LOCUS       NM_025948               3464 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus LSM14A mRNA processing body assembly factor (Lsm14a),
            transcript variant 1, mRNA.
ACCESSION   NM_025948 XM_620592
VERSION     NM_025948.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3464)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3464)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3464)
  AUTHORS   Liu,T.T., Yang,Q., Li,M., Zhong,B., Ran,Y., Liu,L.L., Yang,Y.,
            Wang,Y.Y. and Shu,H.B.
  TITLE     LSm14A Plays a Critical Role in Antiviral Immune Responses by
            Regulating MITA Level in a Cell-Specific Manner
  JOURNAL   J Immunol 196 (12), 5101-5111 (2016)
   PUBMED   27183626
  REMARK    GeneRIF: results suggest that LSm14A plays an important role in
            antiviral innate and adaptive immune responses by modulating MITA
            level in a cell type-specific manner
REFERENCE   4  (bases 1 to 3464)
  AUTHORS   Li,Y., Chen,R., Zhou,Q., Xu,Z., Li,C., Wang,S., Mao,A., Zhang,X.,
            He,W. and Shu,H.B.
  TITLE     LSm14A is a processing body-associated sensor of viral nucleic
            acids that initiates cellular antiviral response in the early phase
            of viral infection
  JOURNAL   Proc Natl Acad Sci U S A 109 (29), 11770-11775 (2012)
   PUBMED   22745163
REFERENCE   5  (bases 1 to 3464)
  AUTHORS   Noordermeer,D., de Wit,E., Klous,P., van de Werken,H., Simonis,M.,
            Lopez-Jones,M., Eussen,B., de Klein,A., Singer,R.H. and de Laat,W.
  TITLE     Variegated gene expression caused by cell-specific long-range DNA
            interactions
  JOURNAL   Nat Cell Biol 13 (8), 944-951 (2011)
   PUBMED   21706023
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3464)
  AUTHORS   McLachlan,S., Lee,S.M., Steele,T.M., Hawthorne,P.L., Zapala,M.A.,
            Eskin,E., Schork,N.J., Anderson,G.J. and Vulpe,C.D.
  TITLE     In silico QTL mapping of basal liver iron levels in inbred mouse
            strains
  JOURNAL   Physiol Genomics 43 (3), 136-147 (2011)
   PUBMED   21062905
REFERENCE   7  (bases 1 to 3464)
  AUTHORS   Hu,J., Wang,F., Zhu,X., Yuan,Y., Ding,M. and Gao,S.
  TITLE     Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing
            components and its dominant-negative mutant caused two-cell-stage
            embryonic arrest
  JOURNAL   Dev Dyn 239 (2), 407-424 (2010)
   PUBMED   20014101
REFERENCE   8  (bases 1 to 3464)
  AUTHORS   van Dijk,T.B., Gillemans,N., Stein,C., Fanis,P., Demmers,J., van de
            Corput,M., Essers,J., Grosveld,F., Bauer,U.M. and Philipsen,S.
  TITLE     Friend of Prmt1, a novel chromatin target of protein arginine
            methyltransferases
  JOURNAL   Mol Cell Biol 30 (1), 260-272 (2010)
   PUBMED   19858291
REFERENCE   9  (bases 1 to 3464)
  AUTHORS   Pepling,M.E., Wilhelm,J.E., O'Hara,A.L., Gephardt,G.W. and
            Spradling,A.C.
  TITLE     Mouse oocytes within germ cell cysts and primordial follicles
            contain a Balbiani body
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 187-192 (2007)
   PUBMED   17189423
REFERENCE   10 (bases 1 to 3464)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX539342.9 and BX537302.12.
