LOCUS       NM_001164185            1973 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus lipolysis stimulated lipoprotein receptor (Lsr),
            transcript variant 3, mRNA.
ACCESSION   NM_001164185
VERSION     NM_001164185.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Higashi,A.Y., Saito,A.C., Higashi,T., Furuse,K., Furuse,M.,
            Chiba,H. and Kazama,J.J.
  TITLE     Bicellular Localization of Tricellular Junctional Protein
            Angulin-3/ILDR2 Allows Detection of Podocyte Injury
  JOURNAL   Am J Pathol 194 (5), 673-683 (2024)
   PUBMED   38311119
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   An,Y., Wang,C., Fan,B., Wang,Z., Li,Y., Kong,F., Zhou,C., Cao,Z.,
            Wang,M., Sun,H., Zhao,S. and Gong,Y.
  TITLE     LSR targets YAP to modulate intestinal Paneth cell differentiation
  JOURNAL   Cell Rep 42 (9), 113118 (2023)
   PUBMED   37703178
  REMARK    GeneRIF: LSR targets YAP to modulate intestinal Paneth cell
            differentiation.
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Kim,Y.S., Fan,R., Lith,S.C., Dicke,A.K., Drexler,H.C.A., Kremer,L.,
            Kuempel-Rink,N., Hekking,L., Stehling,M. and Bedzhov,I.
  TITLE     Rap1 controls epiblast morphogenesis in sync with the pluripotency
            states transition
  JOURNAL   Dev Cell 57 (16), 1937-1956 (2022)
   PUBMED   35998584
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   El Hajj,A., Herzine,A., Calcagno,G., Desor,F., Djelti,F.,
            Bombail,V., Denis,I., Oster,T., Malaplate,C., Vigier,M.,
            Kaminski,S., Pauron,L., Corbier,C., Yen,F.T., Lanhers,M.C. and
            Claudepierre,T.
  TITLE     Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes
            Leads to Olfactory and Memory Deficits in Mice
  JOURNAL   Int J Mol Sci 23 (4), 2049 (2022)
   PUBMED   35216163
  REMARK    GeneRIF: Targeted Suppression of Lipoprotein Receptor LSR in
            Astrocytes Leads to Olfactory and Memory Deficits in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Mesli,S., Javorschi,S., Berard,A.M., Landry,M., Priddle,H.,
            Kivlichan,D., Smith,A.J., Yen,F.T., Bihain,B.E. and Darmon,M.
  TITLE     Distribution of the lipolysis stimulated receptor in adult and
            embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to
            14.5 days of gestation
  JOURNAL   Eur J Biochem 271 (15), 3103-3114 (2004)
   PUBMED   15265030
  REMARK    GeneRIF: expression of LSR is critical for liver and embryonic
            development [LSR]
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Lin,Q., Luo,X. and Sawadogo,M.
  TITLE     Archaic structure of the gene encoding transcription factor USF
  JOURNAL   J Biol Chem 269 (39), 23894-23903 (1994)
   PUBMED   7523363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY028179.1, AK167463.1, AK146807.1 and AC149055.6.
