LOCUS       NM_028185               6453 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus U7 snRNP-specific Sm-like protein LSM11 (Lsm11), mRNA.
ACCESSION   NM_028185
VERSION     NM_028185.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6453)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6453)
  AUTHORS   Ruepp,M.D., Vivarelli,S., Pillai,R.S., Kleinschmidt,N.,
            Azzouz,T.N., Barabino,S.M. and Schumperli,D.
  TITLE     The 68 kDa subunit of mammalian cleavage factor I interacts with
            the U7 small nuclear ribonucleoprotein and participates in 3'-end
            processing of animal histone mRNAs
  JOURNAL   Nucleic Acids Res 38 (21), 7637-7650 (2010)
   PUBMED   20634199
REFERENCE   4  (bases 1 to 6453)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 6453)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   6  (bases 1 to 6453)
  AUTHORS   Azzouz,T.N., Pillai,R.S., Dapp,C., Chari,A., Meister,G.,
            Kambach,C., Fischer,U. and Schumperli,D.
  TITLE     Toward an assembly line for U7 snRNPs: interactions of U7-specific
            Lsm proteins with PRMT5 and SMN complexes
  JOURNAL   J Biol Chem 280 (41), 34435-34440 (2005)
   PUBMED   16087681
REFERENCE   7  (bases 1 to 6453)
  AUTHORS   Azzouz,T.N., Gruber,A. and Schumperli,D.
  TITLE     U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100
            kDa zinc finger processing factor (ZFP100) and a ZFP100-independent
            function in histone RNA 3' end processing
  JOURNAL   Nucleic Acids Res 33 (7), 2106-2117 (2005)
   PUBMED   15824063
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6453)
  AUTHORS   Pillai,R.S., Grimmler,M., Meister,G., Will,C.L., Luhrmann,R.,
            Fischer,U. and Schumperli,D.
  TITLE     Unique Sm core structure of U7 snRNPs: assembly by a specialized
            SMN complex and the role of a new component, Lsm11, in histone RNA
            processing
  JOURNAL   Genes Dev 17 (18), 2321-2333 (2003)
   PUBMED   12975319
  REMARK    GeneRIF: Specifies the assembly of the U7 Sm core, also fulfills an
            important role in U7 snRNP-mediated histone mRNA processing.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB650044.1, AK143661.1 and AL645948.10.
            
            On Sep 23, 2006 this sequence version replaced NM_028185.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143661.1, SRR10662772.2585176.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               BB650044.1         2-584
            584-1394            AK143661.1         577-1387
            1395-6453           AL645948.10        152507-157565       c
FEATURES             Location/Qualifiers
     source          1..6453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.46 cM"
     gene            1..6453
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /note="U7 snRNP-specific Sm-like protein LSM11"
                     /db_xref="GeneID:72290"
                     /db_xref="MGI:MGI:1919540"
     exon            1..474
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1109
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /codon_start=1
