LOCUS       NM_176920               7318 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine-rich repeats and transmembrane domains 1
            (Lrtm1), mRNA.
ACCESSION   NM_176920
VERSION     NM_176920.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7318)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   2  (bases 1 to 7318)
  AUTHORS   Nishihara,H., Kobayashi,N., Kimura-Yoshida,C., Yan,K., Bormuth,O.,
            Ding,Q., Nakanishi,A., Sasaki,T., Hirakawa,M., Sumiyama,K.,
            Furuta,Y., Tarabykin,V., Matsuo,I. and Okada,N.
  TITLE     Coordinately Co-opted Multiple Transposable Elements Constitute an
            Enhancer for wnt5a Expression in the Mammalian Secondary Palate
  JOURNAL   PLoS Genet 12 (10), e1006380 (2016)
   PUBMED   27741242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7318)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   4  (bases 1 to 7318)
  AUTHORS   LopezJimenez,N., Gerber,S., Popovici,V., Mirza,S., Copren,K.,
            Ta,L., Shaw,G.M., Trueb,B. and Slavotinek,A.M.
  TITLE     Examination of FGFRL1 as a candidate gene for diaphragmatic defects
            at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced
            expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm
  JOURNAL   Hum Genet 127 (3), 325-336 (2010)
   PUBMED   20024584
  REMARK    GeneRIF: Reduced expression of Tpm3, sarcomere genes and Lrtm1 in
            the diaphragm of mice with diaphragmatic defects.
REFERENCE   5  (bases 1 to 7318)
  AUTHORS   Zhang,D., Stumpo,D.J., Graves,J.P., DeGraff,L.M., Grissom,S.F.,
            Collins,J.B., Li,L., Zeldin,D.C. and Blackshear,P.J.
  TITLE     Identification of potential target genes for RFX4_v3, a
            transcription factor critical for brain development
  JOURNAL   J Neurochem 98 (3), 860-875 (2006)
   PUBMED   16893423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA244770.1, BC099587.1, AC115760.9 and AK052894.1.
            
            On Dec 8, 2009 this sequence version replaced NM_176920.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.16744.1,
                                           SRR10223971.14007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AA244770.1         2-203
            203-1585            BC099587.1         1-1383
            1586-6594           AC115760.9         77619-82627
            6595-7318           AK052894.1         3396-4119
FEATURES             Location/Qualifiers
     source          1..7318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.8 cM"
     gene            1..7318
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /note="leucine-rich repeats and transmembrane domains 1"
                     /db_xref="GeneID:319476"
                     /db_xref="MGI:MGI:2442106"
     exon            1..402
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..1430
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /note="leucine-rich repeat and transmembrane
                     domain-containing protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and transmembrane
                     domain-containing protein 1 precursor"
                     /protein_id="NP_795894.1"
                     /db_xref="CCDS:CCDS26889.1"
                     /db_xref="GeneID:319476"
                     /db_xref="MGI:MGI:2442106"
