LOCUS       NM_019919               7455 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus latent transforming growth factor beta binding protein
            1 (Ltbp1), transcript variant 1, mRNA.
ACCESSION   NM_019919
VERSION     NM_019919.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7455)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 7455)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
REFERENCE   3  (bases 1 to 7455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7455)
  AUTHORS   Liu,B., Wang,Y., He,D., Han,G., Wang,H., Lin,Y., Zhang,T., Yi,C.
            and Li,H.
  TITLE     LTBP1 Gene Expression in the Cerebral Cortex and its
            Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy
  JOURNAL   Curr Pharm Biotechnol 24 (2), 317-329 (2023)
   PUBMED   35676846
  REMARK    GeneRIF: LTBP1 Gene Expression in the Cerebral Cortex and its
            Neuroprotective Mechanism in Mice with Postischemic Stroke
            Epilepsy.
REFERENCE   5  (bases 1 to 7455)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7455)
  AUTHORS   Oklu,R. and Hesketh,R.
  TITLE     The latent transforming growth factor beta binding protein (LTBP)
            family
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 601-610 (2000)
   PUBMED   11104663
  REMARK    Review article
REFERENCE   7  (bases 1 to 7455)
  AUTHORS   Saharinen,J., Hyytiainen,M., Taipale,J. and Keski-Oja,J.
  TITLE     Latent transforming growth factor-beta binding proteins
            (LTBPs)--structural extracellular matrix proteins for targeting
            TGF-beta action
  JOURNAL   Cytokine Growth Factor Rev 10 (2), 99-117 (1999)
   PUBMED   10743502
  REMARK    Review article
REFERENCE   8  (bases 1 to 7455)
  AUTHORS   Nakajima,Y., Miyazono,K. and Nakamura,H.
  TITLE     Immunolocalization of latent transforming growth factor-beta
            binding protein-1 (LTBP1) during mouse development: possible roles
            in epithelial and mesenchymal cytodifferentiation
  JOURNAL   Cell Tissue Res 295 (2), 257-267 (1999)
   PUBMED   9931372
REFERENCE   9  (bases 1 to 7455)
  AUTHORS   Nakajima,Y., Miyazono,K., Kato,M., Takase,M., Yamagishi,T. and
            Nakamura,H.
  TITLE     Extracellular fibrillar structure of latent TGF beta binding
            protein-1: role in TGF beta-dependent endothelial-mesenchymal
            transformation during endocardial cushion tissue formation in mouse
            embryonic heart
  JOURNAL   J Cell Biol 136 (1), 193-204 (1997)
   PUBMED   9008713
REFERENCE   10 (bases 1 to 7455)
  AUTHORS   Yin,W., Smiley,E., Germiller,J., Mecham,R.P., Florer,J.B.,
            Wenstrup,R.J. and Bonadio,J.
  TITLE     Isolation of a novel latent transforming growth factor-beta binding
            protein gene (LTBP-3)
  JOURNAL   J Biol Chem 270 (17), 10147-10160 (1995)
   PUBMED   7730318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154178.1, AC126550.3, AC154491.2, CT033758.4 and AC118018.20.
            
            On Sep 20, 2016 this sequence version replaced NM_019919.3.
            
            Transcript Variant: This variant (1) is the longest transcript and
            it encodes the longest isoform (LTBP-1L).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-833               AC154178.1         1460-2292           c
            834-904             AC154178.1         420-490             c
            905-1196            AC126550.3         76622-76913         c
            1197-1366           AC154491.2         52286-52455         c
            1367-1534           AC154491.2         24516-24683         c
            1535-1759           CT033758.4         82020-82244         c
            1760-2034           CT033758.4         80159-80433         c
            2035-2137           CT033758.4         58404-58506         c
            2138-2209           CT033758.4         54985-55056         c
            2210-2332           CT033758.4         40790-40912         c
            2333-2500           CT033758.4         33366-33533         c
            2501-2728           CT033758.4         30777-31004         c
            2729-2751           CT033758.4         28426-28448         c
            2752-2851           CT033758.4         24973-25072         c
