LOCUS       NM_017405               2177 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus lipolysis stimulated lipoprotein receptor (Lsr),
            transcript variant 1, mRNA.
ACCESSION   NM_017405
VERSION     NM_017405.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Higashi,A.Y., Saito,A.C., Higashi,T., Furuse,K., Furuse,M.,
            Chiba,H. and Kazama,J.J.
  TITLE     Bicellular Localization of Tricellular Junctional Protein
            Angulin-3/ILDR2 Allows Detection of Podocyte Injury
  JOURNAL   Am J Pathol 194 (5), 673-683 (2024)
   PUBMED   38311119
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   An,Y., Wang,C., Fan,B., Wang,Z., Li,Y., Kong,F., Zhou,C., Cao,Z.,
            Wang,M., Sun,H., Zhao,S. and Gong,Y.
  TITLE     LSR targets YAP to modulate intestinal Paneth cell differentiation
  JOURNAL   Cell Rep 42 (9), 113118 (2023)
   PUBMED   37703178
  REMARK    GeneRIF: LSR targets YAP to modulate intestinal Paneth cell
            differentiation.
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Kim,Y.S., Fan,R., Lith,S.C., Dicke,A.K., Drexler,H.C.A., Kremer,L.,
            Kuempel-Rink,N., Hekking,L., Stehling,M. and Bedzhov,I.
  TITLE     Rap1 controls epiblast morphogenesis in sync with the pluripotency
            states transition
  JOURNAL   Dev Cell 57 (16), 1937-1956 (2022)
   PUBMED   35998584
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   El Hajj,A., Herzine,A., Calcagno,G., Desor,F., Djelti,F.,
            Bombail,V., Denis,I., Oster,T., Malaplate,C., Vigier,M.,
            Kaminski,S., Pauron,L., Corbier,C., Yen,F.T., Lanhers,M.C. and
            Claudepierre,T.
  TITLE     Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes
            Leads to Olfactory and Memory Deficits in Mice
  JOURNAL   Int J Mol Sci 23 (4), 2049 (2022)
   PUBMED   35216163
  REMARK    GeneRIF: Targeted Suppression of Lipoprotein Receptor LSR in
            Astrocytes Leads to Olfactory and Memory Deficits in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
  REMARK    GeneRIF: expression of LSR is critical for liver and embryonic
            development [LSR]
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   10 (bases 1 to 2177)
  AUTHORS   Lin,Q., Luo,X. and Sawadogo,M.
  TITLE     Archaic structure of the gene encoding transcription factor USF
  JOURNAL   J Biol Chem 269 (39), 23894-23903 (1994)
   PUBMED   7523363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149055.6.
            
            On Aug 14, 2009 this sequence version replaced NM_017405.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004672.1, U49507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC149055.6         94488-94877
            391-735             AC149055.6         95745-96089
            736-855             AC149055.6         101869-101988
            856-912             AC149055.6         105090-105146
            913-1059            AC149055.6         105713-105859
            1060-1221           AC149055.6         108643-108804
            1222-1281           AC149055.6         108923-108982
            1282-1413           AC149055.6         109076-109207
            1414-2045           AC149055.6         109337-109968
            2046-2177           AC149055.6         110056-110187
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.27 cM"
     gene            1..2177
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:54135"
                     /db_xref="MGI:MGI:1927471"
     exon            1..390
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2081
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; liver-specific bHLH-Zip transcription factor;
                     lipolysis stimulated receptor; liver-specific gene on
                     mouse chromosome 7 protein; angulin-3"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 1 precursor"
                     /protein_id="NP_059101.1"
                     /db_xref="CCDS:CCDS21119.1"
                     /db_xref="GeneID:54135"
                     /db_xref="MGI:MGI:1927471"
                     /translation="MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDP
