LOCUS       NP_848793                582 aa            linear   ROD 28-APR-2025
DEFINITION  leucine-rich repeat transmembrane neuronal protein 3 precursor [Mus
            musculus].
ACCESSION   NP_848793
VERSION     NP_848793.1
DBSOURCE    REFSEQ: accession NM_178678.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 582)
  AUTHORS   Kim,J., Park,D., Seo,N.Y., Yoon,T.H., Kim,G.H., Lee,S.H., Seo,J.,
            Um,J.W., Lee,K.J. and Ko,J.
  TITLE     LRRTM3 regulates activity-dependent synchronization of synapse
            properties in topographically connected hippocampal neural circuits
  JOURNAL   Proc Natl Acad Sci U S A 119 (3) (2022)
   PUBMED   35022233
  REMARK    GeneRIF: LRRTM3 regulates activity-dependent synchronization of
            synapse properties in topographically connected hippocampal neural
            circuits.
REFERENCE   2  (residues 1 to 582)
  AUTHORS   Ichinose,M., Suzuki,N., Wang,T., Kobayashi,H., Vrbanac,L., Ng,J.Q.,
            Wright,J.A., Lannagan,T.R.M., Gieniec,K.A., Lewis,M., Ando,R.,
            Enomoto,A., Koblar,S., Thomas,P., Worthley,D.L. and Woods,S.L.
  TITLE     The BMP antagonist gremlin 1 contributes to the development of
            cortical excitatory neurons, motor balance and fear responses
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34184027
REFERENCE   3  (residues 1 to 582)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 582)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (residues 1 to 582)
  AUTHORS   Um,J.W., Choi,T.Y., Kang,H., Cho,Y.S., Choii,G., Uvarov,P.,
            Park,D., Jeong,D., Jeon,S., Lee,D., Kim,H., Lee,S.H., Bae,Y.C.,
            Choi,S.Y., Airaksinen,M.S. and Ko,J.
  TITLE     LRRTM3 Regulates Excitatory Synapse Development through Alternative
            Splicing and Neurexin Binding
  JOURNAL   Cell Rep 14 (4), 808-822 (2016)
   PUBMED   26776509
  REMARK    GeneRIF: LRRTM3 is required for dentate gyrus excitatory synapse
            development and regulates activity-dependent AMPAR surface
            expression.
REFERENCE   6  (residues 1 to 582)
  AUTHORS   Tomas-Roca,L., Perez-Aytes,A., Puelles,L. and Marin,F.
  TITLE     In silico identification of new candidate genes for hereditary
            congenital facial paresis
  JOURNAL   Int J Dev Neurosci 29 (4), 451-460 (2011)
   PUBMED   21345367
REFERENCE   7  (residues 1 to 582)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (residues 1 to 582)
  AUTHORS   Haines,B.P. and Rigby,P.W.
  TITLE     Developmentally regulated expression of the LRRTM gene family
            during mid-gestation mouse embryogenesis
  JOURNAL   Gene Expr Patterns 7 (1-2), 23-29 (2007)
   PUBMED   16860615
REFERENCE   9  (residues 1 to 582)
  AUTHORS   Majercak,J., Ray,W.J., Espeseth,A., Simon,A., Shi,X.P., Wolffe,C.,
            Getty,K., Marine,S., Stec,E., Ferrer,M., Strulovici,B., Bartz,S.,
            Gates,A., Xu,M., Huang,Q., Ma,L., Shughrue,P., Burchard,J.,
            Colussi,D., Pietrak,B., Kahana,J., Beher,D., Rosahl,T.,
            Shearman,M., Hazuda,D., Sachs,A.B., Koblan,K.S., Seabrook,G.R. and
            Stone,D.J.
  TITLE     LRRTM3 promotes processing of amyloid-precursor protein by BACE1
            and is a positional candidate gene for late-onset Alzheimer's
            disease
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17967-17972 (2006)
   PUBMED   17098871
REFERENCE   10 (residues 1 to 582)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     A novel gene family encoding leucine-rich repeat transmembrane
            proteins differentially expressed in the nervous system
  JOURNAL   Genomics 81 (4), 411-421 (2003)
   PUBMED   12676565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC116138.21
            and AC158604.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035882.1, AK035858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..582
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 3 precursor"
                     /note="leucine-rich repeat transmembrane neuronal protein
                     3"
                     /calculated_mol_wt=63006
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3101
     mat_peptide     31..582
                     /product="Leucine-rich repeat transmembrane neuronal
                     protein 3. /id=PRO_0000018357"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
                     /calculated_mol_wt=63006
     Region          33..61
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          59..339
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          63..83
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          66..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          86..107
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          87..110
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..131
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          111..134
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          134..155
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          135..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          158..179
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          159..182
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..203
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          183..206
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          206..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          207..230
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          230..251
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          231..254
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          254..275
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          255..279
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          279..300
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          280..300
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            357
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Region          378..410
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     Site            421..441
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ81.2)"
     CDS             1..582
                     /gene="Lrrtm3"
                     /gene_synonym="9630044H04Rik"
                     /coded_by="NM_178678.4:543..2291"
                     /db_xref="CCDS:CCDS35925.1"
                     /db_xref="GeneID:216028"
                     /db_xref="MGI:MGI:2389177"
ORIGIN      
        1 mgfnvirllr gsavavvlap tvlltmlssa ergcpkgcrc egkmvycesq klqeipssis
       61 agclglslry nslqklkynq fkglnqltwl yldhnhisni denafngirr lkelilssnr
      121 isyflnntfr pvtnlrnldl synqlhslgs eqfrglrkll slhlrsnslr tipvrifqdc
      181 rnlelldlgy nrirslarnv fagmirlkel hlehnqfskl nlalfprlvs lqnlymqwnk
      241 isvigqtmsw twsslqrldl sgneieafsg psvfqcvpnl qrlnldsnkl tfigqeilds
      301 wislndisla gniwecsrni cslvnwlrsf kglrentiic aspkelqgvn vidavknysi
      361 cgksttterf dlaralpkpt fkpklprpkh eskpplpptv gatepspetd vdtehisfhk
      421 iiagsvalfl svlvillvmy vswkrypasm kqlqqrslmr rhrkkkrqsl kqmtpgtqef
      481 yvdykptnte tsemllngtg pctysksgsr eceiplsmnv stflaydqpt isycgvhhel
      541 lshksfetna qedtmeshle teldlstits agrisdhkpq la
//
