LOCUS       NM_010733               3544 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus leucine rich repeat protein 3, neuronal (Lrrn3),
            transcript variant 2, mRNA.
ACCESSION   NM_010733
VERSION     NM_010733.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3544)
  AUTHORS   Haines,B.P., Gupta,R., Jones,C.M., Summerbell,D. and Rigby,P.W.
  TITLE     The NLRR gene family and mouse development: Modified differential
            display PCR identifies NLRR-1 as a gene expressed in early somitic
            myoblasts
  JOURNAL   Dev Biol 281 (2), 145-159 (2005)
   PUBMED   15893969
  REMARK    GeneRIF: Analysis of NLRR-3 expression revealed regulated
            expression in the neural system in developing ganglia and motor
            neurons.
REFERENCE   7  (bases 1 to 3544)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   8  (bases 1 to 3544)
  AUTHORS   Aruga,J.
  TITLE     Slitrk6 expression profile in the mouse embryo and its relationship
            to that of Nlrr3
  JOURNAL   Gene Expr Patterns 3 (6), 727-733 (2003)
   PUBMED   14643680
REFERENCE   9  (bases 1 to 3544)
  AUTHORS   Fukamachi,K., Matsuoka,Y., Kitanaka,C., Kuchino,Y. and Tsuda,H.
  TITLE     Rat neuronal leucine-rich repeat protein-3: cloning and regulation
            of the gene expression
  JOURNAL   Biochem Biophys Res Commun 287 (1), 257-263 (2001)
   PUBMED   11549284
REFERENCE   10 (bases 1 to 3544)
  AUTHORS   Taniguchi,H., Tohyama,M. and Takagi,T.
  TITLE     Cloning and expression of a novel gene for a protein with
            leucine-rich repeats in the developing mouse nervous system
  JOURNAL   Brain Res Mol Brain Res 36 (1), 45-52 (1996)
   PUBMED   9011764
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167364.3 and BC069041.1.
            
            On Nov 9, 2012 this sequence version replaced NM_010733.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069041.1, D49802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC167364.3         166596-166901       c
            307-3544            BC069041.1         1-3238
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.94 cM"
     gene            1..3544
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /note="leucine rich repeat protein 3, neuronal"
                     /db_xref="GeneID:16981"
                     /db_xref="MGI:MGI:106036"
     exon            1..487
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            488..3491
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             843..2966
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /note="leucine-rich repeat neuronal protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 3
                     precursor"
                     /protein_id="NP_034863.1"
                     /db_xref="CCDS:CCDS25896.1"
                     /db_xref="GeneID:16981"
                     /db_xref="MGI:MGI:106036"
                     /translation="MKDTPLQVHVLLGLAITTLVQAIDKKVDCPQLCTCEIRPWFTPR
                     SIYMEASTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQN
                     NLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSTISPGAF
                     IGLHNLLRLHLNSNRLQMINSQWFDALPNLEILMLGDNPIIRIKDMNFQPLVKLRSLV
                     IAGINLTEIPDDALAGLENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNPINRIR
                     RGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLP
                     KLESLMLNTNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPD
                     SLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSDLDVEADSYVSLHCRATAEP
                     QPEIYWITPSGKKLLPNTMREKFYVHSEGTLEIRGITPKEGGLYTCIATNLVGADLKS
                     IMIKVGGSVPQDNNGSLNIKIRDIRANSVLVSWKASSKILKSSVKWTAFVKTEDSHAA
                     QSARIPFDVKVYNLTHLKPSTEYKICIDIPTVYQKSRKQCVNVTTKSLEHDGKEYGKN
                     HTVFVACVGGLLGIIGVMCLFSCVSQEGSSEGEHSYAVNHCHKPALAFSELYPPLINL
                     WESSKEKRATLEVKATAIGVPTNMS"
     regulatory      3418..3423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /note="hexamer: AATACA"
     polyA_site      3440
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
     regulatory      3467..3472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /note="hexamer: AATAAA"
     polyA_site      3489
                     /gene="Lrrn3"
                     /gene_synonym="NLRR-3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagctg cgagtgctac atcttggcag tctgaagcga ttggctcctc tctggggagt