            
            Transcript Variant: This variant (3) lacks two alternate exons in
            the central coding region, compared to variant 1. The resulting
            isoform (3) lacks an internal segment, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167463.1, SRR7345562.1075432.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY028179.1         3-64
            63-1458             AK167463.1         2-1397
            1459-1962           AK146807.1         1322-1825
            1963-1973           AC149055.6         110177-110187
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.27 cM"
     gene            1..1973
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="lipolysis stimulated lipoprotein receptor"
                     /db_xref="GeneID:54135"
                     /db_xref="MGI:MGI:1927471"
     exon            1..390
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1877
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; liver-specific bHLH-Zip transcription factor;
                     lipolysis stimulated receptor; liver-specific gene on
                     mouse chromosome 7 protein; angulin-3"
                     /codon_start=1
                     /product="lipolysis-stimulated lipoprotein receptor
                     isoform 3 precursor"
                     /protein_id="NP_001157657.1"
                     /db_xref="CCDS:CCDS52185.1"
                     /db_xref="GeneID:54135"
                     /db_xref="MGI:MGI:1927471"
                     /translation="MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDP
                     YHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAA
                     GNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDS
                     GVYYCSVVSAQDLDGNNEAYAELIVLVYAAGKAATSGVPSIYAPSIYTHLSPAKTPPP
                     PPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDS
                     MRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEE
                     WNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSG
                     RRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRD
                     AGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQAS
                     RERRMKKNLALSRESLVV"
     exon            391..735
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            736..855
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1017
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1077
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1209
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1841
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1973
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="hexamer: AATAAA"
     polyA_site      1968
                     /gene="Lsr"
                     /gene_synonym="ILDR3; Lisch7"
                     /note="major polyA site"
ORIGIN      
        1 agcccccggg ctcccaccct tgtgtacctg ggcggttcca ttcccgggag tgcgcagggg
       61 gtagagtgac ccagagagcc accgcgcgcc gggtcagttg tcttcgggaa gccgaaggca
      121 tgagcttcgt ccaagttcat tttgtaggtt agaactcccc cagtgcgagg aaaatggact
      181 tggaataggg gccgggcgca gcacgcaccc ttctcggccc tggtgctcgc cgcgccccct
      241 actctctgga tacttgggag gggacgcgcg ggcaccgtcg ctgctagacg gccgcgatgg
      301 cgccggcggc cagcgcgtgt gctggggcgc ctggctccca cccggccacc acgatcttcg
      361 tgtgtctttt tctcatcatt tactgcccag accgtgccag tgccatccag gtgaccgtgc
      421 ctgaccccta ccacgtagtg atcctgttcc agccagtgac actacactgc acctaccaga
      481 tgagcaatac cctcacagcc cctatcgtga tctggaagta taagtcgttc tgtcgggacc
      541 gtgttgccga cgccttctcc cctgccagcg tggacaacca gctcaacgcc cagctggcgg
      601 ctggcaaccc cggctacaac ccctatgtgg agtgccagga cagcgtacgc actgtcaggg
      661 tggtggccac caaacagggc aatgctgtga ccctgggaga ctactaccag ggcaggagaa
      721 tcaccatcac aggaaatgct gacctgacct tcgagcagac ggcctgggga gacagtggag
      781 tgtattactg ctccgtggtc tcagcccaag atctggatgg gaacaacgag gcgtacgcag
      841 agctcattgt ccttgtttat gctgctggca aagcagccac ctcaggtgtg ccaagcatct
      901 atgcccccag catctatacc cacctctctc ctgccaagac tccgccacct ccgcctgcca
      961 tgattcccat gcgtcctccc tatgggtacc ctggagactt tgacaggacc agctcagttg
     1021 gtggccacag ctcccaggtg cccctgctgc gtgaagtgga tgggagcgta tcttcagaag
     1081 tacgaagtgg ctacaggatc caggctaacc agcaagatga ctccatgagg gtcctatact
     1141 atatggagaa ggagctagcc aacttcgatc cttcccggcc tggccctccc aatggccgag
     1201 tggaacgggc catgagtgaa gtaacctccc tccatgaaga tgactggcga tctcggcctt
     1261 ccagggctcc tgccctcaca cccatcaggg atgaggagtg gaatcgccac tcccctcgga
     1321 gtcccagaac atgggagcag gaaccccttc aagaacagcc aaggggtggt tgggggtctg
     1381 ggcggcctcg ggcccgctct gtggatgctc tagatgacat caaccggcct ggctccactg
     1441 aatcaggaag gtcttctccc ccaagtagtg gacggagagg gcgggcctat gcacctccga
     1501 gaagtcgcag ccgggatgac ctctatgacc ccgacgatcc tagagacttg ccacattccc
     1561 gagatcccca ctattatgat gatttgaggt ctagggatcc acgtgctgac cccagatccc
     1621 gtcagcgatc ccacgatcct cgggatgctg gcttcaggtc acgggaccct cagtatgatg
     1681 ggcgactctt agaagaggct ttaaagaaaa aaggggctgg ggagagaaga cgcgtttaca
     1741 gggaggaaga agaagaagaa gaggagggcc actatccccc agcacctccg ccttactctg
     1801 agactgactc gcaggcctcg agggagcgga ggatgaaaaa gaatttggcc ctgagtcggg
     1861 aaagtttagt cgtctgatcc cacgttttgt tatgtagctt ttatactttt ttaattggaa
     1921 tattgatgaa actcttcacc aagcctaata aaattcctga tcacaagatc taa
//
