LOCUS       NM_001136071            1696 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus lymphocyte specific 1 (Lsp1), transcript variant 1,
            mRNA.
ACCESSION   NM_001136071
VERSION     NM_001136071.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Smeir,M., Chumala,P., Katselis,G.S. and Liu,L.
  TITLE     Lymphocyte-Specific Protein 1 Regulates Expression and Stability of
            Endothelial Nitric Oxide Synthase
  JOURNAL   Biomolecules 14 (1), 111 (2024)
   PUBMED   38254711
  REMARK    GeneRIF: Lymphocyte-Specific Protein 1 Regulates Expression and
            Stability of Endothelial Nitric Oxide Synthase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Koral,K., Bhushan,B., Orr,A., Stoops,J., Bowen,W.C., Copeland,M.A.,
            Locker,J., Mars,W.M. and Michalopoulos,G.K.
  TITLE     Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced
            Constitutive Androstane Receptor and Subsequent Yes-Associated
            Protein-Activated Hepatocyte Proliferation
  JOURNAL   Am J Pathol 192 (6), 887-903 (2022)
   PUBMED   35390317
  REMARK    GeneRIF: Lymphocyte-Specific Protein-1 Suppresses
            Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent
            Yes-Associated Protein-Activated Hepatocyte Proliferation.
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Scharinger,K., Maxeiner,S., Schalla,C., Rutten,S., Zenke,M. and
            Sechi,A.
  TITLE     LSP1-myosin1e bimolecular complex regulates focal adhesion dynamics
            and cell migration
  JOURNAL   FASEB J 35 (2), e21268 (2021)
   PUBMED   33470457
  REMARK    GeneRIF: LSP1-myosin1e bimolecular complex regulates focal adhesion
            dynamics and cell migration.
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Koral,K., Haynes,M., Bowen,W.C., Orr,A., Mars,W. and
            Michalopoulos,G.K.
  TITLE     Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and
            Hepatocellular Proliferation through Extracellular Signal-Regulated
            Kinase 1/2 Activation
  JOURNAL   Am J Pathol 188 (9), 2074-2086 (2018)
   PUBMED   30126548
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Thompson,A.A., Omori,S.A., Gilly,M.J., May,W., Gordon,M.S.,
            Wood,W.J. Jr., Miyoshi,E., Malone,C.S., Gimble,J., Denny,C.T. and
            Wall,R.
  TITLE     Alternatively spliced exons encode the tissue-specific 5' termini
            of leukocyte pp52 and stromal cell S37 mRNA isoforms
  JOURNAL   Genomics 32 (3), 352-357 (1996)
   PUBMED   8838798
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Matsumoto,N., Kojima,S., Osawa,T. and Toyoshima,S.
  TITLE     Protein kinase C phosphorylates p50 LSP1 and induces translocation
            of p50 LSP1 in T lymphocytes
  JOURNAL   J Biochem 117 (1), 222-229 (1995)
   PUBMED   7775393
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Misener,V.L., Hui,C., Malapitan,I.A., Ittel,M.E., Joyner,A.L. and
            Jongstra,J.
  TITLE     Expression of mouse LSP1/S37 isoforms. S37 is expressed in
            embryonic mesenchymal cells
  JOURNAL   J Cell Sci 107 (Pt 12), 3591-3600 (1994)
   PUBMED   7706408
REFERENCE   8  (bases 1 to 1696)
  AUTHORS   Jongstra,J., Ittel,M.E., Iscove,N.N. and Brady,G.
  TITLE     The LSP1 gene is expressed in cultured normal and transformed mouse
            macrophages
  JOURNAL   Mol Immunol 31 (15), 1125-1131 (1994)
   PUBMED   7935501
REFERENCE   9  (bases 1 to 1696)
  AUTHORS   Gimble,J.M., Dorheim,M.A., Youkhana,K., Hudson,J., Nead,M.,
            Gilly,M., Wood,W.J. Jr., Hermanson,G.G., Kuehl,M., Wall,R. et al.
  TITLE     Alternatively spliced pp52 mRNA in nonlymphoid stromal cells
  JOURNAL   J Immunol 150 (1), 115-121 (1993)
   PUBMED   8417117
REFERENCE   10 (bases 1 to 1696)
  AUTHORS   Jongstra,J., Tidmarsh,G.F., Jongstra-Bilen,J. and Davis,M.M.
  TITLE     A new lymphocyte-specific gene which encodes a putative
            Ca2+-binding protein is not expressed in transformed T lymphocyte
            lines
  JOURNAL   J Immunol 141 (11), 3999-4004 (1988)
   PUBMED   3263441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603651.14.