       61 ggagggtgtt cagttattaa tgaccgctga gcaggcagca ccgtgtcagt gtgacaactg
      121 atctggtgaa cgatgcacca ctaaccacca tggaaacgag gagaaataac gccagctagc
      181 aggatctctc ttcacgggat tgagaggctc agcctgctgc tgccggagag agttccagtc
      241 aaaagaagga atcctagctg caggctcctg ccttccttta tattttagaa aaagagagag
      301 agagaaagag agacaccatt gcttgcatgt gtgcatatct atagtatgta attgtgtgta
      361 ctttattaca catacatatg cacctattta tactggggca agaagacagc catgtgatta
      421 tttcagccaa ggaactgagc aagcaggggc accggaggag ggctatccct gcatctgcta
      481 aggcaagaat aatgcctcta catctgcaag tctgaacaag catgggattt gaatcacaga
      541 gttccaaata aatgaattgc tccatatcct gtgaccatct atacatacac catcttcaaa
      601 gagaccatca agaccctatc tctgaggaga cggcaagcat ctttcctcca cgatgcatgc
      661 aattttgggg aaatatatgt gtggctctcc taagtatttc catgaaggaa acacccacaa
      721 tcctgtggtg ttcatctttt gacaaatgca aatacttccc tcatcagtca gctcctactg
      781 aacttactgg ctgtgactgg aatccttaag ggcctgttaa ctttctgaag acaaaagcta
      841 agatgaagga cacgccactc caagtccatg tgctacttgg cctagctatc actacactag
      901 tacaagctat agataaaaaa gtggattgcc cccaattatg tacctgtgag atcaggcctt
      961 ggtttacccc gagatccatc tatatggaag catcgacagt ggactgtaat gatttagggc
     1021 ttttaaactt cccagccaga ttgcctgccg acacacagat tctgctccta cagactaaca
     1081 atattgcaag aattgaacat tccacagact tcccagtgaa cctgactggc ctggacttat
     1141 ctcaaaacaa tttatcttca gtcactaata ttaatgtaca aaagatgtct cagcttcttt
     1201 ctgtgtacct agaggaaaac aagctaactg agctgccgga aaagtgtcta tatggactga
     1261 gcaacttgca ggaactctac gttaatcaca acctgctctc taccatttct cccggagcct
     1321 tcattggcct acataatctt ctccggcttc atctcaactc aaacagactg cagatgatca
     1381 acagtcaatg gtttgatgct cttcccaatc tcgagattct gatgcttggg gacaacccca
     1441 tcatcaggat caaggacatg aactttcagc ctcttgtcaa gcttcgcagc ctggttatag
     1501 ctggcataaa cctcacggaa ataccagacg acgccttggc tggcctggag aacctagaaa
     1561 gcatctcctt ttatgataac aggctcagta aggttcccca ggttgcactt caaaaagccg
     1621 ttaacctcaa gtttttggat ctaaataaaa atcctattaa cagaatacgg aggggtgatt
     1681 ttagcaatat gctacatttg aaggaattgg ggataaacaa tatgcctgaa cttgtctcca
     1741 ttgacagtct cgctgtggat aacttgccag atttgagaaa aatagaagct actaacaacc
     1801 ccagattgtc ttacattcac cctaatgcat ttttcagact cccaaagcta gaatctctca
     1861 tgctgaacac caacgccctc agtgccctct accacggcac catagagtct ttgccgaacc
     1921 tcaaggaaat cagcatacat agcaatccca tccgttgcga ctgtgtaatc cgctggatta
     1981 acatgaacaa aaccaacatt cggtttatgg aaccagactc gctgttctgt gtggacccac
     2041 ctgaattcca aggccagaat gttcggcaag tgcatttcag ggatatgatg gaaatttgcc
     2101 tccctcttat agctcctgag agctttcctt ctgacctgga tgtagaagct gacagctatg
     2161 tgtcgcttca ctgcagagct actgcagaac cccagccaga aatctactgg atcacacctt
     2221 ctggtaaaaa actattgcca aatacaatga gagagaagtt ctatgttcat tctgaaggca
     2281 cactagagat aagaggcata accccaaagg aaggggggtt gtacacctgc atagcaacta
     2341 acctagtcgg tgctgatttg aagtcgatta tgatcaaagt gggaggttct gttcctcagg
     2401 ataataatgg gtcattgaat attaaaataa gagatatcag ggccaattct gttctggtgt
     2461 cctggaaagc gagctctaaa atcctcaaat ccagcgttaa gtggacagcc tttgtcaaga
     2521 ctgaagactc tcatgctgcc caaagtgctc gaataccatt tgatgtcaag gtatataatc
     2581 ttactcatct gaaaccatct accgagtaca aaatttgtat tgatattccc accgtctatc
     2641 agaaaagcag aaaacaatgt gtgaatgtca ccacaaaaag tctggagcat gacggaaaag
     2701 aatatggaaa gaatcataca gtatttgtgg cctgtgttgg aggccttcta gggatcattg
     2761 gtgtaatgtg tcttttcagc tgtgtctcac aagaagggag cagtgagggt gagcacagct
     2821 atgctgtgaa tcactgtcac aagccagcct tggctttcag tgagctttac cctcctctaa
     2881 tcaacctctg ggagtccagc aaagaaaaac gggcaacact ggaagtaaaa gcaacggcta
     2941 taggagtgcc gacaaatatg tcctaaaaac aaccaaccaa acctacttca aagaaaagct
     3001 ggaaacggca gtactgctta aaaatcaaca acaaaaaata ggcaggggaa tgtcactttc
     3061 tgaaaagaag gctcagtgtc gccaatgctg ctcctgacca agggagaggt gaaagttcgg
     3121 cattttaatt gactggcttc aaagggtact gtggcaacca aataaaacaa ttccattttc
     3181 tagaactttc atgtaacttt tatgtcagga ctgcagttaa acgtgaacat ttctgtattt
     3241 tttttaagta tagaagagta gttgaactga gcaatacctc ctcctgtgtt gtattacaca
     3301 tattagccac gagtttttgc agtgaccaga taaacttgaa ttgacacgtg gtgtaatgga
     3361 aaggacaaat tctgtagagt agacacagtg agtatgtgga cctcttttat aaggaaaaat
     3421 acattttgga ttaaaatcaa ttgcttttgt cttgtttttg tttctaaata aagaataatt
     3481 tctgggaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3541 aaaa
//