                     /translation="MLNEGLCCGAWAMKGTLLLVSSVGLLLPGVGSCPMKCLCHPSSN
                     SVDCSGQGLSKVPRDLPPWTVTLLLQDNRIHWLPALAFQSVSLLSTLNLSNNSLSNLA
                     AEAFYGLPHLRVLNVTQNSLLSIESSFAHALPGLRELDLSSNSLRILPTSLGKPWENL
                     TVFAVQQNHLLHLDRELLEAMPKVRLVLLKDNPWICDCHLLGLKLWLERFTFQGGETD
                     GAICRLPEPWQGKALLSIPHELYQPCSLPSQDLAPSLVQQPGSAPQDAQKSHENSSGQ
                     QDPLECEAKPKPKPTNLRHAVATVVITGVVCGIVCLMMLAAAIYGCTYAAITAQYQGR
                     PLASARKSEKMGSKELMDSSSA"
     exon            403..999
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..7318
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5502..5507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5524
                     /gene="Lrtm1"
                     /gene_synonym="A930016D02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcatgt ctgaatgcta cagctgttca ccaaggtctg accaacattc tttatgtggt
       61 ttgctgtctg aatgagagag gcagagaaga tcctagggag gttgacactt tccaaaaaaa
      121 aaaaaaaaaa aaaaaaaaaa aggaccggac gcaatcaaaa gacccctctt atggagaagg
      181 accacagcag acagagacaa ggggacaggc tgcttaaata agtgacctcc tgaattcagc
      241 aactgttttc tgcactggag aaaagcccat gctggattca gggaaagaga atggaaagct
      301 gggttccaag tctgccgtag cccgggtgtg ttgatctgtg agtcctcagg ccgggatata
      361 tgttgaatga gggtttgtgc tgcggagcct gggccatgaa aggtactctg ctgctggtct
      421 ccagtgtggg tctcctgctc ccaggagtgg gcagctgccc catgaaatgt ttgtgccacc
      481 catcatcaaa ctccgtggac tgcagtggtc aggggctgtc aaaggtcccc cgtgatttac
      541 ccccatggac agttacactg ctcttacaag ataaccggat ccactggctt cctgctcttg
      601 catttcaatc tgtatcactg ctttccacct taaatttatc taacaactct ctttcaaatc
      661 tggctgcaga ggctttctat ggacttccac atttgcgggt tttaaatgta acccaaaatt
      721 ccctgctttc catagaaagc agctttgccc atgcccttcc tgggctcagg gagctagatc
      781 tttcatccaa cagcctcagg atcctcccca cgtctctggg gaagccttgg gagaacctga
      841 ctgtgtttgc tgtgcagcag aaccatcttc tccatctgga tcgtgaactt ctagaggcca
      901 tgcccaaggt gaggctggta cttcttaagg acaacccttg gatttgtgac tgccacttac
      961 tgggtctgaa actctggctg gagagattca cctttcaagg gggagaaaca gatggtgcca
     1021 tctgcaggct gcctgaaccc tggcagggaa aggctctcct ctccattcct cacgaactgt
     1081 accaaccctg ttctctacct tctcaggatt tggcaccctc actagtccag cagcctggtt
     1141 ctgccccgca agatgcccag aagtctcatg agaatagctc aggacagcaa gatcccttgg
     1201 agtgtgaggc caaacccaaa ccaaagccaa ccaacctgcg ccatgctgtg gctactgtgg
     1261 tcatcactgg ggtagtatgt gggatcgtat gtctcatgat gttggcggct gctatctatg
     1321 gatgtaccta tgcagccatc acagcccagt accaagggag acccttggca tcagccagga
     1381 agtctgagaa gatgggaagt aaggaactta tggacagttc atcagcctga gagccttcat
     1441 ttccaaggtc ccctcgatca ctgagggccc ggaagaaata tctgagtgag cttgatgtgt
     1501 tcgatgctcc tgtcccatgt tttatcttcc aaaacaacta aggaaaaaat gtatccaaaa
     1561 aataaaacaa agtactcagt aggaagaagt ttaaatacca tagatataat agacacactc
     1621 atatcttgca actgagaaga tatgacaaga agtctatgtg taggaacaaa aagaagagcg
     1681 acgccatctc ttttaggtac ctgtttctgg attaagctgg attctgcaga gcaataagaa
     1741 ttcggacatg tgtgccaata ggcattttta agagctctgg ggccaccagt tggagtgcct
     1801 gggaattggc tagtgctctt acccgacccg tactggctgc ctcttaattc cagttcatgc
     1861 tagattggta ggatgttgag atgttgcgta tgttacacat ttagtggaaa tgtctgttgg
     1921 ttgggaattt catagctggc cacaagactc agattatatt taattttcta aatcagaaaa
