LOCUS       NM_001372364            2661 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus LSM family member 14B (Lsm14b), transcript variant 1,
            mRNA.
ACCESSION   NM_001372364 XM_006500617
VERSION     NM_001372364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Zhang,H., Zhang,T., Wan,X., Chen,C., Wang,S., Qin,D., Li,L., Yu,L.
            and Wu,X.
  TITLE     LSM14B coordinates protein component expression in the P-body and
            controls oocyte maturation
  JOURNAL   J Genet Genomics 51 (1), 48-60 (2024)
   PUBMED   37481122
  REMARK    GeneRIF: LSM14B coordinates protein component expression in the
            P-body and controls oocyte maturation.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Ding,Y., He,Z., Sha,Y., Kee,K. and Li,L.
  TITLE     Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics
            and leads to subfertility
  JOURNAL   Development 150 (23) (2023)
   PUBMED   38088064
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
  REMARK    GeneRIF: LSM14B is essential for oocyte meiotic maturation by
            regulating maternal mRNA storage and clearance.
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Shan,L.Y., Tian,Y., Liu,W.X., Fan,H.T., Li,F.G., Liu,W.J., Li,A.,
            Shen,W., Sun,Q.Y., Liu,Y.B., Zhou,Y. and Zhang,T.
  TITLE     LSM14B controls oocyte mRNA storage and stability to ensure female
            fertility
  JOURNAL   Cell Mol Life Sci 80 (9), 247 (2023)
   PUBMED   37578641
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Weiss,A.C., Bohnenpoll,T., Kurz,J., Blank,P., Airik,R.,
            Ludtke,T.H., Kleppa,M.J., Deuper,L., Kaiser,M., Mamo,T.M.,
            Costa,R., von Hahn,T., Trowe,M.O. and Kispert,A.
  TITLE     Delayed onset of smooth muscle cell differentiation leads to
            hydroureter formation in mice with conditional loss of the zinc
            finger transcription factor gene Gata2 in the ureteric mesenchyme
  JOURNAL   J Pathol 248 (4), 452-463 (2019)
   PUBMED   30916783
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663067.14.
            
            On Aug 24, 2022 this sequence version replaced NM_001372364.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.252453.1,
                                           SRR13422598.128490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AL663067.14        145851-146186
            337-500             AL663067.14        147509-147672
            501-636             AL663067.14        148774-148909
            637-753             AL663067.14        149832-149948
            754-921             AL663067.14        152235-152402
            922-999             AL663067.14        152668-152745
            1000-1161           AL663067.14        152935-153096
            1162-1312           AL663067.14        153375-153525
            1313-1497           AL663067.14        154560-154744
            1498-2661           AL663067.14        155172-156335
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.54 cM"
     gene            1..2661
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /note="LSM family member 14B"
                     /db_xref="GeneID:241846"
                     /db_xref="MGI:MGI:3040677"
     exon            1..336
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1484
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LSM14 homolog B; mRAP55B; RNA-associated protein
                     55B"
                     /codon_start=1
                     /product="protein LSM14 homolog B isoform 1"
                     /protein_id="NP_001359293.1"
                     /db_xref="GeneID:241846"
                     /db_xref="MGI:MGI:3040677"
                     /translation="MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVR
                     SFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGS
                     ASASPFQPHVPYSPFRGMPPYGQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSS
                     PSPQPVSELDMSSEPPQLTCKGAGFPSTPVGKSPMVEQAVQTSSVDNLNAKKLLPSKV
                     TSATQLNGRQAQPSSKPASDVVQPAPVHTQGQVNDENRRPPRRRSGNRRTRNRSRGQN
                     RPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKADKGEEKDPAVMAQ
                     SEETAAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFL
