LOCUS       NM_178005               5673 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat transmembrane neuronal 2 (Lrrtm2),
            mRNA.
ACCESSION   NM_178005
VERSION     NM_178005.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5673)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5673)
  AUTHORS   Dhume,S.H., Connor,S.A., Mills,F., Tari,P.K., Au-Yeung,S.H.M.,
            Karimi,B., Oku,S., Roppongi,R.T., Kawabe,H., Bamji,S.X., Wang,Y.T.,
            Brose,N., Jackson,M.F., Craig,A.M. and Siddiqui,T.J.
  TITLE     Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing
            and mature hippocampal circuits
  JOURNAL   Elife 11, e64742 (2022)
   PUBMED   35662394
  REMARK    GeneRIF: Distinct but overlapping roles of LRRTM1 and LRRTM2 in
            developing and mature hippocampal circuits.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5673)
  AUTHORS   Chen,P., Liu,Z., Zhang,Q., Lin,D., Song,L., Liu,J., Jiao,H.F.,
            Lai,X., Zou,S., Wang,S., Zhou,T., Li,B.M., Zhu,L., Pan,B.X. and
            Fei,E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   4  (bases 1 to 5673)
  AUTHORS   Yamagata,A., Goto-Ito,S., Sato,Y., Shiroshima,T., Maeda,A.,
            Watanabe,M., Saitoh,T., Maenaka,K., Terada,T., Yoshida,T.,
            Uemura,T. and Fukai,S.
  TITLE     Structural insights into modulation and selectivity of
            transsynaptic neurexin-LRRTM interaction
  JOURNAL   Nat Commun 9 (1), 3964 (2018)
   PUBMED   30262834
  REMARK    GeneRIF: The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated
            interactions and overlaps with the Nrxn-neuroligin interface.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5673)
  AUTHORS   Bhouri,M., Morishita,W., Temkin,P., Goswami,D., Kawabe,H.,
            Brose,N., Sudhof,T.C., Craig,A.M., Siddiqui,T.J. and Malenka,R.
  TITLE     Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA
            receptor transmission and LTP in hippocampal CA1 pyramidal neurons
  JOURNAL   Proc Natl Acad Sci U S A 115 (23), E5382-E5389 (2018)
   PUBMED   29784826
  REMARK    GeneRIF: Genetic deletion of LRRTM1,2 in vivo in CA1 neurons using
            Cre recombinase-expressing lentiviruses dramatically impaired
            long-term potentiation (LTP), an impairment that was rescued by
            simultaneous expression of LRRTM2, but not LRRTM4.
REFERENCE   6  (bases 1 to 5673)
  AUTHORS   Tan,S.L., Nishi,M., Ohtsuka,T., Matsui,T., Takemoto,K.,
            Kamio-Miura,A., Aburatani,H., Shinkai,Y. and Kageyama,R.
  TITLE     Essential roles of the histone methyltransferase ESET in the
            epigenetic control of neural progenitor cells during development
  JOURNAL   Development 139 (20), 3806-3816 (2012)
   PUBMED   22991445
REFERENCE   7  (bases 1 to 5673)
  AUTHORS   Ko,J., Soler-Llavina,G.J., Fuccillo,M.V., Malenka,R.C. and
            Sudhof,T.C.
  TITLE     Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent
            synapse elimination in cultured neurons
  JOURNAL   J Cell Biol 194 (2), 323-334 (2011)
   PUBMED   21788371
  REMARK    GeneRIF: The LRRTM2 acts redundantly to maintain excitatory
            synapses and that synapse elimination caused by the absence of
            LRRTM2 is promoted by synaptic activity and mediated by a
            postsynaptic Ca(2+)/CaM-dependent signaling pathway.
REFERENCE   8  (bases 1 to 5673)
  AUTHORS   Haines,B.P. and Rigby,P.W.
  TITLE     Developmentally regulated expression of the LRRTM gene family
            during mid-gestation mouse embryogenesis
  JOURNAL   Gene Expr Patterns 7 (1-2), 23-29 (2007)
   PUBMED   16860615
REFERENCE   9  (bases 1 to 5673)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     A novel gene family encoding leucine-rich repeat transmembrane
            proteins differentially expressed in the nervous system
  JOURNAL   Genomics 81 (4), 411-421 (2003)
   PUBMED   12676565
REFERENCE   10 (bases 1 to 5673)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046774.1 and AC121874.2.