     1981 ccatttgggg ctctctaagc tgcaggggaa gatgaaggtt ccatgtctgg ataatgggac
     2041 tcaggcccgg agcctgggca aggttttgat gtgaaggaac acagagagaa tagtaaacta
     2101 gaatacaggg cagatatcat caagagacca tatccaccaa gcaatgggaa ccttatccta
     2161 gaactctccc agcagggatg gcttttgctt aggctgaatg gtggctgtgt ctctgcatcc
     2221 acatctacat ctgcagtgca cagagggcat ggatttgtac agctacaccc acacataaac
     2281 acccttggag caatcagctt acccactaat gaaatgcagc cgtgtcgggt gggagccagt
     2341 agctgttgat caccacccag attgtatgct caacactctg ggataggaaa taagaaggaa
     2401 gtttgagggg gagtgggagt tactgggggg tgggcgcggg actcgaggca ctggagggca
     2461 gacatcctgg ctagtgcttc agcatggctt taaaaagttc aggtatggct tgcagagtcc
     2521 acagacttag tctgagagag ttgcatgcaa agtgaatttt tataaattga atcatcattt
     2581 gaatgcagca ggggagctcg ctatttaaag gaacctttca tggaatcttt tctgtaatgg
     2641 aaataattgg ctccagattg atgcattttt tttccaaatt tgcatttcta tgctagggtt
     2701 tcttaaagtg gaatatacct atacctactc tttctgttta cactacaggc acattttagg
     2761 attataactc ttttgcacag gaagagagca cagaggagtt aaagacatgt taaaggcaga
     2821 aaatgacaaa tatggggcaa gctgttcctc tagagcccat gacagacatt gctaatcaat
     2881 cccagctctt ttcccagctg agcctcaaat ataccacaga tggtttctta agacagcact
     2941 ataggcaacc agaactaatc aattggagtt ggttcaaagg ataaagcaca tttgccattc
     3001 agggtactgg ctcgacttca cccctcaagg ccatgtaaaa attggtttgg atccccagtc
     3061 agttgtctac tcctcaaccg gaatataaat gggatgtgca catgttggga tggacagctg
     3121 ttgagtgtgc tataagcaat ggaaaccttg tatataccag tgggctaagg gcagactgtc
     3181 attttggagt atcaattcag ctacataatt ttttttaata gcagaagaag tttaaatgtg
     3241 aatggtcaca atgaacccca ttagtgcatg taattaatat gcattaaaaa ttataacgtg
     3301 taagggaaca gcacaccaag atttcccagc aaaggcccac agctgcatgg gctgtcattt
     3361 gccctgacat ctctcttttg tgccaaggta gctcaattca actgtgtgac tgagtttcta
     3421 ttctaaggat gtagcaacta ctttcaaact aaaaaaaaaa aaagcatttc tttccattgt
     3481 cctaactgca cctttttttt tttccttttg gccaaaaaca taatgcgaga ggaaattgag
     3541 aaagttcctt tactcttcct cttgatttgg ccaaatgttc ttcaagctca cgctgttagc
     3601 aggcatggct cactgttctc atgagcattc ctcatagaat tctgacactc gccccgtgga
     3661 gtcttgggca gctagcacat gccctaagaa ctcccaaggc cagcagtaca tacctcctct
     3721 aacaagtgat ttaggactgc aagtgtactc tgccctgtca gtggtttggc gatgctgcag
     3781 atcagccttg ccctctcctc tcagagatta cataaaagag tttctagtac actgcgcaaa
     3841 ccatgaacgt ggcgcaaacc ctcgcctgtc aacaccctga tcctattaga tgtcgatgta
     3901 cagatgataa cccacgcaaa aggcctctgg cttaataggt agtctttaag cacgaggagt
     3961 taagtgatgc atctgtagac tcagatttct atcatttgcc tacagtcacc acacacagca
     4021 gttggcagtg aaaataatta cttactctga aatgtcaaca gctcctcaga acagaaaaat
     4081 ataaatcaag ttgtttagat gaacaaatgt ggagttatca tttgctaata tgagaaatga
     4141 aatgttttaa ttgcaaaatg cacagcagat gaaagaccca gttttcaggg tattctgcaa
     4201 gaaccacaaa ttatctttca tgagcactgc agctcacgag gggcaattta caaacgcctc
     4261 acagattatt ttcagctgct tattactgcc atcctattca tagagtcccc tgtaagaacg
     4321 tccttccgcc agagcgccag actggaggag gcgctcaggg caaaaggcac gtgtagtgtt
     4381 gcttcagaga aagtcatctg aaatggcatg cttccattaa aagtagcgta accgtgtggt
     4441 gacaggcagg tgatttctgc tcctgcagag acctgagttc acagccactg cagctctctg
     4501 tagtgaagct caaaggagaa gggcatgtca gccatgtgat gctgagagtg aggcagtatg
     4561 tgagaagaaa gacctgctgt caaatcaaaa aagcttgcac aggtaaggtg gggacctcaa
     4621 agcccttgga aagacacttg tgcttaagac gataaaatgc cagtggataa aggagttatc
