LOCUS       NM_020490               1471 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus leukotriene B4 receptor 2 (Ltb4r2), mRNA.
ACCESSION   NM_020490
VERSION     NM_020490.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1471)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 1471)
  AUTHORS   Ermis,E., Nargis,T., Webster,K., Tersey,S.A., Anderson,R.M. and
            Mirmira,R.G.
  TITLE     Leukotriene B4 receptor 2 governs macrophage migration during
            tissue inflammation
  JOURNAL   J Biol Chem 300 (1), 105561 (2024)
   PUBMED   38097183
  REMARK    GeneRIF: Leukotriene B4 receptor 2 governs macrophage migration
            during tissue inflammation.
REFERENCE   3  (bases 1 to 1471)
  AUTHORS   Pernet,E., Sun,S., Sarden,N., Gona,S., Nguyen,A., Khan,N.,
            Mawhinney,M., Tran,K.A., Chronopoulos,J., Amberkar,D., Sadeghi,M.,
            Grant,A., Wali,S., Prevel,R., Ding,J., Martin,J.G.,
            Thanabalasuriar,A., Yipp,B.G., Barreiro,L.B. and Divangahi,M.
  TITLE     Neonatal imprinting of alveolar macrophages via neutrophil-derived
            12-HETE
  JOURNAL   Nature 614 (7948), 530-538 (2023)
   PUBMED   36599368
REFERENCE   4  (bases 1 to 1471)
  AUTHORS   Park,D., Ro,M., Lee,A.J., Kwak,D.W., Chung,Y. and Kim,J.H.
  TITLE     Contributory Role of BLT2 in the Production of Proinflammatory
            Cytokines in Cecal Ligation and Puncture-Induced Sepsis
  JOURNAL   Mol Cells 44 (12), 893-899 (2021)
   PUBMED   34887363
  REMARK    GeneRIF: Contributory Role of BLT2 in the Production of
            Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced
            Sepsis.
REFERENCE   5  (bases 1 to 1471)
  AUTHORS   Jang,J.H., Park,D., Park,G.S., Kwak,D.W., Park,J., Yu,D.Y.,
            You,H.J. and Kim,J.H.
  TITLE     Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor
            formation by promoting interleukin-6-mediated inflammation
  JOURNAL   Exp Mol Med 53 (10), 1559-1568 (2021)
   PUBMED   34635780
  REMARK    GeneRIF: Leukotriene B4 receptor-2 contributes to KRAS-driven lung
            tumor formation by promoting interleukin-6-mediated inflammation.
REFERENCE   6  (bases 1 to 1471)
  AUTHORS   Iizuka,Y., Yokomizo,T., Terawaki,K., Komine,M., Tamaki,K. and
            Shimizu,T.
  TITLE     Characterization of a mouse second leukotriene B4 receptor, mBLT2:
            BLT2-dependent ERK activation and cell migration of primary mouse
            keratinocytes
  JOURNAL   J Biol Chem 280 (26), 24816-24823 (2005)
   PUBMED   15866883
  REMARK    GeneRIF: BLT2 is a leukotriene B4 receptor with a role in ERK
            activation and cell migration of primary mouse keratinocytes
REFERENCE   7  (bases 1 to 1471)
  AUTHORS   Tager,A.M. and Luster,A.D.
  TITLE     BLT1 and BLT2: the leukotriene B(4) receptors
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 69 (2-3), 123-134 (2003)
   PUBMED   12895595
  REMARK    GeneRIF: 360 amino acid sequence determined and aligned with human
            sequence
            Review article
REFERENCE   8  (bases 1 to 1471)
  AUTHORS   Yokomizo,T., Izumi,T. and Shimizu,T.
  TITLE     Leukotriene B4: metabolism and signal transduction
  JOURNAL   Arch Biochem Biophys 385 (2), 231-241 (2001)
   PUBMED   11368003
  REMARK    Review article
REFERENCE   9  (bases 1 to 1471)
  AUTHORS   Yokomizo,T., Kato,K., Terawaki,K., Izumi,T. and Shimizu,T.
  TITLE     A second leukotriene B(4) receptor, BLT2. A new therapeutic target
            in inflammation and immunological disorders
  JOURNAL   J Exp Med 192 (3), 421-432 (2000)
   PUBMED   10934230
REFERENCE   10 (bases 1 to 1471)
  AUTHORS   Kato,K., Yokomizo,T., Izumi,T. and Shimizu,T.
  TITLE     Cell-specific transcriptional regulation of human leukotriene B(4)
            receptor gene
  JOURNAL   J Exp Med 192 (3), 413-420 (2000)
   PUBMED   10934229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098877.3.