            2852-2950           CT033758.4         24382-24480         c
            2951-3076           CT033758.4         17260-17385         c
            3077-3202           CT033758.4         15984-16109         c
            3203-3325           CT033758.4         14522-14644         c
            3326-3445           CT033758.4         11057-11176         c
            3446-3568           AC118018.20        149653-149775       c
            3569-3691           AC118018.20        146833-146955       c
            3692-3814           AC118018.20        144806-144928       c
            3815-3937           AC118018.20        138838-138960       c
            3938-4063           AC118018.20        132609-132734       c
            4064-4189           AC118018.20        111062-111187       c
            4190-4333           AC118018.20        107101-107244       c
            4334-4513           AC118018.20        100462-100641       c
            4514-4600           AC118018.20        99133-99219         c
            4601-4729           AC118018.20        97293-97421         c
            4730-4870           AC118018.20        96453-96593         c
            4871-5041           AC118018.20        95422-95592         c
            5042-5164           AC118018.20        74736-74858         c
            5165-5314           AC118018.20        70352-70501         c
            5315-7455           AC118018.20        67419-69559         c
FEATURES             Location/Qualifiers
     source          1..7455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 46.24 cM"
     gene            1..7455
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /note="latent transforming growth factor beta binding
                     protein 1"
                     /db_xref="GeneID:268977"
                     /db_xref="MGI:MGI:109151"
     exon            1..833
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..5496
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /note="isoform LTBP-1L precursor is encoded by transcript
                     variant 1; latent TGF beta binding protein; transforming
                     growth factor beta-1-binding protein 1; latent
                     transforming growth factor beta binding protein 1L"
                     /codon_start=1
                     /product="latent-transforming growth factor beta-binding
                     protein 1 isoform LTBP-1L precursor"
                     /protein_id="NP_064303.2"
                     /db_xref="CCDS:CCDS28973.1"
                     /db_xref="GeneID:268977"
                     /db_xref="MGI:MGI:109151"
                     /translation="MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGALP
                     LAGPPRTFNVALDARYSRSSTAASSRALAGPPAERTRRTSQPGGAALPGLRSPLPPEP
                     ARPGGPSRQLHSKAGAQTAVTRFAKHGRQVVRSQVQQDAQSAGGSRLQVQQKQQLQGI
                     NVCGGQCCHGWSKPPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGSKGKACEITAAQ
                     DTMPPAFGGQNPGSSWAPLEQAAKHTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQ
                     IHPQVAPLSSQNVMIRHGQTQEYLLKPKYFPAPKVVSAEQSTEGSFSLRYGQEQGTAP
                     FQVSNHTGRIKVVFTPSICKVTCTKGNCQNSCQKGNTTTLISENGHAADTLTATNFRV
                     VICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQQGKALGSHVI
                     HSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDSPGGQKVKEAQP
                     GQSQVSYQGLPVQKTQTVHSTYSHQQLIPHVYPVAAKTQLGRCFQETIGSQCGKALPG
                     LSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQL
                     QGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPVISEEKGPCYRLVSPGRHCM
                     HPLSVHLTKQICCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHQ
                     HIGKEAVYVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSWEHGPRGAEPEVVTAPPEK
                     EIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEASTSSASQ
                     VIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQV
                     RHLCSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFR
                     CEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLD
                     VDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRN
                     TDGSFRCTCGQGYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASV
                     LGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGFQLNDNKGCQDINECAQPGLC
                     GSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCL
                     CYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCR
                     SRVTEDSGVDRQPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIF
                     PCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGEEICKNGYCLNTQ
                     PGYECYCKQGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASE
                     KRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQ
                     CALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEE
                     LQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCK
                     NAKCINTEGSYKCLCLPGYIPSDKPNYCTPLNSALNLDKESDLE"
     exon            834..904
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1196
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1366
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1534
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1759
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2034
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2137
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2209
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2332
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2500
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2728
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2751
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2851
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2950
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3076
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3202
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3325
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3445
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3568
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3691
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3814
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3937
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4063
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4189
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4333
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4513
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4600
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4729
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4870
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            4871..5041
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5164
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5314
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            5315..7455
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6195..6200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /note="hexamer: ATTAAA"
     polyA_site      6222
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
     regulatory      6696..6701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /note="hexamer: AATAAA"
     polyA_site      6718
                     /gene="Ltbp1"
                     /gene_synonym="9430031G15Rik; 9830146M04; b2b1000Clo;
                     Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb"
                     /note="major polyA site"
ORIGIN      
        1 agactttgca gccggggctg cctctgagcg tccagcgctc acggtcgtcc ttgctcaccc
       61 tcgcggggtt ggcgcccgta gcaccccagc cgcacccggc gacacctcgt ctgagccagg
      121 ggaccctcac cttgagcagc tcgcgcccct cccctcctct ccaccccaac tcccgccccc
      181 tgctcgcctc cactcccggc tggggtccgc tgccgctcag ccgcccgcaa agctccctcc
      241 cctgcggcca cccagttggt ctccaccccg cggcgcacgg gctctccgca gagtccttgg
      301 ggataccgag ggagcgcgcc ggggcaggac gagccgcgcg gccggagact gcccgcgatg
      361 gcgggagcct ggctcaggtg gggtctcctg ctctgggcag ggctgctagc gtggtctgcg
      421 cacggccggg tgcggaggat cacgtacgtg gtgcgcccgg gcccgggact gccggccgga
      481 gccttgcctc tggctgggcc cccgcggacc ttcaacgtcg cactggacgc caggtacagc
      541 cggagctcaa cagccgcctc cagccgcgcc ttggctgggc ccccagccga gcggacccgg
      601 cgcaccagcc agcccggcgg cgcggccctg ccggggctcc gatctccgct gccacccgag