     4681 ttgttttgcc ttatgagaac agagacctga aaagagatcc acacctgagc atcctgcaga
     4741 aggctcctgg aagtcaaacc ccattgctga agttcactga gaactactga agacagaccc
     4801 cctctgcctc atactctgaa tattgaaagt ggctaaattg gtttctaaaa tattctatct
     4861 gtgctccata ttcatagtca tacactagtc attcaagacc tgtaacttcc cgtgcagatc
     4921 aggaagtcac tacttccaat gtccatttag attccctaca tgctactgtc agaaacctac
     4981 aagaccagac acctcaacct accaggcatc cctgaacaag atattcttca aaacttcagg
     5041 ggaccatccc atctcccccc tagtggattg attatttatt tatttattta tttaaatgct
     5101 taaattacaa tgaggtctca aagaaacctt tgtctcattc agaggaggcc ttataacttt
     5161 ctgacaggct ttcagattct tgacagggct attcacctct attcccattc caaagacact
     5221 gtctgttcag aatcctcgaa aagaataggc tgtcacctat agcctcacac atccattaag
     5281 cagacccaga aaacaaatcg agggagctag ggaaggccct gaagaccgtt ctgttgaggc
     5341 ctggaaaatg tcagcacagt tgccgttggt ctccttgtcc atcatgggca ttgctaacag
     5401 atcacagcat acttatcaac tgattccagg ccaggcctca gaagcctttc aaatctgttt
     5461 tccaggtgcc cataagagat caactagagt tgacataagg gattaaagtt atttgctacg
     5521 tcgatatagt tcagtgtctt tattttacag ctaggagcta gaagcatgga aaagggaaga
     5581 aacttgccaa aagtcacaca cagttcattg tgtgactgat aaatccagtt gcagaagcat
     5641 gcagttagca tgcataacac aaactaatcc cctattaccc tttgtccatt gtatagttag
     5701 ctgctctatc tagactatga catcattgta ctaatcactt agataaagac aattacagca
     5761 ctgccaacaa tcttcactgg gtgtggtgct ggctagtttt atgccagctt gacacaagct
     5821 agagtcattt ggaaagagga aacctcaaat gagaaaatgc cccaattagg atcggcctgt
     5881 gggcattttt cttaattcat gactaatgtg gaatgaccca gctcatggtg ggtggcatca
     5941 cccttgggaa ggtggccttg agttctataa gagaatgcca ctgtgagaga agccagtggt
     6001 ttctgcctca gttcctgcct ttaagttcct gtcctgactt attcatttat ttatttattt
     6061 tatgacagac tatgatgtgg atatgtaagc tgagattaac actttccacc ccaagttgct
     6121 tttggtcatg gtgttttatc acaacactag aaacctagcc aagacaaaca cccagcttgg
     6181 cgccaggcat cttctaagca cattaattaa ttttctatct accttctaat gaaaaccata
     6241 ggtgtctact gtcccattgc acatgagcct agaaagcaaa agtcctaagt tatcacacca
     6301 gtaaatgatc cagtagaaat tcacataaaa gttgtgatgg ctgattttat gtcaacagaa
     6361 cagaagctag gactatttga aatgagggaa gctcaactga gaaaaatcct ccatcagatc
     6421 cagctgtagg gcatttttct aattagtgat tgatgagggt gggcccagac cactgtaggt
     6481 ggtgccctct cttgactgat ggtcctggat tctataagaa agtagactga gcaatccagt
     6541 aatcagcaat tctcgccggc ctctgcatca gctccttcca ccaggttcct tctctgcctg
     6601 agttcctgtc ctgacttcct tcagtgatgg atagaagtgt ctgccaaaca aaccctttca
     6661 tctccagctt gcttttttgg tcatggtgtt tcctcacaac aatagaaact ctcactgaga
     6721 cacagtcttc cccgaaacct aggtgctttt tgagactgaa cacgtccttt ttgttgttgt
     6781 tgttgttatt ttgagttcct ggttttcaca tcagcacttc tggctagcat actaagtaac
     6841 aaaagaacag gctttgttgt aatgcacatg tgcatcactg caggttgctc agatgctgga
     6901 tgttgtctct gtgcttgccc tcccttgctc ttcagttttg tttttgctag ggtgactctc
     6961 tcagttctct agcttgtaaa tgtcagagga cccagagttc tccatccata ctctctctac
     7021 catggagggt ttgagctcat ccagacactg gttctgattc cagccagagc tgcccacctc
     7081 taccctcaac cccaagcccc tactgcacct cctcatttac tttaaaccaa agtacggtca
     7141 catcatacat ttttcatcaa agttcagtgt atatctttaa aggatagaga tgaatttgca
     7201 tcctcagatg acatgttgtt tcttctaaat gtaagaattc ctaattattt catttctagt
     7261 tgtttcaaat atgccctttt gattattttt gaaaaaggat attaaagtca ttccacct
//