            
            On Aug 22, 2007 this sequence version replaced NM_178005.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122278.1, AK049920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1827              AK046774.1         2-1828
            1828-5673           AC121874.2         80923-84768
FEATURES             Location/Qualifiers
     source          1..5673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.94 cM"
     gene            1..5673
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /note="leucine rich repeat transmembrane neuronal 2"
                     /db_xref="GeneID:107065"
                     /db_xref="MGI:MGI:2389174"
     exon            1..432
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..1976
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /note="leucine-rich repeat transmembrane neuronal protein
                     2; leucine-rich repeat transmembrane neuronal 2 protein"
                     /codon_start=1
                     /product="leucine-rich repeat transmembrane neuronal
                     protein 2 precursor"
                     /protein_id="NP_821072.1"
                     /db_xref="CCDS:CCDS50251.1"
                     /db_xref="GeneID:107065"
                     /db_xref="MGI:MGI:2389174"
                     /translation="MGLHFKWPLGAPMLAAIYAMSVVLKMLPALGMACPPKCRCEKLL
                     FYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKE
                     DAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQ
                     TLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT
                     KINFAHFLRLSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTGNEIKAIDLTVFETM
                     PNLKILLMDNNKLNSLDSKILNSLKSLTTVGLSGNLWECSPRVCALASWLGSFQGRWE
                     HSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTEYTKISSSSYHVG
                     DKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPT
                     LRRIRQCSMIQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIIINGYGQCKCQQL
                     PYKECEV"
     exon            433..5673
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /note="hexamer: ATTAAA"
     polyA_site      2935
                     /gene="Lrrtm2"
                     /gene_synonym="C630011A14Rik; mKIAA0416"
                     /note="major polyA site"
ORIGIN      
        1 aaatccattc ttgtgccgtt tctcggaaaa gcttttcagt aaatgcactc atgctgctcc
       61 agaagctctt ctctgcaaca agccgcccat ctgccatcaa caagttaagg ctgagagaac
      121 taacagctgc gggaaggaaa gccgggagct ctgacgatcg gcagtaatca ggaggaggaa
      181 attattaact tataatcaaa gccggtttag gggatcagag cacagggaaa atgacaccag
      241 tgctttccag aggaatatcc taagggaaaa aacaattcac cctgatagac ttgaatttta
      301 cttgaaaagc ctggggcaca gaaaacagga aactggtcaa aggctcctgc atgttagagc
      361 cttttacaga ctcactgcgt tgagtctgac aacctcgact gaatgcagcc tccaatgtgc
      421 tcagaagaat gggcttacat ttcaagtggc cattaggggc ccctatgctg gcagcaatat
      481 atgcaatgag tgtggtatta aaaatgctgc ctgccctggg tatggcgtgt ccacctaaat
      541 gccgctgtga gaagctgcta ttctactgcg actctcaggg cttccactca gtgccaaacg
      601 ccacagacaa gggttctttg ggtctgtccc tgaggcacaa tcacatcaca gcgcttgaaa