                     /product="U7 snRNA-associated Sm-like protein LSm11"
                     /protein_id="NP_082461.1"
                     /db_xref="CCDS:CCDS36131.1"
                     /db_xref="GeneID:72290"
                     /db_xref="MGI:MGI:1919540"
                     /translation="MEEREWGARSARAGSPASPPSPRLDVSSYSFDPLLALYAPRLPP
                     IPYPNAPCFNNVAEYESFLKGGRTGRGRARGTGEPASAGTSTGTSTGAGSSSRARRRA
                     APTPDPERIQRLRRLMVVKEDTDGTAGARRQGPGRSKKAPRNVLTRMPLHEGSPLGEL
                     HRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERD
                     SSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKVASVWGRGDTDRSSH
                     RRSRSVPSSLQASAREESRSELSGRTTRTEGSSVGGTFSRATTLSRGQSRKKKRKPKV
                     DYQQVFTRHINQIFIRGENVLLVHLAQ"
     exon            475..614
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            615..698
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..6453
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /note="major polyA site"
     regulatory      6434..6439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6453
                     /gene="Lsm11"
                     /gene_synonym="2210404M20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttctgcttgc gggcctttca aacatggagg agcgcgagtg gggggcgagg tcggctcgcg
       61 ccggcagccc agccagcccg cccagcccgc ggctggacgt cagctcctac agcttcgacc
      121 cgctgctggc cttgtacgca cctcgcctgc cgcccattcc ctaccccaac gcgccctgct
      181 tcaacaacgt ggcggagtac gagagcttcc tgaagggcgg gcgcaccggg cgcggtcggg
      241 ctcggggcac gggggagccg gcctcggcgg gaacctccac cggaacctcc acgggagccg
      301 ggagctcgtc cagggcccgt cgccgcgccg cgcccacccc ggatcccgag cgcatccagc
      361 gcctgcgccg gctcatggtg gtcaaggagg acacggacgg cacggccgga gcgcgacgcc
      421 agggcccggg gcgcagcaag aaggcacccc gcaatgtgct tacgcggatg cctttgcatg
      481 aaggtagccc tctgggtgaa ctgcaccgct gcatccgaga gggagtcaag gtgaacgttc
      541 acatccgcac cttcaaggga ctccgcggtg tctgcactgg cttcctcgtc gccttcgaca
      601 agttctggaa tatggccctc actgacgtgg atgagaccta ccgtaaacct gtcttaggaa
      661 aagcatacga acgggattct tcgctgactc tcactaggct atttgatcgg ctgaaacttc
      721 aagattcctc caaaaaggaa gcggattcca aatctgcagt tgaggactcc accctgtctc
      781 gatactccca aacatctact tggaaggtgg cttcggtatg gggacgaggg gacactgacc
      841 ggagctcaca caggcgctcc cgctccgtcc cttcttccct gcaggcatct gcaagggagg
      901 agtccaggtc tgagctgtca gggaggacta cacggacaga agggtccagt gtgggaggta
      961 ccttctccag ggccaccacc ctttcacggg gccagtcccg taagaaaaag cgaaagccca
     1021 aggtggatta ccagcaggta ttcactcggc acataaatca gattttcatt cgaggcgaga
     1081 atgtcctgct ggtccatctg gcccagtgag cagctcagcc cacgtgacct ttgggttgta
     1141 gaaataaagt gcatgaactg ttctctgcta tatcctagtc tcccacacag tgcgagtcgg
     1201 agtgagtccc gctggtcctg cccatgcagg gcacagagct ggctcaccct ctggaaggac
     1261 aggtcagcag gactaaccag gcagaagcca ttcacaggac aggctctgac gggctgtcac
     1321 tggctgctcg agtctccagc gtaagcgctt cactttgact tagggtcata gtacgagggg
     1381 aatccactcc gtggaaacct cggaatgtct gagaagggat aatttcattt ctaaaagctc
     1441 tgagcaccgt gagtttgatc tcgagatgat catgtttgag cgatgtaaag tgcccaagat