            
            On Feb 8, 2018 this sequence version replaced NM_025948.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031521.1, SRR7974084.19413.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX539342.9         40306-40653         c
            349-512             BX539342.9         26177-26340         c
            513-642             BX539342.9         22003-22132         c
            643-765             BX539342.9         16563-16685         c
            766-942             BX539342.9         8714-8890           c
            943-1005            BX539342.9         8382-8444           c
            1006-1188           BX539342.9         4613-4795           c
            1189-1360           BX539342.9         4338-4509           c
            1361-1592           BX539342.9         2234-2465           c
            1593-1649           BX537302.12        211267-211323       c
            1650-3464           BX537302.12        207485-209299       c
FEATURES             Location/Qualifiers
     source          1..3464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.56 cM"
     gene            1..3464
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="LSM14A mRNA processing body assembly factor"
                     /db_xref="GeneID:67070"
                     /db_xref="MGI:MGI:1914320"
     exon            1..348
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1616
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein LSM14 homolog A; RNA-associated protein 55A"
                     /codon_start=1
                     /product="protein LSM14 homolog A isoform 1"
                     /protein_id="NP_080224.1"
                     /db_xref="CCDS:CCDS21140.1"
                     /db_xref="GeneID:67070"
                     /db_xref="MGI:MGI:1914320"
                     /translation="MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSF
                     GTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSS
                     SSFQSVGSYGPFGRMPAYSQFSPSTLVGQQFGAVGVAGNSLTSFGTEASNSGTLSQSN
                     AVGSAFTQDTRSVKPQLAQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAPVGRRSPV
                     PARPLPPTSQKAIDNQEHRRAEVHKVPRPENEQLRNDKRQVVPGVPSAPRRGRGGHRG
                     GRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGE
                     DKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNA
                     ETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGSGRGGTFTAPRGFRAGFRGARGGREFA
                     DFEYRKTTAFGP"
     exon            349..512
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            513..642
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            643..765
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            766..942
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1005
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1188
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1360
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1592
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1649
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..3464
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="hexamer: AATAAA"
     polyA_site      2367
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="major polyA site"
     regulatory      2866..2871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="hexamer: AATAAA"
     polyA_site      2902
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="major polyA site"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="hexamer: AATAAA"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
                     /note="hexamer: AATAAA"
     polyA_site      2948
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
     polyA_site      2962
                     /gene="Lsm14a"
                     /gene_synonym="2700023B17Rik; mRAP55A; Tral"
ORIGIN      
        1 atgccctgcg ccgccgccgc tgctgccgcc gccgccgccg ccgcgccgcg gtttgagggc
       61 gggaggctgg gggagggtaa gcggagccgg cgcggccgcc atgttggttc tgaggcggct
      121 gctgtgaggc gccgacggag ggagcgagcg agcgggcggg cgggcggagc ggcgggcgca