      661 gagatcaatt tgccagcttc agtcaactca cctggctcca cttagatcac aatcaaattt
      721 ccacagtaaa agaagacgct ttccaaggac tgtataaact aaaggagtta atcttaagtt
      781 ccaacaaaat attctacttg ccaaacacaa cttttaccca actgattaat ctgcaaaatt
      841 tggacctgtc ttttaatcag ctgtcatctc tgcatcctga gctcttctat ggccttcgga
      901 agctgcagac cttgcattta cgttccaact ccctgcggac tatcccagta cgcctgttct
      961 gggactgtcg tagtctagag tttctggatc tgagcacaaa ccgtttgcga agtttggctc
     1021 gaaatggatt tgcaggatta atcaaactga gagagcttca tctagagcac aatcagctga
     1081 cgaagattaa ttttgctcac ttcctccggc taagcagtct gcacacactc ttcttacaat
     1141 ggaacaaaat cagcaacttg acgtgtggga tggactggac ctggagcact ttagaaaagc
     1201 tagacctaac tggaaatgaa atcaaagcca tcgacttgac agtgttcgag accatgccta
     1261 atcttaaaat acttctcatg gataacaaca agttaaacag tcttgattcc aaaatcttaa
     1321 actccctgaa atccctcacg accgttggcc tctctggcaa tctgtgggaa tgcagcccca
     1381 gagtgtgtgc tcttgcctcc tggctgggca gtttccaagg tcggtgggag cactccatcc
     1441 tatgccacag ccctgaccac acccaaggag aggatattct agatgcagtc cacgggtttc
     1501 agctctgctg gaatttatca accactgtca ctgccatggc tacaacttat agagatccaa
     1561 ccactgaata tacaaaaata agctcgtcga gttaccatgt aggagacaaa gaaattccaa
     1621 ctactgcagg catagcagtc actacagagg aacactttcc tgaacctgac aatgccatct
     1681 ttactcagag agtaattaca ggaacaatgg ctttattgtt ttctttcttt tttattattt
     1741 ttatagtgtt catttccagg aagtgctgcc ctcccacttt gagaagaatt aggcagtgct
     1801 caatgattca gaaccacagg cagctccgat cccaaacacg actccatatg tcaaacatgt
     1861 cagaccaagg accgtataat gagtatgaac ccacccatga aggacctttc atcatcatta
     1921 atggttatgg acagtgcaag tgtcagcagc tgccatacaa agaatgtgaa gtataatatc
     1981 tacccatcat caaaaatcac atcagataag taacctattt tacatagtag gggctaaata
     2041 catatctaat ttttaccaat ggtgacatta agcctaattt tccaaaccaa gtggagactt
     2101 gagtttttga agtgttaaag tatttttaat tttttaatga aaacatattt taagtgttaa
     2161 gtgaagcaat gctcacatta atttgcactc ttgttggaaa gtctaaatgc ttacttcaat
     2221 ataaaacatt tcatgtatgt aattatatac aactgtatgt aaacatttgc gctaaggtct
     2281 ccatatgttt tttggttttt ttttttactg aaaacagttc caaaagatgc tactaaacaa
     2341 atataggtag ggacaaaaac ctgtttgatt attattctcc atcctatgga ccacaactgg
     2401 cttcctactt aagaaggaga cagcaaagtt ctcttgtaag ataatgtggt atttactcaa
     2461 attataattt actgccagta taagaagtag acttacatgt gtgcttaaga ctggtaaata
     2521 ttaaacgtta ttctttcagt ttggcttggc ttaataaaca ttatctaagt tacatcatga
     2581 aaccagcacc ttttatataa ctctaataaa actgggtgac tctttaatat atttcaacaa
     2641 taaatccaag caattataaa aagatctcat tataataaat caatactaaa taactatgct
     2701 gacttcttat acaactctag tttgacttat aatggacatg ctgatttttg tggcatttag
     2761 cctattattt taaactagta ttaaattcca ttttactaat taacttacta aatcctctat
     2821 tatgtaaaaa tttgcatttg ggaaagagaa aaactgagtc aacttaacaa tcctgatata
     2881 ctccatccag tttgaaaata catcccctct catgattaaa gatgccttga caaactgttt
     2941 aagcctcttc cttctgcctt tttctgatct ttaaacttca aagatccaaa ttaaaaataa
     3001 ttggctacta aaggtgccta accctgattc ttgttatatt ataaaaaaca caaaaaaatt
     3061 actttcaaaa tatgatggta aagcttgccc tttaataaag atacgcattt atatgagtag
     3121 ctccttctga gacaggacca atttccgagg caaaccttaa ggcagaactc ctggcattgc