     1501 cctgcaccca tatcttggaa cttatctttg ttctacatca ttctctcttg atcaagaaat
     1561 gaaatttctt aatccttgaa tattagtaag gtccaggaaa gttaccagct gatggcggag
     1621 tgaagctcag ctcggtggtc gctcagagca gccagtggtc ccctctgctc tgttccctcc
     1681 tcctgtggga agggactcgg aagcttgtct gcccctcacc agaggtggcc tctgcacatg
     1741 gcacaccagc cggggctgta ccgcactcgt ggtggcttgt tgtcctctcg actcctgtgg
     1801 catggtgcta gtgcatgtga cctgtgctgt tgtcacccca tgtgttgtgt gtgacctgtc
     1861 ctcgtgtgcc cttggtgtct gacttcagag agtcctacat gaactcagta atccacatct
     1921 ctcacacagc tgagagtcac ctttccaggc gggcctggcc ttgtgtagaa agtctctggg
     1981 aatggtgtta cgtgaaagag ggattcccgt gtcaagccag tgagggtctt agaaagaagg
     2041 acgggtgtgt cccaagggca cttgactccc gtttgtgctt gagtatcagg aataccaaag
     2101 ggcccagggt gctcctactt gaattatctc actgtctgct tttcaatcac tagtacagaa
     2161 tgggctgcat tttgacatag actgttaggc accattgact tataaagttt tgtttatagt
     2221 tgctctatct cagataactt atgttcaaaa ggagaatgaa gccgggcatg gtggcgcatg
     2281 cctttaatcc cagcgcttgg aggcagaggc aggtggattt ctgagttcga ggccagcctg
     2341 gtctacaaag tgagttccag gacagccagg gctccacaga gaaaccctgt ctcggggaaa
     2401 aaaaaaaaaa gagagagaga gagagagaga gagaatgaga agtagctagc tagttcaaat
     2461 gtatatgtgt gtgtatgcat agagcatctc ccctgccggg tgtgtgaata acattgaagc
     2521 cctctgagaa agcagggcaa atagggtgta aggggcttgg tttttctgtt agcttggacc
     2581 actgcctcat cagacaatat cagcagatgt gcctcagttt ccccatcaga cacctacctc
     2641 accagggcat tgtggcagaa ttttaggaag gcattgtaca gcctctaagc atatctaagt
     2701 gccatgaata cattttccct actctatagc atagctctgt aaaacttgtc ctgtgagcga
     2761 ggcaggtgct atctgagaga gggatcttgc agctgtcatt tctggtcttg tagccttcat
     2821 cagaggctgt tttccatgat ctggtccttc ctccagaaag aagcaggagt tctcagagga
     2881 acacgtcctt ccatccagga gaaagtgact ttctgtctgc ggctgctcca catcccgggc
     2941 ctgcttttca agggtatctg ttctgatact gaagggagag tatgcatcta aaaacagcac
     3001 tgttccccaa gggggtgttc tgggcttctc tctcttctca ctttacctgt ttttatttct
     3061 gcttgtatct aagtgtgaag gcagggcagg tacactgagt ctggaagctc tgggtgaggc
     3121 tcggagcttg aagctctttg atcctgaagt ttgaattccc ctctgcctcc cggcctgggc
     3181 ttgttctcag gtcagccgct gctttgttca ctatcagtct ggagtgactc tatctccagc
     3241 agtgctccct gagtggcagt gttccctcat ccaccctgtt gccccttagc tagaagctgt
     3301 aatggatgct cttttcctcc gattatgtag aaatgtgcat tcaaaaggaa tagaacgaat
     3361 ttctgtcatc ccggtgaccc tcctggtgcc gggctcttgt tgtcataaag ttctcccata
     3421 tttctataag gatggattta taattttccc ctcaacatgg caactctctc tgtgaaaatt
     3481 taaattgtgt gtgttctatc tttagatccc ctccatttat ttgtttaatt tgggtggtga
     3541 ttctgaaatg aatactctct aggaaatgtg caatttcatg gtaattattt tttagaaaag
     3601 tcaatttaat aaattatcgc ctttagcatt gtaacagttt tcaaaaataa agaaaagtag
     3661 gtcctaatga tgtattgctt ccccgaaatg gtatcacaca ggtcatccat gaatcgctgt
     3721 agtggctagg ggtatgtggg actgcggcac tggactgggt gcttcatggt gggccctgtg
     3781 ctctgttaat gagtccctgg catggatgga tgaatacctg agtcaccagc tgaagtgtcc
     3841 cttatgagga aagaagaggc cagggactag aagatgcacc cctttcctcc tgggagcccc
     3901 acgcttcagg agtagactag agccacctca cttgtgttcc gtggggttac atttgcttaa
