LOCUS       NM_015816                953 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus LSM4 homolog, U6 small nuclear RNA and mRNA
            degradation associated (Lsm4), transcript variant 1, mRNA.
ACCESSION   NM_015816
VERSION     NM_015816.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Perez-Santangelo,S., Mancini,E., Francey,L.J., Schlaen,R.G.,
            Chernomoretz,A., Hogenesch,J.B. and Yanovsky,M.J.
  TITLE     Role for LSM genes in the regulation of circadian rhythms
  JOURNAL   Proc Natl Acad Sci U S A 111 (42), 15166-15171 (2014)
   PUBMED   25288739
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Uchibe,K., Shimizu,H., Yokoyama,S., Kuboki,T. and Asahara,H.
  TITLE     Identification of novel transcription-regulating genes expressed
            during murine molar development
  JOURNAL   Dev Dyn 241 (7), 1217-1226 (2012)
   PUBMED   22639370
REFERENCE   3  (bases 1 to 953)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 953)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 953)
  AUTHORS   Yang,Z., Jakymiw,A., Wood,M.R., Eystathioy,T., Rubin,R.L.,
            Fritzler,M.J. and Chan,E.K.
  TITLE     GW182 is critical for the stability of GW bodies expressed during
            the cell cycle and cell proliferation
  JOURNAL   J Cell Sci 117 (Pt 23), 5567-5578 (2004)
   PUBMED   15494374
REFERENCE   6  (bases 1 to 953)
  AUTHORS   Clarke,D., Elgar,G. and Clark,M.S.
  TITLE     Comparative analysis of human 19p12-13 region in Fugu and mouse
  JOURNAL   Mamm Genome 12 (6), 478-483 (2001)
   PUBMED   11353399
REFERENCE   7  (bases 1 to 953)
  AUTHORS   Hirsch,E., Oohashi,T., Ahmad,M., Stamm,S. and Fassler,R.
  TITLE     Peri-implantation lethality in mice lacking the Sm motif-containing
            protein Lsm4
  JOURNAL   Mol Cell Biol 20 (3), 1055-1062 (2000)
   PUBMED   10629062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA322716.1, AK010910.1 and AJ249439.1.
            
            On Nov 2, 2007 this sequence version replaced NM_015816.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026747.1, AK167784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               CA322716.1         1-164
            165-937             AK010910.1         1-773
            938-953             AJ249439.1         776-791
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..953
                     /gene="Lsm4"
                     /note="LSM4 homolog, U6 small nuclear RNA and mRNA
                     degradation associated"
                     /db_xref="GeneID:50783"
                     /db_xref="MGI:MGI:1354692"
     exon            1..227
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..641
                     /gene="Lsm4"
                     /note="isoform 1 is encoded by transcript variant 1; U6
                     snRNA-associated Sm-like protein LSm4; U6 snRNA-associated
                     SM-like protein 4; LSM4 homolog, U6 small nuclear RNA
                     associated"
                     /codon_start=1
                     /product="U6 snRNA-associated Sm-like protein LSm4 isoform
                     1"
                     /protein_id="NP_056631.2"
                     /db_xref="CCDS:CCDS40374.1"
                     /db_xref="GeneID:50783"
                     /db_xref="MGI:MGI:1354692"
                     /translation="MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVI
                     CTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEAAKGRGRGGPQQQKQQKGRG
                     MGGAGRGVFGGRGRGGIPGAGRGQPEKKPGRQAGKQ"
     exon            228..269
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            270..368
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            369..549
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..942
                     /gene="Lsm4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      918..923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm4"
                     /note="hexamer: AATAAA"
     polyA_site      936
                     /gene="Lsm4"
                     /note="major polyA site"
ORIGIN      
        1 cgcactttac ggctacctct caatcccacc gtagaaatac ggtgaggccg tccgtcttgt
       61 tccgtaggta ccgccctagc ccgtcccgat tggatagatg tccgttgagc tgctcgctga
      121 ttggtcatag tttctgccag tctttttcag tctggggcgc gcggtgggcc gccggtggga
      181 gcgcgtgtgt ctgtgccgcg gcggaagtta tcgctgcagg gaagatgctt cccttgtcgc
      241 tgctgaagac agcgcagaat caccccatgc tggtggagct gaagaatggg gagacctaca
      301 acgggcatct ggtgagctgt gacaactgga tgaacatcaa cctccgggag gtgatctgca
      361 cgtcgcggga tggtgacaag ttctggagga tgcctgagtg ctacatccgt ggcagcacca
      421 tcaagtacct gcgcatccct gatgagatca ttgacatggt gcgggaggag gccgccaagg
      481 gccgagggcg aggaggaccg cagcagcaga agcagcagaa aggccgaggc atgggcggcg
      541 ctggccgagg tgtgtttggt ggccggggcc ggggtggcat cccaggtgca ggccgaggcc
      601 agcccgagaa gaagccaggg cggcaggcag gcaaacagtg atcactccct gcctgagccg
      661 agcccagaac ggtgggtgag gcctcagggc acctttgtgt gaagccccac ttggcgtctg
      721 gtccagtgaa gtccctcgct ggccactgac tcagtttctg gaaggttccg agtctgaggt
      781 gcctgtggag ccttagatgc cctttgaagg gctgacttct tccaggcatg tttgagtttc
      841 agttggagct gcaggctcag cccatggcgg ctcacctgtc ctttaccagc cataccctgt
      901 acatcttctg tttgaaaaat aaaagcaaac accatagaaa gaaaaaaaaa aaa
//
