA.
ACCESSION   NM_008520
VERSION     NM_008520.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5194)
  AUTHORS   Singh,K., Sachan,N., Ene,T., Dabovic,B. and Rifkin,D.
  TITLE     Latent transforming growth factor beta binding protein 3 controls
            adipogenesis
  JOURNAL   Matrix Biol 112, 155-170 (2022)
   PUBMED   35933071
REFERENCE   2  (bases 1 to 5194)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5194)
  AUTHORS   Korneva,A., Zilberberg,L., Rifkin,D.B., Humphrey,J.D. and
            Bellini,C.
  TITLE     Absence of LTBP-3 attenuates the aneurysmal phenotype but not
            spinal effects on the aorta in Marfan syndrome
  JOURNAL   Biomech Model Mechanobiol 18 (1), 261-273 (2019)
   PUBMED   30306291
  REMARK    GeneRIF: this study demonstrates that LTBP-3/TGFbeta directly
            affects the biomechanical function of the thoracic aorta.
REFERENCE   4  (bases 1 to 5194)
  AUTHORS   Guo,D.C., Regalado,E.S., Pinard,A., Chen,J., Lee,K., Rigelsky,C.,
            Zilberberg,L., Hostetler,E.M., Aldred,M., Wallace,S.E.,
            Prakash,S.K., Leal,S.M., Bamshad,M.J., Nickerson,D.A., Natowicz,M.,
            Rifkin,D.B. and Milewicz,D.M.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic
            Aneurysms and Dissections
  JOURNAL   Am J Hum Genet 102 (4), 706-712 (2018)
   PUBMED   29625025
REFERENCE   5  (bases 1 to 5194)
  AUTHORS   Morkmued,S., Hemmerle,J., Mathieu,E., Laugel-Haushalter,V.,
            Dabovic,B., Rifkin,D.B., Dolle,P., Niederreither,K. and
            Bloch-Zupan,A.
  TITLE     Enamel and dental anomalies in latent-transforming growth factor
            beta-binding protein 3 mutant mice
  JOURNAL   Eur J Oral Sci 125 (1), 8-17 (2017)
   PUBMED   28084688
REFERENCE   6  (bases 1 to 5194)
  AUTHORS   Nakajima,Y., Miyazono,K., Kato,M., Takase,M., Yamagishi,T. and
            Nakamura,H.
  TITLE     Extracellular fibrillar structure of latent TGF beta binding
            protein-1: role in TGF beta-dependent endothelial-mesenchymal
            transformation during endocardial cushion tissue formation in mouse
            embryonic heart
  JOURNAL   J Cell Biol 136 (1), 193-204 (1997)
   PUBMED   9008713
REFERENCE   7  (bases 1 to 5194)
  AUTHORS   Taylor,B.A. and Phillips,S.J.
  TITLE     Typing recombinant inbred mouse strains for microsatellite markers
            on chromosomes 10, 16, 18, 19, and X
  JOURNAL   Mamm Genome 6 (8), 493-498 (1995)
   PUBMED   8589516
REFERENCE   8  (bases 1 to 5194)
  AUTHORS   Yin,W., Smiley,E., Germiller,J., Mecham,R.P., Florer,J.B.,
            Wenstrup,R.J. and Bonadio,J.
  TITLE     Isolation of a novel latent transforming growth factor-beta binding
            protein gene (LTBP-3)
  JOURNAL   J Biol Chem 270 (17), 10147-10160 (1995)
   PUBMED   7730318
REFERENCE   9  (bases 1 to 5194)
  AUTHORS   Papavasiliou,F., Misulovin,Z., Suh,H. and Nussenzweig,M.C.
  TITLE     The role of Ig beta in precursor B cell transition and allelic
            exclusion
  JOURNAL   Science 268 (5209), 408-411 (1995)
   PUBMED   7716544
REFERENCE   10 (bases 1 to 5194)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134563.5.
