LOCUS       NM_177303               3475 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat neuronal 4 (Lrrn4), mRNA.
ACCESSION   NM_177303
VERSION     NM_177303.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3475)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3475)
  AUTHORS   Nishino,J., Kim,S., Zhu,Y., Zhu,H. and Morrison,S.J.
  TITLE     A network of heterochronic genes including Imp1 regulates temporal
            changes in stem cell properties
  JOURNAL   Elife 2, e00924 (2013)
   PUBMED   24192035
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3475)
  AUTHORS   Bando,T., Morikawa,Y., Hisaoka,T., Komori,T., Miyajima,A. and
            Senba,E.
  TITLE     Dynamic expression pattern of leucine-rich repeat neuronal protein
            4 in the mouse dorsal root ganglia during development
  JOURNAL   Neurosci Lett 548, 73-78 (2013)
   PUBMED   23701859
  REMARK    GeneRIF: The spatiotemporal expression pattern of Lrrn4 contributes
            to the development of synaptic function in the DRG neurons.
REFERENCE   4  (bases 1 to 3475)
  AUTHORS   Bando,T., Morikawa,Y., Hisaoka,T., Komori,T., Miyajima,A. and
            Senba,E.
  TITLE     Expression pattern of leucine-rich repeat neuronal protein 4 in
            adult mouse dorsal root ganglia
  JOURNAL   Neurosci Lett 531 (1), 24-29 (2012)
   PUBMED   23069668
  REMARK    GeneRIF: Lrrn4 is expressed in a subset of nociceptive neurons and
            might contribute to the maintenance of nociceptive circuits.
REFERENCE   5  (bases 1 to 3475)
  AUTHORS   Bando,T., Sekine,K., Kobayashi,S., Watabe,A.M., Rump,A., Tanaka,M.,
            Suda,Y., Kato,S., Morikawa,Y., Manabe,T. and Miyajima,A.
  TITLE     Neuronal leucine-rich repeat protein 4 functions in
            hippocampus-dependent long-lasting memory
  JOURNAL   Mol Cell Biol 25 (10), 4166-4175 (2005)
   PUBMED   15870286
  REMARK    GeneRIF: results suggest that NLRR4 plays a key role in
            hippocampus-dependent long-lasting memory
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK080889.1.
            
            On Apr 5, 2007 this sequence version replaced NM_177303.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080889.1, AY325108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3475              AK080889.1         2-3476
FEATURES             Location/Qualifiers
     source          1..3475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.78 cM"
     gene            1..3475
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="leucine rich repeat neuronal 4"
                     /db_xref="GeneID:320974"
                     /db_xref="MGI:MGI:2445154"
     exon            1..69
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /inference="alignment:Splign:2.1.0"
     exon            70..750
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2291
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="leucine-rich repeat neuronal protein 4; neuronal
                     leucine rich repeat-4; NLRR-4; neuronal leucine-rich
                     repeat protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 4
                     precursor"
                     /protein_id="NP_796277.2"
                     /db_xref="CCDS:CCDS16780.1"