     3961 ggatacacct tactttttaa taaatggttt tgattgttca aactaatttc tagctacctg
     4021 aataattcac agattatagc ttatttttaa ttaatttatt tattttgaaa cagtttcact
     4081 gtgtctgcct gactggtctg aaactcacta agtaaaccag gctagtttca aacacagatc
     4141 tgcctgcctc tgcctgccaa tgctccaact gaagaggcga cctctcaccc tgtggctccg
     4201 ccgttaagag tgaccagctt agccacagtt ctggtgctca gcttgaagac aagtcacagg
     4261 tgggcaagta tcactgcctg aacagggctg ttaaaggtcc atgctcaaat acaagggaga
     4321 caacagatag gacaggacag ggctctgggt gctgtccagg gactaaggaa tacagctaaa
     4381 taaaccaagg gggctaggcc cagtcagcca ttgtacagag gcccagattt ctgtatgtgt
     4441 cgtggtcaat ggctgggttg acagagtggt ctgcctgttt gttgtctgtg ctcagcttgc
     4501 agaagctgcc agctgtgctc acaccaccac ctgggacaac cactcgttgg tcaagttcag
     4561 acaccatcca tggaggttgc aggaaagctg gggaaggtta tgagtgggaa tactgtttcg
     4621 aaagtatcgt gcattaaatg ggcagtgtta atgtagaacc agggttctac cacatgcaag
     4681 tctgtgtcca cagagccgtt cttgaactcc gtatcagtac agctttcacc tgggttgtcc
     4741 gttgtagtgt ctgggaagct tgagggttcc cttcttagga ccagcgggtg gtttgtgaaa
     4801 tgcttagctg gttagcatcc gaggtgaggg tctgaaggag tctctctgtc ttcttctttc
     4861 tttgcctgat gcacatcaag gtagagtgca ttccggtgtg ggtgccaatg aactagctgc
     4921 gagctgctgt cagagtggga gcagactcat cagccttggc agagaaagag tgcccttcag
     4981 gctgtcaggt cacgagctcc gagctgccct tagtccttgt cagcctcaca gaggtctgcg
     5041 cccgacactt ctgccctttg agacaaaaga aacaggccca gcacgagtgg aagtgggtgt
     5101 ctgtgtttct gtttgcactg tttctgtgac agccacccag gcaaaatcat gaaatacact
     5161 cggttctgta aattgcttct ttaaatgtcc cgtagattct tcctgtagga aaacgttaca
     5221 agtattcaaa gacagctagc tgtcactggt gctcccccca aagcgtttca cccccttctg
     5281 tgcatcttag gaatgaaatg gttgctgtgt gcaggtcagg ttaatggaag aacgagtctg
     5341 gtggtatagc gtggtttgag agatgtcttt cagttttctt ttcctgcatc atacctggaa
     5401 tgcatgcagc ctgctgttgg taccctgctc acctgtgtct ttcttaccca ggaggcttct
     5461 ctcagtggtt ggaagtaaaa ccatctcaat gggcctatac aggaaaggct gttaatttaa
     5521 gtctgtcgtt actttctggc gaatttaaca taagccttgg gcacctgtca caattttcta
     5581 aagatggttt gggcttcctt acctcccagt gtgaagtgtt tcaaatgtct gtcagttctc
     5641 ttgcacggtc ctaataaaag tgaaagccct ctgtcacgaa acaacatggg tggtccaaag
     5701 atcaggggca agacaactca gcacacctgg aacccttggg gtctttaagc agccgtgtcc
     5761 aggcttcctg agaacaccgg ctgcaaacac gggcatcccg gggaaagctg ggagtttggt
     5821 tcctggcaca ttgcaatcac ttgattgtga gtccttggga gcaaatgcct gatgctgtat
     5881 tttcacaact ctgaggaaac gtctgggaac tcctaggggt aggcgattga ctgcctgatt
     5941 ttagagcagg gagcccggcc ccttcttttg tcttcctggc aggaaagcaa gacagtgagc
     6001 catgccctaa aacactcaca cctgtaaacc cagtccttag gagactgagg caggaggatc
     6061 cctgtgagtt ccaggccagt ctaagctgca gagggaaagc gtctcaaaaa aaaaaaaaaa
     6121 aaccaaacca accaaacaaa caaaaaaaca aagctaaaat gacagcaacc aaaagtaatt
     6181 tgcttattca gtgggcatgt aaagagtctg gccaccatgt cccctctgca ccgtgacttg
     6241 gtgatggctt tgtggacatg gctgaagctg gatgagatgt ccaggagtgc tcatacagcg
     6301 actgacgtaa ggacccccga ccgacctcat cttgttaagt taacggagac ccttcttgtt
     6361 gaaggggcct gctgctagta acctttgcaa tgttctgctt ttaatatgtg tcaaatggga
     6421 gtctggaaac tgtaataaag atgattgtat cca
//
