LOCUS       NM_010734                418 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus leukocyte specific transcript 1 (Lst1), mRNA.
ACCESSION   NM_010734 XM_359281
VERSION     NM_010734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Fabisik,M., Tureckova,J., Pavliuchenko,N., Kralova,J.,
            Balounova,J., Vicikova,K., Skopcova,T., Spoutil,F., Pokorna,J.,
            Angelisova,P., Malissen,B., Prochazka,J., Sedlacek,R. and
            Brdicka,T.
  TITLE     Regulation of Inflammatory Response by Transmembrane Adaptor
            Protein LST1
  JOURNAL   Front Immunol 12, 618332 (2021)
   PUBMED   33986741
  REMARK    GeneRIF: Regulation of Inflammatory Response by Transmembrane
            Adaptor Protein LST1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 418)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 418)
  AUTHORS   Leist,S.R., Kollmus,H., Hatesuer,B., Lambertz,R.L. and Schughart,K.
  TITLE     Lst1 deficiency has a minor impact on course and outcome of the
            host response to influenza A H1N1 infections in mice
  JOURNAL   Virol J 13, 17 (2016)
   PUBMED   26817701
  REMARK    GeneRIF: The absence of Lst1 leads to a slightly more susceptible
            phenotype. However, deletion of Lst1 in DBA/2 J mice alone does not
            explain the high susceptibility of this strain to PR8M influenza
            infections.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 418)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 418)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   7  (bases 1 to 418)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   8  (bases 1 to 418)
  AUTHORS   de Baey,A., Fellerhoff,B., Maier,S., Martinozzi,S., Weidle,U. and
            Weiss,E.H.
  TITLE     Complex expression pattern of the TNF region gene LST1 through
            differential regulation, initiation, and alternative splicing
  JOURNAL   Genomics 45 (3), 591-600 (1997)
   PUBMED   9367684
REFERENCE   9  (bases 1 to 418)
  AUTHORS   Lanning,D. and Lafuse,W.P.
  TITLE     Localization of the casein kinase II beta-subunit gene within the
            mouse H-2 complex class III region and comparison of expression
            with Bat genes
  JOURNAL   Mamm Genome 8 (7), 519-521 (1997)
   PUBMED   9196000
REFERENCE   10 (bases 1 to 418)
  AUTHORS   Tsuge,I., Shen,F.W., Steinmetz,M. and Boyse,E.A.
  TITLE     A gene in the H-2S:H-2D interval of the major histocompatibility
            complex which is transcribed in B cells and macrophages
  JOURNAL   Immunogenetics 26 (6), 378-380 (1987)
   PUBMED   3117682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI182980.1, AI323110.1 and AI482475.1.
            
            On Jan 29, 2005 this sequence version replaced NM_010734.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI182980.1, BC086881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AI182980.1         1-224
            225-400             AI323110.1         130-305
            401-418             AI482475.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..418
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /note="leukocyte specific transcript 1"
                     /db_xref="GeneID:16988"
                     /db_xref="MGI:MGI:1096324"
     exon            1..84
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..332
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /codon_start=1
                     /product="leukocyte-specific transcript 1 protein"
                     /protein_id="NP_034864.2"
                     /db_xref="CCDS:CCDS50085.1"
                     /db_xref="GeneID:16988"
                     /db_xref="MGI:MGI:1096324"
                     /translation="MTMGSGNNCTTNDFLLNGSLGLGGLLLLLVIILFICLCRFSQRV
                     KRLERNAQVSGQEPHYASLQQLPVSSSDITDMKEDLSTDYACIARSTPT"
     exon            85..180
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /inference="alignment:Splign:2.1.0"
     exon            181..200
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /inference="alignment:Splign:2.1.0"
     exon            201..416
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      390..395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /note="hexamer: AGTAAA"
     polyA_site      408
                     /gene="Lst1"
                     /gene_synonym="B144"
                     /note="major polyA site"
ORIGIN      
        1 tagtttagtc ttgaccttca ggcctgttct cagtccctgg actatgtctg atgacaatgg
       61 gatctggtaa caattgcaca accaatgatt tcctgctaaa tgggagcctg ggactgggag
      121 ggctcctcct cctgcttgtc atcatcctgt tcatctgctt gtgccggttc agtcagagag
      181 tgaagagact ggaaaggaat gcccaggtct cagggcagga gccccactat gcatctctcc
      241 agcagctgcc agtgtccagt agtgatatca cagacatgaa agaagacctc agcactgact
      301 atgcctgcat cgccaggagc acacccactt gagtgccccc aaaagctctc ctcgccctgg
      361 gtgcgtgctc agtcacacta tggtcatcta gtaaagtctg gttccccact tctgcaaa
//