            
            On Oct 13, 2022 this sequence version replaced NM_001136071.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.198939.1, BC044736.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL603651.14        74427-74547         c
            122-268             AL603651.14        50768-50914         c
            269-427             AL603651.14        48888-49046         c
            428-524             AL603651.14        46878-46974         c
            525-617             AL603651.14        46453-46545         c
            618-661             AL603651.14        46221-46264         c
            662-743             AL603651.14        45987-46068         c
            744-878             AL603651.14        45359-45493         c
            879-956             AL603651.14        44971-45048         c
            957-1063            AL603651.14        44728-44834         c
            1064-1696           AL603651.14        40525-41157         c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.93 cM"
     gene            1..1696
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /note="lymphocyte specific 1"
                     /db_xref="GeneID:16985"
                     /db_xref="MGI:MGI:96832"
     exon            1..121
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1046
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /note="isoform 1 is encoded by transcript variant 1; S37
                     protein; 52 kDa phosphoprotein; lymphocyte-specific
                     antigen WP34; leukocyte specific protein 1;
                     lymphocyte-specific protein 1"
                     /codon_start=1
                     /product="lymphocyte-specific protein 1 isoform 1"
                     /protein_id="NP_001129543.1"
                     /db_xref="CCDS:CCDS52450.1"
                     /db_xref="GeneID:16985"
                     /db_xref="MGI:MGI:96832"
                     /translation="MAEAAIDPRCEEQEELHAEDSEGLTTQWREEDEEEAAREQRQRE
                     RERQLQDQDKDKEDDGGHSLEQPGQQTLISLKSSELDEDEGFGDWSQKPEPRQQFWGN
                     EGTAEGTEPSQSERPEEKQTEESSHQAKVHLEESNLSYREPDPEDAVGGSGEAEEHLI
                     RHQVRTPSPLALEDTVELSSPPLSPTTKLADRTESLNRSIKKSNSVKKSQPTLPISTI
                     DERLQQYTQATESSGRTPKLSRQPSIELPSMAVASTKTLWETGEVQSQSASKTPSCQD
                     IVAGDMSKKSLWEQKGGSKISSTIKSTPSGKRYKFVATGHGKYEKVLVDEGSAP"
     exon            122..268
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            269..427
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            428..524
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            525..617
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            618..661
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            662..743
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            744..878
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            879..956
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1063
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1696
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /note="hexamer: AATAAA"
     polyA_site      1428
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /note="major polyA site"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="Lsp1"
                     /gene_synonym="Lsp-1; p50; pp52; WP34"
ORIGIN      
        1 agagaaacac caggagccat aacaagtgca cccacaccga agacaccagg cccatggcgg
       61 aggctgccat cgatcccaga tgcgaggaac aggaagagct ccatgcagaa gacagcgaag
      121 ggctcacaac tcagtggaga gaagaagacg aggaagaggc tgcccgtgag cagcgtcaac
      181 gggagcgaga gaggcagcta caggaccagg acaaagataa agaagatgat ggtggccatt
      241 ccctggaaca gccaggacag cagacactca tcagcctgaa gtcctctgaa ctggatgaag
      301 atgagggttt tggtgactgg tcccaaaagc cggagccacg gcagcaattc tgggggaatg
      361 aggggactgc agaagggact gaaccctctc aaagcgagag accagaggag aaacaaacag
      421 aggagagttc tcaccaagcc aaagtccact tggaggagtc aaacctgagc tacagggagc
      481 ccgatccaga ggatgctgtt gggggttctg gggaggcgga agagcatctg atacgtcatc
      541 aggtcaggac ccccagccct ttggccttag aagacaccgt tgagctgagt tcacctcccc
      601 tgagccctac caccaaactg gctgatagga ccgagtccct gaaccgctcc attaaaaaga
      661 gcaacagtgt gaagaagtct caaccaacct tgcccatttc cacaattgat gaacgcctgc
      721 agcagtatac ccaggccact gagtcttctg gccgaactcc taagctgtcc cgccagccct
      781 ccatagagct gcccagcatg gccgtagcca gtaccaagac tctttgggaa acaggagaag
      841 tgcagagtca gtctgcttct aagacaccct cctgccagga tatagtagct ggagacatga
      901 gcaagaaaag tctgtgggag cagaaaggag gctccaagat ctcatccacc atcaagagca
      961 ccccatctgg aaagcggtac aagttcgtgg ccactggaca tgggaagtac gagaaagtac
     1021 ttgtggatga gggctcagca ccatagacca tgtttgcatc ctggatagac tccggccgga
     1081 tgccactccc agccctgacc aagaaattgc ttcctgttgc cagtctggcc tgctctcctg
     1141 cctccaacaa ccaagctgcc gatagcctct ccttttgctc ctggaccctc catcttctct
     1201 tccctctcat cctttgacca accctccaac tctgcttctc accatcagct aaagggacca
     1261 gtccctaggg gagccaagag ctcccaagga aggatgaagg agagaaggca agcatcccaa
     1321 ccagatccaa ggggacactg tccccatgct gaatgctcag gactcttggg tcctgccctg
     1381 tttacggatc cctcattttg tgtaataaag tgcattgagt gtcccctatg catttggatc
     1441 tcctgtgctc actaacaggg aacacggtga tcaaaacaga aagggccata tctgttggcc
     1501 acttgagact tgatcagctc tgtgggcaac cactctgtct tgtcttttgg ccttgcagtg
     1561 tgttatgttc caggatctga ggtatgaggt gacccaagct ggggtattaa taatggatgt
     1621 ggcctactcc tcttccagaa catgacactt tgatgaccct tccttacttg gaccaaaata
     1681 aacctgaaca agggca
//
