LOCUS       NM_178678               3852 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat transmembrane neuronal 3 (Lrrtm3),
            mRNA.
ACCESSION   NM_178678
VERSION     NM_178678.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Kim,J., Park,D., Seo,N.Y., Yoon,T.H., Kim,G.H., Lee,S.H., Seo,J.,
            Um,J.W., Lee,K.J. and Ko,J.
  TITLE     LRRTM3 regulates activity-dependent synchronization of synapse
            properties in topographically connected hippocampal neural circuits
  JOURNAL   Proc Natl Acad Sci U S A 119 (3) (2022)
   PUBMED   35022233
  REMARK    GeneRIF: LRRTM3 regulates activity-dependent synchronization of
            synapse properties in topographically connected hippocampal neural
            circuits.
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Ichinose,M., Suzuki,N., Wang,T., Kobayashi,H., Vrbanac,L., Ng,J.Q.,
            Wright,J.A., Lannagan,T.R.M., Gieniec,K.A., Lewis,M., Ando,R.,
            Enomoto,A., Koblar,S., Thomas,P., Worthley,D.L. and Woods,S.L.
  TITLE     The BMP antagonist gremlin 1 contributes to the development of
            cortical excitatory neurons, motor balance and fear responses
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34184027
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Um,J.W., Choi,T.Y., Kang,H., Cho,Y.S., Choii,G., Uvarov,P.,
            Park,D., Jeong,D., Jeon,S., Lee,D., Kim,H., Lee,S.H., Bae,Y.C.,
            Choi,S.Y., Airaksinen,M.S. and Ko,J.
  TITLE     LRRTM3 Regulates Excitatory Synapse Development through Alternative
            Splicing and Neurexin Binding
  JOURNAL   Cell Rep 14 (4), 808-822 (2016)
   PUBMED   26776509
  REMARK    GeneRIF: LRRTM3 is required for dentate gyrus excitatory synapse
            development and regulates activity-dependent AMPAR surface
            expression.
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Tomas-Roca,L., Perez-Aytes,A., Puelles,L. and Marin,F.
  TITLE     In silico identification of new candidate genes for hereditary
            congenital facial paresis
  JOURNAL   Int J Dev Neurosci 29 (4), 451-460 (2011)
   PUBMED   21345367
REFERENCE   7  (bases 1 to 3852)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 3852)
  AUTHORS   Haines,B.P. and Rigby,P.W.
  TITLE     Developmentally regulated expression of the LRRTM gene family
            during mid-gestation mouse embryogenesis
  JOURNAL   Gene Expr Patterns 7 (1-2), 23-29 (2007)
   PUBMED   16860615
REFERENCE   9  (bases 1 to 3852)
  AUTHORS   Majercak,J., Ray,W.J., Espeseth,A., Simon,A., Shi,X.P., Wolffe,C.,
            Getty,K., Marine,S., Stec,E., Ferrer,M., Strulovici,B., Bartz,S.,
            Gates,A., Xu,M., Huang,Q., Ma,L., Shughrue,P., Burchard,J.,
            Colussi,D., Pietrak,B., Kahana,J., Beher,D., Rosahl,T.,
            Shearman,M., Hazuda,D., Sachs,A.B., Koblan,K.S., Seabrook,G.R. and
            Stone,D.J.
  TITLE     LRRTM3 promotes processing of amyloid-precursor protein by BACE1
            and is a positional candidate gene for late-onset Alzheimer's
            disease
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17967-17972 (2006)
   PUBMED   17098871
REFERENCE   10 (bases 1 to 3852)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     A novel gene family encoding leucine-rich repeat transmembrane
            proteins differentially expressed in the nervous system
  JOURNAL   Genomics 81 (4), 411-421 (2003)
   PUBMED   12676565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC116138.21
            and AC158604.5.
