LOCUS       NM_008518               1122 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus lymphotoxin B (Ltb), mRNA.
ACCESSION   NM_008518
VERSION     NM_008518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Bessell,E., Finlay,R.E., James,L.K., Ludewig,B., Harris,N.L.,
            Krebs,P., Hepworth,M.R. and Dubey,L.K.
  TITLE     Stromal cell and B cell dialogue potentiates IL-33-enriched
            lymphoid niches to support eosinophil recruitment and function
            during type 2 immunity
  JOURNAL   Cell Rep 43 (8), 114620 (2024)
   PUBMED   39141517
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Lim,V.Y., Feng,X., Miao,R., Zehentmeier,S., Ewing-Crystal,N.,
            Lee,M., Tumanov,A.V., Oh,J.E., Iwasaki,A., Wang,A., Choi,J. and
            Pereira,J.P.
  TITLE     Mature B cells and mesenchymal stem cells control emergency
            myelopoiesis
  JOURNAL   Life Sci Alliance 6 (4), e202301924 (2023)
   PUBMED   36717247
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Zehentmeier,S., Lim,V.Y., Ma,Y., Fossati,J., Ito,T., Jiang,Y.,
            Tumanov,A.V., Lee,H.J., Dillinger,L., Kim,J., Csomos,K.,
            Walter,J.E., Choi,J. and Pereira,J.P.
  TITLE     Dysregulated stem cell niches and altered lymphocyte recirculation
            cause B and T cell lymphopenia in WHIM syndrome
  JOURNAL   Sci Immunol 7 (75), eabo3170 (2022)
   PUBMED   36149943
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Gogoleva,V.S., Kuprash,D.V., Grivennikov,S.I., Tumanov,A.V.,
            Kruglov,A.A. and Nedospasov,S.A.
  TITLE     LTalpha, TNF, and ILC3 in Peyer's Patch Organogenesis
  JOURNAL   Cells 11 (12), 1970 (2022)
   PUBMED   35741098
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Hahne,M., Peitsch,M.C., Irmler,M., Schroter,M., Lowin,B.,
            Rousseau,M., Bron,C., Renno,T., French,L. and Tschopp,J.
  TITLE     Characterization of the non-functional Fas ligand of gld mice
  JOURNAL   Int Immunol 7 (9), 1381-1386 (1995)
   PUBMED   7495745
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Pokholok,D.K., Maroulakou,I.G., Kuprash,D.V., Alimzhanov,M.B.,
            Kozlov,S.V., Novobrantseva,T.I., Turetskaya,R.L., Green,J.E. and
            Nedospasov,S.A.
  TITLE     Cloning and expression analysis of the murine lymphotoxin beta gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 674-678 (1995)
   PUBMED   7846035
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Browning,J.L., Ngam-ek,A., Lawton,P., DeMarinis,J., Tizard,R.,
            Chow,E.P., Hession,C., O'Brine-Greco,B., Foley,S.F. and Ware,C.F.
  TITLE     Lymphotoxin beta, a novel member of the TNF family that forms a
            heteromeric complex with lymphotoxin on the cell surface
  JOURNAL   Cell 72 (6), 847-856 (1993)
   PUBMED   7916655
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Browning,J.L., Androlewicz,M.J. and Ware,C.F.
  TITLE     Lymphotoxin and an associated 33-kDa glycoprotein are expressed on
            the surface of an activated human T cell hybridoma
  JOURNAL   J Immunol 147 (4), 1230-1237 (1991)
   PUBMED   1714477
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Shacks,S.J., Chiller,J. and Granger,G.A.
  TITLE     Studies on in vitro models of cellular immunity: the role of T and
            B cells in the secretion of lymphotoxin
  JOURNAL   Cell Immunol 7 (2), 313-321 (1973)
   PUBMED   4540898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18, U16985.1 and BC064062.1.
            
            On Dec 5, 2007 this sequence version replaced NM_008518.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16985.1, BC114919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CR974444.18        130502-130516
            16-1046             U16985.1           1-1031
            1047-1122           BC064062.1         1369-1444
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..1122
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /note="lymphotoxin B"
                     /db_xref="GeneID:16994"
                     /db_xref="MGI:MGI:104796"
     exon            1..177
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..936
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /note="tumor necrosis factor ligand superfamily member 3;
                     tumor necrosis factor C; TNF-C; LT-beta; tumor necrosis
                     factor ligand 1c"
                     /codon_start=1
                     /product="lymphotoxin-beta"
                     /protein_id="NP_032544.1"
                     /db_xref="CCDS:CCDS28690.1"
                     /db_xref="GeneID:16994"
                     /db_xref="MGI:MGI:104796"
                     /translation="MGTRGLQGLGGRPQGRGCLLLAVAGATSLVTLLLAVPITVLAVL
                     ALVPQDQGRRVEKIIGSGAQAQKRLDDSKPSCILPSPSSLSETPDPRLHPQRSNASRN
                     LASTSQGPVAQSSREASAWMTILSPAADSTPDPGVQQLPKGEPETDLNPELPAAHLIG
                     AWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSR
                     ARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLR
                     SGERVYVNISHPDMVDYRRGKTFFGAVMVG"
     exon            178..493
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1095
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1076..1081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="Ltb"
                     /gene_synonym="LTbeta; p33; Tnfc; Tnfsf3; Tnlg1c"
                     /note="major polyA site"
ORIGIN      
        1 tagttctgag tctggatggg gacacgggga ctgcagggcc tgggtgggag accccagggg
       61 aggggctgcc tcttgctggc tgtggcagga gctacttccc tggtgaccct gttgttggca
      121 gtgcctatca ctgtcctggc tgtgctggcc ttggtgccgc aggatcaggg acgtcgggtt
      181 gagaagatca ttggctcagg agcacaggct cagaaaagac tggatgacag caaaccgtcg
      241 tgcatcttgc cctcaccctc tagcctctca gagactcctg acccccgtct gcatcctcag
      301 agatccaatg cttccaggaa tctagcctcc acatcccagg gccctgttgc gcagtcctct
      361 cgggaggcat ctgcatggat gaccatcctg tctccagctg cggattctac accagatcca
      421 ggggttcaac agctgccaaa gggggaacca gaaactgacc tcaaccctga gctccctgct
      481 gcccacctca taggcgcttg gatgagtggg caagggctca gctgggaggc gagccaagaa
      541 gaagcgtttc tgaggagcgg cgcgcagttc tcccccaccc acgggctggc gctgccacag
      601 gacggcgtct attacctcta ctgccacgtc gggtacaggg gcaggacgcc ccctgccggc
      661 cgaagccgtg ctcgctcgct cacgctgcgc agcgccctgt accgcgcggg gggcgcctac
      721 gggcgaggtt cccccgagtt gctgctggag ggcgcggaga cagtcacacc tgttgtggac
      781 cccatcgggt acgggtcgtt atggtacacg agcgtggggt tcggcggcct ggcgcagctc
      841 cggagcggcg agagggtcta cgttaacatc agtcaccccg acatggtgga ctacaggaga
      901 gggaagacct tcttcggggc ggtgatggtg gggtgacagc catctgtatt cattcctgga
      961 ggatcgactg acggtgcgaa tgtgtgaatc gtgatgtccg ggaccccgac agtcccgagc
     1021 ggccgggggc gtggcggggg ggggggagaa cggaatgtag gacacgaatt ttgaaaataa
     1081 agaatgtaaa ctatgaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