                     /db_xref="GeneID:320974"
                     /db_xref="MGI:MGI:2445154"
                     /translation="MRWTLMLQLLQLLLQLLMAQSQSLERISQDRIPLFRLTQQGDWD
                     SLDRHPTDSLCVGLPAAGVTTLNLANRSLESLPSCLPRTLRSLDGSHNLLRALSEPVL
                     GRLPELRVLTLHHNRISVLHWGRDTLAELRELDLSHNLLTELPPCAGPSGSSLRSLAL
                     AGNPLRALLPRTFACFPALRLLNLSCSELGHIAQEAFAGVDGGPLAALELLDLSGTSL
                     ERVESGWIRNLPKLKSLFLRKMPRLKTLEGDIFKMTPNLRQLDCGDSPALTSVHTEIF
                     QDTPNLQVLQFQNCNLSSFGPWNSSQVLSVSLFGNPLICSCELAWLLVDVNKTVLHRA
                     ADTMCEPALGSTGPFSGPLSLSHLSNVCRSDQSTTLLPSNPGRFDHSVFAPRIQGPSI
                     EQSTALSAQPGGSQQNITKVPSLTMTSPTQGSWMYKDASEETAQSTNSELVYSPSRAL
                     PGAASSGAEQTATHILEPNISSASTPLVSKYLEPLPTSPNPRSLPQTKQRTQATPRAL
                     HTDPPQDEIPVLLLDDDSEEEETRDQVAAPPQDVSCEYHPCKHLQTPCAELQRRFRCR
                     CPGLSGEDTTPDPPTLQGVSEVTDTSVLVHWCAPNSVVLWYQIHYVAEGRSGNQSVVD
                     IYATARQHPLYKLTPGTTYHVCVLAANRAGLSQSQTSGWRRSCATFTTKPSSVVIFWG
                     LCTASGLLLVSTLVLSVCLWRQRWKPHRQFYDTHLVAFKNPARAEEVTQWE"
     exon            751..955
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1087
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..3475
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="hexamer: ATTAAA"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="hexamer: AACAAA"
     polyA_site      2406
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="major polyA site"
     polyA_site      2424
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="major polyA site"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="hexamer: TATAAA"
     polyA_site      3070
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
     regulatory      3277..3282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="hexamer: AATATA"
     polyA_site      3301
                     /gene="Lrrn4"
                     /gene_synonym="B430119L13Rik; Nlrr4"
                     /note="major polyA site"
ORIGIN      
        1 ggttcctaca gtattccaaa gactgaggac ctaaaagggc gcgccacatc ccactgggac
       61 agctgcctgt ctttccctag agacttgaca tgcggtggac gctgatgctg cagctgctgc
      121 agctcctgct acaactgctg atggcgcaga gccagagcct ggaaaggatc tcccaggacc
      181 ggatccccct cttccgactc actcagcagg gagactggga cagcctcgac cgccacccta
      241 ccgactctct ctgtgtagga ctccccgccg cgggagtcac cactctgaac ttggcgaacc
      301 gcagcctgga gagcctgcct agctgcctgc cgcgcacgct gcgcagcctc gatggcagcc
      361 acaacctgct gcgcgccctt agcgagcctg tgctcggccg cctgcccgag ctgcgcgtac
      421 tcacgctgca ccacaaccgc atctccgtgc tacactgggg ccgtgacacg ctggccgagc
      481 tgcgtgagct cgacctcagt cacaacctgc tgaccgagct gccgccctgc gcggggccct
      541 cggggagcag cctgcgctcg ctggcgctgg ccgggaaccc actgcgagcg ctgctgccac
      601 ggacctttgc atgcttccca gcgctgcggc ttctcaacct ctcctgcagc gagctgggcc
      661 acatcgccca ggaggcattc gcgggggtgg acggtgggcc cctggcggca ctggagctct
      721 tggatctgag cggcacgagc ctagaaagag ttgagtctgg gtggatcaga aacctgccaa
      781 agctcaagtc cctcttcctg agaaagatgc ccaggctgaa gacactggag ggagacattt
      841 tcaagatgac tcccaacctg cggcagctgg attgtggaga ctctccagca cttacttctg
