LOCUS       NM_001411508            3751 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus leucine-rich repeats and transmembrane domains 2
            (Lrtm2), transcript variant 4, mRNA.
ACCESSION   NM_001411508 XM_011241276
VERSION     NM_001411508.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Ichise,M., Sakoori,K., Katayama,K.I., Morimura,N., Yamada,K.,
            Ozawa,H., Matsunaga,H., Hatayama,M. and Aruga,J.
  TITLE     Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein
            Sorting in the Striatal Projection System and Its Deficiency Causes
            Disturbances in Motor Responses and Monoamine Dynamics
  JOURNAL   Front Mol Neurosci 15, 856315 (2022)
   PUBMED   35615067
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115816.9.
            
            On Aug 26, 2022 this sequence version replaced XM_011241276.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.313814.1,
                                           SRR17784650.1084213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC115816.9         171468-171767       c
            301-445             AC115816.9         166794-166938       c
            446-653             AC115816.9         165174-165381       c
            654-782             AC115816.9         164622-164750       c
            783-1373            AC115816.9         161394-161984       c
            1374-3751           AC115816.9         156106-158483       c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.73 cM"
     gene            1..3751
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /note="leucine-rich repeats and transmembrane domains 2"
                     /db_xref="GeneID:211187"
                     /db_xref="MGI:MGI:2141485"
     exon            1..300
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     exon            301..445
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     exon            446..653
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     exon            654..782
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     CDS             716..1828
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /note="leucine-rich repeat and transmembrane
                     domain-containing protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and transmembrane
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001398437.1"
                     /db_xref="GeneID:211187"
                     /db_xref="MGI:MGI:2141485"
                     /translation="MLAPGGGPEQRSKLVLQWRQVSWITCWIALCAVEVIPACPFSCT
                     CDSRSLEVDCSGLGLTTVPPDVPAATQSLLLLNNKLSALPSWAFANLSNLQRLDLSNN
                     FLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSINGLAQLPPGLF
                     DGLLALRSLSLRSNRLQSLDRLTFEPLASLQLLQVGDNPWECDCNLREFKHWLEWFSY
                     RGGRLDQLACTLPKELRGKDMRAVPMEMFNYCSQLEDENNSAGLDAPGPPCTKASPEP
                     PKPKPGAEPEPEPSTACPQKQRYRPVSVRRAIGTVIIAGVVCGIVCIMMVVAAAYGCI
                     YASLMAKYHRELKKRQPLMGDPEGEHEDQKQISSVA"
     exon            783..1373
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..3751
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /note="hexamer: AATAAA"
     polyA_site      3751
                     /gene="Lrtm2"
                     /gene_synonym="A230084J22"
                     /note="major polyA site"
ORIGIN      
        1 actccgctgc gcgctctcct ccctctgctt gcttgctgtt gagcacgcgc gctctgatcc
       61 ttctacctct ccccctcttc ggtctgtctt cctcccgccc tccctctttc gcttcagttt
      121 gtcgctgacc ccgcagcccc ctccccggca gcggcagctc agcctgcggg tccgcctcct
      181 tcacaggcgc tgcccagtct cccgctgccc tgaaccagac cggacatccc tgcgttctgc
      241 ctgccaagct gcccgtgtgt ccggctacct ggtctgagca tcaggtcccg gtgcaaaaag
      301 ggcccctgca gggtgacagc cctgaggaag tgggtaaaca gcctgactca gaagcctgtg
      361 acccaccctg actgaccatg taaccttggc aagctgttat gatatctgtg catttgggtg
      421 ctgcagccgg ctcgctattt aacaggtcgt tgtgtctctc aggccagcag cagaagagca
      481 ggaagccctg acctgcggga gttataaatc ggccagctgg cagaagacca agcttgtaat