            
            On Aug 17, 2018 this sequence version replaced NM_008520.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: L40459.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC134563.5         40156-40241         c
            87-1314             AC134563.5         38579-39806         c
            1315-1644           AC134563.5         35372-35701         c
            1645-1847           AC134563.5         35021-35223         c
            1848-1953           AC134563.5         34737-34842         c
            1954-2046           AC134563.5         34406-34498         c
            2047-2169           AC134563.5         34118-34240         c
            2170-2328           AC134563.5         33570-33728         c
            2329-2514           AC134563.5         33285-33470         c
            2515-2531           AC134563.5         32550-32566         c
            2532-2604           AC134563.5         32403-32475         c
            2605-2703           AC134563.5         32173-32271         c
            2704-2829           AC134563.5         30067-30192         c
            2830-2961           AC134563.5         29838-29969         c
            2962-3090           AC134563.5         29614-29742         c
            3091-3213           AC134563.5         29265-29387         c
            3214-3336           AC134563.5         29000-29122         c
            3337-3459           AC134563.5         27386-27508         c
            3460-3579           AC134563.5         27093-27212         c
            3580-3708           AC134563.5         25467-25595         c
            3709-3876           AC134563.5         25042-25209         c
            3877-3960           AC134563.5         24811-24894         c
            3961-4089           AC134563.5         24429-24557         c
            4090-4227           AC134563.5         24210-24347         c
            4228-4389           AC134563.5         23669-23830         c
            4390-4470           AC134563.5         23514-23594         c
            4471-4602           AC134563.5         23299-23430         c
            4603-5194           AC134563.5         22609-23200         c
FEATURES             Location/Qualifiers
     source          1..5194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..5194
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /note="latent transforming growth factor beta binding
                     protein 3"
                     /db_xref="GeneID:16998"
                     /db_xref="MGI:MGI:1101355"
     exon            1..86
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            87..1314
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     CDS             993..4754
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /note="LTBP-3"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 3 precursor"
                     /protein_id="NP_032546.2"
                     /db_xref="CCDS:CCDS37891.1"
                     /db_xref="GeneID:16998"
                     /db_xref="MGI:MGI:1101355"
                     /translation="MPGPRGAAHGLAPAMRQAGALGLLALLLLALLGPGGGAEGGPAG
                     ERGTGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTG
                     SGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAAGTGAGTGSSGPGLARTGA
                     MSTGPLPPLAPEGESVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV
                     QAPPPVVNVRVHHPPEASVQVHRIEGPNAEGPASSQHLLPHPKPQHPRPPTQKPLGRC
                     FQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEV
                     GADCPQGYKRLNSTHCQDINECAMPGMCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI
                     ADKPEEKSLCFRLVSTEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPADGTAAFKE
                     ICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSRAPPLEDTEEERG
                     VTMDPPVSEERSVQQSHPTTTTSPPRPYPELISRPSPPTFHRFLPDLPPSRSAVEIAP
                     TQVTETDECRLNQNICGHGQCVPGPSDYSCHCNAGYRSHPQHRYCVDVNECEAEPCGP
                     GKGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECTKPHLCGDGGFCINFPGHYKC
                     NCYPGYRLKASRPPICEDIDECRDPSTCPDGKCENKPGSFKCIACQPGYRSQGGGACR
                     DVNECSEGTPCSPGWCENLPGSYRCTCAQGYEPAQDGLSCIDVDECEAGKVCQDGICT
                     NTPGSFQCQCLSGYHLSRDRSRCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV
                     GGRKCQDIDECSQDPGLCLPHGACENLQGSYVCVCDEGFTLTQDQHGCEEVEQPHHKK