            
            On May 2, 2007 this sequence version replaced NM_178678.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035882.1, AK035858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               AC116138.21        137716-138261       c
            547-2081            AC116138.21        135854-137388       c
            2082-3852           AC158604.5         36397-38167
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     gene            1..3852
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /note="leucine rich repeat transmembrane neuronal 3"
                     /db_xref="GeneID:216028"
                     /db_xref="MGI:MGI:2389177"
     exon            1..546
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             543..2291
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /note="leucine-rich repeat transmembrane neuronal protein
                     3"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 3 precursor"
                     /protein_id="NP_848793.1"
                     /db_xref="CCDS:CCDS35925.1"
                     /db_xref="GeneID:216028"
                     /db_xref="MGI:MGI:2389177"
                     /translation="MGFNVIRLLRGSAVAVVLAPTVLLTMLSSAERGCPKGCRCEGKM
                     VYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDE
                     NAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLL
                     SLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFS
                     KLNLALFPRLVSLQNLYMQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQC
                     VPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLRSFKGLR
                     ENTIICASPKELQGVNVIDAVKNYSICGKSTTTERFDLARALPKPTFKPKLPRPKHES
                     KPPLPPTVGATEPSPETDVDTEHISFHKIIAGSVALFLSVLVILLVMYVSWKRYPASM
                     KQLQQRSLMRRHRKKKRQSLKQMTPGTQEFYVDYKPTNTETSEMLLNGTGPCTYSKSG
                     SRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMESHLETELDLS
                     TITSAGRISDHKPQLA"
     exon            547..2081
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..3852
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2438..2443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /note="hexamer: GATAAA"
     polyA_site      3092
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaatgacag tctgcgggag tgagctgaga gtgtgcgcgg aacccggctc tcctgccttc
       61 tgggctccaa cgcagctccg aggctgaact gggtgctcac caccacgggt tcgccggact
      121 atggaataca gatgtggcag cacaggtagc cccacgttgc ctagaggaat acattatggg
      181 ttttgagaag aaattgtagg agccagtttt tttctttttt ttttaacaca cacacacaca
      241 cacacacaca cacacacact gtaaagatgc aaaaacgtaa tatccatgaa gatcctatta
      301 cctaggaaga ctcggatgtt ttgctgcgaa tgcggtgttg ggatttattt gttcttggag
      361 tgttctgcat ggctggtaaa gaataatgtt ccaaaatcgg tccatctccc aaggggtcca
      421 atttttcttc ctgggtgtca gcgagccctg actcactcca ctgcagctga caggggctgt
      481 catgcaggcg gcccctaagc caaagcaaaa gacctaagga cgacctttga acaatacaaa
      541 ggatgggttt caatgtaatt aggctactgc gaggatcagc tgtagcggtg gttctagcac
      601 ccactgtctt actgacaatg ctttcttctg ctgaacgagg atgccctaag ggttgtaggt
      661 gtgaaggcaa aatggtatac tgtgagtctc agaaactgca ggagataccc tcgagtatat
      721 ctgccggttg cttgggttta tcccttcgct acaacagcct ccaaaaactt aagtataatc
      781 aatttaaagg gctcaatcag ctcacctggc tctaccttga ccacaaccac atcagcaata
      841 tcgacgagaa tgctttcaat gggatacgca gactcaaaga gttgattctg agttccaaca
      901 gaatctccta tttccttaac aacaccttca gacctgtgac caatttacgg aacttggatc
      961 tgtcctacaa tcagctccat tctctgggat cggaacagtt ccggggcttg aggaagctgc
