LOCUS       NM_008519               1394 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus leukotriene B4 receptor 1 (Ltb4r1), transcript variant
            1, mRNA.
ACCESSION   NM_008519
VERSION     NM_008519.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Haist,K.C., Gibbings,S.L., Jacobelli,J., Mould,K.J., Henson,P.M.
            and Bratton,D.L.
  TITLE     A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in
            chronic granulomatous disease
  JOURNAL   iScience 27 (4), 109589 (2024)
   PUBMED   38623335
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Tang,C., Wang,A., Zhao,Y., Mou,W., Jiang,J., Kuang,J., Sun,B. and
            Tang,E.
  TITLE     Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling
            and apoptotic responses in colorectal cancer
  JOURNAL   Biomol Biomed 24 (4), 968-981 (2024)
   PUBMED   38259082
  REMARK    GeneRIF: Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR
            signaling and apoptotic responses in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Hernandez,J., Schaffer,J., Herden,C., Pflieger,F.J., Reiche,S.,
            Korber,S., Kitagawa,H., Welter,J., Michels,S., Culmsee,C., Bier,J.,
            Sommer,N., Kang,J.X., Mayer,K., Hecker,M. and Rummel,C.
  TITLE     n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the
            Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice
            Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin
            Receptor 23 Knockout
  JOURNAL   Int J Mol Sci 24 (17), 13524 (2023)
   PUBMED   37686333
  REMARK    GeneRIF: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS
            and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1
            Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin
            Receptor 23 Knockout.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Detter,J.C., Zhang,Q., Mules,E.H., Novak,E.K., Mishra,V.S., Li,W.,
            McMurtrie,E.B., Tchernev,V.T., Wallace,M.R., Seabra,M.C.,
            Swank,R.T. and Kingsmore,S.F.
  TITLE     Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse
            reduces Rab prenylation and platelet synthesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4144-4149 (2000)
   PUBMED   10737774
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Boie,Y., Stocco,R., Sawyer,N., Greig,G.M., Kargman,S.,
            Slipetz,D.M., O'Neill,G.P., Shimizu,T., Yokomizo,T., Metters,K.M.
            and Abramovitz,M.
  TITLE     Characterization of the cloned guinea pig leukotriene B4 receptor:
            comparison to its human orthologue
  JOURNAL   Eur J Pharmacol 380 (2-3), 203-213 (1999)
   PUBMED   10513580
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Chiang,N., Gronert,K., Clish,C.B., O'Brien,J.A., Freeman,M.W. and
            Serhan,C.N.
  TITLE     Leukotriene B4 receptor transgenic mice reveal novel protective
            roles for lipoxins and aspirin-triggered lipoxins in reperfusion
  JOURNAL   J Clin Invest 104 (3), 309-316 (1999)
   PUBMED   10430612
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Martin,V., Ronde,P., Unett,D., Wong,A., Hoffman,T.L., Edinger,A.L.,
            Doms,R.W. and Funk,C.D.
  TITLE     Leukotriene binding, signaling, and analysis of HIV coreceptor
            function in mouse and human leukotriene B4 receptor-transfected
            cells
  JOURNAL   J Biol Chem 274 (13), 8597-8603 (1999)
   PUBMED   10085095
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   Huang,W.W., Garcia-Zepeda,E.A., Sauty,A., Oettgen,H.C.,
            Rothenberg,M.E. and Luster,A.D.
  TITLE     Molecular and biological characterization of the murine leukotriene
            B4 receptor expressed on eosinophils
  JOURNAL   J Exp Med 188 (6), 1063-1074 (1998)
   PUBMED   9743525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098877.3.