      541 tcacctcaag gtgatagtgg gctcagaggc agggggtggt gcagcagctc actccctacc
      601 tgtcagcagc agctacaagg gaagggcctc gcctctgcct ccccacagct atggactgac
      661 acgtggcaca tgctgagggg ctctctccag agctgcggag agtgtgggtt tcaccatgtt
      721 ggcaccaggc ggtggcccag agcagaggag caagcttgtc ctgcaatgga ggcaggtctc
      781 ctggatcacc tgctggattg ccctgtgtgc tgtggaggtg atccctgcct gccccttctc
      841 ctgcacatgt gacagtcgca gcttggaggt ggactgcagt ggcctgggtc tcaccactgt
      901 acccccggat gtgcccgcgg ccacccaaag ccttttgctc ctgaacaata agctgagtgc
      961 cctaccaagc tgggcattcg ccaacctgtc caacctgcag cgactggacc tgtccaacaa
     1021 ctttcttgac cagctccccc ggtccatttt cgaggacttg gtcaatctga cagagctcca
     1081 gcttcggaat aacagcatca ggaccctgga cagggacctg ctccagcact ccccactact
     1141 tagacatctg gatttgtcta tcaacggctt ggcccagctg cccccggggc tttttgatgg
     1201 gctcctggct ctgcgctcct tgtccctccg ctccaatcgt ctgcagagcc tggaccggct
     1261 gacgttcgag cccctggcaa gcctgcagct gcttcaggtt ggggacaacc cgtgggagtg
     1321 tgactgcaac cttcgggaat tcaaacactg gctggagtgg ttctcctaca gagggggtcg
     1381 cctggatcag cttgcctgta ccctacccaa ggagctaagg gggaaggaca tgcgtgcggt
     1441 ccccatggag atgtttaact actgttccca gctagaggat gagaacaact ctgctgggct
     1501 agatgctcca ggaccaccct gcaccaaggc cagcccggag cctcctaaac ctaagcctgg
     1561 ggctgagcct gagcccgaac ccagcactgc ctgcccacag aagcagaggt accggcccgt
     1621 gagtgtgcgg cgagccattg gcacagtgat catcgccggg gtcgtgtgtg gcattgtctg
     1681 catcatgatg gtggtggccg ctgcttacgg ctgcatctac gcatctctca tggccaagta
     1741 ccaccgtgag ctcaagaagc gccagccgct gatgggggac cctgagggtg agcatgaaga
     1801 tcagaagcag atctcgtctg tggcatgaga gctgtctgtc tggcccaggt aggacagcaa
     1861 ggagactcca tgggactgct accaaaaggg ctgcccttcc ctccatcaca ggccccgtct
     1921 cagcctgaca ctgggactgc ctccctcagc tccctcgtcc caatctcttt ccaagtttcc
     1981 cagaggcttc cctcgggcca aagattcccg tggaaggtct tctctgggcc tcttgtcttt
     2041 ggaacccctg agcctcgctg taggcttctg gccacaggga ggaaagaacc tactctagag
     2101 acatcatctg cactgagcac ttccctcctg cccagggctg ccagagctgg tgactctccc
     2161 tacctctttc tcattcccac ttcagtctgc attagggcct gggagggagg gacaggaggc
     2221 ccaaaggtag atttctgtga ctccttttaa agccagaaag atgtctcaag tcttttgcag
     2281 tgtgaagctt gtccagctct tagccaatgt gaaaccaccc cagtcctgtg atctgggtcc
     2341 aatgtttaga aaaaccaaag tggctataat gtcccccttg ggtggatgtc attatgtccc
     2401 tttattggct atagactcct ctgactacat tgctccaggt ttacgaattc tatccatact
     2461 ttttgttcta gcgtgaggtt ttgagacagg gccttactct atatactaat tcctctgtca
     2521 ggcagggcat caaagtcaca cacacacaca cacacacaca cagacacaca cacacatcat
     2581 gagaacttgg ggcagaggcc tgctatcccc tgagcccaga ggccacagcc cctcttactt
     2641 cctgactaca gtcttcccat gtcatcaggg gttgggtcct ggacgacaac acagggatcc
     2701 tttgagaccc tcttaagtgg gccaaagtat gcagctggag aaattgcatt gtcctggcag
     2761 ccctagcacc tctcttgcta ggtttaccag aagggtgcac atatgcatga cgggttccag
     2821 gcgtctgaga gctctgttgc agacccccgg gcatgcctag gaacctcttc cctgcaggtt
     2881 ccaggtacac gcagcagttt ctacccctgc agcctggctt ctcctgtctc ctctgtcatc
     2941 tgcatcattt gtgcatgacc tcagagactg ggtctgggct gtgctctgag tttggtgttt
     3001 caccttaagg aaagcagatg tcaggcagta agtccttgag aaggctggct gccttcaaca
     3061 catccccgac agactgcagg aacagggaca ggatggctac attctgttca gagtccttga
     3121 cggtggggct ttctttccca ggggttcatc ggctctgcct ggtttcctgg gagtgtgcaa
     3181 tcgcacctgg actacccagg ctaaaaaaat ggctgcagtc ctatctggtt tggagattct
     3241 tgcccctggg ctgtgcacat tttcaaggtc actgctctct gttctaaact gtcccctcct
     3301 tagagactag atacctctgt aggagatgcc agactgatac cttaccctgg gaaggtcttg
     3361 gtagtagcca ggaacacact taggcactga ctatacacct atgagggcct cagggcagcc
     3421 tctcagccct ccttcttgtc ctcggccacc tattcgacta gcaggggtga gtactggaag
     3481 tctcagaaga gcctccaagg ttgttctctg gcaggtagac agagagcacc ggctgctgtt
     3541 caggatcaca ggatcctcta ggctgggcca cagtcttcct tcctcttttg actggtgggc
     3601 caatcccaga gctgggattt tctaagggcc tgggggaggg agggtgttgt cagtggtgat
     3661 atctttagcc tgagacagaa gatttttaaa ggcaaaatta tatttctggt ttgtcgtttc
     3721 agaagaccaa taaagactat tttcctatgt a
//