      181 gcgcgggatc tgactgagtg cgagcggcgg gcgacggcgg cggcgccatg agcgggggca
      241 ccccttacat cggcagcaag atcagcctca tctccaaggc ggagatccgc tacgagggca
      301 tcctctacac catcgacacc gagaactcca cggtagccct cgccaaagtt cgatccttcg
      361 gtacagaaga cagaccaaca gatcgtccaa taccgcctcg agatgaagtc tttgaatata
      421 ttatattccg cgggagtgat attaaagacc tcactgtttg tgagccaccc aaaccacaat
      481 gttctttgcc tcaggacccg gctattgttc agtcttcact aggttcgtcg tcatcttcat
      541 tccagtcggt gggttcctat ggaccttttg gcaggatgcc agcatacagt cagttcagtc
      601 caagtacatt agttgggcag cagtttggtg ctgttggtgt tgctggaaac tctttgacat
      661 cctttggaac agaagcatca aatagtggta ccttatccca gagcaatgca gttggttcgg
      721 ccttcacaca agacacaaga tctgtaaaac cacagctagc ccaaggtcga tcaagccctc
      781 agttagaccc tttgagaaaa agtccaacca tggaacaagc agtacagacc gcctcggccc
      841 acttacctgc tccagcacct gttgggagaa ggagccctgt accagccagg cctttgccac
      901 ctaccagcca gaaagcaata gacaaccaag agcacaggcg agctgaagta cacaaagtcc
      961 caaggccaga aaatgagcaa ctcagaaatg acaagaggca agtagttcct ggagttcctt
     1021 ctgctccaag aagaggacgt gggggtcatc gaggtggcag gggaagattt ggtatccgtc
     1081 gagatggtcc aatgaaattt gagaaagact ttgactttga aagtgcaaat gcacaattta
     1141 acaaggagga aattgacaga gagtttcata ataaacttaa actgaaagaa gataaacttg
     1201 agaaacaaga gaaacctgta aacggtgaag acaaaggaga ctcaggagtc gacactcaga
     1261 acagtgaagg gaatgctgat gaggaagatc cccttgggcc caactgctac tatgacaaga
     1321 ccaagtcctt ctttgacaac atctcttgtg atgataatag agaaaggaga ccaacttggg
     1381 ctgaagaaag aaggttaaat gctgaaactt ttggcatccc gcttcgtcca aaccgtggcc
     1441 gtggaggcta ccgaggcaga ggaggccttg gcttccgtgg tggcagaggg cgtggtagtg
     1501 gccgaggagg aaccttcact gcccctcgag ggtttcgtgc tggattcaga ggcgctcgtg
     1561 gtggtaggga gtttgcagac tttgaatata ggaaaaccac ggcttttgga ccctaaaagg
     1621 tctggattgg tcatactgct ttctgaaaga aagacaacaa agttgctgca tagtctacaa
     1681 acaagtcttt gaaaataggt gactcctagc tcttcatggt cctggaaagt gctttcagtc
     1741 tttgtgaaga atgaagaagt gaagttgctg tcttgcctgt caccagcact gggttttgtc
     1801 tgttttctgc ttcatttcaa agctacactg cagttgcttt ggggcaggaa ggctcgtctt
     1861 aaaacacaag tataagtgta tgtggagtag cagatggttg tgattccttg tttagagttg
     1921 aactaaagcc agctaaatgg aactgctaag tattttttca tcactgaaag gattttctta
     1981 tcactaatta attgtattcg gcaattactt ccaattgcct gcagataggc cgtgatactg
     2041 tgttttgagc cacagaaggt tttgtgcgtg tgtgtgtgta tgtatgtgtg tgtgcgcgcg
     2101 cgcgtgtatg tgcgtgtctt tttctttttg gagatcctat aatatgaggt agcttatttc
     2161 gacacttaat tagggtgctg gatggtagag aattttgtca gtcaactatg tacacacagg
     2221 taaatactgt ttcttaggca aaggtaactt ttttatatag ttgtaaaatt ccattatatt
     2281 ccattgccaa agaaacatta agaactttgt atagctgtat aaaaagcaac taatttttta
     2341 aagaataaac gttttaaagt cagcaaacat acgtgtcctt gcagaagtca gtgtgctgag
     2401 gagcagggat atgggtgggt ctttcccctt gctttccagg cttaaggttt ttgatttcct
     2461 ttgtactgtt tggactaaag tgaagatttg ataactttat tccattatct aaaaagcata
     2521 aattattcat gcatagtgta tggacttcgt tttgtagcaa atcacaggat ttgttcaaat
     2581 aacagatctt ttaagtgtat gaatgtaaat aatcatagat gagagtgtac ctcgctgtat
     2641 tttcaaataa gtaacctttt taagacatta aaactcaata tatcagttga cccattcctc
     2701 ctgctatgcc tggaattctg ttgtggtaac cgctgactcc tgttttatgt caaaaagatg
     2761 gagttttcag aatcctctgg cacctgtaaa acatcactaa catagtatgc gggcctgtgg
     2821 ccttctaatg actctgtaca cggttgttgc taactgtaaa ttactaataa atcttttttg
     2881 atatttaaac tatagtgaaa aagatctggc cactttgtgt ttttaataaa ggccatggaa
     2941 taaagagatc caaagatttc aatattttta actattttgg tttttgttaa ctttctcact
     3001 aaaacattca gtaatgataa aggcatgtga aactgcactg taggagaatt ggactgctta
     3061 aggatggctg attattttaa attttatatc ttttgtatag agcaacaaga aaatatctta
     3121 taatttggtt tcattgttga gatccagagc ttgacagctg tcgtttcctg tgcgcctgca
     3181 tgtgaacaac taaccctttt gtagggttca cagatcatga gattgaacac atgtttaggc
     3241 atgttaagca tcagagcacg tgctgtgctc acaacacttg taggctgaga tgtcccagcc
     3301 cagttctcta cgctcgtaca aggcgaactt gcactttttc tcagccccct gggtcactga
     3361 ctggggcatg cattgtccca ataataactg gcagcatggt ggccccactg tgcatcttcc
     3421 aatcgcaagg cttttatcct aaaacagaat aaaactcttc aatg
//
