LOCUS       NM_010735               1423 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus lymphotoxin A (Lta), mRNA.
ACCESSION   NM_010735
VERSION     NM_010735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Enamorado,M., Kulalert,W., Han,S.J., Rao,I., Delaleu,J., Link,V.M.,
            Yong,D., Smelkinson,M., Gil,L., Nakajima,S., Linehan,J.L.,
            Bouladoux,N., Wlaschin,J., Kabat,J., Kamenyeva,O., Deng,L.,
            Gribonika,I., Chesler,A.T., Chiu,I.M., Le Pichon,C.E. and
            Belkaid,Y.
  TITLE     Immunity to the microbiota promotes sensory neuron regeneration
  JOURNAL   Cell 186 (3), 607-620 (2023)
   PUBMED   36640762
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Drake,K.A., Chaney,C., Patel,M., Das,A., Bittencourt,J., Cohn,M.
            and Carroll,T.J.
  TITLE     Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal
            Myofibroblasts in the Developing Mouse Kidney
  JOURNAL   J Am Soc Nephrol 33 (9), 1694-1707 (2022)
   PUBMED   35918150
  REMARK    Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. doi:
            10.1681/ASN.0000000000000056.. PMID: 36857501]
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Gogoleva,V.S., Kuprash,D.V., Grivennikov,S.I., Tumanov,A.V.,
            Kruglov,A.A. and Nedospasov,S.A.
  TITLE     LTalpha, TNF, and ILC3 in Peyer's Patch Organogenesis
  JOURNAL   Cells 11 (12), 1970 (2022)
   PUBMED   35741098
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1423)
  AUTHORS   Reticker-Flynn,N.E., Zhang,W., Belk,J.A., Basto,P.A.,
            Escalante,N.K., Pilarowski,G.O.W., Bejnood,A., Martins,M.M.,
            Kenkel,J.A., Linde,I.L., Bagchi,S., Yuan,R., Chang,S.,
            Spitzer,M.H., Carmi,Y., Cheng,J., Tolentino,L.L., Choi,O., Wu,N.,
            Kong,C.S., Gentles,A.J., Sunwoo,J.B., Satpathy,A.T., Plevritis,S.K.
            and Engleman,E.G.
  TITLE     Lymph node colonization induces tumor-immune tolerance to promote
            distant metastasis
  JOURNAL   Cell 185 (11), 1924-1942 (2022)
   PUBMED   35525247
REFERENCE   6  (bases 1 to 1423)
  AUTHORS   Ferreri,N.R., Sarr,T., Askenase,P.W. and Ruddle,N.H.
  TITLE     Molecular regulation of tumor necrosis factor-alpha and lymphotoxin
            production in T cells. Inhibition by prostaglandin E2
  JOURNAL   J Biol Chem 267 (13), 9443-9449 (1992)
   PUBMED   1533632
REFERENCE   7  (bases 1 to 1423)
  AUTHORS   Browning,J.L., Androlewicz,M.J. and Ware,C.F.
  TITLE     Lymphotoxin and an associated 33-kDa glycoprotein are expressed on
            the surface of an activated human T cell hybridoma
  JOURNAL   J Immunol 147 (4), 1230-1237 (1991)
   PUBMED   1714477
REFERENCE   8  (bases 1 to 1423)
  AUTHORS   Montgomery,R.A. and Dallman,M.J.
  TITLE     Analysis of cytokine gene expression during fetal thymic ontogeny
            using the polymerase chain reaction
  JOURNAL   J Immunol 147 (2), 554-560 (1991)
   PUBMED   1649220
REFERENCE   9  (bases 1 to 1423)
  AUTHORS   Walsh,A.C., Slack,J. and Flaherty,L.
  TITLE     Characterization of several new MHC congenic strains
  JOURNAL   Immunogenetics 33 (4), 290-293 (1991)
   PUBMED   1673964
REFERENCE   10 (bases 1 to 1423)
  AUTHORS   Weil,D., Brosset,S. and Dautry,F.
  TITLE     RNA processing is a limiting step for murine tumor necrosis factor
            beta expression in response to interleukin-2
  JOURNAL   Mol Cell Biol 10 (11), 5865-5875 (1990)
   PUBMED   1700275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099464.1.