      661 cccgcgcgtc cgggggggcc cagccggcag ctccactcta aggcgggtgc tcagaccgcg
      721 gtcactcgct tcgccaaaca tggcaggcaa gtcgtgcgct cccaagtgca gcaggacgct
      781 cagagcgccg ggggctccag actgcaggtt cagcagaagc agcagctgca ggggatcaac
      841 gtctgtggag ggcagtgctg ccacgggtgg agtaaacctc ctggctccca gaggtgcacc
      901 aaacccagct gtgttccgcc atgccagaac ggagggatgt gtctacggcc tcagctctgt
      961 gtgtgcaagc cagggtcaaa gggcaaagcc tgcgagatca cagctgccca ggacaccatg
     1021 ccgccagcct ttggagggca gaatcctggg tcttcgtggg ccccccttga gcaagcagca
     1081 aaacatacgt caaccaagaa ggcagacacc ttgcccaggg tcagtccagt ggcccagatg
     1141 accttgaccc tcaagccaaa gccatcaatg ggactctccc agcagataca tcctcaagtt
     1201 gcacccttat cttcccagaa tgtgatgatt cggcatggcc agacccagga gtacctgctc
     1261 aaacccaagt acttcccagc cccgaaggtg gtctctgcgg agcaatccac cgaaggctct
     1321 ttctctttaa gatatgggca ggagcaaggc acggcaccct ttcaggtgag taaccacact
     1381 ggtcgcatca aggtggtctt tactccgagc atctgtaaag tgacctgcac caagggcaac
     1441 tgtcagaaca gctgccagaa ggggaatacc accactctca ttagtgagaa cggccatgca
     1501 gccgacaccc tgacagccac gaacttccga gtggttattt gccatcttcc gtgtatgaat
     1561 ggtggccagt gcagttcaag ggacaaatgt cagtgccctc caaatttcac aggaaagctt
     1621 tgccagatcc ctgtccttgg tgccagtatg cccaaactct accagcacgc ccagcagcag
     1681 ggcaaggcat tggggagtca cgtcatccat tccacacata ccttgcctct aaccatgact
     1741 agccagcaag gggtcaaagt gaaattcccc cccaacatag tcaatatcca tgtgaaacat
     1801 cctcccgagg cttctgtcca gatacaccag gtttccagga ttgacagccc aggaggccag
     1861 aaggtgaagg aagcccaacc aggccagtcc caagtctctt accaaggact tccggtccag
     1921 aagacccaga cagtccattc tacgtactcc caccagcagc ttattcccca tgtgtatccc
     1981 gtggctgcta agacacaact tggccgatgc ttccaggaaa ccattggatc acagtgtggc
     2041 aaagcgctcc ctggcctttc caagcaagag gactgctgtg ggacagtggg gacgtcctgg
     2101 ggctttaaca aatgccagaa gtgccccaag aaacaatcct atcatggata tactcaaatg
     2161 atggaatgcc tacaaggata taaacgggtt aacaacacct tttgtcaaga tattaatgaa
     2221 tgtcagctac aaggtgtatg ccctaatggt gagtgtttga ataccatggg cagctacaga
     2281 tgctcctgca aaatgggatt cgggcctgac cctacctttt caagttgtgt tccggatccc
     2341 cctgtgatct cagaagagaa agggccctgt taccgccttg tcagtcctgg aaggcattgt
     2401 atgcaccctc tctctgttca tctcaccaag cagatctgct gttgtagtgt gggcaaggcc
     2461 tggggcccac attgtgagaa atgtcccctc ccaggcacag ctgcttttaa ggaaatctgt
     2521 cctggtggaa tgggttatac ggtttctggc gttcatagac gcaggccaat ccatcagcat
     2581 ataggtaaag aagctgtata tgtcaagcca aagaacactc aacctgttgc taaaagtact
     2641 catcctccac ctctcccagc caaggaagag cctgtggagg ccctgacctc ctcgtgggaa
     2701 cacgggccga gaggggcgga gcccgaagtg gtaacagcac ctcctgagaa ggaaatacct
     2761 tcactggatc aagagaaaac cagacttgaa cctgggcaac cccagctctc cccaggggtt
     2821 tcaactattc atctgcaccc acagtttcca gtagtggttg aaaagacatc ccctcctgtg
     2881 cctgtggaag tagctcctga agcttccaca tccagtgcca gccaagtgat tgctcctacg
     2941 caagtaacag aaatcaacga atgtactgtg aacccggaca tttgcggagc aggacactgc
     3001 atcaacctgc cggtgcggta tacctgcata tgctacgagg gctacaagtt cagtgaacag
     3061 ctgaggaaat gtgtcgacat tgatgaatgt gctcaggtcc ggcacctctg ctcccagggt
     3121 cgctgtgaga acacagaggg aagtttcctg tgtgtctgcc cggcagggtt tatggccagt
     3181 gaggagggta ctaactgtat agatgtggat gagtgcctga ggcctgatat gtgtagggat
     3241 ggccgctgca tcaacaccgc tggggccttc cggtgcgagt actgtgacag tgggtaccgg
     3301 atgtcacgga gaggctactg tgaggatatt gatgagtgtc tgaagccaag cacttgtccc
     3361 gaggaacagt gtgtgaacac cccgggctct taccagtgtg tgccctgcac agaggggttc
     3421 cgcggctgga atggacaatg ccttgatgtg gacgagtgcc tgcagccaaa ggtctgtacg
     3481 aatggttcct gcaccaacct ggaagggtcc tacatgtgtt cctgccacag gggctacagc
     3541 cccacaccag accatagaca ctgtcaagat attgatgaat gccaacaagg gaatctctgc
     3601 atgaatgggc agtgcagaaa taccgatggc tccttccggt gtacctgtgg acagggctat
     3661 cagctgtcag cagctaaaga ccaatgtgaa gatattgatg aatgcgagca ccatcacctc
     3721 tgctctcacg ggcagtgcag gaacacagag ggctccttcc agtgtgtgtg caaccagggt
     3781 tacagagcat ctgtacttgg agaccactgt gaggatatca atgaatgctt ggaggacagc
     3841 agtgtctgcc agggaggtga ctgcatcaat actgcggggt cctatgattg cacatgcccg
     3901 gatggattcc agctgaacga caataagggc tgtcaagaca ttaatgaatg tgcacagcca
     3961 ggactctgtg gatctcatgg ggagtgtcta aacacacaag gctccttcca ctgtgtctgt
     4021 gaacaggggt tctccatctc tgccgatggc cgtacatgcg aagatattga tgagtgtgtt