            
            On Sep 13, 2022 this sequence version replaced NM_020490.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018029.1, BY717959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC098877.3         77210-77358
            150-1471            AC098877.3         77722-79043
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1471
                     /gene="Ltb4r2"
                     /gene_synonym="5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2;
                     LTB4-R2"
                     /note="leukotriene B4 receptor 2"
                     /db_xref="GeneID:57260"
                     /db_xref="MGI:MGI:1888501"
     exon            1..149
                     /gene="Ltb4r2"
                     /gene_synonym="5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2;
                     LTB4-R2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..1471
                     /gene="Ltb4r2"
                     /gene_synonym="5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2;
                     LTB4-R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1248
                     /gene="Ltb4r2"
                     /gene_synonym="5830462O07Rik; BLT2; LTB4-R 2; LTB4-R-2;
                     LTB4-R2"
                     /note="leukotriene B4 receptor BLT2"
                     /codon_start=1
                     /product="leukotriene B4 receptor 2"
                     /protein_id="NP_065236.1"
                     /db_xref="CCDS:CCDS27128.1"
                     /db_xref="GeneID:57260"
                     /db_xref="MGI:MGI:1888501"
                     /translation="MSVCYRPPGNETLLSWKGSRATGTAFLLLAALLGLPGNGFVVWS
                     LAGWRPTAGRPLAATLVLHLALADGAVLLLTPLFVAFLSQEAWPLGQVGCKAVYYVCA
                     LSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLGVWLAALVLAVPAAVYR
                     HLWGGRVCQLCHPSPVHAAAHLSLETLTAFVLPFGTVLGCYGVTLARLRGARWGSGRQ
                     GTRVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGPLARLGGAGQAARAGTTAL
                     AFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGSRSREGTMELRTTPKLK
                     VMGQGRGNGDPGGGDGGKTEKDSQEW"
ORIGIN      
        1 accatcttgt ccctctccat tcttgactca tcctctccgc aaatgtgaca ggcacggggc
       61 aggattaggc acctcatcca cagcagctgg cttcacctgt caccttccta aatctctctg
      121 cgccccccaa tgctgttctc tcccagcggc tctcccccta gaaggatgtc tgtctgctac
      181 cgtccgcctg ggaatgagac actactgagc tggaagggct cgcgggccac cggcactgcc
      241 tttctactgc tggcggcgtt gctgggactg ccaggcaatg gcttcgtagt atggagctta
      301 gcgggctggc ggcccacggc gggccggcca ctggcggcca cacttgtgct gcacctggcc
      361 ctggccgacg gcgcggtgct gctgctcacg ccgctctttg tggctttcct cagccaagag
      421 gcttggccct tgggccaggt gggctgcaag gcggtgtact acgtgtgcgc gctcagcatg
      481 tacgccagcg tgctgctcac cggcctgctc agcctgcagc gctgcctggc tgtcactcgg
      541 cccttcctgg ctccccgact gcgcagcccg gccctggccc gccgcttgct gctgggggtc
      601 tggctggccg ccctggtgct cgccgtcccg gccgcggtct accgccacct ctggggcggg
      661 cgcgtgtgtc agctgtgcca cccatcgcca gtgcacgcag ctgctcatct gagcctggag
      721 accctgactg ccttcgtctt gccttttggg accgtgctcg gctgctatgg cgtgacgctg
      781 gcgcggttgc gaggagcgcg ctggggctcg gggcgacaag gcacacgggt gggtcgtctg
      841 gtgagcgcca tcgtgctggc ctttggcttg ctctgggctc cctaccacgc ggtcaatctc
      901 ctacaggcgg tggccgcgct cgctccgccg gaaggacccc tggccaggct cggcggggcg
      961 ggccaggcgg cgcgcgctgg aactacagcc ttggctttct tcagttccag cgtcaaccca
     1021 gtgctctatg tcttcactgc gggggatttg ctgccgcggg ccgggcctcg gttccttact
     1081 cgactcttcg agggctctgg ggaggcccga gggggcagcc gctctaggga gggtaccatg
     1141 gaactccgaa ctactcctaa gctgaaagta atggggcagg gcaggggcaa tggagaccct
     1201 ggaggcggag atgggggcaa gacggagaaa gacagtcaag aatggtagac aagaccctaa
     1261 accccacctt ggggctcccc taccactttt cattgtgttc ccagagctct ggagtacttg
     1321 aggacccttc tctgattgca gtttgagttt ggctgaataa ggatttctct atctgaacct
     1381 gattcctcca aaccatggca ttgtgagggt gactgtggcc tatgttcaaa atttgtgctt
     1441 acagtacagc ctggatccgt gtaccaacac t
//