     1021 ttagtttaca cctccgctcc aactcactga gaaccatccc ggtgcggatc ttccaagact
     1081 gtcgcaacct ggaacttctg gacctgggat acaaccggat ccgaagttta gccaggaatg
     1141 tctttgctgg catgatcaga ctcaaagagc ttcacctgga gcacaatcaa ttttccaagc
     1201 tcaacctggc cctgttccca aggctggtga gccttcagaa cttgtacatg cagtggaata
     1261 aaatcagtgt catagggcaa accatgtcct ggacctggag ttccttacag aggctcgacc
     1321 tgtctggtaa tgagatcgaa gccttcagcg gacccagtgt cttccagtgt gttcccaatc
     1381 tgcaacgcct caacctggat tccaacaagc tcacatttat tggacaagag attctggatt
     1441 cttggatctc tctcaatgac atcagtctgg ctgggaatat atgggaatgc agcaggaata
     1501 tctgttccct ggtaaactgg ctgagaagtt ttaaaggtct gagagagaat acaatcatct
     1561 gcgccagtcc caaagagctg cagggggtta acgtgatcga tgcggtgaag aactacagca
     1621 tctgtgggaa gagcactacc acagagaggt ttgacctggc cagggccctc cccaagccca
     1681 catttaagcc caagctcccc aggccgaagc acgagagcaa gcctcctctg ccccccacgg
     1741 tgggagctac cgagcccagc ccagagacag atgtggacac ggagcacatc tccttccata
     1801 agatcatcgc gggcagcgtg gcccttttcc tgtcggtgct ggtcatcctc ctggtgatgt
     1861 acgtgtcctg gaagcggtac cccgcgagca tgaagcagct gcagcagcgc tccctcatgc
     1921 gaaggcaccg gaagaagaaa cggcaatcgc tcaagcagat gactccaggc acccaggaat
     1981 tttatgtaga ttataaaccc accaacacgg agaccagcga gatgctgctg aacggaacgg
     2041 gaccctgcac ctatagcaaa tcaggctcca gggaatgtga gataccttta tcaatgaatg
     2101 tgtcaacctt tctggcatat gaccagccca caataagtta ctgtggggtc catcatgaac
     2161 tcctctccca taagtccttt gaaacgaatg cacaggaaga cacgatggaa agccacctag
     2221 agactgagct ggacttgagc acaatcacgt cagctggccg catcagtgac cataaaccac
     2281 agctggcctg acagagctga gcagcgccca ggcttgctac tcaactataa cctcaaccgc
     2341 agaaagagga gaggacctgc tcattgcgac tcttgagtac aaaacaaaaa caaaactccc
     2401 ctgttcaaat aaacaaaatt ctaagattgg ttcatgaaat aaaagaagac atgaattgtt
     2461 tcaagtctat actttgtaac tagctaagtt gtgcagtatt tttttgactt tgacagagaa
     2521 tgaccctgaa acaaaataat catttttttt ccgaaactca tcctacctac ctgtaaaaaa
     2581 aaattgtaca gcgctaatgt atttttcata ttataaagtt tcaattctag gaacaactgg
     2641 tatgtacaga acagtaattt aatgatgctt ttacgttaca aactttacac ctttcagttt
     2701 ctaaaaattt taaattaaca aacattactt cttgtgttct tgagagttac ttggtttttg
     2761 taggggccgt tttgttactg catttgtgcc cagaaacctt gactctgaaa tctgtgctgt
     2821 gcggacaatg cacgattttt aatcattacc gtgcttactg catagggttt tatctacttg
     2881 ttccagagat aatacattaa ccaaaagaag gttttaattg ttcagacgtg tgagaggttc
     2941 ttcaattaca tagacaggtc tttcttataa atgaaaaaaa aaatcagatt tttttttaac
     3001 agttcttcta agactttaac tgttgccttg aagtacagcc tagtttctaa gtggtgaaat
     3061 gtaatgataa agagggatat tttaacaaaa tatttccgaa tgaatgactc attatttcat
     3121 tcttttgagt aaccattgtt aaaggtaggg gaaagcacgg accaagcatc actggaaaca
     3181 aaggtcgtaa ccacagcaac agacttctat acacttcaga ggtgcagcta aagtgacaaa
     3241 gaaaaacccc tgatacatct cccgttgtca ggccaaggtg ggaggatatg gcataattgt
     3301 acagtagcag ttttttctct taattaaccc aaagtggttt atctaaaaat aaccacgagt
     3361 cagttcaaac tctgtgtggt tcttaaggca agttttcatc tggaagttga aactatattt
     3421 ggggaacatc ttgtaagaaa aatagagatt ttttttttcc ttattgtgtg ccacatctaa
     3481 gaaagaactt tatacatccg gtcctttcag gatagatgtg ctggagccga gaaaagccac
     3541 tacggatcag acagagcaga ctgttccatt gtggatgttg ctgttgattt ggggatctag
     3601 ctacaaatta tccaaaacaa taaccaagag atgttggcca tcagtctaac tcacctattg
     3661 gttatgtgat tgtgtcgtca accgaattca aatcagataa agaaaacctg ttctttctgc
     3721 ccctaaaatg accacttgtt tctgtcatct atctgacagg ttattattga aaatatcaag
     3781 tttgttcatg gtaatcccac attccctttt ctgttttgtt ttgttttgtt tgtttttaat
     3841 gatcatttgg ac
//