     4081 aacaacactg tgtgtgacag tcacggcttc tgtgacaaca cagccggctc tttccgctgc
     4141 ctctgttatc agggctttca agccccacag gatgggcaag ggtgtgtgga tgtgaacgag
     4201 tgtgaactgc tcagtggtgt atgtggggaa gccttctgtg aaaacgtgga aggatccttc
     4261 ctgtgtgtgt gtgccgatga gaaccaggag tacagcccca tgactgggca gtgtcgctct
     4321 cgggtcacgg aagattcagg tgtggatcgt cagcctagag aagagaagaa ggagtgctat
     4381 tataacctca atgatgctag tctctgtgat aatgtcctgg cccccaacgt caccaaacaa
     4441 gagtgctgct gtacgtcagg tgccggctgg ggagacaact gtgagatctt cccttgcccc
     4501 gtccagggaa ctgctgagtt cacggaaatg tgccctagag ggaaaggttt ggtcccggct
     4561 ggagaatcct cttacgacac tggtggcgag aactacaaag atgctgatga atgcttgctg
     4621 tttggagagg aaatctgtaa aaatggttac tgtttgaaca ctcaacctgg gtatgaatgc
     4681 tactgtaagc aagggacata ctatgatcct gtcaaattac agtgctttga tatggatgaa
     4741 tgccaagacc ctaacagttg cattgacggc cagtgtgtga acacagaggg ctcctacaac
     4801 tgcttttgca cccacccaat ggtcctggat gcctctgaga agagatgtgt gcaaccaact
     4861 gaatcaaatg aacaaataga agagaccgat gtctatcaag atctgtgctg ggagcatctg
     4921 agtgaggagt acgtgtgtag ccgtcctctc gtaggcaagc agacgacgta cacagaatgc
     4981 tgctgtttgt acggggaggc ttggggcatg cagtgtgctc tgtgccccat gaaggactca
     5041 gatgactatg cccagctgtg caatatccct gtgactgggc gtcggcggcc atatggacgg
     5101 gatgcattgg tggacttcag tgaacagtat ggcccagaaa cagaccctta cttcatccag
     5161 gatcgctttc taaatagctt tgaggagcta caggctgagg agtgtggcat cctcaatggt
     5221 tgtgaaaacg gccgctgtgt gagagtccag gaaggataca cttgcgattg ctttgatgga
     5281 tatcacctgg atatggccaa gatgacctgt gtcgatgtaa atgaatgcag cgagctgaat
     5341 aatcggatgt ctctctgcaa gaacgccaag tgcattaaca cagaaggctc ctacaaatgc
     5401 ttgtgtctgc caggctacat accatccgac aagcccaact actgtacacc cctgaacagc
     5461 gctttgaatt tagacaaaga aagtgacctg gagtgaagga gaagaagctg cgtaacctat
     5521 gcccatatac tctgcactgt gtaaagggaa agggagagat gtatacttga gacactgcac
     5581 ctaacccaga atgtggcaaa gacagagaca acttggagtt gagtgaaccc ccaaagacag
     5641 tgagcggatg gagctggaac ctgacaggtg caacagacca aatggacatt tcttcaaaaa
     5701 cccagtatat atagtctgtt catatgtaaa attcagtgga aaagaggcag gacatggctg
     5761 tcattttaaa cagaggttgt attattatct tgttttgatt ttttttttta ctattgctta
     5821 aatttggctt ttaaatatta gtggaaatgt tttatgtgat ctttcttttt gctgtgcaga
     5881 tcctcagctg ccgttttttt tttcctccaa tgataatctc aagtgcaaac atctttgata
     5941 aaatattgtt aaactgtatt ataagtaata tgacacaggg ttgtgctgtc ccttggtctg
     6001 gagactttta aaaaaacaag ttgtctgtcc tgtggagcag gcagtaattg ttaaactttt
     6061 ggaggggatg gagaaacatc tttatttcaa tgtattacca gattgcctgt caattggatc
     6121 ccttacctgg atggaagtgg aagagcttca tagagtttat taatattgtg atgtgtaaag
     6181 tcaaccgaga aaaaattaaa aacctgaaca tcccccccca aacatttacc attgtatgtt
     6241 ataagaaaat aaactcacca tttttgtaga aaaaaaaaat ttgagtgtgg aagaagaagt
     6301 tgtccccttc ctcataacag ctcccccatc tctgatcttt taaccactag tcctccatca
     6361 cgctaggctt ctgtaagtta ggactggtta gctactgtta caggttgcta atttccatct
     6421 tagttccagg ctgaagtgct gcatccccgt gctttagaat gcgtggattc tctttggaga
     6481 caagatctct aaggaggaaa tgaaagttac aggagaccag tggagtaaac tgtaacccaa
     6541 gactatgggt gtccttagat gacagggaag taaggacttg tgcagagaaa aggtcatttg
     6601 aagagggctg gaaggcgacc atcttgcaaa agagtgaggc ctcagaggga agccaactct
     6661 gccacagagt ttgacagagt ccagaattat gagaaaataa acttctgttg tcaaacaacc
     6721 tgtctatgat actttcttat ggcctttcca gacaaccaat acagacttgt ataacaggaa
     6781 taatgggcaa acaaggcctt tcaaagtccc ggtctctgat ctcatatgga cgacccctag
     6841 caatgatagc tgcttcactc actgtgaaac ttactgtgcc tcagcaaacc cccatgggaa
     6901 atcccccagt gaacacttcc ttgaggggcc tttgccttct aatgcctgta gcaggcaaag
     6961 tgataacaac ttaaagatat agatcttcta acctatggac tctgtcataa tgaagggaag
     7021 tactgtctca gagaagtctg ccaagtcact tggccccaaa gaggacgatg atcttggatt
     7081 gcctggctat tattactatg taatcaccag gggtgtcctt ggaacattaa aagtggcaag
     7141 acagaaagaa agaagttctg aaaatgtgac atgcaagagg tcaagtacag cactaaagtg
     7201 cttcttgtca ccactgactg gtaaaggaca tgaacccaag atgtggacag ctagtagaag
     7261 ccgggcaaga cgaggagctg gctcttcata gacaatctag aaataagaat agcactatta
     7321 tacctgatac cttgttttca gtctagtgag cctgtgtgaa cctttcacct attgagctgt
     7381 aagataactg ggtattgttt gatgtgactg agtttgtaac aatagaaaat taaagctgct
     7441 tagaagctta aagtc
//