            
            On Sep 13, 2022 this sequence version replaced NM_008519.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044030.1, BC064063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC098877.3         81776-81907
            133-1394            AC098877.3         83047-84308
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1394
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /note="leukotriene B4 receptor 1"
                     /db_xref="GeneID:16995"
                     /db_xref="MGI:MGI:1309472"
     exon            1..132
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /inference="alignment:Splign:2.1.0"
     exon            133..1394
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1197
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /note="LTB4 receptor"
                     /codon_start=1
                     /product="leukotriene B4 receptor 1"
                     /protein_id="NP_032545.1"
                     /db_xref="CCDS:CCDS27129.1"
                     /db_xref="GeneID:16995"
                     /db_xref="MGI:MGI:1309472"
                     /translation="MAANTTSPAAPSSPGGMSLSLLPIVLLSVALAVGLPGNSFVVWS
                     ILKRMQKRTVTALLVLNLALADLAVLLTAPFFLHFLARGTWSFREMGCRLCHYVCGIS
                     MYASVLLITIMSLDRSLAVARPFMSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTV
                     KWNNRTLICAPNYPNKEHKVFHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSR
                     RTGRLVVLIILAFAAFWLPYHLVNLVEAGRTVAGWDKNSPAGQRLRLARYVLIALAFL
                     SSSVNPVLYACAGGGLLRSAGVGFVVKLLEGTGSEVSSTRRGGTLVQTPKDTPACPEP
                     GPTDSFMTSSTIPESSK"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /note="hexamer: ATTAAA"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /note="hexamer: ACTAAA"
     polyA_site      1391
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
     polyA_site      1394
                     /gene="Ltb4r1"
                     /gene_synonym="BLT1; BLTR; LTB4-R1; Ltb4r; mBLTR"
                     /note="major polyA site"
ORIGIN      
        1 acttcctctc tggctgactt agctgacaga cctagaagtg ggaccaggac cctggcacta
       61 agacagattc aaggattgta tatccaacaa ctagacaaga cattaccttc tgatcagcat
      121 cagggaaacc ctgtcctttt gatggctgca aacactacat ctcctgcagc accttcttct
      181 cctggtggca tgtccctgtc tctgttgccc attgttctac tgtctgtggc cctggctgtg
      241 gggcttcctg gcaatagctt tgtagtgtgg agcatcctga aaaggatgca gaaacgcacg
      301 gtcaccgccc tgctggtgct gaacttggcc ctggccgact tggctgtgtt gctcactgct
      361 ccctttttcc tccactttct ggctcgaggc acctggagtt ttagagagat gggttgccgc
      421 ctgtgccact atgtctgtgg aataagcatg tatgccagtg tcctgcttat aaccatcatg
      481 agtctggacc gatcactggc agtggcccgc ccctttatgt cccaaaaggt tcgtactaag
      541 gcctttgccc gatgggtgct ggcaggcatc tgggtggtgt cttttctgct ggccataccg
      601 gtccttgtgt accgtacagt aaaatggaac aacaggactc tgatctgcgc tccgaactat
      661 cccaacaaag agcataaagt cttccatctg ctcttcgaag ccatcacggg cttcctgctg
      721 cccttcctag cggtggtggc cagctactct gacatcgggc gcaggctgca ggctcggcgc
      781 ttccgccgta gtcgccgcac cggccgcctg gtggtgctca ttatcctggc cttcgccgcc
      841 ttctggctgc cttaccacct ggtgaacctg gtggaagccg gccgcacagt ggccggctgg
      901 gacaagaaca gccctgcggg gcagcgtctg aggctggccc gctatgtgct catcgcgctg
      961 gccttcctga gcagcagcgt gaacccggtg ctgtacgcgt gcgcgggcgg cggcctgctg
     1021 cgttcggcgg gcgtgggctt cgtggtcaag ctactggagg gcactggctc ggaggtgtcc
     1081 agcacccgcc gcgggggcac tctggtccag accccgaagg acacacctgc ctgtcctgag
     1141 cctggcccca ccgacagctt catgacttcc tccaccattc ctgagtcttc gaagtgaact
     1201 gcagtaggct gggttatgac acaactcata actctggcct gacccacttc tgtacctgga
     1261 ggagaacatg ttggggactg ggcttaagcg gaagagaggg aggggtgggg caagtcaggg
     1321 cagagagaca ggatgctctg gcctggcttc tgcaggcagc ttcacgatta aaactaaagt
     1381 ctgaaatcgg ctaa
//