            
            On Sep 9, 2009 this sequence version replaced NM_010735.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099464.1, AK080308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..1423
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /note="lymphotoxin A"
                     /db_xref="GeneID:16992"
                     /db_xref="MGI:MGI:104797"
     exon            1..193
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            194..298
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..811
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /note="lymphotoxin-alpha; tumor necrosis factor ligand
                     superfamily member 1; TNF beta; tumor necrosis factor
                     ligand 1e"
                     /codon_start=1
                     /product="lymphotoxin-alpha precursor"
                     /protein_id="NP_034865.1"
                     /db_xref="CCDS:CCDS28692.1"
                     /db_xref="GeneID:16992"
                     /db_xref="MGI:MGI:104797"
                     /translation="MTLLGRLHLLRVLGTPPVFLLGLLLALPLGAQGLSGVRFSAART
                     AHPLPQKHLTHGILKPAAHLVGYPSKQNSLLWRASTDRAFLRHGFSLSNNSLLIPTSG
                     LYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSSQYPFHVPLLSAQKSVYPGLQGPW
                     VRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSSVFFGAFAL"
     exon            299..398
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            399..1383
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1364..1369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /note="hexamer: AATAAA"
     polyA_site      1383
                     /gene="Lta"
                     /gene_synonym="hlb382; LT; LT-alpha; LT-[a]; LTalpha; Ltx;
                     LT[a]; TNF-beta; Tnfb; TNFSF1; Tnfsf1b; Tnlg1e"
                     /note="major polyA site"
ORIGIN      
        1 gtctaagccc ttagcctgcg gttctctcct aggccccagc ctttcctgcc ttcgactgaa
       61 acagcagcat cttctaagcc ctgggggctt ccccaagccc cagccccgac ctagaacccg
      121 cccgctgcct gccacactgc cgcttcctct ataaagggac ccgagcgcca gcgcccagga
      181 ccccgcacag caggttctcc acatgacact gctcggccgt ctccacctct tgagggtgct
      241 tggcacccct cctgtcttcc tcctggggct gctgctggcc ctgcctctag gggcccaggg
      301 actctctggt gtccgcttct ccgctgccag gacagcccat ccactccctc agaagcactt
      361 gacccatggc atcctgaaac ctgctgctca ccttgttggg taccccagca agcagaactc
      421 actgctctgg agagcaagca cggatcgtgc ctttctccga catggcttct ctttgagcaa
      481 caactccctc ctgatcccca ccagtggcct ctactttgtc tactcccagg tggttttctc
      541 tggagaaagc tgctccccca gggccattcc cactcccatc tacctggcac acgaggtcca
      601 gctcttttcc tcccaatacc ccttccatgt gcctctcctc agtgcgcaga agtctgtgta
      661 tccgggactt caaggaccgt gggtgcgctc aatgtaccag ggggctgtgt tcctgctcag
      721 taagggagac cagctgtcca cccacaccga cggcatctcc catctacact tcagccccag
      781 cagtgtattc tttggagcct ttgcactgta gattctaaag aaacccaaga attggattcc
      841 aggcctccat cctgaccgtt gtttcaaggg tcacatcccc acagtctcca gccttcccca
      901 ctaaaataac ctggagctct cacgggagtc tgagacactt caggggacta catcttcccc
      961 agggccactc cagatgctca ggggacgact caagcctacc tagaagttcc tgcacagagc
     1021 agggtttttg tgggtctagg tcggacagag acctggacat gaaggaggga cagacatggg
     1081 agaggtggct gggaacaggg gaaggttgac tatttatgga gagaaaagtt aagttattta
     1141 tttatagaga atagaaagag gggaaaaata gaaagccgtc agatgacaac taggtcccag
     1201 acacaaaggt gtctcacctc agacaggacc catctaagag agagatggcg agagaattag
     1261 atgtgggtga ccaaggggtt ctagaagaaa gcacgaagct ctaaaagcca gccactgctt
     1321 ggctagacat ccacagggac cccctgcacc atctgtgaaa cccaataaac ctcttttctc
     1381 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