                     ECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK
                     GYTQDNNIVNYGIPAHRDIDECILFGAEICKEGKCVNTQPGYECYCKQGFYYDGNLLE
                     CVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMEHAPERREVC
                     WGQRGEDGMCMGPLAGPALTFDDCCCRQGRGWGTQCRPCPPRGTGSQCPTSQSESNSF
                     WDTSPLLLGKSPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVD
                     IDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFTRSRPHGACVPQRRR"
     exon            1315..1644
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1847
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1953
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2046
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2169
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2328
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2514
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2531
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2604
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2703
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2829
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2961
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3090
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3213
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3336
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3459
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3579
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3708
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3876
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3960
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4089
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..4227
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4389
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4470
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4602
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..5194
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5169..5174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /note="hexamer: AATAAA"
     polyA_site      5187
                     /gene="Ltbp3"
                     /gene_synonym="Ltbp2; mFLJ00070"
                     /note="major polyA site"
ORIGIN      
        1 agacactgga tcctggggct tcctagcacg ttctcacagt attgtccaga tccgggacac
       61 cacagcctcc cctttcagac cagtgagcca cagggttctc cccggccagt aaaccctggc
      121 cagaaggtgc tctctcctgc ttaaatcctt tccttcgaga gaagacagga ccaggaataa
      181 ggacccatga cttcagggct tcgagaaccc ctacatgtac aaaggccaat gggcaaaagt
      241 taacagacct ctgatcctcc aagcaaggac catctgcctc ggtttcccca ttttgaccag
      301 gtggaaaagt agttgggcgg gggaggtgtg cacaggcctc tgcaccccgc ccggaggaat
      361 ctggcggagt ccccaggtga ggattcttct ggaaagaacc caggtcggtt cctgcgcggg
      421 gcgggcacct agggggctgc ccccactcca accggcgccc tccctgccgc acatcgtcgc
      481 ttctccgggc agcagcgaaa gacgcttgaa ccagaaggaa aaagagagag gagaaaaaaa
      541 aattgtctcc ctggccccgg gccagcgtcc cagcccccct cgccgccggc gcgctccagc
      601 cagggaaaac aactgctcac ttctccctgc gtcctccccg cgcgctccct gcttcccggc
      661 ggccgcggga gaggagcccg gccaggggga ggcgcggagc gggctggccg cccggccttc
      721 ctctcccctc gctcctcctc tccgcctcca cttgctccgg cctcctcgct gcggcctcag
      781 ttcggggcct ggctgggttt ctcccggcca gggaagtttc ttcgctctac cctcagtgca
      841 gcttccatcg ctctccctcg caacggggat cccggccgct cctgctgtcc cctccctacc
      901 cttggcttct cgccccgctc tgccctctgc taccaacact cgatcccctg ctcgggctcg
      961 acctccaatc tccgagggtc gtgcggcccc ggatgcccgg gccccgaggg gctgcccacg
     1021 gcctggcccc tgcgatgcgc caggccgggg cattggggct gctggcacta ctcctgctgg
     1081 cgctgctggg ccccggcggc ggggccgagg gtgggccggc cggcgagcgg ggcacaggcg
     1141 ggggcggggc gctggcccgc gaacgcttca aggtggtctt tgcgccagtg atctgcaagc
     1201 ggacctgtct gaagggccag tgtcgggaca gctgtcagca gggctccaac atgacgctca
     1261 tcggagagaa cggccacagc accgacacgc tcaccggttc tggcttccgc gtggtggtgt
     1321 gccctctacc ctgcatgaac ggtggccagt gctcttcccg aaaccagtgc ctgtgtcccc
     1381 cggatttcac ggggcgcttc tgccaggtgc ctgctgcagg aaccggagct ggcaccggga
     1441 gttcaggccc cggcctggcc cggaccgggg ccatgtccac aggcccgctg ccgccccttg
     1501 ccccagaagg agagtctgtg gctagcaaac acgccattta cgcggtgcag gtgatcgcag
     1561 atcctcccgg gccgggggag ggtcctcctg cacaacatgc agccttcttg gtgcccctgg
     1621 ggccaggaca aatctcggca gaagtgcagg ctccgccccc cgtggtgaac gtgcgtgtcc