      901 ttcacacaga gatctttcaa gacacaccca atctacaagt ccttcagttt cagaactgca
      961 acttgagttc ctttggtcct tggaattcct cccaggtctt gtccgtcagt ctctttggca
     1021 accctctcat ttgcagctgt gagctggctt ggcttctcgt ggatgtcaac aaaactgtct
     1081 tacacagggc agctgatacc atgtgtgagc ctgctttagg atccacgggc cccttctcag
     1141 gccctctctc cctctcccac ctgtctaatg tgtgcaggtc agaccaaagc accaccctcc
     1201 tgccttcaaa cccaggccgc ttcgatcatt cagtttttgc accacggata caggggcctt
     1261 ccattgaaca gagcacggcc ttgtctgctc agcctggagg aagccaacaa aatatcacca
     1321 aggtcccttc cctcaccatg acttccccca cacaaggatc atggatgtat aaagatgctt
     1381 cagaggaaac tgcccagtcc actaactctg agctagttta tagtccttcc agggctctgc
     1441 ctggtgctgc cagttctggg gcagagcaga ctgccacaca tatccttgag cctaatattt
     1501 catctgcctc taccccatta gtcagcaagt accttgaacc cttgcctact tcaccaaacc
     1561 ccaggagctt acctcagacc aagcagagga cacaagccac gcccagggct ctccacacag
     1621 accctccaca ggatgagatt ccagttttgc tgttagatga tgacagcgag gaggaggaga
     1681 ctcgggacca ggtggcggca cctccccagg acgtctcttg tgaataccac ccctgcaagc
     1741 atctgcagac cccgtgcgca gagctgcaga ggcgcttcag atgccgttgc cctggtctca
     1801 gtggggagga taccactcca gaccctccca cgctgcaggg ggtgtcagag gtgactgaca
     1861 catcagtgct cgtccactgg tgtgccccca actcagtggt gctctggtat cagatccact
     1921 atgtggcaga aggacgatct gggaatcaat ccgtagtgga catctatgct actgccaggc
     1981 agcaccccct gtacaagctg acacctggca ccacctacca tgtgtgtgta ctggcagcca
     2041 acagggctgg cctgagccag tcacagacct caggctggag gaggtcatgt gccactttca
     2101 caaccaagcc cagctctgtg gtcatcttct ggggactgtg taccgccagt ggcctgttac
     2161 tggttagcac cctggtgctg tctgtgtgtc tctggaggca gcgctggaag ccacacaggc
     2221 agttctacga cacacacctg gtggccttca aaaacccagc cagagctgag gaagtaactc
     2281 agtgggagtg acttcctagc ctgtacaagg ccttgggttt atccccaaca tccaaatcag
     2341 acacatttga ggccttgatt ttccttccag caaccagatt aaacaaacca gccttggcca
     2401 cctgcagagg ctccagaact tcaattatcc ccgtgtctcc tatttgaaat acatctgcat
     2461 gcagaaacat gctgatgcct aaggacaaca tgagcttcaa attccctgaa gccaccatgt
     2521 ctcaggctca cacagaacta cactgtgtcc tcctctgttg aaggaatgag tgtatcaccc
     2581 ttcctcctat agttgttctc actacgcctg tcttactagc tcctgtcatt ctgtgacatc
     2641 ctttacattg gtcagtactc cgtatatccc tcagtaccaa gtgagatact acactgaagg
     2701 agatgggata acaaagcagt tgtaagaagg aacaactcct ttagaaatgc catctctaag
     2761 tttcttgcat ggacgttccc ttgtggcccg attttagcac aatgagttct gttggccttg
     2821 agctgatagc caaggtaaga gctattgttg gtttgctaag gccttctgga ttcttacttg
     2881 tatttcaggg tgtgtcaaaa catgtatttc cagagttaca gttaaaactg gccttctggt
     2941 aacatttgtg agacacaggc aatttgcttc caagtctttc tgtatttcac ccatgttggt
     3001 ctcaacttag atccttctgc ctctgtcttt ccaaatggtg ggattataaa catttggagc
     3061 ggaggcaaaa ttgaactcac aacagtgctt atttctattg taaggaaaag ttgtttgaat
     3121 tcatctctca tcttcaaaac aggctgtagc acaaacacca tgctgcagac agcaagttta
     3181 tcaaagctga acctgaatat gaatcacact atacatttct aagtgggtta tccaagcatg
     3241 ttttcaacat tctaaactgt atccttattc tcatcaaata tatgcccagg agaatttgaa
     3301 agatctctct aaatcccact ttaaaactta caaaggcagt ggagtgggag tgggtggggg
     3361 agcaccctca tagaggcaac ggggagcggg ggagagggca gatgtgggat gggaatttgt
     3421 ggaagaggaa ccaggaagag ggatatcatt tgagaagtaa acgaatggaa tgatt
//