                     RGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV"
     exon            337..500
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            501..636
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            637..753
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            754..921
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            922..999
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1161
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1312
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1497
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..2661
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /note="hexamer: AATAAA"
     polyA_site      2661
                     /gene="Lsm14b"
                     /gene_synonym="9430078B04"
                     /note="major polyA site"
ORIGIN      
        1 cccccgctcc cttcagactc gggctaagcg cctcgctctg ctccctctcc ggttcgctcg
       61 tggcccgcag gcccctaggc gcggcaggag gcgcctcgga ggcggcggcg cggagctgcg
      121 caggagtggg aggccaggcc accgcgcggc agcggagcgg gcggggcccg gcgctggtcc
      181 cccgcgccct gcgcgccccg gccgccgcca tgagcggctc gtccggcacc ccgtatctgg
      241 gcagcaagat cagcctcatc tccaaggcgc agatccgcta tgagggcatc ctctacacca
      301 tcgacaccga caactccacc gtggcgctcg ccaaagtgag gtcctttggt actgaagacc
      361 gtcccacaga caggcctgct cccccaagag aggaaattta tgagtacatc attttccggg
      421 gaagtgatat caaggatatt actgtgtgcg aacctccaaa agctcaacat acactccctc
      481 aggatcctgc tattgttcag tcctccctgg gctctgcctc cgcctcgccc ttccagccgc
      541 atgtgcctta cagccccttc agagggatgc caccgtatgg ccagctggca gccagttccc
      601 tgctcagcca gcagtatgcc gcttccttag gtctagagaa gttggtaagc cctccagcct
      661 cagccgctgc ttccagccct agttcttctc catctccaca gcctgtttca gagcttgaca
      721 tgtcctcaga gccacctcag ctcacttgca agggagctgg gttcccatct accccagtcg
      781 gcaagagccc catggtggag caggctgtcc agactagttc tgttgataac ttgaatgcta
      841 agaaactgtt gcccagcaag gtcacctcgg cgacacagct caatggtcgc caggctcagc
      901 caagcagcaa gcctgccagc gatgtagtcc agccggcacc tgtgcacact caagggcagg
      961 tgaatgatga gaacagaaga cctccacgga ggcggtcagg caatcggaga acaagaaatc
     1021 gttccagagg acaaaaccgt ccaactaacg ttaaggaaaa cacaatcaag tttgaaggtg
     1081 actttgattt tgagagtgca aatgcccagt tcaaccgaga ggagcttgat aaagagttta
     1141 agaagaaact gaattttaaa gatgacaaag ccgacaaggg ggaagagaag gacccagctg
     1201 tgatggcgca gagtgaagag actgctgctg aggaggatct tctggggcct aactgttact
     1261 atgacaagtc caagtccttc tttgacaaca tctcttctga actcaaaacc agttctaggc
     1321 ggacaacatg ggctgaagag agaaagctga acactgagac ttttggagtg tcagggaggt
     1381 tccttcgtgg ccgcagttca cgtggtggat tccggggagg cagaggaaat gggacaacac
     1441 ggcgcaaccc cacttcccac cgagctggga ctggccgggt ataagggtgc agtacaaggt
     1501 ccagcagagg cagaggtgct gccctgaaga taaggacaga aggcaacact acagtcagca
     1561 ggagaagtga accttgtgta ccagcctgga aaccctcata ctgctactta gtttggactt
     1621 aacctaactt ggacatggtc tgagatttag aaccacttgg ttttggggaa gtatttgtag
     1681 gtgacctctg aaggtttctc gacctacatt tccttcttgg ttgcacacag cctaatagta
     1741 aggttttggt attttgcaaa aaggtttcta taggcaaagg ctcaatcctc actttgtaac
     1801 tttttttttt ttaatgaccg ctttgactct taaaatggaa ccaaatttta tttggcacat
     1861 gtggtgtcca aatgtgtctc tgcaacccat ctggcccctg gtgctgctgg cctggtaccc
     1921 caactgctaa aagtgggaag tctcaggagc caggcagggc cagcacaggg tgagccagtc
     1981 acacggggtg ggagggccag ggcagggaca gggtgggggg gtgttccatg gatcatgttg
     2041 tgtaatgaac cagtgatgtt cagtgctggg ggctaacggg atgagtgaag tagtgggaag
     2101 ggcgtgagtg tcacgtagag cctgcctgcc ttccacaggc actgaggcat agtgttgaaa
     2161 cccaaggcaa gctcgtgtgg tgtggtgtgt ccaaccttcc tgtctgcttc agcctctggc
     2221 tgcacttaag tgttctcatt cacttttaaa tgagccagtc tttttttttt tttctttttt
     2281 ttaaggtcac tggccttatt tccttgattg taaatagtta tgtgtttatt ttaaaggtgg
     2341 tggagggagg gcggggacat aaatttgttg catgagtaaa tgtgtcagat cttctctata
     2401 agcatgcatc ctctgactga cagggcactg ttgaaaacaa gcaccttgat aacccaaacc
     2461 cttcagaaag ccacagcgct tcagtgctgt gctgatgaag tcacggcgta aaatagccac
     2521 agagctttgg ttctgtactg atgaagccac agcgtgaaag cttggcttta tctttgtgta
     2581 ggacttcaga gctgagagta gaacatagca ctggggccac tgttggggaa atgcaaacta
     2641 aataaacatt ggactcttca a
//