                     YHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASL
                     LFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYT
                     HLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGY
                     RIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRA
                     PALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTE
                     SGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPR
                     SRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPP
                     PYSETDSQASRERRMKKNLALSRESLVV"
     exon            391..735
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            736..855
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            856..912
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1059
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1221
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1281
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1413
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..2045
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2177
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="hexamer: AATAAA"
     polyA_site      2172
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="major polyA site"
ORIGIN      
        1 agcccccggg ctcccaccct tgtgtacctg ggcggttcca ttcccgggag tgcgcagggg
       61 gtagagtgac ccagagagcc accgcgcgcc gggtcagttg tcttcgggaa gccgaaggca
      121 tgagcttcgt ccaagttcat tttgtaggtt agaactcccc cagtgcgagg aaaatggact
      181 tggaataggg gccgggcgca gcacgcaccc ttctcggccc tggtgctcgc cgcgccccct
      241 actctctgga tacttgggag gggacgcgcg ggcaccgtcg ctgctagacg gccgcgatgg
      301 cgccggcggc cagcgcgtgt gctggggcgc ctggctccca cccggccacc acgatcttcg
      361 tgtgtctttt tctcatcatt tactgcccag accgtgccag tgccatccag gtgaccgtgc
      421 ctgaccccta ccacgtagtg atcctgttcc agccagtgac actacactgc acctaccaga
      481 tgagcaatac cctcacagcc cctatcgtga tctggaagta taagtcgttc tgtcgggacc
      541 gtgttgccga cgccttctcc cctgccagcg tggacaacca gctcaacgcc cagctggcgg
      601 ctggcaaccc cggctacaac ccctatgtgg agtgccagga cagcgtacgc actgtcaggg
      661 tggtggccac caaacagggc aatgctgtga ccctgggaga ctactaccag ggcaggagaa
      721 tcaccatcac aggaaatgct gacctgacct tcgagcagac ggcctgggga gacagtggag
      781 tgtattactg ctccgtggtc tcagcccaag atctggatgg gaacaacgag gcgtacgcag
      841 agctcattgt ccttggcagg acctcagaag cccctgagct cctacctggt tttcgggcgg
      901 ggcccttgga agattggctc tttgtggtcg tggtctgcct ggcaagcctc ctcttcttcc
      961 tcctcctggg catctgctgg tgccagtgct gtccccacac ctgctgctgc tatgtcagat
     1021 gtccctgctg cccagacaag tgctgttgcc ctgaggccct ttatgctgct ggcaaagcag
     1081 ccacctcagg tgtgccaagc atctatgccc ccagcatcta tacccacctc tctcctgcca
     1141 agactccgcc acctccgcct gccatgattc ccatgcgtcc tccctatggg taccctggag
     1201 actttgacag gaccagctca gttggtggcc acagctccca ggtgcccctg ctgcgtgaag
     1261 tggatgggag cgtatcttca gaagtacgaa gtggctacag gatccaggct aaccagcaag
     1321 atgactccat gagggtccta tactatatgg agaaggagct agccaacttc gatccttccc
     1381 ggcctggccc tcccaatggc cgagtggaac gggccatgag tgaagtaacc tccctccatg
     1441 aagatgactg gcgatctcgg ccttccaggg ctcctgccct cacacccatc agggatgagg
     1501 agtggaatcg ccactcccct cggagtccca gaacatggga gcaggaaccc cttcaagaac
     1561 agccaagggg tggttggggg tctgggcggc ctcgggcccg ctctgtggat gctctagatg
     1621 acatcaaccg gcctggctcc actgaatcag gaaggtcttc tcccccaagt agtggacgga
     1681 gagggcgggc ctatgcacct ccgagaagtc gcagccggga tgacctctat gaccccgacg
     1741 atcctagaga cttgccacat tcccgagatc cccactatta tgatgatttg aggtctaggg
     1801 atccacgtgc tgaccccaga tcccgtcagc gatcccacga tcctcgggat gctggcttca
     1861 ggtcacggga ccctcagtat gatgggcgac tcttagaaga ggctttaaag aaaaaagggg
     1921 ctggggagag aagacgcgtt tacagggagg aagaagaaga agaagaggag ggccactatc
     1981 ccccagcacc tccgccttac tctgagactg actcgcaggc ctcgagggag cggaggatga
     2041 aaaagaattt ggccctgagt cgggaaagtt tagtcgtctg atcccacgtt ttgttatgta
     2101 gcttttatac ttttttaatt ggaatattga tgaaactctt caccaagcct aataaaattc
     2161 ctgatcacaa gatctaa
//