     1681 atcaccctcc tgaagcttcc gttcaggtgc accgcatcga ggggccgaac gctgaaggcc
     1741 cagcctcttc ccagcacttg ctgccgcatc ccaagcccca gcacccgagg ccacccaccc
     1801 aaaagccact gggccgctgc ttccaggaca cattgcccaa gcagccttgt ggcagcaacc
     1861 ctttgcctgg ccttaccaag caggaagatt gctgcggtag catcggtact gcctggggac
     1921 aaagcaagtg tcacaagtgc ccacagcttc agtatacagg ggtgcagaag cctggacctg
     1981 tacgtgggga ggtgggtgct gactgccccc agggctacaa gaggctcaac agcacccact
     2041 gccaggatat caacgaatgt gcgatgcctg gcatgtgtcg ccatggtgac tgcctcaaca
     2101 accctggctc ttatcgctgt gtctgcccgc ccggtcatag cttgggtccc tcgcgcacac
     2161 agtgcattgc cgacaaacca gaggagaaga gcctgtgttt ccgccttgtg agcaccgaac
     2221 accagtgcca gcaccctctg accacacgcc taacccgcca gctctgctgc tgtagtgtgg
     2281 gtaaagcctg gggtgcccgg tgccagcgct gcccggcaga tggtacagca gccttcaagg
     2341 agatctgccc ggctgggaaa gggtaccata tcctcacctc ccaccagacg ctcaccatcc
     2401 agggggaaag cgacttctcc ctcttcctgc accccgacgg gccacccaaa ccccagcagc
     2461 ttcctgaaag ccccagccga gcaccacccc tcgaggacac agaggaagag agaggagtga
     2521 ccatggatcc accagtgagt gaggagcgat cggtgcagca gagccacccc actaccacca
     2581 cctcaccccc ccggccttac ccagagctca tctctcgccc ctccccacct accttccacc
     2641 ggttcctgcc agacttgccc ccatcccgaa gtgcagtgga gatcgccccc actcaggtca
     2701 cagagaccga tgagtgccga ttgaaccaga atatctgtgg ccatggacag tgtgtgcctg
     2761 gcccctcgga ttactcctgc cactgcaacg ctggctaccg gtcacacccg cagcaccgct
     2821 actgtgttga tgtgaacgag tgcgaggcag agccctgcgg ccccgggaaa ggcatctgta
     2881 tgaacactgg tggctcctac aattgtcact gcaaccgagg ctaccgcctc cacgtgggtg
     2941 cagggggccg ctcgtgcgtg gacctgaacg agtgcaccaa gcctcacctg tgtggggacg
     3001 gtggcttctg catcaacttc cctggtcact acaaatgcaa ctgctatcct ggctaccggc
     3061 tcaaggcctc ccgaccgccc atttgcgaag acatcgacga gtgtcgcgac cctagcacct
     3121 gccctgatgg caaatgtgaa aacaaacctg gcagcttcaa gtgcatcgcc tgccagcctg
     3181 gctaccgtag ccaggggggc ggggcctgtc gtgatgtcaa cgaatgctcc gagggtaccc
     3241 cctgctctcc tggatggtgt gagaaccttc cgggttctta ccgttgcacg tgtgcccagg
     3301 gatacgaacc cgcacaggac ggcctcagtt gcatagacgt ggatgagtgt gaggctggga
     3361 aagtgtgcca agatggcatc tgcacgaaca caccaggctc tttccagtgt cagtgcctct
     3421 ccggctatca tctgtcaagg gatcggagcc gctgtgagga cattgatgaa tgtgacttcc
     3481 ctgcggcctg catcgggggt gactgcatca ataccaatgg ttcctacaga tgtctctgtc
     3541 cccagggtca tcggttggtg ggcggtagga agtgccaaga tatagatgag tgcagccagg
     3601 acccaggcct gtgcctgccc cacggggcct gcgagaacct ccagggctcc tatgtctgtg
     3661 tctgtgatga gggtttcaca ctcacccagg accagcatgg gtgtgaggag gtggagcagc
     3721 cccaccacaa gaaggagtgc taccttaact tcgatgacac agtgttctgt gacagcgtat
     3781 tggctaccaa tgtcactcag caggaatgct gttgctctct gggagctggt tggggagacc
     3841 actgcgaaat ctatccctgt ccagtctaca gctcagccga atttcacagc ctgtgtcctg
     3901 atgggaaagg ctacactcag gacaacaaca ttgtgaacta tggcattcct gcccaccgtg
     3961 acatcgacga atgcatattg tttggggcag agatctgcaa ggagggcaag tgtgtgaaca
     4021 cgcagcccgg ctacgagtgc tactgcaagc agggcttcta ctacgatggc aacctgctgg
     4081 agtgcgtgga cgtggatgag tgcttggatg agtctaactg caggaacgga gtgtgtgaga
     4141 acacacgtgg cggctaccgc tgtgcctgca cgccgccggc agagtacagt cccgcacagc
     4201 gccagtgtct gagcccggag gagatggagc acgccccaga gagacgtgaa gtgtgctggg
     4261 gccagcgagg agaggacggc atgtgtatgg ggcccctggc gggacctgcc ctcacttttg
     4321 atgactgctg ctgccgccag ggccgcggct ggggtaccca gtgcagaccg tgcccgccac
     4381 gtggcaccgg gtcccagtgc ccgacttcac agagtgagag caattcattc tgggacacaa
     4441 gccccctgct actggggaag tctccgcgag acgaagacag ctcagaggag gattcagatg
     4501 agtgccgttg tgtgagcgga cgctgtgtgc cacggccagg cggggcggta tgcgagtgtc
     4561 ctggaggctt tcagctggac gcctcccgtg cccgctgcgt ggacattgat gagtgccgag
     4621 aactgaacca gcggggacta ctgtgtaaga gcgagcggtg cgtgaacacc agtggatcct
     4681 tccgctgtgt ctgcaaagct ggcttcacgc gcagccgccc tcacggggcc tgcgtgcctc
     4741 agcgccgccg ctgatgatgc agccatagcc cacacctcag tgatcgatca tcgagggtat
     4801 tttccactga aagtggagac agacaagtac atcctttgct cctgaccaaa cgagagcatg
     4861 gacccaagga tccttcaggg cccacaaatc tccttcccac accccaacac ccaagggtgc
     4921 tcctgtctgc agagtgctgt ctgctttatc cccaagggtg attcctagaa acttcgacat
     4981 cagatctgcc cctttaattt actcttggct ttcaaggcaa attgatattc acatccaaag
     5041 cgggcagcat caactgcttg gcgggttgga ctgagctggg acccaggatg tgaaatagaa
     5101 tttattgtgg ctctgattat gtacactaga tgtgcctgac ctgctgacca ggctcacatg
     5161 gtttgtacaa taaatacatc cgccgggcct gctc
//