     3181 cctgccgtca cacagcagca agtgaaggca gagtgagtgt gaggggttaa gcccagggaa
     3241 agactttgag tgtggctctc aggttagtgg aagtaactag gcagcaaacg tgatcatgta
     3301 caatttgcac caaataagtg atgctcaggg atctgtatgg tgtggaagga gactctacag
     3361 tgtaaatacg aacactctaa tcacagtaac aattgataat gatgccacat ttttcatgaa
     3421 gaaccacaag tgttcaattc tgacttcttt aaggcaaatg atggcatact ggggaattag
     3481 actcaagtta ccaattcaca tagaattttt tttctacaaa gatggctcca catataggag
     3541 aaaacagaaa atcattactt tgatttcaga aaggaaaaga aaagaagcat ttttatgtgg
     3601 aaaaatatgt aagtccataa cgaaagtcac tactctaaca cagtatcctg cattcaagac
     3661 ttattctctc cccatgattg gactgaaaac gttactatag acctagattc aatcataatt
     3721 gttttccttt agcactgaaa aatataccca catttcaaat ctcttaacaa aaagaagata
     3781 atagtcaggc ttcagtgaaa tatgctcttt gtatttctta tgctgggtga tcagtctagc
     3841 aaagcctcag agcatcccgg ttcggctgat cttgagtggc aagcattccc tctcctgata
     3901 cagcagaagc tcggttcgtc tgagctgaga cagatgctgg ctttccagca cagagcacag
     3961 cacactgctt ccccaccgag gagctgcatc agaagcccta ttacaaatga gctccgtggt
     4021 ctaggattta acaactcatt tatcatggtg accactgccg tttgccaggt gatggacagc
     4081 ttgttcacaa ttcagttttg agcatgcaag aagactccat cggccctaaa cgatgagtgg
     4141 ttttcatcat ttcaaatcac aagcaaaatt aatttaaact gtgaattaaa aagtaagaaa
     4201 tagtaactag gagctccaat taatcctaaa gaattagtaa agtggactgt aagtagcaga
     4261 gcaagccact tagcatccga gggagaacag tgccaagagc catcaaggca aactactagg
     4321 gaggggggag gggcatattt tttcctccta catttttggt aatggtagtg ccaaccaggt
     4381 attttccttt ctcagttaaa gcacagattg ccatttctaa ctgcctacag aaaacaaggc
     4441 tgcatttagt tgatatgtat ttgtattgca gtatctgtgc taccaactgg ccagagtagc
     4501 aaaaccatat atggttccta gtcataaaag tgagggcttt gggtggggtt ttatctctta
     4561 agcattacca ctcaactttc cctctccccc attttaaaat ctagtgaaaa atcagaaaat
     4621 aatttctcag aaaaatgaaa tgtagctagg aatttaaaat tagtttgcaa ctacagttac
     4681 ttatttttgt agcctacagg gaattcaagc ttacctttct aaaaagagtg ggctggtaaa
     4741 tctttaaata aaaaaaaaaa aatcacacaa aactcatatt actggcatca aaaaacaaac
     4801 actattttta agccaaaaaa aattgtatta ccacatgtaa tttcttaatg agtcaaagtt
     4861 aatttctgta ctaattcaat gaatggaatt gactaaactt cctaattcca cactaattat
     4921 taaaacccat ctgcttatta taatgctagt caccaaaagc taaactccat ctttccagta
     4981 aaagcaagct ctatgtagca ctagtctgaa ttctgagata tcaaagtttt attattttct
     5041 taagtcatac tttctacaca tagctatgta agggtggagc taaaaatttc ccctctctct
     5101 attatatata tatatataaa taaatagata atttttagga ctattttaac agttaaatta
     5161 catgataatt ttcctaatac agcaatccag taacagcact atctcaagta tgttttggac
     5221 ataattttca tatattctca gttaaaatgc ttgaatcaga aaagatgttt ttaaaatgat
     5281 aatatgggcc atctatagat aagcatttct ttggctatcc tggggcaaac tcatagcgcc
     5341 cgaataaggc caaaaccaga aaacgaccat tcaccctttc attctgccat tgcagacatt
     5401 tggaaacatc tccaacttct tgaactaatc ttttcttcct tcagttttaa aatcagtatg
     5461 atacatggaa tatttggtga acctgtgaac actgagactg caaactcaaa gaacagtcca
     5521 aacacatttg ttcaattacc ttttagagcc atggggggag ggttgttggg ggataggaag
     5581 aaaatactat tatacaagga attgggttgg tgggactata gtacagtgta cagaaaagtt
     5641 ttgttattaa aattgtgtat actgtaaaaa aaa
//
